WO1999022766A3 - Use of anti-il-12 antibodies in transplantation rejection - Google Patents

Use of anti-il-12 antibodies in transplantation rejection Download PDF

Info

Publication number
WO1999022766A3
WO1999022766A3 PCT/US1998/023264 US9823264W WO9922766A3 WO 1999022766 A3 WO1999022766 A3 WO 1999022766A3 US 9823264 W US9823264 W US 9823264W WO 9922766 A3 WO9922766 A3 WO 9922766A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibodies
transplantation rejection
antibody
administration
alone
Prior art date
Application number
PCT/US1998/023264
Other languages
French (fr)
Other versions
WO1999022766A2 (en
Inventor
Terry Strom
Xian Chang Li
Martin Zand
Xin Xiao Zheng
Original Assignee
Terry Strom
Xian Chang Li
Martin Zand
Xin Xiao Zheng
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terry Strom, Xian Chang Li, Martin Zand, Xin Xiao Zheng filed Critical Terry Strom
Priority to CA002276420A priority Critical patent/CA2276420A1/en
Priority to DE69825976T priority patent/DE69825976T2/en
Priority to AT98956450T priority patent/ATE274920T1/en
Priority to EP98956450A priority patent/EP0969867B1/en
Priority to AU12974/99A priority patent/AU744302B2/en
Publication of WO1999022766A2 publication Critical patent/WO1999022766A2/en
Publication of WO1999022766A3 publication Critical patent/WO1999022766A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Abstract

Methods are disclosed for reducing or ameliorating chronic rejection of a transplanted tissue by administration of an anti-IL-12 antibody, alone or in combination with other beneficial therapeutic agents.
PCT/US1998/023264 1997-10-31 1998-10-30 Use of anti-il-12 antibodies in transplantation rejection WO1999022766A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002276420A CA2276420A1 (en) 1997-10-31 1998-10-30 Use of anti-il-12 antibodies in transplantation rejection
DE69825976T DE69825976T2 (en) 1997-10-31 1998-10-30 USE OF ANTI-IL-12 ANTIBODIES IN TRANSPLANT DISCHARGE
AT98956450T ATE274920T1 (en) 1997-10-31 1998-10-30 USE OF ANTI-IL-12 ANTIBODIES IN TRANSPLANT REJECTION
EP98956450A EP0969867B1 (en) 1997-10-31 1998-10-30 Use of anti-il-12 antibodies in transplantation rejection
AU12974/99A AU744302B2 (en) 1997-10-31 1998-10-30 Use of anti-IL-12 antibodies in transplantation rejection

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6385397P 1997-10-31 1997-10-31
US60/063,853 1997-10-31

Publications (2)

Publication Number Publication Date
WO1999022766A2 WO1999022766A2 (en) 1999-05-14
WO1999022766A3 true WO1999022766A3 (en) 1999-08-05

Family

ID=22051951

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/023264 WO1999022766A2 (en) 1997-10-31 1998-10-30 Use of anti-il-12 antibodies in transplantation rejection

Country Status (6)

Country Link
EP (1) EP0969867B1 (en)
AT (1) ATE274920T1 (en)
AU (1) AU744302B2 (en)
CA (1) CA2276420A1 (en)
DE (1) DE69825976T2 (en)
WO (1) WO1999022766A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8945545B2 (en) 2008-03-18 2015-02-03 Abbvie Inc. Methods of treating psoriasis by administration of antibodies to the p40 subunit of IL-12 and/or IL-23
US9035030B2 (en) 1999-03-25 2015-05-19 AbbVie Deutschland GmbH & Co. KG Human antibodies that bind the P40 subunit of human IL-12 and methods for using the same

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7883704B2 (en) 1999-03-25 2011-02-08 Abbott Gmbh & Co. Kg Methods for inhibiting the activity of the P40 subunit of human IL-12
US7776331B1 (en) 2007-01-16 2010-08-17 Abbott Laboratories Methods of treating plaque psoriasis
NZ580379A (en) 2007-03-29 2012-10-26 Abbott Lab Crystalline anti-human il-12 antibodies
WO2009068630A1 (en) 2007-11-27 2009-06-04 Ablynx N.V. Immunoglobulin constructs

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0998300A1 (en) * 1997-03-18 2000-05-10 Basf Aktiengesellschaft Methods and compositions for modulating responsiveness to corticosteroids

