WO1999033967A3 - Novel nucleic acid and polypeptide with homology to the tnf-receptors - Google Patents

Novel nucleic acid and polypeptide with homology to the tnf-receptors Download PDF

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Publication number
WO1999033967A3
WO1999033967A3 PCT/US1998/027688 US9827688W WO9933967A3 WO 1999033967 A3 WO1999033967 A3 WO 1999033967A3 US 9827688 W US9827688 W US 9827688W WO 9933967 A3 WO9933967 A3 WO 9933967A3
Authority
WO
WIPO (PCT)
Prior art keywords
ntr
mammalian
nucleic acid
provides
tnf
Prior art date
Application number
PCT/US1998/027688
Other languages
French (fr)
Other versions
WO1999033967A2 (en
Inventor
David M Valenzuela
Original Assignee
Regeneron Pharma
David M Valenzuela
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma, David M Valenzuela filed Critical Regeneron Pharma
Priority to EP98966103A priority Critical patent/EP1044267A2/en
Priority to IL13698898A priority patent/IL136988A0/en
Priority to JP2000526625A priority patent/JP2002508934A/en
Priority to AU22079/99A priority patent/AU748167B2/en
Priority to CA002316545A priority patent/CA2316545A1/en
Publication of WO1999033967A2 publication Critical patent/WO1999033967A2/en
Publication of WO1999033967A3 publication Critical patent/WO1999033967A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention provides for nucleic acid sequences that encode novel mammalian receptor polypeptides, designated NTR-5. The invention also provides assay systems that may be used to detect and/or measure ligands that bind the MAMMALIAN NTR-5 gene product. The present invention also provides for diagnostic and therapeutic methods based on the interaction between MAMMALIAN NTR-5 and agents that initiate signal transduction through binding to MAMMALIAN NTR-5. In a specific embodiment, the MAMMALIAN NTR-5 may HUMAN NTR-5 or MOUSE NTR-5.
PCT/US1998/027688 1997-12-29 1998-12-28 Novel nucleic acid and polypeptide with homology to the tnf-receptors WO1999033967A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP98966103A EP1044267A2 (en) 1997-12-29 1998-12-28 Novel nucleic acid and polypeptide with homology to the tnf-receptors
IL13698898A IL136988A0 (en) 1997-12-29 1998-12-28 Novel nucleic acid and polypeptide
JP2000526625A JP2002508934A (en) 1997-12-29 1998-12-28 Novel nucleic acids and polypeptides having homology to the TNF receptor
AU22079/99A AU748167B2 (en) 1997-12-29 1998-12-28 Novel nucleic acid and polypeptide
CA002316545A CA2316545A1 (en) 1997-12-29 1998-12-28 Novel nucleic acid and polypeptide with homology to the tnf-receptors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6892597P 1997-12-29 1997-12-29
US60/068,925 1997-12-29

Publications (2)

Publication Number Publication Date
WO1999033967A2 WO1999033967A2 (en) 1999-07-08
WO1999033967A3 true WO1999033967A3 (en) 1999-09-10

Family

ID=22085585

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/027688 WO1999033967A2 (en) 1997-12-29 1998-12-28 Novel nucleic acid and polypeptide with homology to the tnf-receptors

Country Status (6)

Country Link
EP (1) EP1044267A2 (en)
JP (1) JP2002508934A (en)
AU (1) AU748167B2 (en)
CA (1) CA2316545A1 (en)
IL (1) IL136988A0 (en)
WO (1) WO1999033967A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE360032T1 (en) 1997-09-12 2007-05-15 Biogen Idec Inc CYSTEIN-RICH RECEPTOR TRAIN
WO1999037818A1 (en) * 1998-01-27 1999-07-29 Millennium Pharmaceuticals, Inc. Novel molecules of the tnf receptor superfamily and uses therefor
AU2574200A (en) * 1999-02-19 2000-09-04 Toshio Kitamura Novel tnf receptor-like proteins
AU780060B2 (en) * 1999-07-16 2005-02-24 Human Genome Sciences, Inc. Human tumor necrosis factor receptors TR13 and TR14
US6951738B2 (en) 1999-07-16 2005-10-04 Human Genome Sciences, Inc. Human tumor necrosis factor receptors TR13 and TR14
DE60235418D1 (en) 2001-04-03 2010-04-01 Nestle Sa Osteoprotegerin in milk
US7846438B2 (en) 2004-08-03 2010-12-07 Biogen Idec Ma Inc. Methods of promoting neurite outgrowth with soluble TAJ polypeptides

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997041895A2 (en) * 1996-05-08 1997-11-13 F. Hoffmann-La Roche Ag TREATMENT OF ASTHMA WITH TNFR-Ig
WO1998001554A2 (en) * 1996-07-09 1998-01-15 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
WO1998038304A1 (en) * 1997-02-27 1998-09-03 Ono Pharmaceutical Co., Ltd. Novel polypeptide, dna encoding the same and use thereof
WO1999011791A2 (en) * 1997-09-05 1999-03-11 University Of Washington Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents
WO1999013078A1 (en) * 1997-09-12 1999-03-18 Biogen, Inc. Cysteine rich receptors-train

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997041895A2 (en) * 1996-05-08 1997-11-13 F. Hoffmann-La Roche Ag TREATMENT OF ASTHMA WITH TNFR-Ig
WO1998001554A2 (en) * 1996-07-09 1998-01-15 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
WO1998038304A1 (en) * 1997-02-27 1998-09-03 Ono Pharmaceutical Co., Ltd. Novel polypeptide, dna encoding the same and use thereof
WO1999011791A2 (en) * 1997-09-05 1999-03-11 University Of Washington Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents
WO1999013078A1 (en) * 1997-09-12 1999-03-18 Biogen, Inc. Cysteine rich receptors-train

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE EMEST 19 E.M.B.L. Databases; 17 August 1996 (1996-08-17), MARRA M ET AL: "The WashU-HHMI Mouse EST Project", XP002106029 *
DATABASE EMEST 19 E.M.B.L. Databases; 25 July 1996 (1996-07-25), MARRA M ET AL: "The WashU-HHMI Mouse EST Project", XP002106028 *

Also Published As

Publication number Publication date
EP1044267A2 (en) 2000-10-18
AU2207999A (en) 1999-07-19
IL136988A0 (en) 2001-06-14
CA2316545A1 (en) 1999-07-08
AU748167B2 (en) 2002-05-30
JP2002508934A (en) 2002-03-26
WO1999033967A2 (en) 1999-07-08

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