WO1999026608A1 - Spheroids, preparation method and pharmaceutical compositions - Google Patents

Spheroids, preparation method and pharmaceutical compositions Download PDF

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Publication number
WO1999026608A1
WO1999026608A1 PCT/IB1998/001911 IB9801911W WO9926608A1 WO 1999026608 A1 WO1999026608 A1 WO 1999026608A1 IB 9801911 W IB9801911 W IB 9801911W WO 9926608 A1 WO9926608 A1 WO 9926608A1
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WO
WIPO (PCT)
Prior art keywords
spheroids
active ingredient
spheroids according
coating
film
Prior art date
Application number
PCT/IB1998/001911
Other languages
French (fr)
Inventor
Patrice Debregeas
Gérard LeDuc
Pascal Oury
Pascal Suplie
Original Assignee
Laboratoires Des Produits Ethiques Ethypharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE69817010T priority Critical patent/DE69817010T2/en
Priority to EA200000548A priority patent/EA003324B1/en
Application filed by Laboratoires Des Produits Ethiques Ethypharm filed Critical Laboratoires Des Produits Ethiques Ethypharm
Priority to HU0100562A priority patent/HU230053B1/en
Priority to JP2000521810A priority patent/JP2001523706A/en
Priority to IL13621598A priority patent/IL136215A0/en
Priority to SK756-2000A priority patent/SK284493B6/en
Priority to AT98954683T priority patent/ATE246496T1/en
Priority to NZ504662A priority patent/NZ504662A/en
Priority to BR9814672-6A priority patent/BR9814672A/en
Priority to SI9830492T priority patent/SI1032374T1/en
Priority to CA2310147A priority patent/CA2310147C/en
Priority to MXPA00004959A priority patent/MXPA00004959A/en
Priority to DK98954683T priority patent/DK1032374T3/en
Priority to AU11704/99A priority patent/AU744580B2/en
Priority to EP98954683A priority patent/EP1032374B1/en
Priority to PL98340659A priority patent/PL193878B1/en
Publication of WO1999026608A1 publication Critical patent/WO1999026608A1/en
Priority to IL136215A priority patent/IL136215A/en
Priority to NO20002605A priority patent/NO329728B1/en
Priority to HR20000323A priority patent/HRP20000323B1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Definitions

  • the present invention relates to a new galemic form in the form of spheroids, containing one or more active ingredients with the exception of tiagabine.
  • the present invention further extends to the process for the preparation of such spheroids and to the multiparticulate pharmaceutical preparations containing these spheroids.
  • These pharmaceutical preparations are intended for the delivery of the spheroids which they contain, and are characterized by the absence of an alteration in the release profile of the active ingredient (s) contained in the spheroids.
  • spheroids is understood to mean spherical units the size of which can vary from 0.25 mm to 3 mm, preferably from 0.5 mm to 1 mm.
  • US Patent 4,684,516 describes tablets for oral administration which disintegrate rapidly in an aqueous medium, which comprise coated granules capable of releasing an active principle at a controlled speed for several hours in the intestinal tract, and which comprise 2 to 15% by weight of binding agents and lubricants.
  • US Pat. No. 4,684,516 describes in particular granules obtained by applying a layer of active principle on non-similar, these granules then being coated with a first film containing a mixture of stearic acid, carnauba wax and talc, and a second film is disintegrating agents such as starch, cellulose or algic acid - which also serve to ensure the cohesion of the tablet.
  • Patent application EP 468 436 describes prolonged-release tablets obtained by compression an active principle and a mixture of two powders, one being hydrophobic and the other water-soluble.
  • the hydrophobic powder is obtained by melting and spraying a mixture of stearic acid, glycerin and hydrogenated castor oil.
  • the water-soluble powder is a cellulose mixed with lactose.
  • Patent application EP 548 356 describes ultiparticulate tablets with rapid disintegration which comprise an active substance in the form of single crystals or microgranules.
  • These tablets are obtained by prior granulation of a mixture of excipients consisting of one or more disintegrating agents, of the carboxymethylcellulose or polyvinylpyrrolidone type, of one or more swelling agents, of the starch type, and of a direct compression sugar. like dextrose.
  • the microgranules or single crystals are dry integrated into the mixture of excipients before being compressed.
  • the granules of the prior art are diluted with auxiliary substances, the role of which is to absorb the physical stresses linked to the compression (binding agents) and to allow the disintegration of the tablet (disintegrating agents) in a liquid medium, ie in aqueous solution or in the digestive fluid.
  • the prior art tablet formulations use auxiliary substances added to the granules during compression to avoid cracking of these granules on the surface.
  • the object of the present invention relates to spheroids containing one or more active ingredients with the exception of tiagabine, which can be compressed directly, without the addition of a substantial part of an auxiliary substance, ie less than 5% by weight, preferably less than 1% by weight.
  • the subject of the present invention is spheroids containing one or more active principles, with the exception of tiagabine, comprising:
  • a core and / or a layer coating said core containing at least one thermoplastic excipient, the consistency of which is pasty to semi-solid at a temperature of the order of 20 ° C., and the melting temperature of which is between approximately 25 ° C and approximately 100 ° C, coated with a flexible and deformable film, based on a polymeric material, in particular a film whose glass transition temperature is less than approximately 30 ° C, which provides either protection, be the masking of taste, that is the modified and controlled release of the active ingredient (s).
  • the core can be composed in particular of a mixture of sucrose and starch or microcrystalline cellulose.
  • thermoplastic excipients is understood to mean compounds having a melting point of between 25 and 100 ° C. and characterized by a pasty to semi-solid consistency at a temperature of the order of 20 ° C.
  • thermoplastic excipients The role of thermoplastic excipients is, in particular, during a possible compression step, to allow the spheroids to deform plastically, and thus to absorb part of the stresses which they undergo, so that their surface is not not cracked or torn.
  • the excipients can be advantageously chosen from partially hydrogenated oils, beeswax, carnauba wax, paraffin waxes, silicone waxes, fatty alcohols and C12-C18 fatty acids, semi-synthetic glycerides solids, monoester diesters or triesters of glycerol, polyoxyethylene glycols, glycosylated polyoxyethylene glycerides, and mixtures thereof.
  • the layer containing at least one thermoplastic excipient is coated with a flexible and deformable film, comprising a polymeric material, the glass transition temperature of which is less than approximately 30 ° C, preferably less than approximately 20 ° C.
  • the polymeric film comprises a polymeric material which is either a polymer or a mixture of at least one polymer and a plasticizer. The polymer film can be used, depending on the case, to protect the active ingredient from the environment.
  • the polymer is preferably an acrylic, vinyl or cellulosic polymer or copolymer.
  • Plasticizer is understood to mean a product which makes it possible to reduce the glass transition temperature of the polymer.
  • the plasticizer is preferably chosen from triethyl citrate, acetyl triethyl citrate, tributyl citrate, acetyl tributyl citrate, triacetin, diethyl phthalate, polyethylene glycols, polysorbates, mono- and diacetylated glycerides, and their mixtures.
  • the mechanical properties of the polymer film in particular the percentage of elongation and the breaking strength 0, can serve as criteria for selecting the polymer and / or the plasticizer. These mechanical characteristics can also be determined by the method described in standards DIN53 455 and ISO / RI 184.
  • a polymer or a polymer / plasticizer mixture having a percentage of elongation greater than about 50% is preferably chosen for coating spheroids intended to be compressed.
  • the Eudragit NE30D® 0 polymer sold by the company ROHM which is a neutral copolymer of acrylic and methacrylic acid esters in the form of an aqueous dispersion at 30%, has a percentage elongation of 600% and a breaking strength equal to 8 N / mm 2 which makes it particularly flexible and deformable.
  • the active ingredient (s) are dispersed in the mass of the nucleus.
  • the active ingredient (s) are dispersed in the layer containing at least one thermoplastic excipient.
  • the active ingredient (s) are applied to the surface of the core, then covered with a layer containing at least one thermoplastic excipient.
  • the active principle can be protected, in one of the four preceding variants, by associating it with an antioxidant agent and / or by coating it with a protective film.
  • the active ingredient (s) are dispersed in the mass of the core and in the layer containing at least one thermoplastic excipient.
  • the spheroids according to the invention can advantageously be coated with a water-dispersible outer layer.
  • the outer layer ensures the cohesion of said spheroids during a possible compression step, and ensures the disintegration in an aqueous medium of the tablet obtained.
  • the water-dispersible outer layer is preferably made of an acrylic, vinyl or cellulosic polymer.
  • the present invention also relates to the process for the preparation of the spheroids described above.
  • the manufacturing of the cores can be carried out by turbine assembly from calibrated sucrose crystals, or by extrusion-spheronization.
