WO1999039670A1 - Tongue placed tactile output device - Google Patents
Tongue placed tactile output device Download PDFInfo
- Publication number
- WO1999039670A1 WO1999039670A1 PCT/US1999/001734 US9901734W WO9939670A1 WO 1999039670 A1 WO1999039670 A1 WO 1999039670A1 US 9901734 W US9901734 W US 9901734W WO 9939670 A1 WO9939670 A1 WO 9939670A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tactile
- array
- tactile stimulation
- mouth
- stimulation array
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/08—Devices or methods enabling eye-patients to replace direct visual perception by another kind of perception
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0548—Oral electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
- A61N1/36034—Control systems specified by the stimulation parameters
Definitions
- Tactile vision substitution systems are used to deliver image information to the brain via an array of stimulators in contact with the skin in one of several parts of the body, for example, the abdomen, the back, the thigh or the fingertip. Points of the image are mapped to individual stimulators in the array as either vibrations or direct electrical excitation. With training, perceptual judgments normally used for vision such as depth judgment can be applied to these tactile images.
- a summary of the art in this field is provided in a paper by the present inventors, hereby incorporated by reference, entitled: Electrotactile and Vibrotactile Displays for Sensory Substitution Systems. IEEE Transactions on Biomedical Engineering, Volume 38, No. 1, January 1991.
- TVSS systems have been limited in practical application. Mechanical vibrotacter systems in which the stimulators vibrate are bulky and require considerable energy. Electrotactile systems in which the stimulators produce direct electrical stimulation require relatively high voltage, especially in areas of the fingertips, because there are protective layers of skin between skin surface and the skin's sensory receptors. TVSS systems which use the fingertips as a reception site, limit the use of the hands for other tasks whereas systems using a site such as the abdomen require larger arrays, are less convenient, and require a conductive gel for proper operation.
- the present invention provides an improved human/machine interface (HMI) system using the tongue as a stimulation site.
- the tongue contains a large number of nerve endings, thus permitting the construction of a small array with a high number of stimulators.
- Preliminary data by the inventors shows that users tend to adapt or accommodate stimulation current over time when that current is applied to the fingertip requiring the stimulation current or voltage to be increased.
- subjects maintain a constant or even slightly decreasing current level for tongue stimulation.
- the present invention provides a tactile stimulation array for the tongue having a mouth part sized to be received and stabilized within the mouth and an array of tactile elements positioned over a lower surface of the mouth part to be in contact with the tongue when the mouth part is received within the mouth.
- Excitation circuitry communicates with the tactile elements and receives a spatially encoded signal to excite selected ones of the tactile elements according to the spatial encoding.
- the tactile elements may be electrodes and the excitation circuitry may connect the electrodes to a source of electrical power to excite selected ones of the tactile elements.
- the spatially encoded signal may include a plurality of data points having defined locations and magnitudes and the excitation circuit may map data points to tactile elements having corresponding locations and excite the tactile elements with an electrical pulse according to a function having the data point magnitude as a range and a value selected from the group of: pulse amplitude, pulse duration, and pulse frequency content.
- each point of stimulation may have a varied intensity based on a variety of factors.
- a multidimensional stimulus may be obtained.
- the mouth part may include an upwardly concave plate supporting on its lower surface the tactile elements and sized to fit beneath the hard palate.
- the tongue is highly mobile and may be moved against and away from a tongue based array as required.
- the upwardly concave plate may be flanked at its lateral edges by bite bars wherein the mouth part may be stabilized within the mouth by a pressing of the bite bars between the teeth.
- a dental retainer design may be used with wire brackets engaging the teeth.
- the mouth part may be a nipple sized to be stabilized within the mouth of a sucking infant.
- the array may include a receiver communicating with the excitation circuitry in receiving the spatially encoded signal as a radio wave. It is thus another object of the invention to allow the array to be entirely contained within the mouth without obstructing or cumbersome electrical leads. Because electrical stimulation of the tongue requires only about three percent of the voltage as required by the fingertip and much less current, self-contained battery operation is possible.
