WO1999037308A1 - Method for producing a medicament which quickly dissolves in the mouth and which contains acarbose as an active agent - Google Patents
Method for producing a medicament which quickly dissolves in the mouth and which contains acarbose as an active agent Download PDFInfo
- Publication number
- WO1999037308A1 WO1999037308A1 PCT/EP1999/000131 EP9900131W WO9937308A1 WO 1999037308 A1 WO1999037308 A1 WO 1999037308A1 EP 9900131 W EP9900131 W EP 9900131W WO 9937308 A1 WO9937308 A1 WO 9937308A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- acarbose
- mouth
- producing
- medicament
- active agent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
Definitions
- Acarbose is the first representative of the class of alpha-glucosidase inhibitors, which, by inhibiting the alpha-glucosidase enzymes, delays the cleavage of sucrose, dextrin and starches in the intestine and thus smoothes the blood sugar level
- the method according to the invention describes the composition and production of rapidly disintegrating tablets which dissolve in the mouth by contact with the saliva
- the active ingredient is granulated alone or with parts of the filler with the aid of dry compaction and sieving and compressed to flat wafers on a conventional tablet press
- Particularly suitable fillers are water-insoluble auxiliaries, for example calcium phosphate or microcrystalline cellulose
- the proportion of the active ingredient in the formulation is preferably 40-90%, the proportion of fillers and auxiliaries 10-60%.
- Acarbose, milk sugar and microcrystalline cellulose are mixed in a suitable container.
- the cross-linked polyvinylpyrollidone and the magnesium stearate are added and mixed again.
- the ready-to-press mixture is pressed on a conventional tablet press into tablets which have a diameter of 12 mm.
- the height of the tablets is less than 2 mm.
- the tablet disintegrates in less than 2 minutes.
- Acarbose, calcium hydrogen phosphate and sodium bicarbonate are mixed in a suitable container. After dry compaction and subsequent sieving, the citric acid is added.
- the ready-to-press mixture is compressed in a conventional tablet press to tablets which have a diameter of 12 mm.
- the height of the tablets is less than 2 mm.
- the tablet disintegrates in less than 2 minutes.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU25171/99A AU2517199A (en) | 1998-01-24 | 1999-01-12 | Method for producing a medicament which quickly dissolves in the mouth and whichcontains acarbose as an active agent |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1998102700 DE19802700A1 (en) | 1998-01-24 | 1998-01-24 | Preparation of fast-dissolving tablets for controlling blood sugar levels |
DE19802700.1 | 1998-01-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999037308A1 true WO1999037308A1 (en) | 1999-07-29 |
Family
ID=7855589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1999/000131 WO1999037308A1 (en) | 1998-01-24 | 1999-01-12 | Method for producing a medicament which quickly dissolves in the mouth and which contains acarbose as an active agent |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2517199A (en) |
DE (1) | DE19802700A1 (en) |
WO (1) | WO1999037308A1 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003070227A1 (en) * | 2002-02-21 | 2003-08-28 | Lts Lohmann Therapie-Systeme Ag | Taste-masked film-type or wafer-type medicinal preparation |
WO2011134962A3 (en) * | 2010-04-27 | 2012-05-03 | Bayer Pharma Aktiengesellschaft | Orally disintegrating tablet containing acarbose |
KR101421330B1 (en) * | 2008-12-17 | 2014-07-18 | 사토 세이야쿠 가부시키가이샤 | A disintegrating tablet |
CN104013590A (en) * | 2014-05-09 | 2014-09-03 | 万特制药(海南)有限公司 | Acarbose-containing medicinal composition and preparation method thereof |
WO2016097170A1 (en) * | 2014-12-17 | 2016-06-23 | Empros Pharma Ab | A modified release composition of orlistat and acarbose for the treatment of obesity and related metabolic disorders |