  • the active principle can be mixed with the extruded-spheronized mass.
  • the layer containing at least one thermoplastic excipient, the film containing a polymeric material, and optionally the external protective layer are successively deposited on the cores by spraying, in a granulation turbine, in a turbine. perforated, in a fluidized air bed or by any other suitable means.
  • the method according to the invention comprises two or three stages depending on whether it is desired to prepare spheroids comprising an external layer which is hydrodispersible or not.
  • Spheroids having a water-dispersible outer layer are particularly suitable for the preparation of tablets.
  • the first step consists in depositing the thermoplastic excipient (s) on the cores.
  • the assembly preparation can be, as the case may be, in the form of solid dispersions in aqueous or organic media, in the form of solutions, in the form of emulsions, or in the molten state.
  • the active principle is dispersed in the mass of the layer containing at least one excipient thermoplastic, the active ingredient is incorporated in the assembly preparation.
  • the active principle can be fixed by dusting on the neutral cores previously wetted with the mounting preparation.
  • the second step of the process according to the invention consists in depositing the polymer film making it possible to ensure the protection of the active principle, the masking of taste or the modified release of the active principle.
  • the polymeric coating preparation can be in the form of solutions or dispersions in an aqueous or organic medium.
  • the optional third step of the process according to the invention consists in depositing the external protective layer by spraying the coating preparation which can be in the form of a solution or dispersion in an aqueous or organic medium.
  • an anti-adhering agent such as talc, a plasticizer such as polyethylene glycol, an antioxidant agent such as dl-alpha-tocopherol.
  • a disintegrating agent can advantageously be added to the outer protective layer so as to accelerate the release of the spheroids in an aqueous medium, when these have been compressed.
  • the disintegrating agent is for example crosslinked carboxymethylcellulose, crosslinked polyvinylpyrrolidone or sodium carboxymethyl starch.
  • the present invention also relates to the mul tiparticular pharmaceutical preparations containing the spheroids described above which can be obtained by the process of the invention.
  • the multiparticulate pharmaceutical preparations according to the invention are preferably without the form of capsules filled with said spheroids, or tablets of said spheroids.
  • Said tablets are advantageously prepared without the substantial addition of auxiliary substances. Up to 5% by weight of a lubricating agent such as talc can be added to the spheroids before compression.
  • Said tablets advantageously comprise spheroids protected by a water-dispersible layer consisting of an acrylic, vinyl, cellulosic polymer or a water-dispersible thermoplastic excipient, or any other excipient soluble in an aqueous medium.
  • This layer has the role of ensuring the cohesion of the spheroids between them, thus ensuring the hardness of the tablet, and of allowing the tablet to disintegrate when it is immersed in solution.
  • the tablets according to the invention are dispersible in solution and restore independent spheroids, so that the release profile of the tablet and of the spheroids which constitute it are practically equivalent. Indeed, the tablets according to the invention allow the delivery of spheroids without the release profile of the active ingredient (s) they contain is altered by compression.
  • the tablets according to the invention can be composed only of the spheroids according to the invention or of a mixture of spheroids and placebos spheroids, that is to say spheroids conform to the present invention but devoid of active principle.
  • the stresses exerted on the spheroids, during the compression step, can vary from 5 N to 50 kN but preferably between 5 kN and 15 kN.
  • the hardness of the tablets is preferably between 10 N and 100 N, more preferably between 10 N and 50 N.
  • the disintegration time of the tablets in an aqueous medium at 37 ° C. is less than 60 min.
  • the tablets according to the invention preferably have a mass of between 0.1 g and 1 g.
  • Their shape can be round, oval, oblong, have a flat or concave surface, and have engravings or score bars.
  • the tablets according to the invention can be the subject of a final protective or coloring coating.
  • the single figure represents the mass percentage of in vitro dissolution of a particular active principle, isosorbide mononitrate, for the spheroids according to the invention not compressed (curve 1) and for a tablet of spheroids according to the invention (curve 2) .
  • Precirol® is a thermoplastic compound which, by softening and spreading in contact with the charge maintained at 50 ° C, will form a uniform film around the cores.
  • talc can be added to Précirol®.
  • the spheroid mixture is compressed on a Frogerais OA alternative press.
  • the active ingredient is dosed by ultraviolet spectrophotometry.
  • NP-PHARM in a coating turbine, a perforated turbine or a fluidized air bed
  • Example 2 Place a fraction of the microgranules obtained according to Example 1 in a perforated turbine or a fluidized air bed,
  • the spheroids are then compressed on a rotary instrumented machine of the Fette P1200 type.
  • the compressive forces applied are between 10 kN and 30 kN.
  • the active principle is dosed by HPLC at the wavelength 285 nm.
  • Talc 14.74 g. Mix the powders (use a cubic or planetary mixer).
  • the spheroids are then compressed on a rotary instrumented machine of the Fette P1200 type.
  • the compression forces applied are between 10 KN and 30 KN.
  • Pallet dissolution device in accordance with the standard (USP XXIII, ⁇ 711> device 2). Medium 500 ml, Purified water at 37 ° C. Stirring speed 100 revolutions / minute. The active principle is dosed by UV continuously at wavelengths: 285-320 nm.

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  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
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Abstract

The invention concerns a novel galenical preparation having the form of spheroids, containing one or several active principles except tiagabin. It further concerns a method for preparing such spheroids and multiparticulate pharmaceutical compositions containing said spheroids. Said pharmaceutical compositions are designed to release the spheroids they contain, and are characterised by the absence of alteration of the releasing profile of the active principle(s) following an optional compressing step.

Description

Sphéroïdes , procédé de préparation et compositions pharmaceutiques Spheroids, preparation process and pharmaceutical compositions
La présente invention concerne une nouvelle forme galémque se présentant sous la forme de sphéroïdes, contenant un ou plusieurs principes actifs à l'exception de la tiagabine. La présente invention s'étend en outre au procédé de préparation de tels sphéroïdes et aux préparations pharmaceutiques multiparticulaires contenant ces sphéroïdes . Ces préparations pharmaceutiques sont destinées à la délivrance des sphéroïdes qu'elles contiennent, et sont caractérisées par l'absence d'une altération du profil de libération du ou des principes actifs contenus dans les sphéroïdes.The present invention relates to a new galemic form in the form of spheroids, containing one or more active ingredients with the exception of tiagabine. The present invention further extends to the process for the preparation of such spheroids and to the multiparticulate pharmaceutical preparations containing these spheroids. These pharmaceutical preparations are intended for the delivery of the spheroids which they contain, and are characterized by the absence of an alteration in the release profile of the active ingredient (s) contained in the spheroids.
On entend par sphéroïdes des unités sphériques dont la taille peut varier de 0,25 mm à 3 mm, de préférence de 0 , 5 mm à 1 mm .The term “spheroids” is understood to mean spherical units the size of which can vary from 0.25 mm to 3 mm, preferably from 0.5 mm to 1 mm.
Le brevet US 4 684 516 décrit des comprimés pour administration orale qui se désintègrent rapidement en milieu aqueux, qui comprennent des granules enrobés capables de libérer un principe actif à une vitesse contrôlée pendant plusieurs heures dans la voie intestinale, et qui comprennent 2 à 15% en poids d'agents liants et lubrifiants.US Patent 4,684,516 describes tablets for oral administration which disintegrate rapidly in an aqueous medium, which comprise coated granules capable of releasing an active principle at a controlled speed for several hours in the intestinal tract, and which comprise 2 to 15% by weight of binding agents and lubricants.
Le brevet US 4 684 516 décrit en particulier des granules obtenus par application d'une couche de principe actif sur des non-pareils, ces granules étant ensuite enrobés d'un premier film contenant un mélange d'acide stearique, de cire de carnauba et de talc, et d'un deuxième f lm constitue d'agents désintégrants comme l'amidon, la cellulose ou l'acide alg nique - qui servent également à assurer la cohésion du comprimé.US Pat. No. 4,684,516 describes in particular granules obtained by applying a layer of active principle on non-similar, these granules then being coated with a first film containing a mixture of stearic acid, carnauba wax and talc, and a second film is disintegrating agents such as starch, cellulose or algic acid - which also serve to ensure the cohesion of the tablet.
La demande de brevet EP 468 436 décrit des comprimes a libération prolongée obtenus par compression d'un principe actif et d'un mélange de deux poudres, l'une étant hydrophobe et l'autre hydrosoluble . La poudre hydrophobe est obtenue par fusion et pulvérisation d'un mélange d'acide stearique, de glycérine et d'huile de ricin hydrogénée. La poudre hydrosoluble est une cellulose mélangée à du lactose.Patent application EP 468 436 describes prolonged-release tablets obtained by compression an active principle and a mixture of two powders, one being hydrophobic and the other water-soluble. The hydrophobic powder is obtained by melting and spraying a mixture of stearic acid, glycerin and hydrogenated castor oil. The water-soluble powder is a cellulose mixed with lactose.
