WO1999047963A8 - Confocal microscopy imaging system - Google Patents
Confocal microscopy imaging systemInfo
- Publication number
- WO1999047963A8 WO1999047963A8 PCT/US1999/005589 US9905589W WO9947963A8 WO 1999047963 A8 WO1999047963 A8 WO 1999047963A8 US 9905589 W US9905589 W US 9905589W WO 9947963 A8 WO9947963 A8 WO 9947963A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- imaging system
- confocal microscopy
- microscopy imaging
- ccd
- directed
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/008—Details of detection or image processing, including general computer control
- G02B21/0084—Details of detection or image processing, including general computer control time-scale detection, e.g. strobed, ultra-fast, heterodyne detection
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0028—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders specially adapted for specific applications, e.g. for endoscopes, ophthalmoscopes, attachments to conventional microscopes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5002—Partitioning blood components
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0052—Optical details of the image generation
- G02B21/006—Optical details of the image generation focusing arrangements; selection of the plane to be imaged
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0052—Optical details of the image generation
- G02B21/0064—Optical details of the image generation multi-spectral or wavelength-selective arrangements, e.g. wavelength fan-out, chromatic profiling
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0052—Optical details of the image generation
- G02B21/0072—Optical details of the image generation details concerning resolution or correction, including general design of CSOM objectives
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0052—Optical details of the image generation
- G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
Landscapes
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Radiology & Medical Imaging (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Surgery (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Microscoopes, Condenser (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL13849699A IL138496A0 (en) | 1998-03-16 | 1999-03-16 | Confocal microscopy imaging system |
AU33547/99A AU758571B2 (en) | 1998-03-16 | 1999-03-16 | Confocal microscopy imaging system |
BRPI9908767-7A BR9908767B1 (en) | 1998-03-16 | 1999-03-16 | confocal imaging system, focusing system for use with a substrate, and processes for examining an object, and focusing for use with a substrate. |
CA2324262A CA2324262C (en) | 1998-03-16 | 1999-03-16 | Confocal microscopy imaging system |
EP99914908A EP1064579A4 (en) | 1998-03-16 | 1999-03-16 | Confocal microscopy imaging system |
JP2000537103A JP4812937B2 (en) | 1998-03-16 | 1999-03-16 | Confocal microscope imaging system |
US09/333,749 US6388788B1 (en) | 1998-03-16 | 1999-06-15 | Method and apparatus for screening chemical compounds |
NO20004601A NO20004601L (en) | 1998-03-16 | 2000-09-15 | A system for confocal microscopy imaging |
US09/724,253 US6400487B1 (en) | 1998-03-16 | 2000-11-28 | Method and apparatus for screening chemical compounds |
US10/227,552 US20030036855A1 (en) | 1998-03-16 | 2002-08-16 | Method and apparatus for screening chemical compounds |
IL16431904A IL164319A0 (en) | 1998-03-16 | 2004-09-28 | Confocal microscopy imaging system |
US12/028,345 US7957911B2 (en) | 1998-03-16 | 2008-02-08 | Method and apparatus for screening chemical compounds |
US13/150,532 US20110255756A1 (en) | 1998-03-16 | 2011-06-01 | Method and apparatus for screening chemical compounds |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4252798A | 1998-03-16 | 1998-03-16 | |