WO2018064795A1 (en) * | 2016-10-05 | 2018-04-12 | Boai Nky Pharmaceuticals Ltd. | Tablet compositions containing crosslinked polyvinylpyrrolidone and their use in beverage applications |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2367900A (en) * | 1998-12-18 | 2000-07-03 | Bayer Corporation | Chewable drug delivery system |
RU2010128019A (en) * | 2007-12-08 | 2012-01-20 | Байер Шеринг Фарма Акциенгезельшафт (DE) | ORAL DISPERSABLE TABLET |
TR201100150A2 (en) * | 2011-01-06 | 2012-07-23 | Bi̇lgi̇ç Mahmut | Water soluble dosage forms |
WO2013115745A1 (en) * | 2012-01-31 | 2013-08-08 | Mahmut Bilgic | A process for production of pharmaceutical (effervescent) composition comprising alpha - glucosidase inhibitor (e.g. vogliobose and metformin) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0226121A2 (en) * | 1985-12-13 | 1987-06-24 | Bayer Ag | Composition containing very pure acarbose |
EP0638317A1 (en) * | 1993-08-05 | 1995-02-15 | F. Hoffmann-La Roche Ag | Pharmaceutical composition |
-
1998
- 1998-01-24 DE DE1998102700 patent/DE19802700A1/en not_active Withdrawn
-
1999
- 1999-01-12 WO PCT/EP1999/000131 patent/WO1999037308A1/en not_active Application Discontinuation
- 1999-01-12 AU AU25171/99A patent/AU2517199A/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0226121A2 (en) * | 1985-12-13 | 1987-06-24 | Bayer Ag | Composition containing very pure acarbose |
EP0638317A1 (en) * | 1993-08-05 | 1995-02-15 | F. Hoffmann-La Roche Ag | Pharmaceutical composition |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003070227A1 (en) * | 2002-02-21 | 2003-08-28 | Lts Lohmann Therapie-Systeme Ag | Taste-masked film-type or wafer-type medicinal preparation |
US7615235B2 (en) | 2002-02-21 | 2009-11-10 | Lts Lohmann Therapie-Systeme Ag | Film-shaped or wafer-shaped pharmaceutical preparation with masked taste |
KR101421330B1 (en) * | 2008-12-17 | 2014-07-18 | 사토 세이야쿠 가부시키가이샤 | A disintegrating tablet |
WO2011134962A3 (en) * | 2010-04-27 | 2012-05-03 | Bayer Pharma Aktiengesellschaft | Orally disintegrating tablet containing acarbose |
CN104013590A (en) * | 2014-05-09 | 2014-09-03 | 万特制药(海南)有限公司 | Acarbose-containing medicinal composition and preparation method thereof |
CN107405309A (en) * | 2014-12-17 | 2017-11-28 | 安普洛德制药公司 | The tune of orlistat and acarbose for treating obesity and related metabolic disturbance releases composition |
WO2016097170A1 (en) * | 2014-12-17 | 2016-06-23 | Empros Pharma Ab | A modified release composition of orlistat and acarbose for the treatment of obesity and related metabolic disorders |
CN107405309B (en) * | 2014-12-17 | 2019-04-16 | 安普洛德制药公司 | Tune for the orlistat and acarbose for the treatment of obesity and related metabolic disturbance releases composition |
EA033448B1 (en) * | 2014-12-17 | 2019-10-31 | Empros Pharma Ab | Modified release composition of orlistat and acarbose for the treatment of obesity and related metabolic disorders |
US10561617B2 (en) | 2014-12-17 | 2020-02-18 | Empros Pharma Ab | Modified release composition of orlistat and acarbose for the treatment of obesity and related metabolic disorders |
EP3943076A3 (en) * | 2014-12-17 | 2022-04-13 | Empros Pharma AB | A modified release composition of orlistat and acarbose for the treatment of obesity and related metabolic disorders |
US11975105B2 (en) | 2014-12-17 | 2024-05-07 | Empros Pharma Ab | Modified release composition of orlistat and acarbose for the treatment of obesity and related metabolic disorders |
WO2018064795A1 (en) * | 2016-10-05 | 2018-04-12 | Boai Nky Pharmaceuticals Ltd. | Tablet compositions containing crosslinked polyvinylpyrrolidone and their use in beverage applications |
CN109803931A (en) * | 2016-10-05 | 2019-05-24 | 博爱新开源医疗科技集团股份有限公司 | Tablet composition containing crosslinked polyvinylpyrrolidone and its purposes in beverage application |
US11535740B2 (en) | 2016-10-05 | 2022-12-27 | Boai Nky Medical Holdings Ltd. | Tablet compositions containing crosslinked polyvinylpyrrolidone and their use in beverage applications |
Also Published As
Publication number | Publication date |
---|---|
DE19802700A1 (en) | 1999-07-29 |
AU2517199A (en) | 1999-08-09 |
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