- FIG. 1 is a perspective view of a first embodiment of the mouth-based human/machine interface system of the present invention seen from below according to its orientation within a user's mouth;
- Fig. 2 is a phantom view of a person's head showing placement of the array within the mouth and showing the path of reception via free-space electromagnetic waves of image data from a camera attached to the frame of a pair of glasses;
- Fig. 3 is a block diagram showing the circuit elements of the embodiments of Figs. 1 and 2 including a switch array eliminating the need for a continuous ground plane;
- Fig. 4 is a plan view of the bottom of a second embodiment of the human/machine interface system of the present invention in which the array is incorporated into a pacifier for infant use;
- Fig. 5 is a timing diagram showing the delivery of electrical stimulation to three elements of the array of Figs. 1 or 4 for producing various intensities or multidimensional stimulation;
- Fig. 6 is a fragmentary cross-sectional view taken along line 6—6 of Fig. 1 showing the placement of the electrodes for stimulation in wells within an insulating plate against which the tongue may be placed;
- Fig. 7 is a fragmentary cross sectional view taken along lines 6—6 of Fig. 1 showing an alternative embodiment of the electrode design without wells using a flexible printed circuit element;
- Fig. 8 is a fragmentary plan view of the alternative embodiment of Fig. 7 showing an alternative ground plane construction;
- Fig. 9 is a perspective view of the printed circuit element of Fig. 7 removed from the supporting structure;
- Fig. 10 is block diagram of an alternative embodiment of the mouth-based human/machine interface of the present invention providing for bi-directional communication to provide an integrated control device.
- a first embodiment of the mouth-placed tactile array unit 10 of the present invention includes a horseshoe shaped bite bar 12 sized to be held between the teeth of a typical adult user.
- An upwardly concave plate 14 spans the distance between the opposing legs of the bite bar 12 so as to fit against the hard palate of a user when the bite bar is held between the teeth.
- the bite bar may be eliminated and the concave plate 14 used alone in the manner of a dental retainer, shown in Fig. 10, such as is well understood in the art.
- an array 16 of electrodes 18 exposed at a lower surface of plate 14 so as to receive the upper surface of the user's tongue, is an array 16 of electrodes 18 arranged generally in parallel rows and columns. It will be understood, however, that a regular spacing of the electrodes 18 need not be adhered to but that a variation in the spacing may occur for example to provide higher spatial resolution for certain portions of the tongue than others. In this regard, several peripheral electrodes 20 may be placed at the edges of the plate 14 to contact the sides of the tongue.
- each electrode 18 may be surrounded by a matrix of insulating material 22 and placed within a well 24 opening toward the tongue 26 when the tactile array unit 10 is in place within the mouth.
- the electrodes 18 may be flat-topped stainless steel pins.
- Individual wells 24 are spaced along the lower surface of the plate 14 by interwell regions of the insulating material 22 to encourage electrical stimulation of the tongue 26 rather than direct current flow between electrodes 18.
- the wells remove the electrodes 18 from direct contact with the tongue 26 but allow for electrical conduction through saliva 28 which is refreshed by the action of the saliva glands in the mouth. Referring now to Figs. 7, 8 and 9, more recent research has suggested that the wells 24 (of Fig.
- a gap between the electrode 18 and the tongue 26 may cause variation in the perceived stimulation and cause adverse mechanical sensation during scanning. Further, because the tongue 26 appears to effectively continuously clean the electrode surface, a completely flat surface may be the best choice for a tongue electrode because saliva cannot build up in gaps. Accordingly, in an alternative embodiment, the wells are eliminated and the surface of the electrodes 18 are made flush or projecting above the insulating material 22.
- the electrodes may be realized as disk shaped pads 18' on the lower surface of a flexible printed circuit board 63 fabricated by standard lithographic techniques known in the art.
- the electrodes 18' may be etched copper that is then gold plated for bio-compatibility purposes on the surface of an insulating carrier 65 connected to photographically etched connector leads 64 on the other side of the carrier 65 by means of plate-through holes 66 known in the art.
- the flexible printed circuit board 63 may include an upper insulating layer 68 then embedded in the material of the plate 14.
- a ground plane 70 of copper plated with gold may be formed around the electrodes 18' by etching annular gaps 72 about each electrode 18' so that the electrodes 18' are exposed within the gaps and the area outside the gaps 72 is electrically interconnected.
- the ground plane 70 is connected to provide a return path for electrical current from the electrodes 18'.
- the flexibility of the flexible printed circuit board 63 allows increased flexibility of the retainer structure and the promise of improved comfort.
- the carrier 65 is preferably a polyester to maintain bio-compatibility and provide for minimal water absorption in the oral environment.
- the electrodes 18 in either embodiment may be stainless steel, titanium, platinum, gold or other bio-compatible conductor.
- An example electrode array fabricated in this manner might include 144 electrodes arranged on a 2.3 mm grid to form an array approximately 3 cm square. The size and number of electrodes may be readily varied according to the following guidelines. Generally smaller electrodes can produce a stinging sensation whereas larger electrodes produce a comfortable vibratory perception at the expense of resolution. Presently 0.6
- the electrodes 18 and 20 communicate with a circuit block 30 which may be attached to the plate 14 toward its rear so as to minimize interference with the tongue.