La demande de brevet EP 548 356 décrit des comprimés ultiparticulaires à délitement rapide qui comprennent une substance active sous forme de monocristaux ou de microgranules.Patent application EP 548 356 describes ultiparticulate tablets with rapid disintegration which comprise an active substance in the form of single crystals or microgranules.
Ces comprimés sont obtenus par granulation préalable d'un mélange d'excipients constitué d'un ou plusieurs agents de délitement, du type carboxyméthylcellulose ou polyvinylpyrrolidone, d'un ou plusieurs agents gonflants, du type amidon, et d'un sucre de compression directe comme le dextrose. Les microgranules ou les monocristaux sont intégrés à sec au mélange d'excipients avant d'être comprimés.These tablets are obtained by prior granulation of a mixture of excipients consisting of one or more disintegrating agents, of the carboxymethylcellulose or polyvinylpyrrolidone type, of one or more swelling agents, of the starch type, and of a direct compression sugar. like dextrose. The microgranules or single crystals are dry integrated into the mixture of excipients before being compressed.
Il a été montré que les excipients utilisés habituellement pour enrober les granules non comprimés, comme les dérivés de cellulose, ne peuvent pas absorber normalement les contraintes mécaniques que subissent les granules lors de la compression (International Journal of Pharmaceutics, n°143, 13-23, 1996) . La compression de granules enrobés est une opération délicate car elle modifie la structure du film d'enrobage par l'apparition de fissures ou par rupture, ce qui conduit à la perte partielle ou totale des propriétés du film. La fissuration des granules modifie irréversiblement le profil de libération du ou des principes actifs qu'ils contiennent. De façon à conserver les caractéristiques du film d'enrobage des granules après compression, les granules de l'art antérieur sont dilués avec des substances auxiliaires, dont le rôle est d'absorber les contraintes physiques liées à la compression (agents liants) et de permettre la désagrégation du comprimé (agents désintégrants) en milieu liquide, i.e. en solution aqueuse ou dans le fluide digestif.It has been shown that the excipients usually used to coat uncompressed granules, such as cellulose derivatives, cannot normally absorb the mechanical stresses which the granules undergo during compression (International Journal of Pharmaceutics, n ° 143, 13- 23, 1996). The compression of coated granules is a delicate operation because it modifies the structure of the coating film by the appearance of cracks or by rupture, which leads to the partial or total loss of the properties of the film. Cracking the granules irreversibly changes the release profile of the active ingredient (s) they contain. In order to preserve the characteristics of the coating film of the granules after compression, the granules of the prior art are diluted with auxiliary substances, the role of which is to absorb the physical stresses linked to the compression (binding agents) and to allow the disintegration of the tablet (disintegrating agents) in a liquid medium, ie in aqueous solution or in the digestive fluid.
Les formulations de comprimés de l'art antérieur utilisent des substances auxiliaires ajoutées aux granules lors de la compression pour éviter la fissuration de ces granules en surface.The prior art tablet formulations use auxiliary substances added to the granules during compression to avoid cracking of these granules on the surface.
L'objet de la présente invention concerne des sphéroïdes contenant un ou plusieurs principes actifs à l'exception de la tiagabine, compressibles directement, sans l'ajout d'une partie substantielle d'une substance auxiliaire, i.e. moins de 5 % en poids, de préférence moins de 1 % en poids .The object of the present invention relates to spheroids containing one or more active ingredients with the exception of tiagabine, which can be compressed directly, without the addition of a substantial part of an auxiliary substance, ie less than 5% by weight, preferably less than 1% by weight.
La présente invention a pour objet des sphéroïdes contentant un ou plusieurs principes actifs, à l'exception de la tiagabine, comprenant:The subject of the present invention is spheroids containing one or more active principles, with the exception of tiagabine, comprising:
- un noyau et/ou une couche enrobant ledit noyau contenant au moins un excipient thermoplastique, dont la consistance est pâteuse à semi-solide à une température de l'ordre de 20°C, et dont la température de fusion est comprise entre environ 25°C et environ 100°C, enrobée d' un film souple et déformable, à base d'un matériau polymérique, en particulier un film dont la température de transition vitreuse est inférieure à environ 30°C, qui assur , soit la protection, soit le masquage du goût, soit la libération modifiée et contrôlée du ou des principes actifs.a core and / or a layer coating said core containing at least one thermoplastic excipient, the consistency of which is pasty to semi-solid at a temperature of the order of 20 ° C., and the melting temperature of which is between approximately 25 ° C and approximately 100 ° C, coated with a flexible and deformable film, based on a polymeric material, in particular a film whose glass transition temperature is less than approximately 30 ° C, which provides either protection, be the masking of taste, that is the modified and controlled release of the active ingredient (s).
Le noyau peut être composé en particulier d'un mélange de saccharose et d'amidon ou de cellulose microcristalline.The core can be composed in particular of a mixture of sucrose and starch or microcrystalline cellulose.
Dans le cadre de la présente invention, on entend par excipients thermoplastiques des composés ayant un point de fusion compris entre 25 et 100°C et caractérisés par une consistance pâteuse à semi-solide à une température de l'ordre de 20°C.In the context of the present invention, the term “thermoplastic excipients” is understood to mean compounds having a melting point of between 25 and 100 ° C. and characterized by a pasty to semi-solid consistency at a temperature of the order of 20 ° C.
Le rôle des excipients thermoplastiques est, en particulier, lors d'une éventuelle étape de compression, de permettre aux sphéroïdes de se déformer plastiquement, et ainsi d'absorber une partie des contraintes qu'ils subissent, si bien que leur surface n'est pas fissurée ou déchirée.The role of thermoplastic excipients is, in particular, during a possible compression step, to allow the spheroids to deform plastically, and thus to absorb part of the stresses which they undergo, so that their surface is not not cracked or torn.
Les excipients peuvent être avantageusement choisis parmi les huiles partiellement hydrogénées, la cire d'abeille, la cire de carnauba, les cires de paraffine, les cires de silicone, les alcools gras et les acides gras en C12-C18, les glycérides semi-synthétiques solides, les monoester-diesters ou triesters du glycérol , les polyoxyéthylèneglycols , les glycérides polyoxyéthylénés glycosylés, et leurs mélanges. La couche contenant au moins un excipient thermoplastique est enrobée d'un film souple et déformable, comprenant un matériau polymérique, dont la température de transition vitreuse est inférieure à environ 30°C, de préférence inférieure à environ 20°C. Le film polymérique comprend un matériau polymérique qui est, soit un polymère, soit un mélange d'au moins un polymère et d'un plastifiant. Le film polymérique peut servir selon les cas à protéger le principe actif vis à vis de l'environnementThe excipients can be advantageously chosen from partially hydrogenated oils, beeswax, carnauba wax, paraffin waxes, silicone waxes, fatty alcohols and C12-C18 fatty acids, semi-synthetic glycerides solids, monoester diesters or triesters of glycerol, polyoxyethylene glycols, glycosylated polyoxyethylene glycerides, and mixtures thereof. The layer containing at least one thermoplastic excipient is coated with a flexible and deformable film, comprising a polymeric material, the glass transition temperature of which is less than approximately 30 ° C, preferably less than approximately 20 ° C. The polymeric film comprises a polymeric material which is either a polymer or a mixture of at least one polymer and a plasticizer. The polymer film can be used, depending on the case, to protect the active ingredient from the environment.
(dégradation par la lumière, par l'humidité ambiante) , à masquer le goût du principe actif, ou à modifier sa(degradation by light, by ambient humidity), to mask the taste of the active ingredient, or to modify its
5. libération (libération prolongée, retardée ou programmée) .5. release (extended, delayed or scheduled release).
Le polymère est de préférence un polymère ou un copolymère acrylique, vinylique ou cellulosique.The polymer is preferably an acrylic, vinyl or cellulosic polymer or copolymer.
On entend par plastifiant un produit permettant de 0 diminuer la température de transition vitreuse du polymère .Plasticizer is understood to mean a product which makes it possible to reduce the glass transition temperature of the polymer.
Le plastifiant est de préférence choisi parmi le triéthyl citrate, l'acétyl triéthyl citrate, le tributyl citrate, l'acétyl tributyl citrate, la triacétine, le 5 diéthyl phtalate, les polyéthylène glycols, les polysorbates , les glycérides mono- et diacétylés , et leurs mélanges .The plasticizer is preferably chosen from triethyl citrate, acetyl triethyl citrate, tributyl citrate, acetyl tributyl citrate, triacetin, diethyl phthalate, polyethylene glycols, polysorbates, mono- and diacetylated glycerides, and their mixtures.
