WO1999037280A1 - Composition servant a eclaircir la peau - Google Patents

Composition servant a eclaircir la peau Download PDF

Info

Publication number
WO1999037280A1
WO1999037280A1 PCT/EP1998/008147 EP9808147W WO9937280A1 WO 1999037280 A1 WO1999037280 A1 WO 1999037280A1 EP 9808147 W EP9808147 W EP 9808147W WO 9937280 A1 WO9937280 A1 WO 9937280A1
Authority
WO
WIPO (PCT)
Prior art keywords
skin
weight
composition according
composition
skin lightening
Prior art date
Application number
PCT/EP1998/008147
Other languages
English (en)
Inventor
John Brian Bartolone
Govindarajan Raman
Pushker Sona
Ramesh Surianaraynan
Sushama Shripad Wagh
Original Assignee
Unilever Plc
Unilever N.V.
Hindustan Lever Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Plc, Unilever N.V., Hindustan Lever Limited filed Critical Unilever Plc
Priority to AU21612/99A priority Critical patent/AU2161299A/en
Priority to BR9814787-0A priority patent/BR9814787A/pt
Priority to JP2000528264A priority patent/JP2002501013A/ja
Publication of WO1999037280A1 publication Critical patent/WO1999037280A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin

Definitions

  • Melanin is the black pigment of hair and skin and is synthesized from the a ino acid tyrosine by melanosomes .
  • Melamosomes are organelles found in melanocytes, a cell type present at the dermis-epidermis junction. Tyrosine is acted upon by an enzyme, tyrosinase, which is the key step in melanogenesis .
  • inhibitors of tyrosinase such as hydroquinone and its derivatives, catechols, mercaptoamines, alpha hydroxy acids and others have been used in cosmetic compositions to regulate skin pigmentation. However, only some of these are reversible and show no undesirable side effects.
  • melanin is synthesised from monomers and is transferred to the neighbouring keratinocytes .
  • the keratinocytes divide and differentiate and thus transport the melanosome to the surface of the skin.
  • the intensity of the skin colour is directly related to the number, the size, the melanin content, the rate of formation and migration transfer of melanosomes to the keratinocytes.
  • alkali metal and alkaline earth metal salts of ⁇ -hydroxy and ⁇ -acyloxyl-carboxylic acids also have a skin lightening effect and, advantageously, that these salts can effectively be delivered to the skin in a vanishing cream base.
  • the skin lightening effected by the composition of the invention is reversible and without any side effects.
  • the composition according to the invention is active during both day and night .
  • the composition most preferably comprises C14-18 fatty acids.
  • the fatty acid soap preferably comprises 1-5% by weight of the composition.
  • the fatty acids and fatty acid derivatives are preferably saturated.
  • a cosmetic method for lightening human skin by topically applying to the skin a skin lightening composition according to the invention.
  • composition may also comprise an additional skin lightening agent which may be chose from any known such agent for example: niacin, niacinamide, placenta extract, hydroquinone and derivatives (e.g. arbutin) , kojic acid, dicarboxylic acids (azelaic acid, sebacic acid) , represented by the formula HOOC- (CxH y ) -COOH where x ranges from 4 to 20 and y ranges from 6 to 40, ascorbic acid and derivatives thereof and ferulic acid.
  • an additional skin lightening agent which may be chose from any known such agent for example: niacin, niacinamide, placenta extract, hydroquinone and derivatives (e.g. arbutin) , kojic acid, dicarboxylic acids (azelaic acid, sebacic acid) , represented by the formula HOOC- (CxH y ) -COOH where x ranges from 4 to 20 and
  • moisturisers and humectants include polyols, glycerol, cetyl alcohol, paraffin oils, lanolin and its derivatives, fatty acid esters, etc. Silicone compounds such as silicone oil, cyclomethicones, dimethicones, dimethiconols may also be included.
  • a panel of 25 volunteers was maintained for each assessment after screening the forearms of the panelists for uniformity of colour. Measured dose of the cream (Example 1, 2 or 3) was applied to one of the forearms twice a day. Visual assessment was carried out for a period of 8 weeks. The level of skin lightening is presented in Table 2.
  • a skin lightening composition which is reversible and without any side effects.
  • the composition is active both during the day and night.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