US09/042,527 | 1998-03-16 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US4252798A Continuation-In-Part | 1998-03-16 | 1998-03-16 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US4252798A Continuation | 1998-03-16 | 1998-03-16 | |
US30033599A Continuation | 1998-03-16 | 1999-04-27 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO1999047963A1 WO1999047963A1 (en) | 1999-09-23 |
WO1999047963A8 true WO1999047963A8 (en) | 1999-11-18 |
WO1999047963A9 WO1999047963A9 (en) | 1999-12-23 |
Family
ID=21922413
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/005589 WO1999047963A1 (en) | 1998-03-16 | 1999-03-16 | Confocal microscopy imaging system |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1064579A4 (en) |
JP (1) | JP4812937B2 (en) |
KR (2) | KR100618502B1 (en) |
CN (1) | CN100380160C (en) |
AU (1) | AU758571B2 (en) |
BR (1) | BR9908767B1 (en) |
CA (1) | CA2324262C (en) |
IL (2) | IL138496A0 (en) |
NO (1) | NO20004601L (en) |
WO (1) | WO1999047963A1 (en) |
Families Citing this family (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5876946A (en) * | 1997-06-03 | 1999-03-02 | Pharmacopeia, Inc. | High-throughput assay |
US20030036855A1 (en) | 1998-03-16 | 2003-02-20 | Praelux Incorporated, A Corporation Of New Jersey | Method and apparatus for screening chemical compounds |
GB2338568B (en) * | 1998-06-19 | 2000-12-20 | Optiscan Pty Ltd | Two photon endoscope or microscope method and apparatus |
US6690463B2 (en) * | 2000-02-10 | 2004-02-10 | Evotec Biosystems Ag | Fluorescence intensity and lifetime distribution analysis |
ATE277386T1 (en) * | 2000-10-27 | 2004-10-15 | Amersham Biosciences Corp | METHOD FOR SCREENING CHEMICAL COMPOUNDS |
FR2820828B1 (en) * | 2001-02-09 | 2003-05-02 | Commissariat Energie Atomique | SAMPLE OBSERVATION DEVICE BY FLUORESCENCE, IN PARTICULAR SEQUENTIALLY |
DE10117723A1 (en) * | 2001-04-09 | 2002-10-17 | Evotec Ag | Carrier for biological or synthetic samples has a sample holding plate with reservoirs and a dosing plate with projections, fitted with membranes, of an optically transparent material with trouble-free light beam transparency |
US7219016B2 (en) | 2001-04-20 | 2007-05-15 | Yale University | Systems and methods for automated analysis of cells and tissues |
DE10122607B4 (en) * | 2001-05-10 | 2006-11-30 | Leica Microsystems Cms Gmbh | Method and arrangement for direct Fourier imaging of samples |
DE10157511A1 (en) | 2001-11-23 | 2003-06-12 | Evotec Ag | Method and device for correcting the size and / or shape of a measurement volume in a chemical and / or biological sample |
JP2003177131A (en) * | 2001-12-11 | 2003-06-27 | Olympus Optical Co Ltd | Method for detecting biological bonding affinity |
GB0211068D0 (en) * | 2002-05-14 | 2002-06-26 | Amersham Biosciences Uk Ltd | Method for assessing biofilms |
GB0211072D0 (en) * | 2002-05-15 | 2002-06-26 | Amersham Biosciences Uk Ltd | Reagent and method for the determination of changes in a cellular morphological parameter |
US6982166B2 (en) * | 2002-05-16 | 2006-01-03 | Applera Corporation | Lens assembly for biological testing |
US9157860B2 (en) | 2002-05-16 | 2015-10-13 | Applied Biosystems, Llc | Achromatic lens array |
DE102004014048B4 (en) * | 2004-03-19 | 2008-10-30 | Sirona Dental Systems Gmbh | Measuring device and method according to the basic principle of confocal microscopy |
US7170675B2 (en) | 2004-05-19 | 2007-01-30 | Celloptic, Inc. | Method and system for wide-field multi-photon microscopy having a confocal excitation plane |
DE102004034970A1 (en) * | 2004-07-16 | 2006-02-02 | Carl Zeiss Jena Gmbh | Scanning microscope and use |
CN101031837B (en) * | 2004-07-23 | 2011-06-15 | 通用电气医疗集团尼亚加拉有限公司 | Method and apparatus for fluorescent confocal microscopy |
CN1310023C (en) * | 2004-11-10 | 2007-04-11 | 哈尔滨工业大学 | Three-differential focasing micro-three-dimensional super-resolution imaging method |
