WO1999054470A3 - Bacterial ygjd polypeptide family - Google Patents

Bacterial ygjd polypeptide family Download PDF

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Publication number
WO1999054470A3
WO1999054470A3 PCT/EP1999/002635 EP9902635W WO9954470A3 WO 1999054470 A3 WO1999054470 A3 WO 1999054470A3 EP 9902635 W EP9902635 W EP 9902635W WO 9954470 A3 WO9954470 A3 WO 9954470A3
Authority
WO
WIPO (PCT)
Prior art keywords
bacterial
ygjd
family
polypeptide family
polypeptides
Prior art date
Application number
PCT/EP1999/002635
Other languages
French (fr)
Other versions
WO1999054470A2 (en
Inventor
Fabrizio Arigoni
Michael David Edgerton
Hannes Loferer
Manuel C Peitsch
Original Assignee
Glaxo Group Ltd
Fabrizio Arigoni
Michael David Edgerton
Hannes Loferer
Manuel C Peitsch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, Fabrizio Arigoni, Michael David Edgerton, Hannes Loferer, Manuel C Peitsch filed Critical Glaxo Group Ltd
Priority to AU37088/99A priority Critical patent/AU3708899A/en
Publication of WO1999054470A2 publication Critical patent/WO1999054470A2/en
Publication of WO1999054470A3 publication Critical patent/WO1999054470A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Botany (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

This invention relates to a family of bacterial polypeptides which are considered essential for growth of both gram negative and gram positive bacteria. The family has been identified by a number of methods including computer based algorithms. The use of such polypeptides and the genes which encode them as tools for identifying novel broad spectrum antibiotics is described.
PCT/EP1999/002635 1998-04-22 1999-04-20 Bacterial ygjd polypeptide family WO1999054470A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU37088/99A AU3708899A (en) 1998-04-22 1999-04-20 Bacterial ygjd polypeptide family

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9808423.9 1998-04-22
GBGB9808423.9A GB9808423D0 (en) 1998-04-22 1998-04-22 Bacterial polypeptide family

Publications (2)

Publication Number Publication Date
WO1999054470A2 WO1999054470A2 (en) 1999-10-28
WO1999054470A3 true WO1999054470A3 (en) 2000-03-30

Family

ID=10830678

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/002635 WO1999054470A2 (en) 1998-04-22 1999-04-20 Bacterial ygjd polypeptide family

Country Status (3)

Country Link
AU (1) AU3708899A (en)
GB (1) GB9808423D0 (en)
WO (1) WO1999054470A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004275929A1 (en) 2003-09-30 2005-04-07 Enkam Pharmaceuticals A/S A method of modulating cell survival, differentiation and/or synaptic plasticity
WO2007051477A2 (en) * 2005-11-07 2007-05-10 Copenhagen University Neurotrophin-derived peptide sequences
JPWO2008133131A1 (en) * 2007-04-16 2010-07-22 味の素株式会社 Method for producing organic acid

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992013078A2 (en) * 1991-01-15 1992-08-06 The University Of Guelph Pasteurella haemolytica glycoprotease gene and the purified enzyme
WO1996033276A1 (en) * 1995-04-21 1996-10-24 Human Genome Sciences, Inc. NUCLEOTIDE SEQUENCE OF THE HAEMOPHILUS INFLUENZAE Rd GENOME, FRAGMENTS THEREOF, AND USES THEREOF
WO1996040893A1 (en) * 1995-06-07 1996-12-19 Astra Aktiebolag Nucleic acid and amino acid sequences relating to helicobacter pylori for diagnostics and therapeutics
EP0756006A2 (en) * 1995-06-07 1997-01-29 The Institute For Genomic Research Nucleotide sequence of the mycoplasma genitalium genome, fragments thereof, and uses thereof
WO1998026072A1 (en) * 1996-12-13 1998-06-18 Eli Lilly And Company Streptococcus pneumoniae dna sequences
WO1998059034A2 (en) * 1997-06-24 1998-12-30 Human Genome Sciences, Inc. Treponema pallidum polynucleotides and sequences
WO1998058943A1 (en) * 1997-06-20 1998-12-30 Human Genome Sciences, Inc. Borrelia burgdorferi polynucleotides and sequences

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992013078A2 (en) * 1991-01-15 1992-08-06 The University Of Guelph Pasteurella haemolytica glycoprotease gene and the purified enzyme
WO1996033276A1 (en) * 1995-04-21 1996-10-24 Human Genome Sciences, Inc. NUCLEOTIDE SEQUENCE OF THE HAEMOPHILUS INFLUENZAE Rd GENOME, FRAGMENTS THEREOF, AND USES THEREOF
WO1996040893A1 (en) * 1995-06-07 1996-12-19 Astra Aktiebolag Nucleic acid and amino acid sequences relating to helicobacter pylori for diagnostics and therapeutics
EP0756006A2 (en) * 1995-06-07 1997-01-29 The Institute For Genomic Research Nucleotide sequence of the mycoplasma genitalium genome, fragments thereof, and uses thereof
WO1998026072A1 (en) * 1996-12-13 1998-06-18 Eli Lilly And Company Streptococcus pneumoniae dna sequences
WO1998058943A1 (en) * 1997-06-20 1998-12-30 Human Genome Sciences, Inc. Borrelia burgdorferi polynucleotides and sequences
WO1998059034A2 (en) * 1997-06-24 1998-12-30 Human Genome Sciences, Inc. Treponema pallidum polynucleotides and sequences

