WO1999058454A1 - Method for preventing replication in cryptosporidium parvum using ultraviolet light - Google Patents

Method for preventing replication in cryptosporidium parvum using ultraviolet light Download PDF

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Publication number
WO1999058454A1
WO1999058454A1 PCT/US1999/009800 US9909800W WO9958454A1 WO 1999058454 A1 WO1999058454 A1 WO 1999058454A1 US 9909800 W US9909800 W US 9909800W WO 9958454 A1 WO9958454 A1 WO 9958454A1
Authority
WO
WIPO (PCT)
Prior art keywords
ultraviolet light
cryptosporidium parvum
test
cryptosporidium
oocysts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/009800
Other languages
English (en)
French (fr)
Inventor
James R. Bolton
R. D. Samuel Stevens
Bertrand Dussert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Calgon Carbon Corp
Original Assignee
Calgon Carbon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22141995&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1999058454(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to IL13955699A priority Critical patent/IL139556A0/xx
Priority to DK99921674.0T priority patent/DK1084080T4/da
Priority to AT99921674T priority patent/ATE303346T1/de
Priority to BR9911778-9A priority patent/BR9911778A/pt
Priority to AU38819/99A priority patent/AU745173C/en
Priority to KR1020007012689A priority patent/KR20010071249A/ko
Priority to DE69927020T priority patent/DE69927020T3/de
Priority to EP99921674A priority patent/EP1084080B2/en
Priority to NZ508008A priority patent/NZ508008A/xx
Application filed by Calgon Carbon Corp filed Critical Calgon Carbon Corp
Priority to ES99921674T priority patent/ES2244193T5/es
Priority to CA002331525A priority patent/CA2331525C/en
Priority to JP2000548264A priority patent/JP2002514504A/ja
Publication of WO1999058454A1 publication Critical patent/WO1999058454A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/30—Treatment of water, waste water, or sewage by irradiation
    • C02F1/32—Treatment of water, waste water, or sewage by irradiation with ultraviolet light
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F2201/00—Apparatus for treatment of water, waste water or sewage
    • C02F2201/32—Details relating to UV-irradiation devices
    • C02F2201/326—Lamp control systems

Definitions

  • the present invention relates to a method for preventing the replication of Cryptosporidium Parvum in water and in particular to a method for the prevention of cryptosporidium oocyst and similar organism infections in water using low levels of ultraviolet light.
  • UV ultraviolet
  • Snowball and coworkers (UK Patent Application #9416287.2, 08 Nov., 1984; Wat. Res., 1995, 29, 2583-2586) developed an apparatus that first filtered out Cryptosporidium oocysts and then exposed them to UV doses of 350 - 400 mJ/cm 2 .
  • the patent teaches the use of membrane filters to trap Crysptosporidium oocysts which is then irradiated with a bank of low pressure Hg lamps for a UV dose of 350-400 mJ/cm 2 .
  • the filter is then backwashed onto a second filter and the irradiation is repeated.
  • the patent discloses that the treatment "kills" the organisms.
  • the method of the present invention prevents replication (cell mitosis) by cross-linking the DNA to prevent infection.
  • the UN doses required to prevent replication are orders of magnitude lower than required to "kill” or “inactivate” the oocysts. This means that the cost of UV treatment to prevent infection by Cryptosporidium oocysts will be markedly lower.
  • UV ultraviolet light
  • the present invention utililzes a broadband (200 - 300 nm) medium pressure UV lamp to achieve the prevention.
  • the dose required can be as low as 10 mJ/cm 2 .
  • Doses overr 30 mJ/cm 2 provide more than 4.5 logs removal measured by mouse infectivity.
  • the dose levels are significantly lower than used before resulting in significantly lower power levels needed to achieve the results.
  • the method provides a substantial increase in the cost effectiveness of UV reduction in cryptosporidium oocysts infection in drinking water.
  • Other advantages will become apparent from a perusal of the following detailed description of a presently preferred embodiment of the invention.
  • Figure 1 is a chart showing the difference between the infectivity assay and the in vitro (excystation and vital dyes) assays, and
  • Figure 2 is a chart that shows the correlation between bench scale and pilot tests.
  • the UV does were calculated from the average irradiance (determined from a sophisticated mathematical model of the reactor) times the residence time in the reactor (about 8.3 s). The dose was varied by turning one or two lamps on and at low or high power.
  • Inocula delivered 50 500 5,000 per mouse
  • Inocula delivered 1,000 10,000 100,000 per mouse
  • Inocula delivered 1,000 10,000 100,000 per mouse
  • Inocula delivered 1,000 10,000 100,000 per mouse

