CN1227764A - Method of filtering and collecting blood or blood products - Google Patents
Method of filtering and collecting blood or blood products Download PDFInfo
- Publication number
- CN1227764A CN1227764A CN98120415A CN98120415A CN1227764A CN 1227764 A CN1227764 A CN 1227764A CN 98120415 A CN98120415 A CN 98120415A CN 98120415 A CN98120415 A CN 98120415A CN 1227764 A CN1227764 A CN 1227764A
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- CN
- China
- Prior art keywords
- blood
- bag
- product
- blood product
- filtering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D36/00—Filter circuits or combinations of filters with other separating devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
- A61M1/0218—Multiple bag systems for separating or storing blood components with filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
- A61M1/0231—Multiple bag systems for separating or storing blood components with gas separating means, e.g. air outlet through microporous membrane or gas bag
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
- A61M1/3633—Blood component filters, e.g. leukocyte filters
Abstract
A method of filtering and collecting blood or blood products is disclosed. The method includes filtering blood or blood product using a filtration device, collecting the blood or blood product in a receiving bag, allowing blood or blood products to remain in a first length of downstream tubing, mixing the blood or blood product within the receiving bag, sealing the first length of tubing into one or more segments having blood or blood product remaining therein to be later used for cross-matching of the blood or blood product, expressing blood or blood product from the receiving bag into a second length of tubing connected to the receiving bag, and sealing the second length of tubing into one or more segments having blood or blood products therein to be later used for quality control testing.
Description
Put it briefly and the present invention relates to the liquid filtering technology.More specifically, the present invention relates to can be used for to filter method with the online gravity filtration liquid of collection of biological fluid such as blood or blood product.
Typically, blood filter device allows liquid to retain in the defecator usually after filtration is finished.This retain liquid of hold-up volume that is called as is usually than desired maximum height.Simultaneously, blood filter device allows the air admission do not expected in a large number wherein and retain in and be subjected in the blood bag.
Authorize October 5 nineteen ninety-five, title is the 5th of " can be used for removing the defecator of leucocyte-removing and other blood constituent " the, 472, No. 605 United States Patent (USP)s, and in nineteen ninety-five JIUYUE 6 days application, title is the 08/524th of " a kind of blood that can be used for; the online defecator of blood products etc. " the, No. 049 U.S. Patent application, and in May 24 nineteen ninety-five application, title is the 08/449th of " a kind of defecator that can be used for removing leucocyte-removing and other blood constituent " the, No. 362 U.S. Patent applications, and on June 11st, 1996 application, title is the 08/661st of " a kind of defecator that can be used for removing leucocyte-removing and other blood constituent " the, in No. 804 U.S. Patent applications, some defecators that disclose.They are incorporated herein by reference and constitute the disclosed part of the present patent application.Adopt the filter method of these types of devices be difficult for to allow preservation, and be difficult for allowing being used for the preservation of the filtering blood of the whole filter quality that has filtered blood sample of accurately test for the filtering blood of cross matching.
It may be desired obtaining following a kind of liquid filtration method, and this method is provided for the filtering blood sample of cross matching, and a kind of preservation that is used for the filtering blood biased sample of quality control is provided.
Filter method according to the principle of the invention can reduce defective of the prior art and reach aforesaid target.But filter method filtering blood of the present invention is with the chemical agent that removes leucocyte-removing, other blood constituent, cell and be used for processing blood.
In one aspect of the invention, a kind of method of filtering and collecting blood or blood product comprises: filtering blood or blood products, with blood or blood product collect one accept bag (as, conventional transportation or storage bag) in, allow blood or blood product to remain in the first segment pipeline, in accepting bag, mix blood or blood product, sealing first segment pipeline constitutes one or more sections that wherein retain blood or blood product, blood or blood product is squeezed in the second pipe joint road from accept bag, and seal the second pipe joint road and constitute one or more sections.The blood that is sealed in the sections of first segment pipeline can be used for cross matching, and/or the blood that is sealed in the sections in the second pipe joint road can be used for quality control testing.