Composition cosmétique servant à éclaircir la peau par application localisée et comprenant (A) 5-25 % en poids d'acides gras, (B) 0,1-10 % en poids de savon d'acides gras et (C) 0,05-10 % en poids d'alcali ou d'un sel de métal terreux alcalin d'acide α-hydroxy carboxylique et/ou d'acide α-acyloxy carboxylique.
PCT/EP1998/008147 1998-01-26 1998-12-08 Composition servant a eclaircir la peau WO1999037280A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU21612/99A AU2161299A (en) 1998-01-26 1998-12-08 Skin lightening composition
BR9814787-0A BR9814787A (pt) 1998-12-08 1998-12-08 Composição cosmética o clareamento da pele a aplicação tópica sobre a pele humana, e, processo cosmético para o clareamento da pele
JP2000528264A JP2002501013A (ja) 1998-01-26 1998-12-08 皮膚美白用組成物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9801597.7A GB9801597D0 (en) 1998-01-26 1998-01-26 Skin lightening composition
GB9801597.7 1998-01-26

Publications (1)

Publication Number Publication Date
WO1999037280A1 true WO1999037280A1 (fr) 1999-07-29

Family

ID=10825885

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/008147 WO1999037280A1 (fr) 1998-01-26 1998-12-08 Composition servant a eclaircir la peau

Country Status (7)

Country Link
JP (1) JP2002501013A (fr)
CN (1) CN1161098C (fr)
AU (1) AU2161299A (fr)
GB (1) GB9801597D0 (fr)
ID (1) ID28137A (fr)
WO (1) WO1999037280A1 (fr)
ZA (1) ZA9811444B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001070187A1 (fr) * 2000-03-21 2001-09-27 Unilever Plc CREME DE JOUR A FAIBLE pH ET A TENEUR ELEVEE EN ACIDE GRAS
WO2001082884A1 (fr) * 2000-05-03 2001-11-08 Unilever Plc Composition detergente en pain contenant des agents benefiques
KR100748056B1 (ko) * 2000-02-07 2007-08-09 코니스 프랑스, 에스.에이.에스. 월터리아 인디카 추출물을 함유하는 화장품 제제
WO2012045550A3 (fr) * 2010-10-04 2012-12-20 Unilever Nv Composition d'éclaircissement de la peau

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0423929A1 (fr) * 1989-09-20 1991-04-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Agent de blanchiment de la peau
WO1995005153A1 (fr) * 1993-08-13 1995-02-23 Unilever Plc Composition cosmetique contenant des derives d'hydroxy-alcanoate
WO1997047280A1 (fr) * 1996-06-14 1997-12-18 Unilever Plc Procede et composition destines a l'eclaircissement de la peau
WO1998027193A1 (fr) * 1996-12-16 1998-06-25 The Procter & Gamble Company Composition d'hygiene personnelle, sous forme de pain, contenant du lauroyl-lactylate de sodium

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0423929A1 (fr) * 1989-09-20 1991-04-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Agent de blanchiment de la peau
US5262153A (en) * 1989-09-20 1993-11-16 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkujo Skin-whitening agent
WO1995005153A1 (fr) * 1993-08-13 1995-02-23 Unilever Plc Composition cosmetique contenant des derives d'hydroxy-alcanoate
WO1997047280A1 (fr) * 1996-06-14 1997-12-18 Unilever Plc Procede et composition destines a l'eclaircissement de la peau
WO1998027193A1 (fr) * 1996-12-16 1998-06-25 The Procter & Gamble Company Composition d'hygiene personnelle, sous forme de pain, contenant du lauroyl-lactylate de sodium

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100748056B1 (ko) * 2000-02-07 2007-08-09 코니스 프랑스, 에스.에이.에스. 월터리아 인디카 추출물을 함유하는 화장품 제제
WO2001070187A1 (fr) * 2000-03-21 2001-09-27 Unilever Plc CREME DE JOUR A FAIBLE pH ET A TENEUR ELEVEE EN ACIDE GRAS
WO2001082884A1 (fr) * 2000-05-03 2001-11-08 Unilever Plc Composition detergente en pain contenant des agents benefiques
WO2012045550A3 (fr) * 2010-10-04 2012-12-20 Unilever Nv Composition d'éclaircissement de la peau
EA023007B1 (ru) * 2010-10-04 2016-04-29 Юнилевер Нв Отбеливающая кожу композиция

Also Published As

Publication number Publication date
ZA9811444B (en) 2000-06-14
AU2161299A (en) 1999-08-09
GB9801597D0 (en) 1998-03-25
CN1283988A (zh) 2001-02-14
CN1161098C (zh) 2004-08-11
JP2002501013A (ja) 2002-01-15
ID28137A (id) 2001-05-03

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