WO1999054473A3 - Bacterial yjeq polypeptide family - Google Patents

Bacterial yjeq polypeptide family Download PDF

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Publication number
WO1999054473A3
WO1999054473A3 PCT/EP1999/002636 EP9902636W WO9954473A3 WO 1999054473 A3 WO1999054473 A3 WO 1999054473A3 EP 9902636 W EP9902636 W EP 9902636W WO 9954473 A3 WO9954473 A3 WO 9954473A3
Authority
WO
WIPO (PCT)
Prior art keywords
bacterial
yjeq
family
polypeptide family
polypetides
Prior art date
Application number
PCT/EP1999/002636
Other languages
French (fr)
Other versions
WO1999054473A2 (en
Inventor
Fabrizio Arigoni
Michael David Edgerton
Hannes Loferer
Manuel C Peitsch
Original Assignee
Glaxo Group Ltd
Fabrizio Arigoni
Michael David Edgerton
Hannes Loferer
Manuel C Peitsch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, Fabrizio Arigoni, Michael David Edgerton, Hannes Loferer, Manuel C Peitsch filed Critical Glaxo Group Ltd
Priority to JP2000544805A priority Critical patent/JP2002517983A/en
Priority to EP99920711A priority patent/EP1073746A2/en
Priority to AU38191/99A priority patent/AU3819199A/en
Publication of WO1999054473A2 publication Critical patent/WO1999054473A2/en
Publication of WO1999054473A3 publication Critical patent/WO1999054473A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

This invention relates to a family of bacterial polypeptides which are considered essential for growth of both gram negative and gram positive bacteria. The family has been identified by a number of methods including computer based algorithms. The use of such polypetides and the genes which encode them as tools for identifying novel broad spectrum antibiotics is described.
PCT/EP1999/002636 1998-04-22 1999-04-20 Bacterial yjeq polypeptide family WO1999054473A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2000544805A JP2002517983A (en) 1998-04-22 1999-04-20 Bacterial yjeQ polypeptide family
EP99920711A EP1073746A2 (en) 1998-04-22 1999-04-20 Bacterial yjeq polypeptide family
AU38191/99A AU3819199A (en) 1998-04-22 1999-04-20 Bacterial yjeq polypeptide family

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9808366.0 1998-04-22
GBGB9808366.0A GB9808366D0 (en) 1998-04-22 1998-04-22 Bacterial polypeptide family

Publications (2)

Publication Number Publication Date
WO1999054473A2 WO1999054473A2 (en) 1999-10-28
WO1999054473A3 true WO1999054473A3 (en) 2000-03-23

Family

ID=10830641

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/002636 WO1999054473A2 (en) 1998-04-22 1999-04-20 Bacterial yjeq polypeptide family

Country Status (5)

Country Link
EP (1) EP1073746A2 (en)
JP (1) JP2002517983A (en)
AU (1) AU3819199A (en)
GB (1) GB9808366D0 (en)
WO (1) WO1999054473A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996033276A1 (en) * 1995-04-21 1996-10-24 Human Genome Sciences, Inc. NUCLEOTIDE SEQUENCE OF THE HAEMOPHILUS INFLUENZAE Rd GENOME, FRAGMENTS THEREOF, AND USES THEREOF
EP0756006A2 (en) * 1995-06-07 1997-01-29 The Institute For Genomic Research Nucleotide sequence of the mycoplasma genitalium genome, fragments thereof, and uses thereof
WO1997043303A1 (en) * 1996-05-14 1997-11-20 Smithkline Beecham Corporation Novel compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996033276A1 (en) * 1995-04-21 1996-10-24 Human Genome Sciences, Inc. NUCLEOTIDE SEQUENCE OF THE HAEMOPHILUS INFLUENZAE Rd GENOME, FRAGMENTS THEREOF, AND USES THEREOF
EP0756006A2 (en) * 1995-06-07 1997-01-29 The Institute For Genomic Research Nucleotide sequence of the mycoplasma genitalium genome, fragments thereof, and uses thereof
WO1997043303A1 (en) * 1996-05-14 1997-11-20 Smithkline Beecham Corporation Novel compounds

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
ARIGONI F ET AL.: "A genome-based approach for the identification of essential bacterial genes.", NATURE BIOTECHNOLOGY, vol. 16, September 1998 (1998-09-01), pages 851 - 856, XP002124132 *
BAIROCH A ET AL.: "The PROSITE database, its status in 1997", NUCLEIC ACIDS RESEARCH, vol. 25, no. 1, 1 January 1997 (1997-01-01), pages 217 - 221, XP002126094 *
BALTZ ET AL: "DNA sequence sampling of the Streptococcus pneumoniae genome to identify novel targets for antibiotic development", MICROBIAL DRUG RESISTANCE,US,LIEBERT, vol. 4, no. 1, 21 March 1998 (1998-03-21), pages 1-9, XP002112153, ISSN: 1076-6294 *
DATABASE EMBL 1 January 1998 (1998-01-01), KUNST F ET AL.: "YloQ protein", XP002125844 *
DATABASE EMBL 1 July 1997 (1997-07-01), BADCOCK K ET AL.: "Hypothetical 34.9 kD protein", XP002125837 *
DATABASE EMBL 16 December 1997 (1997-12-16), FRASER C M ET AL.: "Borrelia burgdorferi (section 8 0f 70) of the complete genome", XP002125834 *
DATABASE EMBL 30 March 1998 (1998-03-30), DECKERT G ET AL.: "Aquifex aeolicus section 8 of 109 of the complete genome", XP002125843 *
DATABASE SWISSPROT 1 February 1995 (1995-02-01), BURLAND ET AL.: "Hypothetical 39.2 kD protein in the psd-amiB intergenic region", XP002125845 *
DATABASE SWISSPROT 1 November 1995 (1995-11-01), FLEISCHMANN R D ET AL.: "Hypothetical protein HI1714", XP002125836 *
DATABASE SWISSPROT 1 November 1997 (1997-11-01), HIMMELREICH R ET AL.: "Hypothetical protein MG110 homolog", XP002125840 *
DATABASE SWISSPROT 1 October 1996 (1996-10-01), FRASER C M ET AL.: "Hypothetical protein MG110", XP002125839 *
DATABASE SWISSPROT 1 October 1996 (1996-10-01), KANEKO T ET AL.: "Hypothetical 41.9 kD protein SSL0898", XP002125835 *
HENIKOFF S: "Scores for sequence searches and alignments", CURRENT OPINION IN STRUCTURAL BIOLOGY, vol. 6, June 1996 (1996-06-01), pages 353 - 360, XP002126095 *

Also Published As

Publication number Publication date
EP1073746A2 (en) 2001-02-07
JP2002517983A (en) 2002-06-25
GB9808366D0 (en) 1998-06-17
WO1999054473A2 (en) 1999-10-28
AU3819199A (en) 1999-11-08

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