Les propriétés mécaniques du film polymérique, en particulier le pourcentage d'élongation et la résistance 0 à la rupture, peuvent servir de critères de sélection du polymère et/ou du plastifiant. Ces caractéristiques mécaniques peuvent en outre être déterminées par la méthode décrite dans les normes DIN53 455 et ISO/RI 184.The mechanical properties of the polymer film, in particular the percentage of elongation and the breaking strength 0, can serve as criteria for selecting the polymer and / or the plasticizer. These mechanical characteristics can also be determined by the method described in standards DIN53 455 and ISO / RI 184.
Dans le cadre de la présente invention, on choisit 5 de façon préférentielle un polymère ou un mélange polymère/plastifiant ayant un pourcentage d'élongation supérieur à environ 50 %, pour enrober des sphéroïdes destinés à être comprimés.In the context of the present invention, a polymer or a polymer / plasticizer mixture having a percentage of elongation greater than about 50% is preferably chosen for coating spheroids intended to be compressed.
A titre d'exemple le polymère Eudragit NE30D® 0 commercialisé par la société ROHM, qui est un copolymère neutre d'esters d'acides acrylique et méthacrylique sous forme d'une dispersion aqueuse à 30%, présente un pourcentage d'élongation de 600% et une résistance à- la rupture égale à 8 N/mm2 ce qui le rend particulièrement souple et déformable.By way of example, the Eudragit NE30D® 0 polymer sold by the company ROHM, which is a neutral copolymer of acrylic and methacrylic acid esters in the form of an aqueous dispersion at 30%, has a percentage elongation of 600% and a breaking strength equal to 8 N / mm 2 which makes it particularly flexible and deformable.
Selon une première variante de l'invention, le ou les principes actifs sont dispersés dans la masse du noyau .According to a first variant of the invention, the active ingredient (s) are dispersed in the mass of the nucleus.
Selon une deuxième variante, le ou les principes actifs sont dispersés dans la couche contenant au moins un excipient thermoplastique. Selon une troisième variante, le ou les principes actifs sont appliqués à la surface du noyau, puis recouverts d' une couche contenant au moins un excipient thermoplastique .According to a second variant, the active ingredient (s) are dispersed in the layer containing at least one thermoplastic excipient. According to a third variant, the active ingredient (s) are applied to the surface of the core, then covered with a layer containing at least one thermoplastic excipient.
Le principe actif peut être protégé, dans l'une des quatre variantes précédentes, en lui associant un agent antioxydant et/ou en l'enrobant d'un film de protection.The active principle can be protected, in one of the four preceding variants, by associating it with an antioxidant agent and / or by coating it with a protective film.
Enfin, selon une quatrième et dernière variante, le ou les principes actifs sont dispersés dans la masse du noyau et dans la couche contenant au moins un excipient thermoplastique.Finally, according to a fourth and last variant, the active ingredient (s) are dispersed in the mass of the core and in the layer containing at least one thermoplastic excipient.
Les sphéroïdes selon l'invention peuvent avantageusement être enrobés d'une couche externe hydrodispersible .The spheroids according to the invention can advantageously be coated with a water-dispersible outer layer.
La couche externe assure la cohésion desdits sphéroïdes lors d'une éventuelle étape de compression, et assure le délitement en milieu aqueux du comprimé obtenu .The outer layer ensures the cohesion of said spheroids during a possible compression step, and ensures the disintegration in an aqueous medium of the tablet obtained.
La couche externe hydrodispersible est de préférence constituée d'un polymère acrylique, vinylique ou cellulosique. La présente invention a également pour objet le procédé de préparation des sphéroïdes décrits précédemment .The water-dispersible outer layer is preferably made of an acrylic, vinyl or cellulosic polymer. The present invention also relates to the process for the preparation of the spheroids described above.
La fabrication des noyaux peut être réalisée par montage en turbine à partir de cristaux calibrés de saccharose, ou par extrusion-sphéronisation .The manufacturing of the cores can be carried out by turbine assembly from calibrated sucrose crystals, or by extrusion-spheronization.
Lorsque les noyaux sont préparés par extrusion- sphéronisation, le principe actif peut être mélangé à la masse extrudée-sphéronisée. Selon le procédé de préparation de l'invention la couche contenant au moins un excipient thermoplastique, le film contenant un matériau polymérique, et éventuellement la couche de protection externe sont successivement déposés sur les noyaux par pulvérisation, dans une turbine de granulation, dans une turbine perforée, en lit d'air fluidisé ou par tout autre moyen approprié .When the cores are prepared by extrusion-spheronization, the active principle can be mixed with the extruded-spheronized mass. According to the preparation process of the invention, the layer containing at least one thermoplastic excipient, the film containing a polymeric material, and optionally the external protective layer are successively deposited on the cores by spraying, in a granulation turbine, in a turbine. perforated, in a fluidized air bed or by any other suitable means.
Le procédé selon l'invention comprend deux ou trois étapes selon que l'on souhaite préparer des sphéroïdes comportant une couche externe hydrodispersible ou non.The method according to the invention comprises two or three stages depending on whether it is desired to prepare spheroids comprising an external layer which is hydrodispersible or not.
Les sphéroïdes comportant une couche externe hydrodispersible sont particulièrement adaptés à la préparation de comprimés .Spheroids having a water-dispersible outer layer are particularly suitable for the preparation of tablets.
La première étape, appelée étape de montage, consiste à déposer le ou les excipients thermoplastiques sur les noyaux. La préparation de montage peut se présenter, selon les cas, sous forme de dispersions solides en milieux aqueux ou organiques, sous forme de solutions, sous forme d'émulsions, ou à l'état fondu. Lorsque le principe actif est dispersé dans la masse de la couche contenant au moins un excipient thermoplastique, le principe actif est incorporé à la préparation de montage.The first step, called the mounting step, consists in depositing the thermoplastic excipient (s) on the cores. The assembly preparation can be, as the case may be, in the form of solid dispersions in aqueous or organic media, in the form of solutions, in the form of emulsions, or in the molten state. When the active principle is dispersed in the mass of the layer containing at least one excipient thermoplastic, the active ingredient is incorporated in the assembly preparation.
Selon une autre variante du procédé selon l'invention, le principe actif peut être fixé par poudrage sur les noyaux neutres préalablement mouillés avec la préparation de montage.According to another variant of the process according to the invention, the active principle can be fixed by dusting on the neutral cores previously wetted with the mounting preparation.
La deuxième étape du procédé selon l'invention consiste à déposer le film polymérique permettant d'assurer la protection du principe actif, le masquage de goût ou la libération modifiée du principe actif. La préparation d'enrobage polymérique peut se présenter sous forme de solutions ou de dispersions en milieu aqueux ou organique.The second step of the process according to the invention consists in depositing the polymer film making it possible to ensure the protection of the active principle, the masking of taste or the modified release of the active principle. The polymeric coating preparation can be in the form of solutions or dispersions in an aqueous or organic medium.
La troisième étape facultative du procédé selon l'invention consiste à déposer la couche externe de protection en pulvérisant la préparation d'enrobage qui peut se présenter sous forme de solution ou de dispersion en milieu aqueux ou organique.The optional third step of the process according to the invention consists in depositing the external protective layer by spraying the coating preparation which can be in the form of a solution or dispersion in an aqueous or organic medium.
En fonction des besoins, on peut avantageusement ajouter aux préparations de montage et d'enrobage un agent anti-adhérant tel que le talc, un plastifiant tel que le polyéthylène glycol, un agent antioxydant tel que le dl-alpha-tocophérol .Depending on the needs, it is advantageous to add to the mounting and coating preparations an anti-adhering agent such as talc, a plasticizer such as polyethylene glycol, an antioxidant agent such as dl-alpha-tocopherol.
A la couche externe de protection on peut avantageusement ajouter un agent désintégrant de façon à accélérer la libération des sphéroïdes en milieu aqueux, lorsque ceux-ci ont été comprimés.A disintegrating agent can advantageously be added to the outer protective layer so as to accelerate the release of the spheroids in an aqueous medium, when these have been compressed.
L'agent désintégrant est par exemple la carboxyméthylcellulose réticulée, la polyvinylpyrrolidone réticulée ou le carboxyméthyl amidon sodique . La présente invention a également pour objet les préparations pharmaceutiques mul tiparticulaires contenant les sphéroïdes décrits précédemment susceptibles d'être obtenus par le procédé de 1 ' invention .The disintegrating agent is for example crosslinked carboxymethylcellulose, crosslinked polyvinylpyrrolidone or sodium carboxymethyl starch. The present invention also relates to the mul tiparticular pharmaceutical preparations containing the spheroids described above which can be obtained by the process of the invention.
