WO1999044718A1 - System and method of filtering and collecting blood or blood products - Google Patents
System and method of filtering and collecting blood or blood products Download PDFInfo
- Publication number
- WO1999044718A1 WO1999044718A1 PCT/US1999/004544 US9904544W WO9944718A1 WO 1999044718 A1 WO1999044718 A1 WO 1999044718A1 US 9904544 W US9904544 W US 9904544W WO 9944718 A1 WO9944718 A1 WO 9944718A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- blood
- tubing
- length
- product
- blood product
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D36/00—Filter circuits or combinations of filters with other separating devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
- A61M1/0218—Multiple bag systems for separating or storing blood components with filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
- A61M1/0231—Multiple bag systems for separating or storing blood components with gas separating means, e.g. air outlet through microporous membrane or gas bag
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
- A61M1/3633—Blood component filters, e.g. leukocyte filters
Definitions
- This invention relates generally to liquid filtration techniques. More
- this invention relates to an in-line gravity driven liquid filtration method usable to filter and collect biological liquids such as blood or blood products.
- blood filtration devices allow liquid filtrate to remain within the
- This remaining liquid referred to as a
- filtration devices allow an undesirably high amount of air that is purged therefrom to
- the filtration method of the present invention is useable when
- blood products involves filtering the blood or blood product, collecting the blood or
- a receiving bag e.g., a conventional transfer or storage bag
- the blood in the sealed segments of the first length of tubing may then be used for cross-matching, and/or the blood sealed in the segments of the second length of tubing may be used for
- the air within the receiving bag may be expressed into an air bag which is
- the blood or blood product may be filtered for removal of cells and
- the blood or blood product within the segments of the second length of tubing may be any blood or blood product within the segments of the second length of tubing.
- the filtered cells may be
- the blood or blood product may be filtered
- first and second lengths of tubing may be sealed using a heat sealing device.
- the blood or blood product may be filtered for removal of cells and
- the blood or blood product within the segments of the second length of tubing may be any blood or blood product within the segments of the second length of tubing.
- the filtered cells may be
- the blood or blood product may be filtered
- first and second lengths of tubing may be sealed using a heat sealing device.
- Figure 1 depicts a filtration device in an operational assembly with a blood
- Figure 2 depicts an isometric view of a receiving blood bag, air bag, air bag
- upstream, top or up refers to a location of the flow of liquid prior to filtration through filter elements within the filtration device of
- the present invention is intended to be used for in-line gravity filtration of
- the filtration device used should automatically drain the upstream side when filtration is complete. Preferably, draining occurs without the manipulation of
- One type of filtration device, useable in the present invention incorporates an
- a filtration device 223 is depicted in operational
- bag 294 air bag 295, inlet tube clamp 266, outlet tube clamp 267, and air tube clamp
- inlet tube clamp 266 For performing filtration, inlet tube clamp 266,
- tube clamp 267 is opened and air tube clamp 268, preferably located close to the air
- socket 287 above the center of inlet section 201 may now be attached to a feed blood
- feed blood bag 293 may be hung from hook 297 on blood bag pole
- Receiving blood bag 294 and air bag 295 could be placed on a surface such as a
- feed blood bag 293 is empty it will be collapsed and therefore, close the inlet end of
- tube clamp 267 located between the filtration device
- tube clamp 267 can be sealed, typically by heat using a conventional heat
- safety device which closes portions of tubing by melting the same, by clamping the tubing closed or by any other means to temporarily or permanently seal or close the
- the blood may now be mixed to ensure consistency, and preferably the blood is mixed after the air is removed, though mixing could occur before removing the air if desired.
- mixed blood from receiving blood bag 294 can be expressed into air bag tubing 298 to
- Tube clamp 268 can now be closed and air bag tubing 298 sealed near
- Air bag 295 can be any of the means similar to that for tubing 218. Air bag 295 can be any of the means similar to that for tubing 218. Air bag 295 can be any of the means similar to that for tubing 218. Air bag 295 can be any of the means similar to that for tubing 218. Air bag 295 can be any of the means similar to that for tubing 218. Air bag 295 can be any of the means similar to that for tubing 218. Air bag 295 can be any of the air bag 295, using any of the means similar to that for tubing 218. Air bag 295 can be any of the means similar to that for tubing 218. Air bag 295.
- Both outlet tubing 218 and air bag tubing 298 may have segment marks
- Figure 2 depicts the segment marks 292 on air bag tubing 298.
- the blood that is sealed in the segments in outlet tubing 218 may be tested for its compatibility with a patient
- segments of air bag tubing 298 may be tested for the concentration of filtered matter
- the filtered blood sealed in tubing 298 may be tested for the presence and
- agents can be tested for the presence and concentration of such agents after filtration.
