WO1999055907A3 - Method for screening antimycotic substances using essential genes from s. cerevisiae - Google Patents

Method for screening antimycotic substances using essential genes from s. cerevisiae Download PDF

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Publication number
WO1999055907A3
WO1999055907A3 PCT/EP1999/002722 EP9902722W WO9955907A3 WO 1999055907 A3 WO1999055907 A3 WO 1999055907A3 EP 9902722 W EP9902722 W EP 9902722W WO 9955907 A3 WO9955907 A3 WO 9955907A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene
screening
essential gene
cerevisiae
antimycotic substances
Prior art date
Application number
PCT/EP1999/002722
Other languages
French (fr)
Other versions
WO1999055907A2 (en
Inventor
Anita Diu-Hercend
Karl-Dieter Entian
Peter Koetter
Original Assignee
Hoechst Marion Roussel Inc
Diu Hercend Anita
Entian Karl Dieter
Peter Koetter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP98401007A external-priority patent/EP0972847A3/en
Application filed by Hoechst Marion Roussel Inc, Diu Hercend Anita, Entian Karl Dieter, Peter Koetter filed Critical Hoechst Marion Roussel Inc
Priority to EP99920745A priority Critical patent/EP1073768A2/en
Priority to AU38207/99A priority patent/AU759732B2/en
Priority to JP2000546050A priority patent/JP2002512812A/en
Publication of WO1999055907A2 publication Critical patent/WO1999055907A2/en
Publication of WO1999055907A3 publication Critical patent/WO1999055907A3/en
Priority to AU2003212061A priority patent/AU2003212061A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material

Abstract

The present invention concerns a method for the screening of antimycotic substances wherein an essential gene from mycetes or a functionally similar mycete gene, or the corresponding encoded protein, is used as target and wherein the essential gene is selected from the group consisting in YML114c, YLR186w, YLR215c, YLR222c, YLR243w, YLR272c, YLR275w, YLR276c, YLR317w, YLR359w, YLR373c, YLR424w, YLR437c, YLR440c, YML023c, YML049c, YML077w, YML093w, YML127w, YMR032w, YMR093w, YMR131c, YMR185w, YMR212c, YMR213w, YMR218c, YMR281w, YMR288w, YMR290c, YMR211w, YMR049c, YMR134w, YDR196c, YDR299w, YDR365c, YDR396w, YDR407c, YDR416w, YDR449c, YDR472w, YDR499w, YDR141c, YDR324c, YDR325w, YDR398w, YDR246w, YDR236c, YDR361c, YDR367w, YDR339c, YDR413c, YDR429c, YDR468c, YDR489w, YDR527w, YDR288w, YDR201w, YDR434w, YDR181c, YDR531w, YPL126w, YPL093w, YPL063w, YPL024w, YPL020c, YPL012w, YPL007c, YPL233w, YPL146c, YIL091c, YIL083c, YIL019w, YIL109c, YIL104c, YFL024c, YFR003c, YFR027w, YFR042w, YIR010w, YIR015w, YPR048w, YPR072w, YPR082c, YPR085c, YPR105c, YPR112c, YPR137w, YPR143w, YPR144c and YPR169w.
PCT/EP1999/002722 1998-04-24 1999-04-22 Method for screening antimycotic substances using essential genes from s. cerevisiae WO1999055907A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99920745A EP1073768A2 (en) 1998-04-24 1999-04-22 Method for screening antimycotic substances using essential genes from s. cerevisiae
AU38207/99A AU759732B2 (en) 1998-04-24 1999-04-22 Method for screening antimycotic substances using essential genes from S. cerevisiae
JP2000546050A JP2002512812A (en) 1998-04-24 1999-04-22 Screening method using essential genes from Saccharomyces cerevisiae as antifungal substances
AU2003212061A AU2003212061A1 (en) 1998-04-24 2003-07-10 Method for screening antimycotic substances using essential genes from S. Cerevisiae (2)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP98401007A EP0972847A3 (en) 1998-04-24 1998-04-24 Method for screening antimycotic substances
EP98401007.4 1998-04-24
EP98402254.1 1998-09-11
EP98402254 1998-09-11

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09674109 A-371-Of-International 2001-06-21
US10/872,929 Continuation US20040229276A1 (en) 1998-04-24 2004-06-21 Method for screening antimycotic substances substances using essential genes from S. cerevisiae

Publications (2)

Publication Number Publication Date
WO1999055907A2 WO1999055907A2 (en) 1999-11-04
WO1999055907A3 true WO1999055907A3 (en) 2000-03-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/002722 WO1999055907A2 (en) 1998-04-24 1999-04-22 Method for screening antimycotic substances using essential genes from s. cerevisiae

Country Status (4)