Accept air in the bag can be pressed into by the second pipe joint road with accept air bag that bag links to each other.This operation can be carried out blood or blood product is squeezed into the ducted operation of second joint from accept bag before.Blood or blood product is by removing by filter cell, and the blood or blood product of test in the sections in the second pipe joint road is to detect existing of these cells.For example, the cell that is filtered can be a leukocyte.Perhaps, or in addition, blood or blood product is by removing by filter chemistry or biological agent wherein, and the blood or blood product of test in the sections in the second pipe joint road is to detect existing of these medicaments.Can adopt the heat sealing device with first segment and the sealing of the second pipe joint road.
By doing in conjunction with the accompanying drawings and, can understanding the present invention best, wherein with reference to detailed description of the preferred embodiments:
Fig. 1 has shown a defecator, this defecator and blood supply bag, one operationally be assembled together by blood bag and an air bag, it can be used for blood filtration and collection method according to the principle of the invention.
Fig. 2 has shown the isometric drawing that is subjected to the segment mark on blood bag, air bag, air bag pipe and the air bag pipe that is installed on the defecator downstream according to the present invention.
The position that fluid flow through before as described herein, term upstream, top or top referred to not filter by filter element in defecator of the present invention.Term downstream, bottom or the bottom of being adopted in contrast, refers to filter the position that the back fluid flows through by filter element.
The present invention is designed to the multiple fluid that online gravity filtration comprises biofluid.But the method disclosed in the present is particularly suitable for filtering blood and/or blood products, describes its filtration to blood at this as reference.
Although can use multiple defecator according to the present invention, the defecator that when filtration is finished, is adopted should be able to be automatically with the drain of upstream extremity.Preferably, need not handle a plurality of elements when draining operation, and defecator should not exclusively drain its downstream.
Can be used for defecator of the present invention a type and be equipped with an automatic vent filter, import department, export department, filter element and parts and the parts that after filtration is finished, drain defecator upstream extremity liquid automatically that gas is removed from defecator by outlet.Disclose such defecator in the 08/812nd, No. 717 U.S. Patent application of on March 6th, 1997 application, the content of this patent application herein as a reference and constitute the disclosed part of the present patent application.
As shown in Figure 1, defecator 223 is depicted as with inlet tube 217, outlet 218, send blood bag 293, is subjected to blood bag 294, air bag 295, import pipe clamp 266, outlet pipe clamp 267 and air pipe clamp 268 constitute the operation confined states.Preferably, user can be buied and not comprise sealed, the sterile shown in Figure 1 whole assembly aseptic with the maintenance system of entrance point that send blood bag 293 (it will be used to hold the erythrocyte as by the donation after operating except that blood plasma) and inlet tube 217.For filtering, close preferred import pipe clamp 266 near inlet tube 217 entrance points.Then open outlet pipe clamp 267, and close preferred near the air pipe clamp 268 that is subjected to the venthole of blood bag 294.Can and send blood bag 293 to couple together with the inlet tube in the pipeline jack 287 that is connected in more than import department 201 centers 217 by a well known aseptic docking facilities in this area, or be connected on another blood supply source that comprises direct access patient.In case connecting, aseptic butt joint finishes, can be with on the hook 297 that send blood bag 293 to be suspended on blood bag bar 296.Be subjected to blood bag 294 and air bag 295 should place a surface, or be draped as on desktop, chest or the analog.This moment, package unit was used for preparation to filter.Inlet tube link 211 and outlet link 212 have been fixed inlet tube 217 and outlet 218 separately, make defecator 223 vertically hang.
Make gravity force blood to flow out by opening import pipe clamp 266, enter in the defecator 223, filter thus through inlet tube 217 from sending blood bag 293.Blood filtration will proceed to and send blood bag 293 to be drained or the blood flow in entering defecator is stopped.Therefore it also close shrinkage the entrance point of inlet tube 217 when sending blood bag 293 to be drained.But blood can remain in the filter element and outlet 218 of defecator.