- a circuit block 30 may be attached to the plate 14 toward its rear so as to minimize interference with the tongue.
- a study of retainers for a cross section of the populations suggests that a space of 23 by 15 by 2 mm is available at the back of the plate 14 or two spaces 12 by 9 by 4 mm. Theses spaces may hold a circuit block 30 together with a battery power source (not shown) encapsulated in the same insulating material 22 holding the array 16 and forming the bite bars 12.
- the circuit block 30 may communicate with external devices without direct connection thereto, by radio or the like.
- the printed circuit material or a cable connected to the conductors of the printed circuit material may extend outside the mouth for direct connection to external processing electronics including the circuit block 30 eliminating the need for in-mouth electronic processing.
- the circuit block may be incorporated into the plate but may derive its power from an external source, for example, low frequency induction or the like.
- Each electrode 18 is connected to a switch array 34 within the circuit block 30.
- the individual leads connecting the electrodes 18 to the switch array 34 are embedded in an insulated matrix which may be cast or formed about the electronics.
- Flexible printed circuit technology may be used to provide interconnections between the electrodes and the electronics in the case where the electrodes are not part of the printed circuits.
- An insulating cover is placed over the printed circuit wiring so that the latter is sandwiched between the insulating substrate of the printed circuit material and the insulating cover.
- the switch array holds a series of solid state switches 36 activated by multiplexer lines 38 from a multiplexer 40.
- Each solid state switch 36 has a throw connected to one electrode 18 and two poles allowing the throw to be connected to either a pulse source 42 or ground 44 depending on the state of a multiplexer line 38.
- the multiplexer 40 controlling the multiplexer lines 38, and the pulse source 42 receive data from a receiver 47 comprising location information 46 and intensity or multidimensional stimulation information 50.
- the location information 46 is the location of a pixel value within the image and the intensity information is the intensity of the pixel (when the image is black and white) or the full or partial color value of the pixel.
- the location information 46 is passed to the multiplexer typically based on an implicit ordering of the data points received by the receiver 47.
- the multiplexer 40 drives selected ones of the multiplexer lines 38 to scan through the electrodes 18 activating one electrode 18 at a time by connecting it through solid state switch 36 to the pulse source 42 and connecting the surrounding electrodes or all other electrodes to ground 44 or other return via their solid state switches 36.
- the particular electrode 18 being stimulated is successively changed according to the location information so that all electrodes 18 are stimulated in sequence over a period of a scan.
- the electrodes 18 will be scanned in a raster pattern moving across each row and then returning to the first row at the next column until all electrodes have been scanned.
- the electrodes may be scanned to follow the outline of the object as determined by standard edge detecting morphometric techniques.
- the amount of stimulation of a given electrode 18 is according to the intensity information 50.
- the intensity information is binary and each electrode 18 receives either a monophasic (zero net DC) pulse or no pulse so that simple shapes may be detected.
- the electrode is pulsed for 5-50 ⁇ s at a rate of 10-400 pulses per second.
- the pulses may be either current controlled (0.4-4.0 ma) or voltage controlled (5- 15 volts).
- current control means the value of the current is defined and the voltage adjusted to produce that current at the tongue, whereas voltage control means the voltage is defined and the current adjusted to produce that voltage at the tongue.
- multidimensional intensity information 50 is provided to the pulse source 42 which produces a pulse 52 that may vary in any one of six parameters: pulse height (measured as current or voltage or power), pulse width, the interval between pulses, the number of pulses in a burst, the interval between bursts and the frame rate (i.e., the time between successive scans of the array), as a function of the intensity information 50.
- pulse height measured as current or voltage or power
- pulse width the interval between pulses
- the number of pulses in a burst the interval between bursts and the frame rate (i.e., the time between successive scans of the array)
- the frame rate i.e., the time between successive scans of the array
- each pulse 52 is composed of subpulses 51 which allow simple control of the frequency content and energy of the pulse 52.
- the other electrodes e.g., 18b and 18c
- pulse 18b has a lower amplitude 54 and different frequency content than pulse 18a and pulse 18c has a different pulse width 55.
- the pulses 52 may convey multidimensional information in much the same way that the eye perceives color from the independent stimulation of different color receptors.
- each pulse 52 is completed prior to the next electrode 18 being selected by the multiplexer 40, it will be understood that this need not be the case but that the subpulses 51 of the pulses 52 may be interleaved with the subpulses 51 of other pulses 52 to allow faster scanning and lower frequency content pulses 52.