Country Link
EP (1) EP1073768A2 (en)
JP (1) JP2002512812A (en)
AU (2) AU759732B2 (en)
WO (1) WO1999055907A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2392300A (en) * 1998-12-31 2000-07-31 Millennium Pharmaceuticals, Inc. Use of essential (saccharomyces) genes and polypeptides
DE10159264A1 (en) * 2001-12-03 2003-09-04 Bayer Cropscience Ag Use of acetoacetyl-CoA thiolase to identify new fungicidally active substances

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0188677A2 (en) * 1984-10-30 1986-07-30 Phillips Petroleum Company Genes from pichia histidine pathway and uses thereof
EP0554042A1 (en) * 1992-01-30 1993-08-04 Dowelanco Method for screening fungicides utilizing dihydro orotate dehydrogenase (DHOD) inhibitor
EP0626453A1 (en) * 1993-05-25 1994-11-30 American Cyanamid Company Cytochrome P-450 reductase screen for ergosterol biosynthesis inhibitors
EP0626454A1 (en) * 1993-05-25 1994-11-30 American Cyanamid Company Spindle pole body screen for fungicides
EP0644262A2 (en) * 1993-05-24 1995-03-22 Takara Shuzo Co. Ltd. Gene coding for a protein regulating aureobasidin sensitivity
WO1995011969A1 (en) * 1993-10-25 1995-05-04 Ribogene, Inc. Methods for screening for antimycotics
WO1996008264A1 (en) * 1994-09-13 1996-03-21 Ceres Technologies, Inc. Synthetic antibiotics
US5614377A (en) * 1994-02-28 1997-03-25 Myco Pharmaceuticals, Incorporated Methods for identifying inhibitors of fungal pathogenicity
WO1997036925A1 (en) * 1996-04-01 1997-10-09 Scriptgen Pharmaceuticals, Inc. Candida albicans tata-binding protein, nucleic acid and assays
EP0816511A1 (en) * 1996-06-27 1998-01-07 HANS-KNÖLL-INSTITUT FÜR NATURSTOFF-FORSCHUNG e.V. Method of screening substances
WO1998044135A2 (en) * 1997-04-02 1998-10-08 Hoechst Aktiengesellschaft Method for screening antimycotically active substances

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0188677A2 (en) * 1984-10-30 1986-07-30 Phillips Petroleum Company Genes from pichia histidine pathway and uses thereof
EP0554042A1 (en) * 1992-01-30 1993-08-04 Dowelanco Method for screening fungicides utilizing dihydro orotate dehydrogenase (DHOD) inhibitor
EP0644262A2 (en) * 1993-05-24 1995-03-22 Takara Shuzo Co. Ltd. Gene coding for a protein regulating aureobasidin sensitivity
EP0626453A1 (en) * 1993-05-25 1994-11-30 American Cyanamid Company Cytochrome P-450 reductase screen for ergosterol biosynthesis inhibitors
EP0626454A1 (en) * 1993-05-25 1994-11-30 American Cyanamid Company Spindle pole body screen for fungicides
WO1995011969A1 (en) * 1993-10-25 1995-05-04 Ribogene, Inc. Methods for screening for antimycotics
US5614377A (en) * 1994-02-28 1997-03-25 Myco Pharmaceuticals, Incorporated Methods for identifying inhibitors of fungal pathogenicity
WO1996008264A1 (en) * 1994-09-13 1996-03-21 Ceres Technologies, Inc. Synthetic antibiotics
WO1997036925A1 (en) * 1996-04-01 1997-10-09 Scriptgen Pharmaceuticals, Inc. Candida albicans tata-binding protein, nucleic acid and assays
EP0816511A1 (en) * 1996-06-27 1998-01-07 HANS-KNÖLL-INSTITUT FÜR NATURSTOFF-FORSCHUNG e.V. Method of screening substances
WO1998044135A2 (en) * 1997-04-02 1998-10-08 Hoechst Aktiengesellschaft Method for screening antimycotically active substances

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KURTZ M B AND DOUGLAS C M: "Lipopeptide inhibitors of fungal glucan synthase", JOURNAL OF MEDICAL AND VETERINARY MYCOLOGY, vol. 2, no. 35, 1 January 1997 (1997-01-01), pages 79 86, XP002078810 *
SIKORSKI J A ET AL.: "Selective peptidic and peptidomimetic inhibitors of Candida albicans myristoylCoA: Protein N-myristoyltransferase: A new approach to antifungal therapy", PEPTIDE SCIENCE, vol. 43, no. 1, 1997, XP002119360 *

Also Published As

Publication number Publication date
AU3820799A (en) 1999-11-16
JP2002512812A (en) 2002-05-08
AU759732B2 (en) 2003-04-17
EP1073768A2 (en) 2001-02-07
AU2003212061A1 (en) 2003-08-14
WO1999055907A2 (en) 1999-11-04

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