WO1999024109A2 - Cuff electrode and method for manufacturing the same - Google Patents
Cuff electrode and method for manufacturing the same Download PDFInfo
- Publication number
- WO1999024109A2 WO1999024109A2 PCT/DE1998/003328 DE9803328W WO9924109A2 WO 1999024109 A2 WO1999024109 A2 WO 1999024109A2 DE 9803328 W DE9803328 W DE 9803328W WO 9924109 A2 WO9924109 A2 WO 9924109A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- electrodes
- arrangement according
- electrode
- electrode arrangement
- nerve
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
- A61N1/0556—Cuff electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
- A61B2562/125—Manufacturing methods specially adapted for producing sensors for in-vivo measurements characterised by the manufacture of electrodes
Definitions
- the invention relates to an arrangement of electrodes according to the preamble of claim 1 for use in the biological and medical field.
- the electrodes known today for stimulating or measuring electrical signals in the human body consist either of individual wires which are introduced into the tissue or of flat metal plates manually embedded between silicon layers (selfsizing cuff electrodes, Claude Verrat et al “Selective Control of Muscle Activation with a Multipolar Nerve Cuff Electrode ", IEEE Transaction of Biomedical Engineering, Vol. 40 No 7, July 93).
- the variant proposed by Grill, Creasey, Ksienski, Verrart and Mortimer represents a further development of the above-mentioned manually produced cuff electrodes (WO 93/20887).
- the electrodes are produced on a film of polymer material using thin-film technology.
- the advantage here is that the electrode structures can be produced with much higher precision than in the manually manufactured variant. In order for this electrode to be placed around the nerve, it must be just like the manually made variant embedded between two elastomer sheets (preferably silicone), a certain tensile stress being generated in a sheet before the stack is glued by well-defined stretching.
- a nerve cranial nerve, spinal cord nerve or peripheral nerve
- the aim of every stimulation must be to selectively select individual nerve fibers of an overall nerve to irritate without damaging the cell structure of the nerve
- Individual nerve fibers of a nerve differ in terms of their location in the nerve and in terms of their fiber diameter Until now it was only possible to selectively stimulate with regard to fiber diameter or fiber localization, but not to consider both selection criteria at the same time.
- the object of the invention is to provide electrode arrangements with a higher number of electrical poles, well-defined electrode areas, precise spacing of the electrodes from one another and from the tissue, in order to be able to carry out simultaneous location- and parameter-selective stimulation in the ⁇ m range.
- Another requirement for the electrode is that it should be very thin-walled ( ⁇ 100 ⁇ m).
- Such electrode arrangements can be used, for example, to stimulate spinal nerves or the optic nerve.
- Another object of the invention is to control different electrodes in a short time sequence in such a way that the sum potential of axons remote from electrodes becomes above threshold without activating axons near the electrodes.
- a polymer carrier on which a conductor structure has been applied, has to be formed into a "sleeve" with a diameter corresponding to the nerve size in the range from a few millimeters to a few tenths of a millimeter. It has to wrap around a nerve without “squeezing” it , but also be firm enough to prevent movement relative to the nerve.
- a special feature with regard to the requirements for this “cuff” is that the shape of the nerve does not necessarily have to be circular, but that it should be adapted to the profile of the nerve cross section. A method for this is described below.
- the novel cuff electrode is produced by connecting two polymer films with a high modulus of elasticity via an intermediate layer. standing from an elastomer with a low modulus of elasticity in the desired final shape, as described in claim 1.
- Fig. 1 Schematic arrangement of the application of a system with 8 dual-selective scanner electrodes around nerve roots.
- Fig. 2a Execution of a dual-selective scanner electrode.
- Fig. 2b Scheme of a 3-polar axial / 6-polar radial electrode.
- Carrier foil (2) and electronics (4) are not shown for illustration.
- Electrode. Fig. 4 Perspective-schematic representation of a novel cuff electrode. The electrode openings or contact openings in the inner passivation layer are not shown. To represent the
- the scanner electrode is to be implanted together with the control and evaluation electronics as a system (Fig. 1) in order to create sensitive and motorized biotechnical connections (bladder control, standing and walking apparatus) in patients with interrupted stimulus conduction (e.g. cross-sectional damage).
- An overall system consists of several dual-selective electrodes. (Fig. 2a, 2b), which are each arranged on a bandage of flexible carrier films 2, which are wrapped around the nerves 3. In this way, in connection with the electronics 4 arranged decentrally on the carriers, local detection of sensory signals and local stimulation of the tissue can be achieved.
- each carrier For this purpose, an arrangement of several electrodes that read or stimulate independently of one another must be arranged on each carrier (FIG. 2b, example for 3-polar axial / 6-polar radial arrangement).
- the 3-polar axial arrangement remains the same for all applications, while the radial arrangement of the electrodes can be multiplied for higher spatial resolutions.
- a flexible plastic eg polyimide or silicone
- a metal conductor structure 2b is produced on this film via additive or subtractive structure transfer (see, for example, SM Sze, VLSI Technology McGraw-Hill, 1988).