GB0427050D0 (en) * | 2004-12-10 | 2005-01-12 | Amersham Biosciences Uk Ltd | Method of,and apparatus and computer software for,imaging biological objects |
DE202005010588U1 (en) * | 2005-07-04 | 2005-10-13 | Weiss Umwelttechnik Gmbh Simulationsanlagen-Messtechnik | Testing chamber for photostability of pharmaceuticals and cosmetics in storage, includes mechanical filter promoting uniform illumination of samples |
US7329860B2 (en) | 2005-11-23 | 2008-02-12 | Illumina, Inc. | Confocal imaging methods and apparatus |
KR100737170B1 (en) * | 2006-01-20 | 2007-07-10 | 경북대학교 산학협력단 | Portable quantum dot flurescent detector |
US7567346B2 (en) * | 2006-03-01 | 2009-07-28 | General Electric Company | System and method for multimode imaging |
CA2650776A1 (en) | 2006-05-05 | 2007-11-15 | Yale University | Immunohistochemical methods for determining signal transduction activity in tumors |
WO2008008500A2 (en) | 2006-07-13 | 2008-01-17 | Yale University | Methods for making cancer prognoses based on the subcellular localization of biomarkers |
US7838302B2 (en) | 2006-08-07 | 2010-11-23 | President And Fellows Of Harvard College | Sub-diffraction limit image resolution and other imaging techniques |
GB0625775D0 (en) | 2006-12-22 | 2007-02-07 | Isis Innovation | Focusing apparatus and method |
JP4957458B2 (en) * | 2007-08-27 | 2012-06-20 | 株式会社Jvcケンウッド | Voice coil and speaker |
JPWO2009048142A1 (en) * | 2007-10-11 | 2011-02-24 | 株式会社ニコン | Observation device |
CN101918816B (en) * | 2007-12-21 | 2015-12-02 | 哈佛大学 | Sub-diffraction limit image resolution in three-dimensional |
WO2009115108A1 (en) * | 2008-03-19 | 2009-09-24 | Ruprecht-Karls-Universität Heidelberg | A method and an apparatus for localization of single dye molecules in the fluorescent microscopy |
KR101532611B1 (en) * | 2009-04-28 | 2015-07-01 | 삼성전자주식회사 | Apparatus and method for processing digital image expressing zooming shot effect |
CN102782479B (en) * | 2010-03-01 | 2014-04-30 | 奥林巴斯株式会社 | Optical analysis device, optical analysis method |
US8692708B2 (en) * | 2010-03-30 | 2014-04-08 | Sony Corporation | Radiometric imaging device and corresponding method |
US8767069B2 (en) * | 2010-06-30 | 2014-07-01 | Luminex Corporation | Apparatus, system, and method for increasing measurement accuracy in a particle imaging device using light distribution |
JP5877155B2 (en) | 2010-07-26 | 2016-03-02 | オリンパス株式会社 | Method for detecting dilute particles in solution using luminescent probe |
CN103097878B (en) | 2010-09-10 | 2015-07-22 | 奥林巴斯株式会社 | Optical analysis method using optical intensity of single light-emitting particle |
JP5893564B2 (en) | 2010-09-10 | 2016-03-23 | オリンパス株式会社 | Optical analysis method using optical measurement in multiple wavelength bands |
CN103119421B (en) * | 2010-09-21 | 2015-04-08 | 奥林巴斯株式会社 | Photometric analysis method using single light-emitting particle detection |
JP5737704B2 (en) * | 2010-09-27 | 2015-06-17 | 株式会社ライフテック | Fluorescent single particle detection method and detection system |
JP5904947B2 (en) * | 2010-10-13 | 2016-04-20 | オリンパス株式会社 | Method for measuring particle diffusion characteristics using single luminescent particle detection |
EP2620763A4 (en) * | 2010-10-19 | 2015-05-27 | Olympus Corp | Optical analysis device for observing polarisation characteristics of single light-emitting particle, optical analysis method and optical analysis computer program therefor |
CN103229042B (en) | 2010-11-25 | 2016-06-29 | 奥林巴斯株式会社 | The light analytical equipment and the light that utilize the wavelength characteristic of the light of single incandescnet particle analyze method |
JP5856983B2 (en) | 2011-01-20 | 2016-02-10 | オリンパス株式会社 | Optical analysis method and optical analysis apparatus using light detection from single luminescent particles |
WO2012102326A1 (en) | 2011-01-26 | 2012-08-02 | オリンパス株式会社 | Method for identifying polymorphism of nucleic acid molecule |