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
B. WASOWSKA ET AL.: "Rapamycin and cyclosporine A treatment: A novel regimen to prevent chronic allograft rejection in sensitized hosts.", TRANSPLANTATION PROCEEDINGS, vol. 29, no. 1-2, February 1997 (1997-02-01), New York, NY, USA, pages 333, XP002099943 *
K. SAITO ET AL.: "Effect of CD80 and CD86 blockade and anti-interleukin-12 treatment on mouse acute graft-versus-host disease.", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 26, no. 12, December 1996 (1996-12-01), Weinheim, Germany, pages 3098 - 3106, XP002099939 *
M. BERTAGNOLLI ET AL.: "Evidence that rapamycin inhibits interleukin-12-induced proliferation of activated T lymphocytes.", TRANSPLANTATION, vol. 58, no. 10, 27 November 1994 (1994-11-27), Baltimore, MD, USA, pages 1091 - 1096, XP002099940 *
P. NICKERSON ET AL.: "Manipulation of cytokine networks in transplantation.", TRANSPLANTATION, vol. 63, no. 4, 27 February 1997 (1997-02-27), Baltimore, MD, USA, pages 489 - 494, XP002099942 *
R. CARTER ET AL.: "Production and characterization of monoclonal antibodies to human interleukin-12.", HYBRIDOMA, vol. 16, no. 4, August 1997 (1997-08-01), New York, NY, USA, pages 363 - 369, XP002099941 *
X. LI ET AL.: "On histocompatibility barriers, Th1 to Th2 immune deviation, and the nature of the allograft responses.", THE JOURNAL OF IMMUNOLOGY, vol. 161, no. 5, 1 September 1998 (1998-09-01), Baltimore, MD, USA, pages 2241 - 2247, XP002099985 *
Y. WADA ET AL.: "Treatment with anti-interleukin-12 monoclonal antibody alleviates acute rejection of mouse islet allografts.", GASTROENTEROLOGY, vol. 114, no. 4 part 2 suppl., 15 April 1998 (1998-04-15), Baltimore, MD, USA, pages A1433, XP002099944 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9035030B2 (en) 1999-03-25 2015-05-19 AbbVie Deutschland GmbH & Co. KG Human antibodies that bind the P40 subunit of human IL-12 and methods for using the same
US8945545B2 (en) 2008-03-18 2015-02-03 Abbvie Inc. Methods of treating psoriasis by administration of antibodies to the p40 subunit of IL-12 and/or IL-23

Also Published As

Publication number Publication date
AU744302B2 (en) 2002-02-21
DE69825976T2 (en) 2005-09-01
WO1999022766A2 (en) 1999-05-14
AU1297499A (en) 1999-05-24
EP0969867B1 (en) 2004-09-01
ATE274920T1 (en) 2004-09-15
EP0969867A2 (en) 2000-01-12
CA2276420A1 (en) 1999-05-14
DE69825976D1 (en) 2004-10-07

Similar Documents

Publication Publication Date Title
EP0679093A1 (en) Methods of delivering agents to target cells.
WO2003072736A3 (en) Reagents and treatment methods for autoimmune diseases
AR007249A1 (en) CONCENTRATED PREPARATION OF ANTIBODIES
CA2163989A1 (en) Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
WO1998018826A3 (en) Anti-CCR5 antibodies and methods of use therefor
EP0351789A3 (en) Improved monoclonal antibodies reactive with cachectin
EP1717251A3 (en) Methods of therapy for B-cell malignancies using human anti-CD40 antibodies
FR2713919B1 (en) Absorbent article provided with means for dynamic adjustment to the body of the wearer.
IS7747A (en) Spirol [1-azabicyclo [2.2.2] octane-3,2 '(3'H) -furo [2,3-b] pyridine] for use in the treatment of psychiatric disorders and cognitive disorders
AU2001257620A1 (en) Supplemental heart pump methods and systems for supplementing blood through the heart
WO1997026912A3 (en) Anti-cd18 antibodies for use against stroke
CA2194369A1 (en) Methods and compositions for the specific coagulation of vasculature
CA2120506A1 (en) Treatment of Ocular Inflammation by Blockage of Cell Adhesion Molecules
WO2001009138A3 (en) Chemokine receptor antagonists and methods of use therefor
WO1999022766A3 (en) Use of anti-il-12 antibodies in transplantation rejection
EP1488806A3 (en) A blocking monoclonal antibody to VLA-1 and its use for the treatment of vascular disorders
AU7960600A (en) Monoclonal antibody, hybridoma, immunoassay method and diagnosis kit
EP0341684A3 (en) Human monoclonal antibody, hybridoma producing the same and pharmaceutical
WO1993006852A3 (en) Methods of improving allograft or xenograft tolerance by administration of an lfa-3 or cd2 binding protein
EP2641611A3 (en) Combination therapy
WO2001040302A3 (en) Organ transplant rejection and associated conditions
AU2547995A (en) Monoclonal antibody specific for vascular endothelial cell antigen endoglyx-1, the antigen itself, and uses thereof
EP1516630A3 (en) Use of anti-il-12 antibodies in transplantation rejection
IL131478A0 (en) Methods for treatment of scar tissue
EP1186301A3 (en) Monoclonal antibodies that recognize flk-2 receptors and the isolation of primitive hematopoietic stem cell populations

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

ENP Entry into the national phase

Ref document number: 2276420

Country of ref document: CA

Ref country code: CA

Ref document number: 2276420

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: PA/a/1999/006105

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 12974/99

Country of ref document: AU

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 1998956450

Country of ref document: EP

AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM HR HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWP Wipo information: published in national office

Ref document number: 1998956450

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 12974/99

Country of ref document: AU

WWG Wipo information: grant in national office

Ref document number: 1998956450

Country of ref document: EP