- a thin, biocompatible insulating film (a passivation layer, 2c) is applied over this metal conductor structure.
- the passivation 2c of the metallization is carried out, for example, by spinning on liquid silicone, which is structured after the crosslinking reaction has taken place, for example using laser ablation or photolithography and dry etching techniques, in order to expose the electrodes 5a and the contact points 5b to the electronics 4.
- a second polyimide film 2f is applied to the still uncrosslinked silicone of the first film and this
- the entire subsystem is encapsulated with liquid silicone 10.
- the individual subsystems are connected by covered wires 9.
- the stimulation pattern applied via the scanner electrodes is adapted to the individual situation of the patient via a neural network integrated in the electronics 4, 11.
- newly developed multitrapezoidal current impulses with the setting parameters stimulus form, stimulus distance, stimulus frequency, stimulation current and
- Stimulus rhythm (on-off phases) used.
Landscapes
- Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Electrotherapy Devices (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU20454/99A AU2045499A (en) | 1997-11-12 | 1998-11-11 | Cuff electrode and method for manufacturing the same |
DE19881702T DE19881702D2 (en) | 1997-11-12 | 1998-11-11 | Cuff electrode and process for its manufacture |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1997150043 DE19750043A1 (en) | 1997-11-12 | 1997-11-12 | Novel cuff electrode and method for producing it |
DE19750043.9 | 1997-11-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999024109A2 true WO1999024109A2 (en) | 1999-05-20 |
WO1999024109A3 WO1999024109A3 (en) | 1999-08-19 |
Family
ID=7848440
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DE1998/003328 WO1999024109A2 (en) | 1997-11-12 | 1998-11-11 | Cuff electrode and method for manufacturing the same |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2045499A (en) |
DE (2) | DE19750043A1 (en) |
WO (1) | WO1999024109A2 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009527296A (en) * | 2006-02-21 | 2009-07-30 | アイエムアイ インテリジェント メディカル インプランツ アクチエンゲゼルシャフト | Device with flexible multi-layer system for contacting or electrically stimulating biological tissue cells or nerves |
WO2013159136A1 (en) | 2012-04-26 | 2013-10-31 | Medizinische Universität Wien | Nerve cuff electrode arrangement |
US20140188251A1 (en) * | 2011-07-20 | 2014-07-03 | Otto Bock Healthcare Gmbh | Device with a wall designed to tightly enclose a body part |
RU2587967C2 (en) * | 2011-07-20 | 2016-06-27 | Отто Бок Хелткэр Гмбх | Device with wall made for tight coverage of body |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2338805A1 (en) * | 1998-07-27 | 2000-02-10 | J.Thomas Mortimer | Device and method for production of visual sensations by optic nerve stimulation |
AUPQ202699A0 (en) | 1999-08-04 | 1999-08-26 | University Of Melbourne, The | Prosthetic device for incontinence |
US7010351B2 (en) | 2000-07-13 | 2006-03-07 | Northstar Neuroscience, Inc. | Methods and apparatus for effectuating a lasting change in a neural-function of a patient |
US7672730B2 (en) | 2001-03-08 | 2010-03-02 | Advanced Neuromodulation Systems, Inc. | Methods and apparatus for effectuating a lasting change in a neural-function of a patient |
US7024247B2 (en) | 2001-10-15 | 2006-04-04 | Northstar Neuroscience, Inc. | Systems and methods for reducing the likelihood of inducing collateral neural activity during neural stimulation threshold test procedures |
US7831305B2 (en) | 2001-10-15 | 2010-11-09 | Advanced Neuromodulation Systems, Inc. | Neural stimulation system and method responsive to collateral neural activity |
US7756584B2 (en) | 2000-07-13 | 2010-07-13 | Advanced Neuromodulation Systems, Inc. | Methods and apparatus for effectuating a lasting change in a neural-function of a patient |
US7305268B2 (en) | 2000-07-13 | 2007-12-04 | Northstar Neurscience, Inc. | Systems and methods for automatically optimizing stimulus parameters and electrode configurations for neuro-stimulators |
US7221981B2 (en) * | 2002-03-28 | 2007-05-22 | Northstar Neuroscience, Inc. | Electrode geometries for efficient neural stimulation |
WO2004011083A1 (en) * | 2002-07-25 | 2004-02-05 | The Regents Of The University Of California | Reinforcement elements in a silicone electrode array |
US7236830B2 (en) | 2002-12-10 | 2007-06-26 | Northstar Neuroscience, Inc. | Systems and methods for enhancing or optimizing neural stimulation therapy for treating symptoms of Parkinson's disease and/or other movement disorders |
US20050075680A1 (en) | 2003-04-18 | 2005-04-07 | Lowry David Warren | Methods and systems for intracranial neurostimulation and/or sensing |