JP5856984B2 (en) | 2011-01-26 | 2016-02-10 | オリンパス株式会社 | Nucleic acid molecule polymorphism identification method |
US9477072B2 (en) * | 2011-03-01 | 2016-10-25 | Ge Healthcare Bio-Sciences Corp. | Systems and methods for illumination phase control in fluorescence microscopy |
CN103460026B (en) | 2011-03-29 | 2015-06-10 | 奥林巴斯株式会社 | Photometric analysis device, photometric analysis method, and computer program for photometric analysis, using single light-emitting particle detection |
CN103477210B (en) | 2011-04-13 | 2015-09-23 | 奥林巴斯株式会社 | The light analytical equipment utilizing single incandescnet particle to detect, light analytical approach and light analysis computer program |
EP2700935A4 (en) | 2011-04-18 | 2014-10-22 | Olympus Corp | Quantitative determination method for target particles, photometric analysis device, and computer program for photometric analysis |
CN103733047B (en) | 2011-08-11 | 2016-03-30 | 奥林巴斯株式会社 | The detection method of intended particle |
EP2746748B1 (en) | 2011-08-15 | 2017-12-06 | Olympus Corporation | Photometric analysis device using single light emitting particle detection, photometric analysis method and computer program for photometric analysis, |
CN103765195B (en) | 2011-08-26 | 2018-06-01 | 奥林巴斯株式会社 | Single particle detection device, single particle detection method and the single particle detection computer program analyzed using light |
CN103765196B (en) | 2011-08-26 | 2016-03-02 | 奥林巴斯株式会社 | The light analytical equipment utilizing single incandescnet particle to detect and light analytical approach |
WO2013031377A1 (en) | 2011-08-30 | 2013-03-07 | オリンパス株式会社 | Optical analyzer using single light-emitting particle detection, optical analysis method, and computer program for optical analysis |
EP2752655A4 (en) | 2011-08-30 | 2015-06-17 | Olympus Corp | Method for detecting target particles |
CN103782155B (en) * | 2011-09-06 | 2016-11-16 | 皇家飞利浦有限公司 | There is the optical biosensor of multiple sensor region |
CN103930768B (en) | 2011-11-10 | 2016-05-18 | 奥林巴斯株式会社 | The light analytical equipment, light analytical method and the light analysis computer program that utilize single incandescnet particle to detect |
DE102011087196A1 (en) * | 2011-11-28 | 2013-05-29 | Leica Microsystems Cms Gmbh | Microscope illumination system and method |
EP2816344A4 (en) | 2012-02-17 | 2015-09-23 | Olympus Corp | Optical analysis device using single particle detection technique, optical analysis method and computer program for optical analysis |
EP2818850B1 (en) | 2012-02-22 | 2016-08-03 | Olympus Corporation | Method for detecting a target particle |
CH706326A2 (en) * | 2012-03-14 | 2013-09-30 | Tecan Trading Ag | Procedures and microplate readers for study of biological cells or cell cultures. |
WO2013140890A1 (en) | 2012-03-21 | 2013-09-26 | オリンパス株式会社 | Method for detecting target nucleic acid molecule |
WO2013157319A1 (en) | 2012-04-18 | 2013-10-24 | オリンパス株式会社 | Single-particle detection device using photoanalysis, single-particle detection method, and computer program for single-particle detection |
WO2013157283A1 (en) | 2012-04-18 | 2013-10-24 | オリンパス株式会社 | Method for detecting target particles |
CN102841083B (en) * | 2012-06-11 | 2014-08-20 | 北京大学 | Method and system of laser scanning phase-microscope imaging |
US8654352B1 (en) * | 2012-08-08 | 2014-02-18 | Asm Technology Singapore Pte Ltd | Chromatic confocal scanning apparatus |
CN104155279B (en) * | 2013-05-13 | 2017-04-26 | 中国科学院大连化学物理研究所 | Linear confocal ultraviolet Raman spectrometer |
JP6360481B2 (en) | 2013-07-31 | 2018-07-18 | オリンパス株式会社 | Optical microscope apparatus using single luminescent particle detection technique, microscope observation method, and computer program for microscope observation |
JP6313776B2 (en) | 2013-10-07 | 2018-04-18 | オリンパス株式会社 | Optical analysis apparatus using single luminescent particle detection, optical analysis method, and computer program for optical analysis |
