MXPA00007158A - Skin lightening composition - Google Patents
Skin lightening compositionInfo
- Publication number
- MXPA00007158A MXPA00007158A MXPA/A/2000/007158A MXPA00007158A MXPA00007158A MX PA00007158 A MXPA00007158 A MX PA00007158A MX PA00007158 A MXPA00007158 A MX PA00007158A MX PA00007158 A MXPA00007158 A MX PA00007158A
- Authority
- MX
- Mexico
- Prior art keywords
- skin
- weight
- composition
- lightening
- composition according
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 35
- 206010040829 Skin discolouration Diseases 0.000 title abstract description 9
- 210000003491 Skin Anatomy 0.000 claims abstract description 33
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 14
- 239000000194 fatty acid Substances 0.000 claims abstract description 14
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 13
- 239000002537 cosmetic Substances 0.000 claims abstract description 12
- -1 alkaline earth metal salt Chemical class 0.000 claims abstract description 10
- 239000011780 sodium chloride Substances 0.000 claims abstract description 10
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims abstract description 7
- 239000000344 soap Substances 0.000 claims abstract description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 229910052783 alkali metal Inorganic materials 0.000 claims description 7
- 150000001340 alkali metals Chemical class 0.000 claims description 6
- 229940071209 stearoyl lactylate Drugs 0.000 claims description 3
- 125000004423 acyloxy group Chemical group 0.000 claims description 2
- 159000000000 sodium salts Chemical class 0.000 claims description 2
- 230000000699 topical Effects 0.000 abstract 1
- 210000002780 Melanosomes Anatomy 0.000 description 6
- 239000006071 cream Substances 0.000 description 5
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 5
- 102000003425 EC 1.14.18.1 Human genes 0.000 description 4
- 108060008724 EC 1.14.18.1 Proteins 0.000 description 4
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N benzohydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 235000014655 lactic acid Nutrition 0.000 description 4
- 239000004310 lactic acid Substances 0.000 description 4
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 4
- 231100000486 side effect Toxicity 0.000 description 4
- 230000000475 sunscreen Effects 0.000 description 4
- 239000000516 sunscreening agent Substances 0.000 description 4
- 210000002510 Keratinocytes Anatomy 0.000 description 3
- 229940053487 Niacinamide Drugs 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 239000007854 depigmenting agent Substances 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 229960003966 nicotinamide Drugs 0.000 description 3
- 230000002441 reversible Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N ARBUTIN Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 2
- 229940061720 Alpha Hydroxy Acids Drugs 0.000 description 2
- 210000000245 Forearm Anatomy 0.000 description 2
- BEJNERDRQOWKJM-UHFFFAOYSA-N Kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 229940053207 Niacin Drugs 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- 150000001280 alpha hydroxy acids Chemical class 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005755 formation reaction Methods 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 2
- 230000003061 melanogenesis Effects 0.000 description 2
- 235000005152 nicotinamide Nutrition 0.000 description 2
- 239000011570 nicotinamide Substances 0.000 description 2
- 229960003512 nicotinic acid Drugs 0.000 description 2
- 235000001968 nicotinic acid Nutrition 0.000 description 2
- 239000011664 nicotinic acid Substances 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 1
- 150000005206 1,2-dihydroxybenzenes Chemical class 0.000 description 1
- 229960000271 Arbutin Drugs 0.000 description 1
- BDJRBEYXGGNYIS-UHFFFAOYSA-N Azelaic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 description 1
- YCIMNLLNPGFGHC-UHFFFAOYSA-N Catechol Natural products OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N Cetyl alcohol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-N Ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 1
- 229940039717 Lanolin Drugs 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl methoxycinnamate Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 1
- 210000003463 Organelles Anatomy 0.000 description 1
- 206010062080 Pigmentation disease Diseases 0.000 description 1
- 210000002826 Placenta Anatomy 0.000 description 1
- 229940080352 Sodium Stearoyl Lactylate Drugs 0.000 description 1
- ODFAPIRLUPAQCQ-UHFFFAOYSA-M Sodium stearoyl lactylate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(C)C(=O)OC(C)C([O-])=O ODFAPIRLUPAQCQ-UHFFFAOYSA-M 0.000 description 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Vitamin C Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003712 anti-aging Effects 0.000 description 1
- 229940053200 antiepileptics Fatty acid derivatives Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 210000004027 cells Anatomy 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 239000008278 cosmetic cream Substances 0.000 description 1
- 150000001991 dicarboxylic acids Chemical class 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 230000001804 emulsifying Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 229940114124 ferulic acid Drugs 0.000 description 1
- 235000001785 ferulic acid Nutrition 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229960004705 kojic acid Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000036564 melanin content Effects 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 230000003020 moisturizing Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 230000002335 preservative Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000002884 skin cream Substances 0.000 description 1
- 230000036548 skin texture Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 230000002087 whitening Effects 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Abstract
A cosmetic skin lightening composition for topical application to human skin comprising (A) 5-25%by weight fatty acids, (B) 0.1-10%by weight fatty acid soap and (C) 0.05-10%by weight alkali or alkaline earth metal salt of a-hydroxy carboxylic acid and/or a-acyloxy carboxylic acid.