Les préparations pharmaceutiques multiparticulaires selon l'invention sont de préférence sans la forme de gélules remplies desdits sphéroïdes, ou de comprimés desdits sphéroïdes. Lesdits comprimés sont avantageusement préparés sans l'addition substantielle de substances auxiliaires. On peut ajouter aux sphéroïdes avant la compression, jusqu'à 5 % en poids d'un agent lubrifiant comme le talc. Lesdits comprimés comprennent avantageusement des de sphéroïdes protégés par une couche hydrodispersible constituée par un polymère acrylique, vinylique, cellulosique ou un excipient thermoplastique hydrodispersible, ou tout autre excipient soluble en milieu aqueux.The multiparticulate pharmaceutical preparations according to the invention are preferably without the form of capsules filled with said spheroids, or tablets of said spheroids. Said tablets are advantageously prepared without the substantial addition of auxiliary substances. Up to 5% by weight of a lubricating agent such as talc can be added to the spheroids before compression. Said tablets advantageously comprise spheroids protected by a water-dispersible layer consisting of an acrylic, vinyl, cellulosic polymer or a water-dispersible thermoplastic excipient, or any other excipient soluble in an aqueous medium.
Cette couche a pour rôle d'assurer la cohésion des sphéroïdes entre eux, d'assurer ainsi la dureté du comprimé, et de permettre au comprimé de se désagréger lorsqu'il est plongé en solution. Les comprimés selon l'invention sont dispersibles en solution et restituent des sphéroïdes indépendants, de sorte que le profil de libération du comprimé et des sphéroïdes qui le constituent sont pratiquement équivalents . En effet, les comprimés selon l'invention permettent la délivrance de sphéroïdes sans que le profil de libération du ou des principes actifs qu'ils contiennent ne soit altéré sous l'effet de la compression .This layer has the role of ensuring the cohesion of the spheroids between them, thus ensuring the hardness of the tablet, and of allowing the tablet to disintegrate when it is immersed in solution. The tablets according to the invention are dispersible in solution and restore independent spheroids, so that the release profile of the tablet and of the spheroids which constitute it are practically equivalent. Indeed, the tablets according to the invention allow the delivery of spheroids without the release profile of the active ingredient (s) they contain is altered by compression.
Les comprimés selon l'invention peuvent être composés uniquement des sphéroïdes selon l'invention ou d'un mélange de sphéroïdes et de sphéroïdes placebos, c' est-à-dire des sphéroïdes conforment à la présente invention mais dépourvus de principe actif.The tablets according to the invention can be composed only of the spheroids according to the invention or of a mixture of spheroids and placebos spheroids, that is to say spheroids conform to the present invention but devoid of active principle.
Les contraintes exercées sur les sphéroïdes, lors de l'étape de compression, peuvent varier de 5 N à 50 kN mais de préférence entre 5 kN et 15 kN.The stresses exerted on the spheroids, during the compression step, can vary from 5 N to 50 kN but preferably between 5 kN and 15 kN.
La dureté des comprimés est de préférence comprise entre 10 N et 100 N, plus préférentiellement entre 10 N et 50 N.The hardness of the tablets is preferably between 10 N and 100 N, more preferably between 10 N and 50 N.
Le temps de désagrégation des comprimés en milieu aqueux à 37°C est inférieur à 60 min.The disintegration time of the tablets in an aqueous medium at 37 ° C. is less than 60 min.
Les comprimés selon l'invention ont de préférence une masse comprise entre 0,1 g et 1 g.The tablets according to the invention preferably have a mass of between 0.1 g and 1 g.
Leur forme peut être ronde, ovale, oblongue, présenter une surface plate ou concave, et présenter des gravures ou des barres de sécabilité.Their shape can be round, oval, oblong, have a flat or concave surface, and have engravings or score bars.
Les comprimés selon l'invention peuvent faire l'objet d'un enrobage final de protection ou de coloration .The tablets according to the invention can be the subject of a final protective or coloring coating.
La présente invention sera plus particulièrement décrite à l'aide des exemples suivants et de la figure unique qui ne doivent pas être considérés comme limitatifs de l'invention.The present invention will be more particularly described with the aid of the following examples and the single figure which should not be considered as limiting the invention.
La figure unique représente le pourcentage massique de dissolution in vitro d'un principe actif particulier, l'isosorbide mononitrate, pour les sphéroïdes selon l'invention non comprimés (courbe 1) et pour un comprimé de sphéroïdes selon l'invention (courbe 2) . EXEMPLE 1The single figure represents the mass percentage of in vitro dissolution of a particular active principle, isosorbide mononitrate, for the spheroids according to the invention not compressed (curve 1) and for a tablet of spheroids according to the invention (curve 2) . EXAMPLE 1
Etape de montageAssembly step
Préparer une solution aqueuse de montage contenant le principe actif et de 1 ' hydroxypropyl-méthyl-cellulosePrepare an aqueous mounting solution containing the active ingredient and hydroxypropyl-methyl-cellulose
(Pharmacoat 603® commercialisé par la société(Pharmacoat 603® marketed by the company
SHIN ETSU) ,SHIN ETSU),
Dans une turbine perforée, pulvériser la solution décrite précédemment à la surface de Neutres 26® (commercialisés par NP Pharm) de façon à obtenir une enveloppe composée de Pharmacoat 603® et de principe actif,In a perforated turbine, spray the solution described above onto the surface of Neutrals 26® (marketed by NP Pharm) so as to obtain an envelope composed of Pharmacoat 603® and active ingredient,
Transférer la charge ainsi obtenue dans une turbine conventionnelle; chauffer la charge jusqu'à une température d'environ 50°C,Transfer the charge thus obtained to a conventional turbine; heat the load to a temperature of about 50 ° C,
- Appliquer par poudrage sur la charge chaude en rotation du Précirol® atomisé (commercialisé par la société Gattefossé) . Le Précirol® est un composé thermoplastique qui, par ramollissement et étalement au contact de la charge maintenue à 50°C, va former un film uniforme autour des noyaux.- Apply by dusting on the hot load in rotation of atomized Précirol® (sold by the company Gattefossé). Precirol® is a thermoplastic compound which, by softening and spreading in contact with the charge maintained at 50 ° C, will form a uniform film around the cores.
Pour réduire le collage entre les noyaux, du talc peut être ajouté au Précirol®.To reduce sticking between the cores, talc can be added to Précirol®.
Etape d'enrobageCoating step
La charge obtenue précédemment est divisée en deux. Une partie seulement est enrobée:The charge previously obtained is divided in two. Only part is coated:
Préparer une solution aqueuse composée d'un polymère acrylique, I'Eudragit RS30D® (commercialisé par la société ROHM) et d'un plastifiant le Myvacet 9.45® (commercialisé par la société Eastman Kodak) , Dans une turbine perforée, pulvériser la solution d'enrobage sur les noyaux montés, Sécher la charge ainsi obtenue.Prepare an aqueous solution composed of an acrylic polymer, Eudragit RS30D® (sold by the company ROHM) and a plasticizer Myvacet 9.45® (sold by the company Eastman Kodak), In a perforated turbine, spray the coating solution on the mounted cores, Dry the charge thus obtained.
Etape de mélange mélanger dans les proportions massiques 27/73 la partie enrobée et la partie montée; le détail des compositions des deux lots et du mélange apparaît ci- dessous :Mixing step mix in the mass proportions 27/73 the coated part and the mounted part; the details of the compositions of the two batches and of the mixture appear below:
Figure imgf000014_0001
Figure imgf000014_0001
Etape de compressionCompression step
Le mélange de sphéroïdes est comprimé sur une presse alternative Frogerais OA.The spheroid mixture is compressed on a Frogerais OA alternative press.
Résultats de dissolution in vitro:In vitro dissolution results:
Un test de dissolution in vitro est réalisé sur les comprimés selon la méthode décrite dans la pharmacopéee (USP XXIII, <711> appareil 2) . Conditions : appareil à palette tournante, - milieu : pH 6,0, 500 ml, 37°C. 9/26608An in vitro dissolution test is carried out on the tablets according to the method described in the pharmacopoeia (USP XXIII, <711> device 2). Conditions: rotating paddle device, - medium: pH 6.0, 500 ml, 37 ° C. 9/26608
1313
Le principe actif est dosé par spectrophotométπe ultra-violet.The active ingredient is dosed by ultraviolet spectrophotometry.
Le tableau suivant donne le pourcentage de principe actif libéré par les sphéroïdes avant et après compression en fonction du temps:The following table gives the percentage of active principle released by the spheroids before and after compression as a function of time:
Figure imgf000015_0001
Figure imgf000015_0001
Les résultats présentés sur la figure unique montrent qu'il n'y a pas de différence significative entre les profils de dissolution du principe actif avant et après compression .The results presented in the single figure show that there is no significant difference between the dissolution profiles of the active principle before and after compression.