CN106662530A (en) * | 2014-09-05 | 2017-05-10 | 特莫费希尔科学公司 | Method and apparatus for optical measurement of liquid sample |
CN104296684B (en) * | 2014-11-05 | 2016-11-30 | 哈尔滨工业大学 | Film thickness error bearing calibration based on surface coating confocal microscopy topography measurement device |
GB2534402A (en) * | 2015-01-22 | 2016-07-27 | Idea Biomedical Ltd | Auto-focussing method and device |
CN104677884B (en) * | 2015-03-17 | 2017-07-11 | 北京理工大学 | High-space resolution laser light splitting pupil differential confocal mass spectrum micro imaging method and device |
CN104697452A (en) * | 2015-03-24 | 2015-06-10 | 宁波高新区零零七工业设计有限公司 | Laser imaging system |
US9599807B2 (en) * | 2015-06-30 | 2017-03-21 | General Electric Company | Optical microscope and method for detecting lens immersion |
JPWO2017098597A1 (en) | 2015-12-09 | 2018-10-11 | オリンパス株式会社 | Optical analysis method and optical analysis apparatus using single luminescent particle detection |
LU93022B1 (en) * | 2016-04-08 | 2017-11-08 | Leica Microsystems | Method and microscope for examining a sample |
CN108061964B (en) * | 2017-10-25 | 2020-03-27 | 中国科学技术大学 | High-speed three-dimensional microscopic imaging device and method for large sample |
CN108319008B (en) * | 2018-02-02 | 2019-11-12 | 华中科技大学 | A kind of optical microscope imaging method and device |
CN108680542B (en) * | 2018-03-26 | 2020-01-10 | 华中科技大学 | Array type line scanning fluorescence microscopic imaging device |
CN108445619A (en) * | 2018-05-11 | 2018-08-24 | 中国工程物理研究院流体物理研究所 | Optical scanning system and method |
WO2021152562A1 (en) * | 2020-01-31 | 2021-08-05 | Stellenbosch University | Method for determining mitochondrial events |
CN111239047B (en) * | 2020-03-09 | 2023-10-27 | 深圳中科飞测科技股份有限公司 | Optical device and method for realizing automatic focusing |
EP4211508A1 (en) | 2020-09-14 | 2023-07-19 | Singular Genomics Systems, Inc. | Methods and systems for multidimensional imaging |
KR102447224B1 (en) * | 2020-10-26 | 2022-09-27 | 한국생산기술연구원 | apparatus for qualitative and quantitative analysis of fine particles |
CN114813706B (en) * | 2022-06-29 | 2022-12-13 | 国科大杭州高等研究院 | Blood cell hyperspectral optical tweezers capture energy resonance transfer analyzer |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63306413A (en) * | 1987-06-09 | 1988-12-14 | Olympus Optical Co Ltd | Scanning type optical microscope |
US4844617A (en) * | 1988-01-20 | 1989-07-04 | Tencor Instruments | Confocal measuring microscope with automatic focusing |
US5020891A (en) * | 1988-09-14 | 1991-06-04 | Washington University | Single aperture confocal scanning biomicroscope and kit for converting single lamp biomicroscope thereto |
US5034613A (en) * | 1989-11-14 | 1991-07-23 | Cornell Research Foundation, Inc. | Two-photon laser microscopy |
US5274240A (en) * | 1990-01-12 | 1993-12-28 | The Regents Of The University Of California | Capillary array confocal fluorescence scanner and method |
GB9015793D0 (en) * | 1990-07-18 | 1990-09-05 | Medical Res Council | Confocal scanning optical microscope |
JPH04221917A (en) * | 1990-12-25 | 1992-08-12 | Tamron Co Ltd | Automatically focusing method and device for microscope |
US5162641A (en) * | 1991-02-19 | 1992-11-10 | Phoenix Laser Systems, Inc. | System and method for detecting, correcting and measuring depth movement of target tissue in a laser surgical system |
US5784162A (en) * | 1993-08-18 | 1998-07-21 | Applied Spectral Imaging Ltd. | Spectral bio-imaging methods for biological research, medical diagnostics and therapy |
US5465147A (en) * | 1991-04-29 | 1995-11-07 | Massachusetts Institute Of Technology | Method and apparatus for acquiring images using a ccd detector array and no transverse scanner |