Description
COMPOSITION FOR SKIN LIGHTING DESCRIPTION OF THE INVENTION The present invention relates to a cosmetic composition for lightening the skin. The invention also relates to a method for locally applying to the skin a skin lightening composition according to the invention. Melanin is the black pigment of hair and skin and is synthesized from the amino acid tyrosine by melanosomes. Melanosomes are organelles found in melanosites, a type of cell present at confluence in the dermis-epidermis. The enzyme tyrosinase acts on tyrosine, which is the main stage in melanogenesis. There are several reports in which tyrosinase inhibitors, such as hydroquinone and its derivatives, catechols, capitanogens, alpha hydroxy acids and others have been used in cosmetic compositions to regulate skin pigmentation. However, only some of these are reversible and show no undesirable side effects. In melanosomes melanin is synthesized from monomers and transferred to neighboring keratinocytes. The keratinocytes divide and differentiate and thus transport the melanosome to the surface of the skin. The intensity of skin color is directly related to the number, size, melanin content, speed of formation and migration of melanosomes to keratinocytes. The compositions with encionales to lighten the skin are based on sunscreens or agents to lighten the skin. It is believed that the latter control the dispersion of melanosomes or inhibit tyrosinase. Sun filters alone can not lighten the skin beyond the color of natural skin and its only action is to reduce the entry of environmental ultraviolet radiation into the skin. Thus, they exert their effect only during the day, some of the compounds used as skin lightening agents are also known to have undesirable side effects. The use of α-hydroxy acids in cosmetic compositions to impart various skin benefits such as improving skin texture, increasing softness, firmness, moisture content is reported in US Patent 5658580. US Patent 5,262,153 describes the acid lactic acid and its derivatives as useful agents for skin whitening which can act by suppressing melanogenesis by inhibiting tyrosinase formation. Cosmetic compositions for supplying different beneficial agents are prepared using different emulsifying systems and vehicles. The base of the desferred cream to which it generally comprises fatty acids and alkali metal soaps is one of the preferred forms of such cosmetically acceptable vehicles, as this gives a desirable matt feel to the skin. Unfortunately, however, lactic acid, which is known as a skin-lightening agent, can not be used in soap creams since lactic acid substantially lowers the pH and therefore s and s to the base. It has now been found that the alkali metal and alkaline earth metal salts of α-hydroxy and α-acycloxycarboxylic acids also have an effect for lightening the skin and, advantageously, these salts can be effectively delivered to the skin. skin in a scented cream base a. It is therefore an object of the present invention to provide a cosmetic composition for delivering lactic acid derivatives to the skin through a skin cream to obtain the benefit of rinsing the skin. Accordingly, the present invention relates to a cosmetic composition for lightening the skin for local application to human skin comprising: A. 5-25% by weight of C 12 -C 20 fatty acids; B. 0.1-10% by weight of fatty acid soap; C. 0.05-10% by weight of alkali metal or alkaline earth metal salt of α-hydroxy carboxylic acid and / or α-acyloxy carboxylic acid. The lightening of the skin effected by the composition of the invention is reversible and without any side effects. The composition according to the invention is active during the day and night. Preferably, the alkali metal or alkaline earth metal salt is lactic acid and / or acyloxy lactylate. More preferably the salt is stearoyl lactylate. According to the most preferred aspect of the invention, the cosmetic composition comprises at least 0.05% by weight of an alkali metal salt of stearoyl lactylate.