Landscapes

  • Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hydrology & Water Resources (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental & Geological Engineering (AREA)
  • Water Supply & Treatment (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physical Water Treatments (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Photometry And Measurement Of Optical Pulse Characteristics (AREA)
  • Radiation-Therapy Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Luminescent Compositions (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PCT/US1999/009800 1998-05-13 1999-05-05 Method for preventing replication in cryptosporidium parvum using ultraviolet light Ceased WO1999058454A1 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
JP2000548264A JP2002514504A (ja) 1998-05-13 1999-05-05 紫外線を使用する、クリプトスポリジウムパルビウムの複製を防止するための方法
DE69927020T DE69927020T3 (de) 1998-05-13 1999-05-05 Methode zur verhinderung der vermehrung von cryptosporidium parvum mit ultraviolettem licht
AT99921674T ATE303346T1 (de) 1998-05-13 1999-05-05 Methode zur verhinderung der vermehrung von cryptosporidium parvum mit ultraviolettem licht
BR9911778-9A BR9911778A (pt) 1998-05-13 1999-05-05 Método para prevenir a replicação em cryptosporidium parvum empregando-se luz ultravioleta
AU38819/99A AU745173C (en) 1998-05-13 1999-05-05 Method for preventing replication in cryptosporidium parvum using ultraviolet light
KR1020007012689A KR20010071249A (ko) 1998-05-13 1999-05-05 자외선을 사용한 크립토스포리듐 파르붐의 복제 방지 방법
EP99921674A EP1084080B2 (en) 1998-05-13 1999-05-05 Method for preventing replication in cryptosporidium parvum using ultraviolet light
IL13955699A IL139556A0 (en) 1998-05-13 1999-05-05 Method for preventing replication in cryptosporidium parvum using ultraviolet light
NZ508008A NZ508008A (en) 1998-05-13 1999-05-05 Method for preventing replication in cryptosporidium parvum using ultraviolet light
DK99921674.0T DK1084080T4 (da) 1998-05-13 1999-05-05 Fremgangsmåde til forhindring af opformering af Cryptosporidium parvum under anvendelse af ultraviolet lys
ES99921674T ES2244193T5 (es) 1998-05-13 1999-05-05 Método para evitar la replicación en cryptosporidium parvum utilizando luz ultravioleta
CA002331525A CA2331525C (en) 1998-05-13 1999-05-05 Method for preventing replication in cryptosporidium parvum using ultraviolet light

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/078,116 1998-05-13
US09/078,116 US6129893A (en) 1998-05-13 1998-05-13 Method for preventing replication in Cryptosporidium parvum using ultraviolet light

Publications (1)

Publication Number Publication Date
WO1999058454A1 true WO1999058454A1 (en) 1999-11-18

Family

ID=22141995

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/009800 Ceased WO1999058454A1 (en) 1998-05-13 1999-05-05 Method for preventing replication in cryptosporidium parvum using ultraviolet light

Country Status (16)

Country Link
US (1) US6129893A (https=)
EP (1) EP1084080B2 (https=)
JP (1) JP2002514504A (https=)
KR (1) KR20010071249A (https=)
AT (1) ATE303346T1 (https=)
AU (1) AU745173C (https=)
BR (1) BR9911778A (https=)
CA (1) CA2331525C (https=)
DE (1) DE69927020T3 (https=)
DK (1) DK1084080T4 (https=)
ES (1) ES2244193T5 (https=)
IL (1) IL139556A0 (https=)
NL (1) NL1012059C2 (https=)
NZ (1) NZ508008A (https=)
PT (1) PT1084080E (https=)
WO (1) WO1999058454A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001002302A1 (en) * 1999-04-27 2001-01-11 Calgon Carbon Corporation Method for the inactivation of cryptosporidium parvum and giardia cysts using ultraviolet light
NL1032315C2 (nl) * 2006-08-14 2008-02-15 Nedap Nv Regelsysteem voor UV-lampen, alsmede controlesysteem voor het bepalen van de viabiliteit van micro-organismen.