US7684866B2 (en) | 2003-08-01 | 2010-03-23 | Advanced Neuromodulation Systems, Inc. | Apparatus and methods for applying neural stimulation to a patient |
EP1786510A4 (en) | 2004-07-15 | 2009-12-02 | Northstar Neuroscience Inc | Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy |
US7565200B2 (en) | 2004-11-12 | 2009-07-21 | Advanced Neuromodulation Systems, Inc. | Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of Parkinson's disease, other movement disorders, and/or drug side effects |
US7729773B2 (en) | 2005-10-19 | 2010-06-01 | Advanced Neuromodualation Systems, Inc. | Neural stimulation and optical monitoring systems and methods |
US8929991B2 (en) | 2005-10-19 | 2015-01-06 | Advanced Neuromodulation Systems, Inc. | Methods for establishing parameters for neural stimulation, including via performance of working memory tasks, and associated kits |
US7856264B2 (en) | 2005-10-19 | 2010-12-21 | Advanced Neuromodulation Systems, Inc. | Systems and methods for patient interactive neural stimulation and/or chemical substance delivery |
US20080027524A1 (en) | 2006-07-26 | 2008-01-31 | Maschino Steven E | Multi-electrode assembly for an implantable medical device |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993020887A1 (en) | 1992-04-20 | 1993-10-28 | Case Western Reserve University | Thin film implantable electrode and method of manufacture |
WO1996008290A1 (en) | 1994-09-16 | 1996-03-21 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Cuff electrode |
Family Cites Families (11)
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US4341221A (en) * | 1980-10-07 | 1982-07-27 | Medtronic, Inc. | Shielded recording electrode system |
US4662884A (en) * | 1984-04-25 | 1987-05-05 | University Of Utah Research Foundation | Prostheses and methods for promoting nerve regeneration |
US4877029A (en) * | 1987-03-30 | 1989-10-31 | Brown University Research Foundation | Semipermeable nerve guidance channels |
US5031621A (en) * | 1989-12-06 | 1991-07-16 | Grandjean Pierre A | Nerve electrode with biological substrate |
US5092332A (en) * | 1990-02-22 | 1992-03-03 | Medtronic, Inc. | Steroid eluting cuff electrode for peripheral nerve stimulation |
US5388577A (en) * | 1990-06-08 | 1995-02-14 | Boston University | Electrode array microchip |
EP0585933B1 (en) * | 1992-09-04 | 2005-12-21 | Matsushita Electric Industrial Co., Ltd. | Planar electrode |
US5344438A (en) * | 1993-04-16 | 1994-09-06 | Medtronic, Inc. | Cuff electrode |
US5400784A (en) * | 1993-10-15 | 1995-03-28 | Case Western Reserve University | Slowly penetrating inter-fascicular nerve cuff electrode and method of using |
US5505201A (en) * | 1994-04-20 | 1996-04-09 | Case Western Reserve University | Implantable helical spiral cuff electrode |
US5897583A (en) * | 1994-07-13 | 1999-04-27 | Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Flexible artificial nerve plates |
-
1997
- 1997-11-12 DE DE1997150043 patent/DE19750043A1/en not_active Withdrawn
-
1998
- 1998-11-11 DE DE19881702T patent/DE19881702D2/en not_active Expired - Lifetime
- 1998-11-11 AU AU20454/99A patent/AU2045499A/en not_active Abandoned
- 1998-11-11 WO PCT/DE1998/003328 patent/WO1999024109A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993020887A1 (en) | 1992-04-20 | 1993-10-28 | Case Western Reserve University | Thin film implantable electrode and method of manufacture |
WO1996008290A1 (en) | 1994-09-16 | 1996-03-21 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Cuff electrode |
Non-Patent Citations (1)
Title |
---|
C.VERRAT ET AL.: ""SELECTIVE CONTROL OF MUSCLE ACTIVATION WITH A MULTIPOLAR NERVCUFF ELECTRODE"", IEEE TRANSACTION OF BIOMEDICAL ENGINEERING,, vol. 40, no. 7, July 1993 (1993-07-01) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009527296A (en) * | 2006-02-21 | 2009-07-30 | アイエムアイ インテリジェント メディカル インプランツ アクチエンゲゼルシャフト | Device with flexible multi-layer system for contacting or electrically stimulating biological tissue cells or nerves |
US8918186B2 (en) | 2006-02-21 | 2014-12-23 | Pixium Vision Sa | Device with flexible multilayer system for contacting or electrostimulation of living tissue cells or nerves |
US20140188251A1 (en) * | 2011-07-20 | 2014-07-03 | Otto Bock Healthcare Gmbh | Device with a wall designed to tightly enclose a body part |
RU2587967C2 (en) * | 2011-07-20 | 2016-06-27 | Отто Бок Хелткэр Гмбх | Device with wall made for tight coverage of body |
US10292841B2 (en) * | 2011-07-20 | 2019-05-21 | Ottobock Se & Co. Kgaa | Device with a wall designed to tightly enclose a body part |
WO2013159136A1 (en) | 2012-04-26 | 2013-10-31 | Medizinische Universität Wien | Nerve cuff electrode arrangement |
Also Published As
Publication number | Publication date |
---|---|
DE19881702D2 (en) | 2002-08-01 |
DE19750043A1 (en) | 1999-05-20 |
WO1999024109A3 (en) | 1999-08-19 |
AU2045499A (en) | 1999-05-31 |
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