Particularly the suitable salt of the α-hydroxy carboxylic acid or of the α-α-cycloalkyl-1-carboxylic acid is the sodium salt. The composition preferably comprises 10-20% by weight of C 12 -C 20 fatty acids. The most preferable composition comprises C14-18 fatty acids. The fatty acid soap preferably comprises 1-5% by weight of the composition. The fatty acids and the fatty acid derivatives are preferably saturated. According to a further aspect of the present invention there is provided a cosmetic method for lightening human skin by locally applying a skin lightening composition according to the invention to the skin. The composition may also comprise an additional skin lightening agent which may be chosen from any known agent for example: niacin, niacinamide, placenta extract, hydroquinone and derivatives (eg arbutin), kojic acid, dicarboxylic acids (azelaic acid, sebacic), represented by the formula HOOC- (CxHy) -COOH where x varies from 4 to 20 and varies from 6 to 40, ascorbic acid and derivatives thereof and ferulic acid. Additional agents for skin lightening may be retinol and derivatives, organic sunscreens such as 4-tertiary butyl-4'-methyloxy dibenzolamine, and / or 2-ethyl hexylmethoxy cinnamate, inorganic sunscreens such as micronized titanium dioxide, zinc oxide or other UV A and UV B sunscreens and other known skin lightening compounds. Preferred agents for skin lightening are niacin and niacinamide. The composition may comprise 0-10% by weight of the additional agent for lightening the skin. The composition according to the invention may also comprise cosmetically compatible preservatives, thickeners, perfume, color, skin benefit materials such as humectants, emollients, and anti-aging compounds. The composition may also comprise small amounts of other cosmetic emulsifiers preferably not more than 10% by weight, more preferably less than 5%. Examples of humectants and moisturizing emulsions include polyols, glycerol, cetyl alcohol, paraffin oils, lanolin and its derivatives, fatty acid esters, etc. Silicone compounds such as silicone oil, organic compounds, dimethicones, dimethiconols may also be included. All percentages referred to herein and in the appended claims are by weight of the composition unless otherwise indicated. The invention will now be illustrated by means of examples. The examples are for illustration only and do not restrict the scope of the invention in any way.
EXAMPLE A. Composition of the creams The invention will now be illustrated with reference to the following examples of the cosmetic creams presented in Table 1.
TABLE 1
# 5% lactate + 2% sodium stearoyl lactylate + 1 sodium stearoyl niacinamide @ lactylate * 8% lactate
The numbers in the table represent percentages of the composition by weight.
B. Effect on skin lightening A panel of 25 volunteers was maintained for each evaluation after selecting the forearms of the panelists for uniformity of color. Measured dose of the cream (example 1, 2 or 3) was applied to one of the forearms twice a day. The visual valuation was carried out over a period of 8 weeks. The level of skin clarification is presented in Table 2.
TABLE 2
It is therefore possible by means of the present invention to provide a skin lightening composition which is reversible and without any side effects. The composition is active during the day and night.
Claims (8)
1. Cosmetic composition for lightening the skin by local application to human skin comprising: A) 5-25% by weight of C 12 -C 20 fatty acids; B) 0.1-10% by weight of fatty acid soap; C) 0.05-10% by weight of an alkali metal or alkaline earth metal salt of α-acyloxy carboxylic acid.
2. Composition according to claim 2, wherein the alkali metal or alkaline earth metal salt is from a1 to x1 to a1 to a1.
3. Composition according to rei indication 3, wherein the acyloxy lactylate is stearoyl lactylate.
4. Composition according to any preceding claim comprising the sodium salt of α-acyloxy carboxylic acid.
5. Composition according to any preceding claim comprising 10-20% by weight of the C12-C20 fatty acids.
6. Composition according to any preceding claim comprising 1-5% by weight of the fatty acid soap.
7. Composition according to any preceding claim comprising an additional agent for lightening the skin.
8. Cosmetic method for lightening the skin by applying locally to the skin a composition in accordance with any preceding indication.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9801597.7 | 1998-01-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA00007158A true MXPA00007158A (en) | 2001-07-03 |
Family
ID=
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU725960B2 (en) | Cosmetic composition with long chain unsaturated retinol fatty acid esters | |
| US8524204B2 (en) | Cosmetic compositions and methods for inhibiting or reducing trypsin activity | |
| EP3103434B1 (en) | Compositions for lightening skin color | |
| TWI337085B (en) | A synergistic skin lightening composition | |
| JP2950772B2 (en) | Cosmetic and / or dermatological composition containing salicylic acid derivative for depigmentation of skin | |
| CN1993102B (en) | Compositions comprising an amidine and an alkane polyol | |
| US5728732A (en) | Skin treatment with salicylic acid esters and retinoids | |
| JP2001511185A (en) | Skin lightning composition | |
| US6153177A (en) | Skin lightening composition | |
| EP1351647B1 (en) | Compositions and methods for treating hyperpigmentation | |
| US5814662A (en) | Skin treatment with alpha-hydroxycarboxylic acids of mixed chain length | |
| JP3803540B2 (en) | Use of DHEA or its precursors or metabolic derivatives as depigmenting agents | |
| WO1997030690A1 (en) | Skin treatment with salicylic acid esters | |
| AU2161299A (en) | Skin lightening composition | |
| CA2233222C (en) | Skin treatment with salicylic acid esters and retinoids | |
| MXPA00007158A (en) | Skin lightening composition | |
| JP2001131031A (en) | Composition for scalp and hair | |
| CA2338325C (en) | Novel uses of ascorbyl-phosphoryl-cholesterol and compositions for practicing same | |
| KR20150036213A (en) | Compositions comprising substituted phenols and topical application thereof | |
| US11419803B2 (en) | Skin darkening composition | |
| SA99200457B1 (en) | Cosmetic Skin Lightening Composition |