Non-Patent Citations (20)

* Cited by examiner, † Cited by third party
Title
ABDULLAH K M ET AL.: "Cloning, nucleotide sequence, and expression of the Pasteurella haemolytica A1 glycoprotease gene", JOURNAL OF BACTERIOLOGY, vol. 173, no. 18, September 1991 (1991-09-01), pages 5597 - 5603, XP000857698 *
ARIGONI F ET AL.: "A genome-based approach for the identification of essential bacterial genes.", NATURE BIOTECHNOLOGY, vol. 16, September 1998 (1998-09-01), pages 851 - 856, XP002124132 *
BAIROCH A ET AL.: "The PROSITE database, its status in 1997", NUCLEIC ACIDS RESEARCH, vol. 25, no. 1, 1 January 1997 (1997-01-01), pages 217 - 221, XP002126094 *
BALTZ ET AL: "DNA sequence sampling of the Streptococcus pneumoniae genome to identify novel targets for antibiotic development", MICROBIAL DRUG RESISTANCE,US,LIEBERT, vol. 4, no. 1, pages 1-9-9, XP002112153, ISSN: 1076-6294 *
DATABASE EMBL 1 January 1998 (1998-01-01), ROUNSLEY S D ET AL.: "Putative sialoglycoprotease", XP002125769 *
DATABASE EMBL 1 October 1996 (1996-10-01), TABATA S: "Synechocystis sp. PCC6803 complete genome, 13/27, 1576593-1719643", XP002125767 *
DATABASE EMBL 17 July 1998 (1998-07-17), FRASER C M ET AL.: "Trepanoma pallidum section 58 of 87 of the complete genome", XP002125765 *
DATABASE EMBL 22 January 1994 (1994-01-22), SMITH D R: "Mycobacterium leprae cosmid B1620", XP002125773 *
DATABASE EMBL 23 July 1996 (1996-07-23), COLE S T ET AL.: "Mycobacterium tuberculosis H37Rv complete genome; segment 145/162", XP002125772 *
DATABASE PIR 13 February 1998 (1998-02-13), FRASER C M ET AL.: "Sialoglycoproteinase (gcp) homolog - Lyme disease spirochete", XP002125763 *
DATABASE PROSITE June 1994 (1994-06-01), XP002125762 *
DATABASE SWISSPROT 1 February 1996 (1996-02-01), FRASER C M ET AL.: "Putative O-sialoglycoprotein endopeptidase (EC 3.4.24.57) (glycoprotease)", XP002125775 *
DATABASE SWISSPROT 1 June 1994 (1994-06-01), ABDULLAH K M ET AL.: "O-sialoglycoprotein endopeptidase (EC 3.4.24.57) (glycoprotease)", XP002125774 *
DATABASE SWISSPROT 1 November 1988 (1988-11-01), NESIN M ET AL.: "hypothetical 36.0 kD protein in ttdB-rpsU intergenic region (orf-X), probable O-sialoglycoprotein endopeptidase (EC 3.4.24.57) (glycoprotease)", XP002125781 *
DATABASE SWISSPROT 1 November 1995 (1995-11-01), FLEISCHMANN R D ET AL.: "Probable O-sialoglycoprotein endopeptidase (EC 3.4.24.57) (glycoprotease)", XP002125770 *
DATABASE SWISSPROT 1 November 1997 (1997-11-01), HIMMELREICH R ET AL.: "Putative O-sialoglycoprotein endopeptidase (EC 3.4.24.57) (glycoprotease)", XP002125777 *
DATABASE SWISSPROT 1 November 1997 (1997-11-01), TOMB J-F ET AL.: "Putative O-sialoglycoprotein endopeptidase (EC 3.4.24.57) (glycoprotease)", XP002125768 *
DATABASE SWISSPROT 15 July 1998 (1998-07-15), SADAIE Y ET AL.: "Hypothetical 36.8 kD protein in phoB-groES intergenic region, probable O-sialoglycoprotein endopeptidase (EC 3.4.24.57) (glycoprotease)", XP002125780 *
HENIKOFF S: "Scores for sequence searches and alignments", CURRENT OPINION IN STRUCTURAL BIOLOGY, vol. 6, June 1996 (1996-06-01), pages 353 - 360, XP002126095 *
SADAIE Y ET AL.: "Nucleotide sequence and analysis of the phoB-rrnE-groESL region of the Bacillus subtilis chromosome", MICROBIOLOGY, vol. 143, no. 6, June 1997 (1997-06-01), pages 1861 - 1866, XP002084430 *

Also Published As

Publication number Publication date
WO1999054470A2 (en) 1999-10-28
AU3708899A (en) 1999-11-08
GB9808423D0 (en) 1998-06-17

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