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE515317C2 (sv) * 1999-10-14 2001-07-16 Josab Internat Ab Anordning och förfarande för att rena vatten från mikroorganismer
AUPQ629100A0 (en) * 2000-03-16 2000-04-15 Btf Pty Ltd Process for preparing controlled samples of particles such as microorganisms and cells
JP4115090B2 (ja) * 2001-01-10 2008-07-09 新日本製鐵株式会社 原虫類の不活性化方法
US6803587B2 (en) 2001-01-11 2004-10-12 Waterhealth International, Inc. UV water disinfector
US7494502B2 (en) * 2002-02-11 2009-02-24 Keraderm, Llc Alteration of the skin and nail for the prevention and treatment of skin and nail infections
US6960201B2 (en) * 2002-02-11 2005-11-01 Quanticum, Llc Method for the prevention and treatment of skin and nail infections
US6784440B2 (en) 2002-07-26 2004-08-31 Boc, Inc. Food sanitizing cabinet
US7160566B2 (en) 2003-02-07 2007-01-09 Boc, Inc. Food surface sanitation tunnel
US7612492B2 (en) * 2003-06-06 2009-11-03 Inventive Holdings Llc Lighting apparatus and system for decontamination
WO2007126864A1 (en) * 2006-03-27 2007-11-08 Micronova Technologies, Inc. Systems and processes for disinfecting liquids
US20080208295A1 (en) * 2007-02-28 2008-08-28 Cumbie William E Phototherapy Treatment and Device to Improve the Appearance of Nails and skin
US20080287912A1 (en) * 2007-05-14 2008-11-20 Horrigan Corporation Method, Device And Formulation For The Treatment Of Nail Disorders
US8506886B2 (en) * 2007-06-20 2013-08-13 Uvcleaning Systems, Inc. Ultraviolet photoreactor for the purification of fluids
US7862728B2 (en) 2007-09-27 2011-01-04 Water Of Life, Llc. Ultraviolet water purification system
US8529770B2 (en) * 2007-09-27 2013-09-10 Water Of Life, Llc. Self-contained UV-C purification system
US8685238B2 (en) * 2008-12-18 2014-04-01 Andrew Gunter Point-of-use solar powered water disinfection device and associated custom water storage container
US9593026B2 (en) * 2011-05-06 2017-03-14 Johnson Matthey Public Limited Company Organic contaminant destruction using chlorine or mixed oxidant solution and ultraviolet light
EP3477164B1 (en) 2017-10-25 2020-04-01 TrennTech GmbH Valve for controlling a fluid flow

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997015332A1 (en) * 1995-10-26 1997-05-01 Purepulse Technologies, Inc. Improved deactivation of organisms using high-intensity pulsed polychromatic light

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB902760A (en) 1958-02-14 1962-08-09 Wellcome Found Improvements in or relating to the production of vaccines
GB2292097B (en) * 1994-08-11 1998-04-08 Water Recovery Plc Fluid treatment apparatus

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997015332A1 (en) * 1995-10-26 1997-05-01 Purepulse Technologies, Inc. Improved deactivation of organisms using high-intensity pulsed polychromatic light

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RANSOME ET AL: "Effects of disinfectants on the viability of Cryptosporidium parvum oocysts", WATER SUPPLY, vol. 11, 1993, pages 103 - 117, XP002113177 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001002302A1 (en) * 1999-04-27 2001-01-11 Calgon Carbon Corporation Method for the inactivation of cryptosporidium parvum and giardia cysts using ultraviolet light
EP1181249A1 (en) 1999-04-27 2002-02-27 Calgon Carbon Corporation Method for the inactivation of cryptosporidium parvum and giardia cysts using ultraviolet light
NL1032315C2 (nl) * 2006-08-14 2008-02-15 Nedap Nv Regelsysteem voor UV-lampen, alsmede controlesysteem voor het bepalen van de viabiliteit van micro-organismen.
WO2008033016A1 (en) * 2006-08-14 2008-03-20 N.V. Nederlandsche Apparatenfabriek Nedap Control system for uv lamps, and check system for determining the viability of microorganisms

Also Published As

Publication number Publication date
ES2244193T5 (es) 2012-06-12
AU745173B2 (en) 2002-03-14
JP2002514504A (ja) 2002-05-21
ES2244193T3 (es) 2005-12-01
DE69927020T2 (de) 2006-02-02
NL1012059A1 (nl) 1999-11-16
PT1084080E (pt) 2005-11-30
CA2331525A1 (en) 1999-11-18
DK1084080T4 (da) 2012-05-21
NZ508008A (en) 2002-09-27
EP1084080B2 (en) 2012-02-15
US6129893A (en) 2000-10-10
NL1012059C2 (nl) 2000-01-25
DE69927020D1 (de) 2005-10-06
DK1084080T3 (da) 2005-09-19
DE69927020T3 (de) 2012-04-19
AU745173C (en) 2004-11-04
EP1084080A1 (en) 2001-03-21
AU3881999A (en) 1999-11-29
IL139556A0 (en) 2002-02-10
ATE303346T1 (de) 2005-09-15
EP1084080B1 (en) 2005-08-31
CA2331525C (en) 2002-02-19
BR9911778A (pt) 2001-10-02
KR20010071249A (ko) 2001-07-28

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