- each subpulse 51 may be on the order of 25 microseconds but separated by five milliseconds from the next with the scanning period for an electrode array being less than 5 milliseconds so that the first subpulse 51 for each electrode 18 may occur before the second subpulse 51.
- the pulses may be either current or voltage controlled and thus the height depicted in Fig. 5 may be a current or voltage, the two being related by the intrinsic resistance of the tongue electrode interface. Generally both current and voltage limits are imposed on the pulses 52.
- the electrodes 18 of the array 16 may be used including those which consider not only the intensity information 50 of individual data points but the intensity information 50 of adjacent data points to provide edge enhancement and the like. Further the mapping of the location information 46 data points and the particular electrodes 18 may be changed so as to provide for a zooming effect in which the image is "enlarged" on the array 16. The amount of zoom could be controlled by an external controller (not shown) or by sensing electrodes in the mouth itself. Particularly with regard to zooming, the peripheral electrodes 20 may be used to provide an indication of a composite intensity information 50 of groups of data points outside of the array 16 so as to, for example, mimic peripheral vision in which a presence of an object off-center may be detected though not fully resolved.
- the visual data received by the receiver may be image data from a miniaturized camera 56, for example, employing a solid state CCD or charge-coupled device type detector.
- that data may be transmitted by radio waves via transmitting and receiving antennae 45 according to techniques well known in the art.
- FM modulated radio frequency signals may be used, or given the close proximity of the camera 56 to the tactile array unit 10, directly modulated low frequency magnetic fields employed.
- radio waves should be held to embrace electromagnetic waves of any frequency.
- the wire clips of the retainer structure could serve as an antenna.
- the camera 56 may be mounted on glass frames 58 and the necessary transmitting electronics supported on a temple 61 of the glass frames to be close to and stabily positioned with respect to the circuit block 30 holding the receiver 47.
- Proximity sensing electronics may be incorporated to conserve battery power for the tactile array unit 10 when it has been removed from the mouth of a user.
- the array 16 may have its electrodes 18 exposed from the lower surface of a nipple 60 forming a part of a pacifier 62 having an outward shape similar to ordinary pacifiers well known in the art.
- mouth suction control is present at the earliest age and so the nipple 60 could be retained and stabilized within the mouth by such suction action.
- the camera 56 is positioned on the portion of the pacifier 62 extending out of the baby's mouth normally reserved for a pivoting ring or the like and aligned optically with the long axis of the nipple 60 so that the infant's face is directed toward the source of the image in a natural manner.
- the circuit block 30 is in this case retained within the body of the pacifier itself a portion of which remains outside the infant's mouth.
- a direct connection between the camera 56 and the electronics may be had eliminating the need for the radio link. It is believed that the stimulation provided to sight impaired infants could help develop the neural pathways used in image processing.
- the pacifier configuration may also be used for adults and that the signal providing for zoom or other control of the tactile image or for other output purposes may be provided by the user by biting switches positioned between the teeth.
- the cameras described above may employ CMOS type image circuitry to create so-called "active pixel" devices in which image processing may be performed on the same die as that which hold the light sensing array.
- Such processing may include but is not limited to compression, edge or contrast enhancement, motion detection and even generation of the stimulus pattern to be used by the electrode array.
- a camera suitable for use with the present invention is commercially available from Austria Micro Systems of Austria and features a matrix of 64 by 64 pixels in a 2 by 2 mm square using conventional 1.3 ⁇ m double metal double poly CMOS process and providing on-chip logarithmic compression with different gains and time constants for static and dynamic illumination so as to mimic the human retina. This camera has demonstrated a dynamic range of about eight orders of magnitude in incident light intensity and a slope ratio of about 30:1 between the static and dynamic cases. Digitization of the signals is accomplished on chip. Referring now to Fig.
- the data received by the tactile array unit 10 need not be visual data but for example may provide tactile data for example from a sensor 80, for persons with a limb prosthesis or astronauts who must wear heavy gloves or operators of remote manipulators.
- the tactile data may include information about shape, shear forces, pressure and slip.
- One promising tactile sensor employs an elliptically shaped elastomeric membrane filled with a clear fluid the inner surface of the membrane is imprinted with a pattern so that deformation of the membrane by touching an object deforms the pattern in a way detectable by a camera aimed at the membranes inner 5 surface.
- Gloves for leprosy patients with insensate hands or insoles for diabetic patients with insensate feet can be used with the present invention where the tactile data is conveyed to the mouth.
- the present invention may accept tactile data from a penile sheath for spinal cord injured patients who have lost sexual sensation.
- the tactile data may be received by processing electronics 82, for example, a o microprocessor processing the image from the camera system described above, and then transmitted by transceiver 84 to the tactile array unit 10.