EXEMPLE 2EXAMPLE 2
Etape de montageAssembly step
Préparation de la suspension de montagePreparation of the mounting suspension
Peser les excipients dans les proportions indiquées ci- dessous .
Figure imgf000016_0001
Weigh the excipients in the proportions indicated below.
Figure imgf000016_0001
Teneur en extrait sec : 45,2 %Dry extract content: 45.2%
Chauffer l'eau purifiée à 37°C,Heat the purified water to 37 ° C,
Ajouter le PEG 6000 (Empakol® - commercialisé par ICI) et le faire fondre jusqu'à obtenir une solution homogène ,Add PEG 6000 (Empakol® - sold by ICI) and melt it until a homogeneous solution is obtained,
Chauffer la cire Novata AB® (commercialisée parHeat the Novata AB® wax (sold by
Henkel) à 37°C,Henkel) at 37 ° C,
Ajouter à la cire le polysorbate 80 (commercialisé par ICI) et le dl-α-tocophérol (commercialisé parAdd to the wax the polysorbate 80 (sold by HERE) and the dl-α-tocopherol (sold by
Roche) ,Rock) ,
Mélanger à 37°C, à l'aide d'un agitateur de typeMix at 37 ° C, using a type stirrer
Heidolph la solution aqueuse et la solution huileuse afin d'obtenir une émulsion de type huile dans eau, - Refroidir de façon à ramener la température aux environs de 25°C,Heidolph the aqueous solution and the oily solution in order to obtain an oil-in-water emulsion, - Cool so as to bring the temperature back to around 25 ° C,
Ajouter le principe actif,Add the active ingredient,
Broyer la suspension à l'aide d'une turbine de typeGrind the suspension using a turbine type
Ultra-Turrax®, - Ajouter en final le talc et maintenir la suspension sous agitation pendant l'opération de montage. Montage sur des noyaux neutresUltra-Turrax®, - Finally add the talc and keep the suspension under stirring during the assembly operation. Installation on neutral cores
Placer 550 g de neutres taille 30 (commercialisé parPlace 550 g of size 30 neutrals (sold by
NP-PHARM) , dans une turbine à dragéification , une turbine perforée ou un lit d'air fluidisé,NP-PHARM), in a coating turbine, a perforated turbine or a fluidized air bed,
Effectuer le montage par pulvérisation en continue de la suspension décrite ci-dessus,Perform the assembly by continuous spraying of the suspension described above,
Maintenir la température entre 20 et 23°C pendant toute l'opération,Maintain the temperature between 20 and 23 ° C throughout the operation,
Tamiser la masse de microgranules obtenue.Sieve the mass of microgranules obtained.
Formule finale :Final formula:
Figure imgf000017_0001
Figure imgf000017_0001
Etape d'enrobageCoating step
1 / Préparation de la suspension d'enrobage à libération prolongée1 / Preparation of the extended-release coating suspension
Peser les excipients d'enrobage suivants dans les proportions indiquées :
Figure imgf000018_0001
Weigh the following coating excipients in the proportions indicated:
Figure imgf000018_0001
Teneur en extrait sec : 24,0Dry extract content: 24.0
Placer l'eau purifiée dans un récipient sous agitation,Place the purified water in a stirred container,
Solubiliser le PEG 6000 jusqu'à obtention d'une solution homogène,Solubilize PEG 6000 until a homogeneous solution is obtained,
Ajouter lentement l'Eudragit NE 30D® (commercialisé par la société ROHM) , agiter jusqu'à obtenir une suspension homogène,Slowly add Eudragit NE 30D® (sold by the company ROHM), shake until a homogeneous suspension is obtained,
Maintenir l'agitation pendant toute la phase d' enrobage .Maintain agitation throughout the coating phase.
Enrobage des sphéroïdes montésCoating of mounted spheroids
Placer une fraction des microgranules obtenus selon l'exemple 1 dans une turbine perforée ou un lit d'air fluidisé,Place a fraction of the microgranules obtained according to Example 1 in a perforated turbine or a fluidized air bed,
Effectuer l'enrobage de sphéroïdes montés par pulvérisation continue de la suspension décrite ci- dessus en maintenant le lit de sphéroïdes à une température inférieure à 25°C,Coating mounted spheroids by continuous spraying of the suspension described above while maintaining the bed of spheroids at a temperature below 25 ° C.,
Sécher puis tamiser la masse ainsi obtenue.Dry and then sieve the mass thus obtained.
2 / Préparation de la suspension d' enrobage de protection Peser les excipients d'enrobage suivants dans les proportions indiquées •
Figure imgf000019_0001
2 / Preparation of the protective coating suspension Weigh the following coating excipients in the proportions indicated •
Figure imgf000019_0001
Teneur en extrait sec : 10,0 %Dry extract content: 10.0%
Placer l'eau purifiée dans un récipient sous agitation,Place the purified water in a stirred container,
Solubiliser le PEG 6000 jusqu'à obtention d'une solution homogène,Solubilize PEG 6000 until a homogeneous solution is obtained,
Ajouter lentement l'Opadry OYB® (commercialisé par la société COLORCON) , agiter jusqu'à obtenir une solution homogène,Slowly add the Opadry OYB® (sold by the company COLORCON), shake until a homogeneous solution is obtained,
Maintenir l'agitation pendant toute la phase d' enrobage .Maintain agitation throughout the coating phase.
Enrobage des sphéroïdes à libération prolongée - Placer une fraction des sphéroïdes obtenus précédemment dans une turbine perforée ou un lit d'air fluidisé,Coating of the prolonged release spheroids - Place a fraction of the spheroids obtained previously in a perforated turbine or a fluidized air bed,
Effectuer l'enrobage de sphéroïdes à libération prolongée par pulvérisation continue de la solution décrite ci-dessus en maintenant le lit de sphéroïdes à une température inférieure à 25°C,Coating of sustained release spheroids by continuous spraying of the solution described above while maintaining the bed of spheroids at a temperature below 25 ° C.,
Sécher à 30°C/35°C en fin d'enrobage puis tamiser la masse ainsi obtenue. Formule finale correspondant à 35 % p/p d'enrobage à libération prolongée et à 5 % p/p d' enrobage de protection :Dry at 30 ° C / 35 ° C at the end of coating then sieve the mass thus obtained. Final formula corresponding to 35% w / w of extended-release coating and 5% w / w of protective coating:
Figure imgf000020_0001
Figure imgf000020_0001
Les sphéroïdes sont ensuite comprimés sur une machine instrumentée rotative de type Fette P1200. Les forces de compression appliquées se situent entre 10 kN et 30 kN.The spheroids are then compressed on a rotary instrumented machine of the Fette P1200 type. The compressive forces applied are between 10 kN and 30 kN.
Caractéristiques des comprimés mesurées sur 10 unités :Characteristics of the tablets measured on 10 units:
Figure imgf000020_0002
Figure imgf000020_0002
Résultats de dissolution in vitro Conditions : appareil de dissolution à palette conforme à la norme LJSP XXIII, <711> appareil 2, milieu : 900 ml d'eau purifiée à 37°C agité à 100 tours/minutes .In vitro dissolution results Conditions: paddle dissolution apparatus in accordance with standard LJSP XXIII, <711> apparatus 2, medium: 900 ml of purified water at 37 ° C. stirred at 100 rpm.
Le principe actif est dosé par HPLC à la longueur d'onde 285 nm.The active principle is dosed by HPLC at the wavelength 285 nm.
Le tableau suivant donne le pourcentage de principe actif libéré par les sphéroïdes avant et après compression en fonction du temps .The following table gives the percentage of active principle released by the spheroids before and after compression as a function of time.
Figure imgf000021_0001
Figure imgf000021_0001
EXEMPLE 3 Etape de montageEXAMPLE 3 Installation step
Préparation de la suspension de montagePreparation of the mounting suspension
Peser les excipients dans les proportions indiquées ci- dessous Weigh the excipients in the proportions indicated below
Figure imgf000022_0001
Figure imgf000022_0001
Teneur en extrait sec :24,22 %Dry extract content: 24.22%
Mode opératoireProcedure
Dans un récipient Inox, introduire successivement l'eau purifiée puis sous agitation le principe actif par petites quantités. Ajouter progressivement toujours sous agitation le diéthylphtalate puis le talc.In a stainless steel container, successively introduce the purified water and then, with stirring, the active principle in small quantities. Gradually always add the diethylphthalate and then the talc with stirring.
Mélanger la suspension à l'aide d'une turbine ultra-Mix the suspension using an ultra-
Turrax®.Turrax®.