JPH05188301A (en) * | 1991-09-09 | 1993-07-30 | Sumitomo Electric Ind Ltd | Laser microscope |
JPH05332733A (en) * | 1992-05-27 | 1993-12-14 | Hitachi Ltd | Detection optical system and method for detecting three-dimensional form |
JPH07128596A (en) * | 1993-09-08 | 1995-05-19 | Nikon Corp | Confocal microscope |
US5587832A (en) * | 1993-10-20 | 1996-12-24 | Biophysica Technologies, Inc. | Spatially light modulated confocal microscope and method |
JP3450406B2 (en) * | 1994-03-10 | 2003-09-22 | オリンパス光学工業株式会社 | Position adjustment device for observation image and scanning optical microscope |
JPH07281100A (en) * | 1994-04-05 | 1995-10-27 | Nikon Corp | Sandwiched sample body for automatic focusing microscope |
US5515864A (en) * | 1994-04-21 | 1996-05-14 | Zuckerman; Ralph | Method and apparatus for the in vivo measurement of oxygen concentration levels by the indirect determination of fluoescence lifetime |
WO1997043611A1 (en) * | 1996-05-16 | 1997-11-20 | Affymetrix, Inc. | Systems and methods for detection of labeled materials |
US5900949A (en) * | 1996-05-23 | 1999-05-04 | Hewlett-Packard Company | CCD imager for confocal scanning microscopy |
US5880465A (en) * | 1996-05-31 | 1999-03-09 | Kovex Corporation | Scanning confocal microscope with oscillating objective lens |
US5915048A (en) * | 1996-06-05 | 1999-06-22 | Zetetic Institute | Method and apparatus for discriminating in-focus images from out-of-focus light signals from background and foreground light sources |
JPH09329749A (en) * | 1996-06-11 | 1997-12-22 | Nikon Corp | Optical scanning type microscope |
DE19627568A1 (en) * | 1996-07-09 | 1998-01-15 | Zeiss Carl Jena Gmbh | Arrangement for confocal microscopy with top and lower carrier discs |
DE19632594A1 (en) * | 1996-08-13 | 1998-02-19 | Johannes Prof Dr Schwider | Confocal microscopy method using refractive microlens fields |
US5760901A (en) * | 1997-01-28 | 1998-06-02 | Zetetic Institute | Method and apparatus for confocal interference microscopy with background amplitude reduction and compensation |
JP3816632B2 (en) * | 1997-05-14 | 2006-08-30 | オリンパス株式会社 | Scanning microscope |
-
1999
- 1999-03-16 EP EP99914908A patent/EP1064579A4/en not_active Withdrawn
- 1999-03-16 AU AU33547/99A patent/AU758571B2/en not_active Ceased
- 1999-03-16 CN CNB998062219A patent/CN100380160C/en not_active Expired - Fee Related
- 1999-03-16 BR BRPI9908767-7A patent/BR9908767B1/en not_active IP Right Cessation
- 1999-03-16 WO PCT/US1999/005589 patent/WO1999047963A1/en active IP Right Grant
- 1999-03-16 IL IL13849699A patent/IL138496A0/en not_active IP Right Cessation
- 1999-03-16 JP JP2000537103A patent/JP4812937B2/en not_active Expired - Fee Related
- 1999-03-16 CA CA2324262A patent/CA2324262C/en not_active Expired - Fee Related
- 1999-03-16 KR KR1020057015316A patent/KR100618502B1/en not_active IP Right Cessation
- 1999-03-16 KR KR1020007010258A patent/KR100560588B1/en not_active IP Right Cessation
-
2000
- 2000-09-15 NO NO20004601A patent/NO20004601L/en not_active Application Discontinuation
-
2004
- 2004-09-28 IL IL16431904A patent/IL164319A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
IL164319A0 (en) | 2005-12-18 |
JP4812937B2 (en) | 2011-11-09 |
WO1999047963A9 (en) | 1999-12-23 |
KR100618502B1 (en) | 2006-09-01 |
EP1064579A4 (en) | 2007-11-07 |
KR20010041945A (en) | 2001-05-25 |
KR20050088500A (en) | 2005-09-06 |
NO20004601L (en) | 2000-11-10 |
AU3354799A (en) | 1999-10-11 |
BR9908767A (en) | 2001-10-16 |
IL138496A0 (en) | 2001-10-31 |
JP2002507762A (en) | 2002-03-12 |
EP1064579A1 (en) | 2001-01-03 |
WO1999047963A1 (en) | 1999-09-23 |
CN100380160C (en) | 2008-04-09 |
BR9908767B1 (en) | 2011-09-06 |
KR100560588B1 (en) | 2006-03-16 |
CA2324262C (en) | 2010-05-25 |
AU758571B2 (en) | 2003-03-27 |
NO20004601D0 (en) | 2000-09-15 |
CN1301357A (en) | 2001-06-27 |