With reference to figure 1, can close on the outlet 218 at defecator 223 and be subjected to pipe clamp 267 between the blood bag 294.Then, adopt by the conventional thermal safety device of fusion pipeline the outlet 218 of pipe clamp more than 267 sealed, outlet 218 is cut off with the upper part in sealing then its sealing typically by heat.Can will send blood bag 293, inlet tube 217 and defecator 223 to abandon in the mode of safety this moment.Then open pipe clamp 268, make to be subjected to the air in the blood bag 294 to be forced out and to enter in the air bag 295 through air bag pipe 298.This moment, the blood in being subjected to blood bag 294 can be mixed to guarantee uniformity, though the blood mixing also can be carried out before air is discharged from if necessary, preferably mixes when air is discharged from laggard promoting the circulation of blood liquid.In case after from be subjected to blood bag 294, extruded by air in the blood bag 294, can from be subjected to blood bag 294, extrude and mix blood and enter in the air bag pipe 298 and be full of this pipeline.Can close pipe clamp 268 this moment, then near air bag 295 place's occluded air bag pipes 298.Can downcut air bag 295 and abandon in the mode of safety from the sealing that has just made this moment with the upper part.Therefore, be retained by blood bag 294 and outlet 218 and air bag 298.
All segment mark can be arranged on outlet 218 and the air bag pipe 298.Fig. 2 has shown the segment mark 292 on the air bag pipe 298.Therefore, if desired can be on ready-formed segment mark closing pipe line.Be closed in blood in outlet 218 sections and can be used for testing itself and a patient or other receiver's the compatibility, promptly be used for cross matching.In addition, be closed in concentration and other quality control that mixing blood in air bag pipe 298 sections can be used for testing filtering material.If for example blood is filtered and is used for removing leucocyte-removing, the filtering blood that is closed in the pipeline 298 can be tested to check leukocytic the existence and concentration.Similarly, filtration is used to test existing and concentration with this medicament after the inspection filtration with the blood of removing chemical agent.Because the blood in the air bag pipe is used to quality control, before blood being got in the air bag pipe, preferably mixes or stir the blood that is subjected in the blood bag.Mix or stir and to help to minimize or prevent to be used for the Concentraton gradient that quality control is tested the composition of blood.
Although invention has been described in conjunction with embodiment described here, technical staff for field of the present invention, clearly under the situation of the scope of the invention that does not deviate from following claims and defined, can much revise these embodiments.
Claims (23)
1, a kind of method of filtering and collecting blood or blood product, it comprises:
Adopt defecator filtering blood or blood products;
Blood or blood product is collected one to be accepted in the bag;
After filtering described blood or blood product, allow blood or blood product to remain in and be positioned at the defecator downstream, in the first segment pipeline of described acceptance bag upstream;
In described acceptance bag, mix blood or blood product;
Sealing first segment pipeline constitutes one or more sections that wherein retain blood or blood product, and the described blood or blood product in this sections is used for cross match blood test;
Blood or blood product squeezed into from accept bag with described be subjected in the second pipe joint road that the blood bag links to each other; And
Seal the second pipe joint road and constitute one or more sections that blood or blood product is wherein arranged, the described blood or blood product in this sections is used for quality control testing.
2, the method for claim 1, it comprises that further the described air extrusion of accepting in the bag is advanced one to be accepted in the air bag that bag links to each other with described.
3, method as claimed in claim 2, wherein, described air is extruded through the described second pipe joint road and enters in the described air bag.
4, method as claimed in claim 2, wherein, with blood or blood product before described acceptance bag squeezes into the described second pipe joint road, described air is extruded through the described second pipe joint road and enters in the described air bag.
Whether 5, as claim 1 or 4 described methods, it further comprises the blood or blood product of testing in the sections that is sealed in the first segment pipeline, be complementary with the described blood or blood product of accepting in the bag to determine described blood or blood product.
6, method as claimed in claim 5, it further comprises the ducted blood or blood product of test second joint, to determine the filter quality of described blood or blood product.
7, method as claimed in claim 6, wherein, described blood or blood product is filtered removing cell, and test at the ducted described blood or blood product of second joint to check existing of described cell.
8, method as claimed in claim 7, wherein, described cell comprises leukocyte.
9, method as claimed in claim 6, wherein, described blood or blood product is filtered removing chemistry or biological agent wherein, and test at the ducted described blood or blood product of second joint to check existing of described medicament.
10, method as claimed in claim 9, wherein, the described first or second pipe joint road adopts the sealing of heat sealing device.