- the tactile array unit 10 may include one or more mouth-based sensors 79 that may be activated by the tongue 26 (not shown).
- the sensors 79 are conventional mechanical switches such as membrane switches incorporated into the material of the plate 14 but may also be electronic sensors detecting tongue placement using conventional impedance sensing techniques.
- the signal output from the sensors 80 of the tactile array unit 10 may be received by the transceiver 84 and conveyed through the processing electronics 82 to an actuator 86 such as a robot hand.
- Such a system could provide, for example, control of a robotics hand for persons with quadriplegia where the sensor 80 is one or more tactile sensors and the actuator is one or more robot axis motors.
- the mouth-based sensors 79 may detect mouth chemistry using techniques known in the art, and may be combined with the tactile array unit 10 of the present invention to provide the user with an indication of blood levels of Nitrogen or CO 2 or the like, such as may be useful for divers.
- a camera When a camera is the input sensor to the tactile array unit 10, it need not be 5 limited to a visible light range but may be a night vision camera or infrared vision camera (for example, for pilots or drivers) where bypassing the retina in favor of the tongue eliminates retinal delay.
- Image or non-image data may be used to augment visual information received by sighted individuals for example in infrared regions, ultrasonic or radar images for avionics and the like.
- the input be conventional sensory type o inputs such as vision or touch or sound but may be fundamental data, for example, such as navigational direction and orientation for scuba divers and the like prone to becoming disoriented.
- the mouth-based HMI of the present invention relieves over-dependence on the visual pathways and may have as an input "take immediate action” indicators, such as those from collision avoidance systems in aircraft, 5 or may provide expanded “peripheral vision” about enemy planes or missiles approaching from the side or rear.
- General communication functions could be provided through such an HMI for secret communications.
- the tactile array unit may be used to augment video game output or provide for communication in very noisy environments or where sound is not permitted and for operation of machinery requiring extensive use of the hands such as crane operators or those manipulating contaminated nuclear materials.
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Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ505891A NZ505891A (en) | 1998-02-06 | 1999-01-28 | Tongue placed tactile output device |
DE69925813T DE69925813T2 (en) | 1998-02-06 | 1999-01-28 | ON TONGUE PUBLISHED KEY OUTPUT DEVICE |
JP2000530173A JP3643033B2 (en) | 1998-02-06 | 1999-01-28 | Tactile output device placed on tongue |
AU23457/99A AU743482B2 (en) | 1998-02-06 | 1999-01-28 | Tongue placed tactile output device |
EP99903438A EP1052957B9 (en) | 1998-02-06 | 1999-01-28 | Tongue placed tactile output device |
CA002319525A CA2319525C (en) | 1998-02-06 | 1999-01-28 | Tongue placed tactile output device |
AT99903438T ATE297707T1 (en) | 1998-02-06 | 1999-01-28 | TASTE DISPENSING DEVICE LOCATED ON THE TONGUE |
US09/601,717 US6430450B1 (en) | 1998-02-06 | 1999-01-28 | Tongue placed tactile output device |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7387398P | 1998-02-06 | 1998-02-06 | |
US60/073,873 | 1998-02-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999039670A1 true WO1999039670A1 (en) | 1999-08-12 |
Family
ID=22116322
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/001734 WO1999039670A1 (en) | 1998-02-06 | 1999-01-28 | Tongue placed tactile output device |
Country Status (10)
Country | Link |
---|---|
US (1) | US6430450B1 (en) |
EP (1) | EP1052957B9 (en) |
JP (1) | JP3643033B2 (en) |
AT (1) | ATE297707T1 (en) |
AU (1) | AU743482B2 (en) |
CA (1) | CA2319525C (en) |
DE (1) | DE69925813T2 (en) |
ES (1) | ES2242377T3 (en) |
NZ (1) | NZ505891A (en) |
WO (1) | WO1999039670A1 (en) |
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AU743482B2 (en) | 2002-01-24 |
EP1052957B1 (en) | 2005-06-15 |
EP1052957A1 (en) | 2000-11-22 |
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JP3643033B2 (en) | 2005-04-27 |
CA2319525A1 (en) | 1999-08-12 |
AU2345799A (en) | 1999-08-23 |
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DE69925813D1 (en) | 2005-07-21 |
DE69925813T2 (en) | 2006-05-04 |
JP2002502631A (en) | 2002-01-29 |
NZ505891A (en) | 2002-11-26 |
CA2319525C (en) | 2004-06-01 |
ES2242377T3 (en) | 2005-11-01 |
EP1052957B9 (en) | 2006-03-08 |
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