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- External Artificial Organs (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99909743A EP1059989A4 (en) | 1998-03-02 | 1999-03-02 | System and method of filtering and collecting blood or blood products |
CA002321762A CA2321762A1 (en) | 1998-03-02 | 1999-03-02 | System and method of filtering and collecting blood or blood products |
IL13808299A IL138082A0 (en) | 1998-03-02 | 1999-03-02 | System and method for filtering and collecting blood or blood products |
BR9908445-7A BR9908445A (en) | 1998-03-02 | 1999-03-02 | System and method of filtration and collection of blood or blood products |
KR1020007009657A KR20010074437A (en) | 1998-03-02 | 1999-03-02 | System and method of filtering and collecting blood or blood products |
JP2000534310A JP2003501112A (en) | 1998-03-02 | 1999-03-02 | Systems and methods for filtering and collecting blood or blood products |
AU28882/99A AU2888299A (en) | 1998-03-02 | 1999-03-02 | System and method of filtering and collecting blood or blood products |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7655898P | 1998-03-02 | 1998-03-02 | |
US60/076,558 | 1998-03-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999044718A1 true WO1999044718A1 (en) | 1999-09-10 |
WO1999044718A8 WO1999044718A8 (en) | 2000-02-10 |
Family
ID=22132781
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/004544 WO1999044718A1 (en) | 1998-03-02 | 1999-03-02 | System and method of filtering and collecting blood or blood products |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1059989A4 (en) |
JP (1) | JP2003501112A (en) |
KR (1) | KR20010074437A (en) |
CN (1) | CN1227764A (en) |
AU (1) | AU2888299A (en) |
BR (1) | BR9908445A (en) |
CA (1) | CA2321762A1 (en) |
IL (1) | IL138082A0 (en) |
WO (1) | WO1999044718A1 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1222935A1 (en) * | 2000-12-04 | 2002-07-17 | Terumo Kabushiki Kaisha | Method and device for obtaining a leucocyte-free blood preparation with reduced side effects |
DE102004035352A1 (en) * | 2004-07-21 | 2006-02-16 | Gerätezentrale für Bluttransfusion des Österreichischen Roten Kreuzes GmbH | Closed sterile system and method for filtering biological or medical fluids, especially whole blood |
US9782707B2 (en) | 2014-03-24 | 2017-10-10 | Fenwal, Inc. | Biological fluid filters having flexible walls and methods for making such filters |
US9796166B2 (en) | 2014-03-24 | 2017-10-24 | Fenwal, Inc. | Flexible biological fluid filters |
US9968738B2 (en) | 2014-03-24 | 2018-05-15 | Fenwal, Inc. | Biological fluid filters with molded frame and methods for making such filters |
US10159778B2 (en) | 2014-03-24 | 2018-12-25 | Fenwal, Inc. | Biological fluid filters having flexible walls and methods for making such filters |
US10335802B2 (en) | 2015-03-18 | 2019-07-02 | Terumo Kabushiki Kaisha | Centrifuge and segment holder |
US10376627B2 (en) | 2014-03-24 | 2019-08-13 | Fenwal, Inc. | Flexible biological fluid filters |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2536202A1 (en) * | 2004-08-12 | 2006-02-12 | Jms Co., Ltd. | Filtration equipment and filtration method |
CN106577636B (en) * | 2016-12-29 | 2018-01-30 | 银丰生物工程集团有限公司 | A kind of novel cell for meeting sterile working requirement freezes bag and application method |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5180504A (en) * | 1991-05-22 | 1993-01-19 | Baxter International Inc. | Systems and methods for removing undesired matter from blood cells |
US5512187A (en) * | 1991-05-08 | 1996-04-30 | Baxter International Inc. | Methods for processing red cell products for long term storage free of microorganisms |
US5527472A (en) * | 1993-06-14 | 1996-06-18 | Baxter International Inc. | Closed systems and methods for removing undesired matter from blood cells |
US5601730A (en) * | 1992-09-02 | 1997-02-11 | Pall Corporation | Process and apparatus for removal of unwanted fluids from processed blood products |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0349188B1 (en) * | 1988-06-23 | 1992-09-02 | ASAHI MEDICAL Co., Ltd. | Method for separating blood into blood components, and blood components separator unit |