Montage sur noyaux NeutresMounting on Neutral cores
Placer 153 g de Neutres 26® dans une turbine à dragéification ou turbine perforée au lit d'air fluidisé .Place 153 g of Neutrals 26® in a coating or perforated turbine in a fluidized air bed.
Effectuer le montage du principe actif par pulvérisation continue de la suspension décrite ci-dessus.Mount the active ingredient by continuous spraying of the suspension described above.
Enrobage protecteurProtective coating
Peser dans un récipient Inox les excipients suivants :Weigh the following excipients in a stainless steel container:
Précirol® : 36,85 gPrécirol®: 36.85 g
Talc : 14,74 g. Procéder au mélange de poudres (utilisation d'un mélangeur cubique ou planétaire) .Talc: 14.74 g. Mix the powders (use a cubic or planetary mixer).
Application du mélange sur les granulesApplication of the mixture on the granules
Introduire dans la cuve de l'appareil retenu (turbine conventionnelle, lit d'air fluidisé, turbine perforée) les granules actifs.Introduce the active granules into the tank of the selected device (conventional turbine, fluidized air bed, perforated turbine).
Réchauffer ces microgranules jusqu'à obtention d'une température d'environ 50°C.Reheat these microgranules until a temperature of around 50 ° C is obtained.
Appliquer par poudrage le mélange ci-dessus décrit et dans le cas d'utilisation de la technologie du lit d'air fluidisé, par pulvérisation du mélange fondu.Apply the above-described mixture by dusting and, if the fluidized air bed technology is used, by spraying the molten mixture.
Enrobage primaire peser dans un récipient Inox les excipients ci-dessusPrimary coating weigh the above excipients in a stainless steel container
Figure imgf000023_0001
Figure imgf000023_0001
Teneur en extrait sec 21,5Dry extract content 21.5
- Mettre sous agitation et homogénéiser à l'aide d'une turbine Ultra-Turrax® la suspension décrite ci- dessus .- Stir and homogenize using an Ultra-Turrax® turbine the suspension described above.
Effectuer l'enrobage des granules décrits précédemment par pulvérisation continue de la suspension préparée ci-dessus en maintenant, quelle que soit la technologie retenue, une température du lit de granules inférieure à 23°C.Coating the granules described above by continuous spraying of the suspension prepared above while maintaining, whatever the technology chosen, a temperature of the bed of granules below 23 ° C.
Enrobage secondaireSecondary coating
Peser dans un récipient Inox les excipients ci- dessous .Weigh the excipients below in a stainless steel container.
Figure imgf000024_0001
Figure imgf000024_0001
Incorporer successivement dans l'eau, le PEG puis le Pharmacoat® sous agitation et maintenir celle-ci jusqu'à complète dissolution.Incorporate successively in the water, the PEG then the Pharmacoat® with stirring and maintain this until complete dissolution.
Effectuer l'enrobage des granules décrits précédemment par pulvérisation continue de la solution préparée ci-dessus. Coating the granules described above by continuous spraying of the solution prepared above.
Formule finaleFinal formula
Matières Pourcentage massiqueMaterials Mass percentage
Neutres 26® 30,28 Sulfate de morphine 36,33 Diéthylphtalate 5,46 Talc 6,74Neutrals 26® 30.28 Morphine sulfate 36.33 Diethylphthalate 5.46 Talc 6.74
Précirol® 7,29Precirol® 7.29
Eudragit NE 30D® 10,73 Pharmacoat 603® 2,85 PEG 400 0,29Eudragit NE 30D® 10.73 Pharmacoat 603® 2.85 PEG 400 0.29
Teneur théorique en sulfate de morphine 235 , 67 mg/gTheoretical content of morphine sulfate 235, 67 mg / g
Les sphéroïdes sont ensuite comprimés sur une machine instrumentée rotative de type Fette P1200.The spheroids are then compressed on a rotary instrumented machine of the Fette P1200 type.
Les forces de compression appliquées se situent entre 10 KN et 30 KN.The compression forces applied are between 10 KN and 30 KN.
Caractéristiques des comprimés obtenusCharacteristics of the tablets obtained
Figure imgf000025_0001
Figure imgf000025_0001
Résultats de dissolution in vitro,In vitro dissolution results,
Conditions :Conditions:
Appareil de dissolution à palettes conformes à la norme (USP XXIII, <711> appareil 2). Milieu 500 ml, Eau purifiée à 37°C. Vitesse d'agitation 100 tours/minute. Le principe actif est dosé par U.V en continu aux longueurs d'onde : 285-320 nm.Pallet dissolution device in accordance with the standard (USP XXIII, <711> device 2). Medium 500 ml, Purified water at 37 ° C. Stirring speed 100 revolutions / minute. The active principle is dosed by UV continuously at wavelengths: 285-320 nm.
Figure imgf000026_0001
Figure imgf000026_0001

Claims

REVENDICATIONS
1. Sphéroïdes contenant un ou plusieurs principes actifs, à l'exception de la tiagabine, comprenant: - un noyau et/ou une couche enrobant ledit noyau contenant au moins un excipient thermoplastique, dont la consistance est pâteuse à semi-solide à une température de l'ordre de 20°C, et dont la température de fusion est comprise entre environ 25°C et environ 100°C, enrobée d* un film souple et deformable, à base d'un matériau polymérique, en particulier un film dont la température de transition vitreuse est inférieure à environ 30°C, qui assure, soit la protection, soit le masquage du goût, soit la libération modifiée et contrôlée du ou des principes actifs.1. Spheroids containing one or more active ingredients, with the exception of tiagabine, comprising: - a core and / or a layer coating said core containing at least one thermoplastic excipient, the consistency of which is pasty to semi-solid at a temperature of the order of 20 ° C., and the melting point of which is between approximately 25 ° C. and approximately 100 ° C., coated with a flexible and deformable film, based on a polymeric material, in particular a film of which the glass transition temperature is less than approximately 30 ° C., which provides either protection or masking of the taste, or modified and controlled release of the active ingredient (s).
2. Sphéroïdes selon la revendication 1, caractérisés en ce que l'excipient thermoplastique est choisi parmi les huiles partiellement hydrogénées, la cire d'abeille, la cire de carnauba, les cires de paraffine, les cires de silicone, les alcools gras et les acides gras en C12-C18, les glycérides semi- synthétiques solides, les monoester-diesters ou triesters du glycérol , les polyoxyéthylèneglycols , les glycérides polyoxyéthylénés glycosylés, et leurs mélanges .2. Spheroids according to claim 1, characterized in that the thermoplastic excipient is chosen from partially hydrogenated oils, beeswax, carnauba wax, paraffin waxes, silicone waxes, fatty alcohols and C12-C18 fatty acids, semisynthetic solid glycerides, monoester diesters or triesters of glycerol, polyoxyethylene glycols, polyoxyethylene glycosylated glycerides, and mixtures thereof.
3. Sphéroïdes selon la revendication 1 ou 2, caractérisés en ce que la température de transition vitreuse du film souple et deformable est inférieure à environ 20°C. 3. Spheroids according to claim 1 or 2, characterized in that the glass transition temperature of the flexible and deformable film is less than about 20 ° C.
4. Sphéroïdes selon l'une des revendications 1 à 3, caractérisés en ce que le matériau polymérique est un polymère ou un mélange d'au moins un polymère et d'un plastifiant.4. Spheroids according to one of claims 1 to 3, characterized in that the polymeric material is a polymer or a mixture of at least one polymer and of a plasticizer.
5. Sphéroïdes selon la revendication 4, caractérisés en ce que le plastifiant est choisi parmi le triéthyl citrate, l'acétyl triéthyl citrate, le tributyl citrate, l'acétyl tributyl citrate, la triacétine, le diéthyl phtalate, les polyéthylèneglycols , les polysorbates, les glycérides mono- et diacétylés, et leurs mélanges .5. Spheroids according to claim 4, characterized in that the plasticizer is chosen from triethyl citrate, acetyl triethyl citrate, tributyl citrate, acetyl tributyl citrate, triacetin, diethyl phthalate, polyethylene glycols, polysorbates, mono- and diacetylated glycerides, and mixtures thereof.
6. Sphéroïdes selon l'une des revendications 1 à 5, caractérisé en ce que le matériau polymérique présente un pourcentage d'élongation supérieur à environ 50%.6. Spheroids according to one of claims 1 to 5, characterized in that the polymeric material has a percentage of elongation greater than about 50%.
7. Sphéroïdes selon l'une des revendications précédentes, caractérisés en ce qu'ils sont enrobés d'une couche externe hydrodispersible qui assure la cohésion desdits sphéroïdes lors d'une éventuelle étape de compression et qui assure le délitement en milieu aqueux du comprimé obtenu.7. Spheroids according to one of the preceding claims, characterized in that they are coated with a water-dispersible outer layer which ensures the cohesion of said spheroids during a possible compression step and which ensures the disintegration in aqueous medium of the tablet obtained .