11, a kind of method of filtering and sealing blood or blood product, it comprises:
Adopt defecator filtering blood or blood products;
The described blood or blood product first segment pipeline of flowing through, and described blood or blood product is collected one accept in the bag;
In described acceptance bag, mix described blood or blood product;
With blood or blood product from described accept to squeeze into the bag with described be subjected in the second pipe joint road that the blood bag links to each other;
Seal the described second pipe joint road and constitute one or more sections that wherein contain blood or blood product; Then
Test is sealed in described blood or blood product the existing with the filtering component of inspection in one or more sections.
12, method as claimed in claim 11, it comprises that further the described air extrusion of accepting in the bag is advanced one to be accepted in the air bag that bag links to each other with described.
13, method as claimed in claim 12 wherein, squeezes into described air in the described air bag through the described second pipe joint road by pushing described acceptance bag.
14, method as claimed in claim 11, wherein, described blood or blood product is filtered removing cell, and test at the ducted described blood or blood product of second joint to check existing of described cell.
15, method as claimed in claim 14, wherein, described cell comprises leukocyte.
16, method as claimed in claim 12, wherein, described blood or blood product is filtered removing chemistry or biological agent wherein, and test at the ducted described blood or blood product of second joint to check existing of described medicament.
17, as claim 13 or 16 described methods, it further comprises after filtering described blood or blood product, allow blood or blood product to remain in the described first segment pipeline, and the one or more sections that wherein contain blood or blood product of sealing first segment pipeline formation, the described blood or blood product in the sections is used for cross match blood test.
18, method as claimed in claim 17, whether it further comprises the blood or blood product of testing in the sections that is sealed in the first segment pipeline, be complementary with the described blood or blood product of accepting in the bag to determine described blood or blood product subsequently.
19, as claim 4 or 13 described methods, it further comprises the described second pipe joint road of sealing, and the position between described sealing and described air bag cuts off the described second pipe joint road.
20, method as claimed in claim 19, it further comprises the described first segment pipeline of sealing, and the position between described sealing and described defecator cuts off described first segment pipeline.
21, a kind of gathering system of blood or blood product, it comprises:
An acceptance bag that wherein has filtering blood or blood product, described filtering blood flows out from a feeding bag, enters in the described acceptance bag through a defecator;
Accept the first segment pipeline that bag extends out and wherein has filtering blood or blood product from described for one, described first segment pipeline is connected with described defecator in advance, and downcuts then from it and seal; With
Accept the second pipe joint road that bag extends out and wherein has filtering mixing blood or blood product from described for one, the described second pipe joint road is accepted bag with described air in advance and is connected, and downcuts then from it and seal.
22, system as claimed in claim 21, wherein, described first segment pipeline is sealed to a plurality of sections, has filtering blood in this sections.
23, the system as claimed in claim 22, wherein, the described second pipe joint road is sealed to a plurality of sections, has in this sections through blended filtering blood.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7655898P | 1998-03-02 | 1998-03-02 | |
US60/076,558 | 1998-03-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN1227764A true CN1227764A (en) | 1999-09-08 |
Family
ID=22132781
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN98120415A Pending CN1227764A (en) | 1998-03-02 | 1998-10-14 | Method of filtering and collecting blood or blood products |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1059989A4 (en) |