CN1084426A (en) * | 1992-07-13 | 1994-03-30 | 帕尔公司 | Handle the automated systems and methods of biofluid |
US6010633A (en) * | 1997-03-06 | 2000-01-04 | Hemasure Inc. | Method of preventing air from becoming entrapped within a filtration device |
DE19712298C2 (en) * | 1997-03-24 | 1999-05-20 | Fresenius Ag | Device and method for separating blood into blood components |
-
1998
- 1998-10-14 CN CN98120415A patent/CN1227764A/en active Pending
-
1999
- 1999-03-02 EP EP99909743A patent/EP1059989A4/en not_active Withdrawn
- 1999-03-02 BR BR9908445-7A patent/BR9908445A/en not_active Application Discontinuation
- 1999-03-02 AU AU28882/99A patent/AU2888299A/en not_active Abandoned
- 1999-03-02 JP JP2000534310A patent/JP2003501112A/en active Pending
- 1999-03-02 KR KR1020007009657A patent/KR20010074437A/en active Search and Examination
- 1999-03-02 WO PCT/US1999/004544 patent/WO1999044718A1/en not_active Application Discontinuation
- 1999-03-02 CA CA002321762A patent/CA2321762A1/en not_active Abandoned
- 1999-03-02 IL IL13808299A patent/IL138082A0/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5512187A (en) * | 1991-05-08 | 1996-04-30 | Baxter International Inc. | Methods for processing red cell products for long term storage free of microorganisms |
US5180504A (en) * | 1991-05-22 | 1993-01-19 | Baxter International Inc. | Systems and methods for removing undesired matter from blood cells |
US5601730A (en) * | 1992-09-02 | 1997-02-11 | Pall Corporation | Process and apparatus for removal of unwanted fluids from processed blood products |
US5527472A (en) * | 1993-06-14 | 1996-06-18 | Baxter International Inc. | Closed systems and methods for removing undesired matter from blood cells |
Non-Patent Citations (1)
Title |
---|
See also references of EP1059989A4 * |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1222935A1 (en) * | 2000-12-04 | 2002-07-17 | Terumo Kabushiki Kaisha | Method and device for obtaining a leucocyte-free blood preparation with reduced side effects |
US6796954B2 (en) | 2000-12-04 | 2004-09-28 | Terumo Kabushiki Kaisha | Method for preparing leucocyte-free blood preparation and blood administration set |
DE102004035352A1 (en) * | 2004-07-21 | 2006-02-16 | Gerätezentrale für Bluttransfusion des Österreichischen Roten Kreuzes GmbH | Closed sterile system and method for filtering biological or medical fluids, especially whole blood |
DE102004035352B4 (en) * | 2004-07-21 | 2007-05-10 | Gerätezentrale für Bluttransfusion des Österreichischen Roten Kreuzes GmbH | Closed sterile system for filtering biological or medical fluids, especially whole blood |
US7910008B2 (en) | 2004-07-21 | 2011-03-22 | Fresenius Hemocare Austria Gmbh | Sealed sterile system and method for filtering biological or medical fluids, in particular whole blood |
US9796166B2 (en) | 2014-03-24 | 2017-10-24 | Fenwal, Inc. | Flexible biological fluid filters |
US9782707B2 (en) | 2014-03-24 | 2017-10-10 | Fenwal, Inc. | Biological fluid filters having flexible walls and methods for making such filters |
US9968738B2 (en) | 2014-03-24 | 2018-05-15 | Fenwal, Inc. | Biological fluid filters with molded frame and methods for making such filters |
US10159778B2 (en) | 2014-03-24 | 2018-12-25 | Fenwal, Inc. | Biological fluid filters having flexible walls and methods for making such filters |
US10183475B2 (en) | 2014-03-24 | 2019-01-22 | Fenwal, Inc. | Flexible biological fluid filters |
US10343093B2 (en) | 2014-03-24 | 2019-07-09 | Fenwal, Inc. | Biological fluid filters having flexible walls and methods for making such filters |
US10376627B2 (en) | 2014-03-24 | 2019-08-13 | Fenwal, Inc. | Flexible biological fluid filters |
US10335802B2 (en) | 2015-03-18 | 2019-07-02 | Terumo Kabushiki Kaisha | Centrifuge and segment holder |
Also Published As
Publication number | Publication date |
---|---|
EP1059989A4 (en) | 2001-08-22 |
WO1999044718A8 (en) | 2000-02-10 |
JP2003501112A (en) | 2003-01-14 |
EP1059989A1 (en) | 2000-12-20 |
CA2321762A1 (en) | 1999-09-10 |
IL138082A0 (en) | 2001-10-31 |
CN1227764A (en) | 1999-09-08 |
BR9908445A (en) | 2000-11-14 |
AU2888299A (en) | 1999-09-20 |
KR20010074437A (en) | 2001-08-04 |
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