CA2324262A1 (en) | 1999-09-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1999047963A8 (en) | Confocal microscopy imaging system | |
IT1277740B1 (en) | SUPERCONDUCTOR CABLE FOR HIGH POWER | |
AU9016798A (en) | Ultra-broadband uv microscope imaging system with wide range zoom capability | |
AU4028797A (en) | Scanning confocal microscope | |
DE69717538D1 (en) | Confocal scanning microscope | |
AU1975197A (en) | Microlens scanner for microlithography and wide-field confocal microscopy | |
DE69618046D1 (en) | Optical system, image observation device and image pickup device using the same | |
AU2114797A (en) | Microscopic imaging of properties of room-temperature objects | |
AU1595700A (en) | Imaged document optical correlation and conversion system | |
HK1023622A1 (en) | Microscope with adaptive optics system | |
DE69638126D1 (en) | scanning Electron Microscope | |
AU8746998A (en) | Object observation device and object observation method | |
DE60036587D1 (en) | Multi-beam optical scanner and imaging device using the same | |
DE69611739D1 (en) | Scanning electron microscope | |
AU6184196A (en) | Confocal ultrasonic imaging system | |
EP0998690A4 (en) | Microscope camera adapter | |
WO1998011459A3 (en) | An enhanced resolution image guide | |
EP0646768A3 (en) | Confocal optical microscope and length measuring device using this microscope. | |
PL336293A1 (en) | Fibre optics cable connection holder | |
DE69624192D1 (en) | scanning Electron Microscope | |
AU1192999A (en) | Microscope attachment for high precision and efficient imaging | |
IT1286140B1 (en) | PROCEDURE AND DEVICE FOR THE GENERATION OF ULTRA SHORT OPTICAL IMPULSES. | |
AU5161598A (en) | Scalable non-contact optical backscatter insertion probe | |
BR9612676A (en) | Process of providing an image on an image receiving means and image receiving means | |
AU8295898A (en) | Microscope with improved camera mount and illumination system |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 99806221.9 Country of ref document: CN |
|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
AK | Designated states |
Kind code of ref document: C1 Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: C1 Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
CFP | Corrected version of a pamphlet front page | ||
CR1 | Correction of entry in section i | ||
AK | Designated states |
Kind code of ref document: C2 Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: C2 Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
COP | Corrected version of pamphlet |
Free format text: PAGES 10-49, DESCRIPTION, REPLACED BY NEW PAGES 10-50; PAGES 50 AND 51, CLAIMS, RENUMBERED AS PAGES 51 AND 52; PAGES 52-70, AMENDED CLAIMS, RENUMBERED AS PAGES 53-71; PAGES 1/25-25/25, DRAWINGS, REPLACED BY NEW PAGES 1/23-23/23; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 1999914908 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 2324262 Country of ref document: CA Ref document number: 2324262 Country of ref document: CA Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 33547/99 Country of ref document: AU Ref document number: PA/a/2000/009100 Country of ref document: MX Ref document number: 138496 Country of ref document: IL |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020007010258 Country of ref document: KR |
|
ENP | Entry into the national phase |
Ref document number: 2000 537103 Country of ref document: JP Kind code of ref document: A |
|
WWP | Wipo information: published in national office |
Ref document number: 1999914908 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: 1020007010258 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 10227552 Country of ref document: US |
|
WWG | Wipo information: grant in national office |
Ref document number: 33547/99 Country of ref document: AU |
|
WWG | Wipo information: grant in national office |
Ref document number: 1020007010258 Country of ref document: KR |