JP (1) | JP2003501112A (en) |
KR (1) | KR20010074437A (en) |
CN (1) | CN1227764A (en) |
AU (1) | AU2888299A (en) |
BR (1) | BR9908445A (en) |
CA (1) | CA2321762A1 (en) |
IL (1) | IL138082A0 (en) |
WO (1) | WO1999044718A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100386131C (en) * | 2004-08-12 | 2008-05-07 | 株式会社Jms | Filtration apparatus and filtration method |
CN106577636A (en) * | 2016-12-29 | 2017-04-26 | 银丰生物工程集团有限公司 | Novel cell cryopreservation bag meeting sterile operation requirements and use method |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002173433A (en) * | 2000-12-04 | 2002-06-21 | Terumo Corp | Method for preparing blood preparation from which leukocyte is removed and blood set |
DE102004035352B4 (en) * | 2004-07-21 | 2007-05-10 | Gerätezentrale für Bluttransfusion des Österreichischen Roten Kreuzes GmbH | Closed sterile system for filtering biological or medical fluids, especially whole blood |
US9968738B2 (en) | 2014-03-24 | 2018-05-15 | Fenwal, Inc. | Biological fluid filters with molded frame and methods for making such filters |
US9782707B2 (en) | 2014-03-24 | 2017-10-10 | Fenwal, Inc. | Biological fluid filters having flexible walls and methods for making such filters |
US10159778B2 (en) | 2014-03-24 | 2018-12-25 | Fenwal, Inc. | Biological fluid filters having flexible walls and methods for making such filters |
US9796166B2 (en) | 2014-03-24 | 2017-10-24 | Fenwal, Inc. | Flexible biological fluid filters |
US10376627B2 (en) | 2014-03-24 | 2019-08-13 | Fenwal, Inc. | Flexible biological fluid filters |
US10335802B2 (en) | 2015-03-18 | 2019-07-02 | Terumo Kabushiki Kaisha | Centrifuge and segment holder |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU617265B2 (en) * | 1988-06-23 | 1991-11-21 | Asahi Medical Co. Ltd. | Method for separating blood into blood components, and blood components separator unit |
WO1992019355A1 (en) * | 1991-05-08 | 1992-11-12 | Baxter International Inc. | Methods for processing red blood cell products for long term storage free of microorganisms |
US5180504A (en) * | 1991-05-22 | 1993-01-19 | Baxter International Inc. | Systems and methods for removing undesired matter from blood cells |
GB2284909B (en) * | 1992-07-13 | 1996-11-13 | Pall Corp | Automated system and method for processing biological fluid |
GB9218581D0 (en) * | 1992-09-02 | 1992-10-14 | Pall Corp | Removal of unwanted fluids from processed blood products |
US5527472A (en) * | 1993-06-14 | 1996-06-18 | Baxter International Inc. | Closed systems and methods for removing undesired matter from blood cells |
US6010633A (en) * | 1997-03-06 | 2000-01-04 | Hemasure Inc. | Method of preventing air from becoming entrapped within a filtration device |
DE19712298C2 (en) * | 1997-03-24 | 1999-05-20 | Fresenius Ag | Device and method for separating blood into blood components |
-
1998
- 1998-10-14 CN CN98120415A patent/CN1227764A/en active Pending
-
1999
- 1999-03-02 JP JP2000534310A patent/JP2003501112A/en active Pending
- 1999-03-02 IL IL13808299A patent/IL138082A0/en unknown
- 1999-03-02 BR BR9908445-7A patent/BR9908445A/en not_active Application Discontinuation
- 1999-03-02 WO PCT/US1999/004544 patent/WO1999044718A1/en not_active Application Discontinuation
- 1999-03-02 EP EP99909743A patent/EP1059989A4/en not_active Withdrawn
- 1999-03-02 AU AU28882/99A patent/AU2888299A/en not_active Abandoned
- 1999-03-02 CA CA002321762A patent/CA2321762A1/en not_active Abandoned
- 1999-03-02 KR KR1020007009657A patent/KR20010074437A/en active Search and Examination
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100386131C (en) * | 2004-08-12 | 2008-05-07 | 株式会社Jms | Filtration apparatus and filtration method |
CN106577636A (en) * | 2016-12-29 | 2017-04-26 | 银丰生物工程集团有限公司 | Novel cell cryopreservation bag meeting sterile operation requirements and use method |
CN106577636B (en) * | 2016-12-29 | 2018-01-30 | 银丰生物工程集团有限公司 | A kind of novel cell for meeting sterile working requirement freezes bag and application method |
Also Published As
Publication number | Publication date |
---|---|
EP1059989A4 (en) | 2001-08-22 |
IL138082A0 (en) | 2001-10-31 |
CA2321762A1 (en) | 1999-09-10 |
EP1059989A1 (en) | 2000-12-20 |
JP2003501112A (en) | 2003-01-14 |
AU2888299A (en) | 1999-09-20 |
KR20010074437A (en) | 2001-08-04 |
WO1999044718A1 (en) | 1999-09-10 |
WO1999044718A8 (en) | 2000-02-10 |
BR9908445A (en) | 2000-11-14 |
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