8. Sphéroïdes selon la revendication 7, caractérisés en ce que la couche externe hydrodispersible est constituée d'un polymère acrylique, vinylique ou cellulosique. 8. Spheroids according to claim 7, characterized in that the water-dispersible outer layer consists of an acrylic, vinyl or cellulosic polymer.
9. Sphéroïdes selon l'une des revendications 1 à 8, caractérisés en ce que le ou les principes actifs sont dispersés dans la masse du noyau.9. Spheroids according to one of claims 1 to 8, characterized in that the active ingredient (s) are dispersed in the mass of the nucleus.
10. Sphéroïdes selon l'une des revendications 1 à 8, caractérisés en ce que le ou les principes actifs sont dispersés dans la couche contenant au moins un excipient thermoplastique.10. Spheroids according to one of claims 1 to 8, characterized in that the active ingredient (s) are dispersed in the layer containing at least one thermoplastic excipient.
11. Sphéroïdes selon l'une des revendications 1 à 8, caractérisés en ce que le ou les principes actifs sont dispersés dans la masse du noyau et dans la couche contenant au moins un excipient thermoplastique .11. Spheroids according to one of claims 1 to 8, characterized in that the active ingredient (s) are dispersed in the mass of the core and in the layer containing at least one thermoplastic excipient.
12. Sphéroïdes selon l'une des revendications 1 à 8, caractérisés en ce que le ou les principes actifs sont appliqués à la surface du noyau, puis recouverts d'une couche contenant au moins un excipient thermoplastique.12. Spheroids according to one of claims 1 to 8, characterized in that the active principle or principles are applied to the surface of the core, then covered with a layer containing at least one thermoplastic excipient.
13. Procédé de préparation des sphéroïdes selon l'une des revendications 1 à 12, caractérisé en ce que la couche contenant au moins un excipient thermoplastique, le film contenant un matériau polymérique, et éventuellement la couche externe, sont successivement déposés sur les noyaux par pulvérisation, dans une turbine de granulation, dans une turbine perforée, en lit d'air fluidisé ou par tout autre moyen approprié. 13. Process for the preparation of spheroids according to one of claims 1 to 12, characterized in that the layer containing at least one thermoplastic excipient, the film containing a polymeric material, and optionally the outer layer, are successively deposited on the cores by spraying, in a granulation turbine, in a perforated turbine, in a fluidized air bed or by any other suitable means.
14. Préparations pharmaceutiques multiparticulaires contenant les sphéroïdes selon l'une des revendications 1 à 12 susceptibles d' être obtenus selon le procédé de la revendication 13.14. Multiparticulate pharmaceutical preparations containing the spheroids according to one of claims 1 to 12 capable of being obtained according to the process of claim 13.
15. Préparations pharmaceutiques selon la revendication 14, caractérisées en ce qu'elles sont sous la forme de gélules remplies desdits sphéroïdes .15. Pharmaceutical preparations according to claim 14, characterized in that they are in the form of capsules filled with said spheroids.
16. Préparations pharmaceutiques selon la revendication 14, caractérisées en ce qu'elles sont sous la forme de comprimés desdits sphéroïdes.16. Pharmaceutical preparations according to claim 14, characterized in that they are in the form of tablets of said spheroids.
17. Procédé de fabrication des préparations selon la revendication 16, caractérisé en ce que les comprimés sont préparés sans l'ajout d'une quantité substantielle d'une substance auxiliaire.17. A method of manufacturing preparations according to claim 16, characterized in that the tablets are prepared without the addition of a substantial amount of an auxiliary substance.
18. Procédé selon la revendication 17, caractéri-sé en ce qu'on ajoute aux sphéroïdes avant la compression, jusqu'à 5 % en poids d'un agent lubrifiant comme le talc. 18. The method of claim 17, caractéri-se in that added to the spheroids before compression, up to 5% by weight of a lubricating agent such as talc.
PCT/IB1998/001911 1997-11-21 1998-11-19 Spheroids, preparation method and pharmaceutical compositions WO1999026608A1 (en)

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MXPA00004959A MXPA00004959A (en) 1997-11-21 1998-11-19 Spheroids, preparation method and pharmaceutical compositions.
EA200000548A EA003324B1 (en) 1997-11-21 1998-11-19 Spheroids, preparation method and pharmaceutical compositions
IL13621598A IL136215A0 (en) 1997-11-21 1998-11-19 Spheroids, preparation method and pharmaceutical compositions
SK756-2000A SK284493B6 (en) 1997-11-21 1998-11-19 Spheroids, method for their preparation and pharmaceutical preparations containing thereof
AT98954683T ATE246496T1 (en) 1997-11-21 1998-11-19 SPHEROIDS, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL FORMS CONTAINING SAME
NZ504662A NZ504662A (en) 1997-11-21 1998-11-19 Spheroids having a core coated with a coating having an thermoplastic excipient
BR9814672-6A BR9814672A (en) 1997-11-21 1998-11-19 Pharmaceutical preparation in the form of spheroid tablets and manufacturing process
DE69817010T DE69817010T2 (en) 1997-11-21 1998-11-19 SPHEROIDS, PROCESS FOR PRODUCING THE SAME AND MEDICINAL PRODUCTS CONTAINING THEM
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AU11704/99A AU744580B2 (en) 1997-11-21 1998-11-19 Spheroids, preparation method and pharmaceutical compositions
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PL98340659A PL193878B1 (en) 1997-11-21 1998-11-19 Spheroides, method of obtaining them and pharmacological compositions
IL136215A IL136215A (en) 1997-11-21 2000-05-18 Spheroids, preparation method and pharmaceutical compositions
NO20002605A NO329728B1 (en) 1997-11-21 2000-05-19 Spheroids containing ± one or more active principles, with the exception of tiagabine, processes for forming the same and multiparticulates, pharmaceutical preparations containing the spheroids, and their preparation.
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FR2845289A1 (en) * 2002-10-04 2004-04-09 Ethypharm Sa SPHEROIDS, PROCESS FOR PREPARATION AND PHARMACEUTICAL COMPOSITIONS.
US9446002B2 (en) 2002-10-04 2016-09-20 Ethypharm Spheroids and multiparticulate tablets comprising them
EP2468263A1 (en) 2010-12-23 2012-06-27 Laboratorios Del. Dr. Esteve, S.A. Compressed solid dosage forms
WO2012085194A1 (en) 2010-12-23 2012-06-28 Laboratorios Del Dr. Esteve, S.A. Compressed solid dosage forms

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CA2310147C (en) 2010-05-25
BG104511A (en) 2001-04-30
BR9814672A (en) 2000-10-03
EP1032374B1 (en) 2003-08-06
TR200002130T2 (en) 2000-12-21
ATE246496T1 (en) 2003-08-15
DE69817010D1 (en) 2003-09-11
FR2771291A1 (en) 1999-05-28
SK284493B6 (en) 2005-05-05
DK1032374T3 (en) 2003-11-24
EP1032374A1 (en) 2000-09-06
YU31000A (en) 2002-11-15
NO329728B1 (en) 2010-12-06
EA200000548A1 (en) 2000-12-25
BG65117B1 (en) 2007-03-30
IL136215A0 (en) 2001-05-20
MXPA00004959A (en) 2002-10-17
JP2001523706A (en) 2001-11-27
CN1282239A (en) 2001-01-31
AU744580B2 (en) 2002-02-28
PT1032374E (en) 2003-12-31
ZA9810631B (en) 1999-05-24
SK7562000A3 (en) 2001-06-11
KR20010032329A (en) 2001-04-16
HUP0100562A3 (en) 2002-08-28
NO20002605D0 (en) 2000-05-19
PL193878B1 (en) 2007-03-30
HRP20000323A2 (en) 2001-06-30
CA2310147A1 (en) 1999-06-03
EA003324B1 (en) 2003-04-24
FR2771291B1 (en) 2000-02-25
NO20002605L (en) 2000-07-05
HUP0100562A2 (en) 2002-05-29
KR100502938B1 (en) 2005-07-25
ES2203989T3 (en) 2004-04-16
CZ20001849A3 (en) 2000-10-11
CN1223341C (en) 2005-10-19
PL340659A1 (en) 2001-02-12
IL136215A (en) 2006-12-31
AU1170499A (en) 1999-06-15
US6077544A (en) 2000-06-20
DE69817010T2 (en) 2004-05-27
HRP20000323B1 (en) 2006-07-31
CZ299110B6 (en) 2008-04-23
HU230053B1 (en) 2015-06-29
NZ504662A (en) 2002-09-27

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