WO1999013930A1 - Intranasal administration device - Google Patents

Intranasal administration device Download PDF

Info

Publication number
WO1999013930A1
WO1999013930A1 PCT/EP1998/005900 EP9805900W WO9913930A1 WO 1999013930 A1 WO1999013930 A1 WO 1999013930A1 EP 9805900 W EP9805900 W EP 9805900W WO 9913930 A1 WO9913930 A1 WO 9913930A1
Authority
WO
WIPO (PCT)
Prior art keywords
cavity
air inlet
cover member
inlet slots
air
Prior art date
Application number
PCT/EP1998/005900
Other languages
French (fr)
Inventor
Gregor John Mclennan Anderson
Duncan Robertson
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Priority to AU10231/99A priority Critical patent/AU1023199A/en
Publication of WO1999013930A1 publication Critical patent/WO1999013930A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/08—Inhaling devices inserted into the nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows

Definitions

  • the present invention relates to devices by which powdered medicaments may be intranasally administered.
  • a device specifically adapted for the intranasal administration of powdered medicaments.
  • the device comprises a body portion which is preferably in two parts, a cavity in which the substance to be administered is deposited, at least two air inlet slots in communication with the cavity, an outlet nozzle communicating with the cavity and a nasal adapter which in operation communicates between the patient's nostril and the outlet nozzle.
  • the air inlet slots which are in communication with the cavity are adapted so that air flowing through them into the cavity is caused to rotate within the cavity.
  • the swirling motion of the air effects the dispersal of the medicament within the cavity and ensures that the required amount of the medicament is efficiently expelled from the cavity and out through the outlet nozzle.
  • the air inlet slots may radiate outwards from the cavity at an angle which is upwardly inclined in relation to the plane of the cavity.
  • the air inlet slots are in tangential communication with the cavity.
  • the air inlet slots are in tangential communication with the cavity and radiate outwards from the cavity at an angle which is upwardly inclined in relation to the plane of the cavity.
  • the device will posses at least two air inlet slots.
  • the device will comprise three air inlet slots.
  • the nasal adapter of the present device is specifically adapted to ensure that in substantially all of the patients using the device an effective seal is formed between the nasal adapter and the patient's nose, thereby ensuring efficient operation of the device.
  • the nasal adapter will be suitably shaped to provide a snug fit with the patient's nostril.
  • the nasal adapter will be a hollow tapering member projecting from the body potion of the device such that as the member projects away from the body portion of the device the exterior diameter of the adapter decreases.
  • the medicament to be administered by the device flows from the cavity to the nasal adapter via the outlet nozzle.
  • the outlet nozzle may adapted to ensure that the medicament is administered to the patient at an effective rate.
  • the device may be fabricated from any suitable material. Suitable materials include plastics, card, paper and metals. Preferred materials comprise thermo- plastic elastomers. A particularly preferred material is acrylonitrile-butadiene- styrene.
  • the body portion of the device is composed of two parts; one part, conventionally called the cover member, partly enclosing the other part, conventionally called the base.
  • the cover member includes the outlet nozzle which communicates with the cavity.
  • the base includes the cavity and the air inlet slots.
  • the cover member may be removably attached to the base, such attachment may be accomplished by any suitable means for example by gripping engagement, snap fit connection or screw thread engagement.
  • the cover member may be in hinged engagement with the base portion of the device, pivotal movement about the hinge allowing access to the cavity. When the two parts of the device are in engagement, there is an opening between the cover member and the base to allow air to flow through into the air inlet slots and on into the cavity.
  • incorporación of a detachable cover member allows the device to be refilled and thereby used more than once.
  • the device may also be presented in a form suitably adapted for the administration of only one single dose.
  • the device may be adapted for the administration of a plurality of doses, for example by providing a reservoir of the medicament which can be metered out into the required unit dose quantities.
  • the medicament to be dispensed is placed within the cavity.
  • air is drawn in to the cavity through the air inlet slots.
  • the arrangement of the air inlet slots cause the air to rotate within the cavity.
  • the swirling motion of the air disperses the medicament within the cavity and picks up the powder.
  • the device may incorporate baffles to ensure efficient dispersal of the medicament.
  • the required amount of powder is drawn up the outlet nozzle in a rotating column of air and out through the nasal adapter and enters the patient's nose.
  • the device according to the invention has thus far been described for use in intranasal administration of medicaments, it is also suitable for the administration of medicaments by inhalation.
  • the necessary adaptation for this mode of administration will be readily apparent to those skilled in the art and may take the form of a mouthpiece rather than a nasal adapter.
  • the device is adapted to deliver up to 20 mg of powder, suitably up to 15 mg of powder, preferably up to 10 mg of powder.
  • Figure 1 is a section view through the complete dispensing device;
  • Figure 2 is a plan view of the cover member from below;
  • Figure 3 is a section view through the cover member
  • Figure 4 is a perspective view of the cover member from above;
  • Figure 5 is a perspective view of the cover member from below;
  • Figure 6 is a section view through the base of the device;
  • Figure 7 is a perspective view of the base from above; and
  • Figure 8 is a plan view of the base of the device.
  • the device comprises two portions, the cover member (1 ) and the base (2).
  • the medicament to be dispensed is placed in the cavity (3), the nasal adapter (4) is sealed against the nostril of the patient and the patient inhales, thereby air is drawn in through the small space (5) between the cover member (1 ) and the base (2).
  • the air flows into the cavity (3) via the air inlet slots (6) which by their arrangement cause the air to rotate within the cavity (3).
  • the swirling motion of the air disperses the medicament within the cavity (3) and picks up the powder.
  • the powder is drawn up the outlet nozzle (7) in a rotating column of air and out through the nasal adapter (4).
  • FIGS 2, 3, 4 and 5 illustrate the cover member (1 ) of the device, which comprises the outlet nozzle (7).
  • the outlet nozzle (7) is formed by a cylindrical aperture which extends all the way through the cover member (1 ).
  • the outlet nozzle (7) protrudes from the cover member at one end to form the nasal adapter (4) and protrudes form the cover member at the other end to engage with the cavity (3).
  • the circumference of the cover member is raised to form a rim (8) which engages on the base of the device.
  • the nasal adapter (4) is a hollow tapering member projecting from the cover member (1 ) of the device such that as the member projects away from the body portion of the device the exterior diameter of the nasal adapter (4) decreases.
  • Figures 6, 7 and 8 illustrate the base of the device (2) which comprises the cavity (3) in which the substance to be administered is deposited and the air inlet slots (6a, 6b, 6c).
  • the three the air inlet slots (6a, 6b, 6c) are equally spaced around the cavity and are in tangential communication with the cavity radiating outwards from the cavity at an upwardly inclined angle in relation to the plane of the cavity.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

The present invention relates to a device for the intranasal administration of powdered medicaments. Specifically, the device comprises a cavity where the medicament to be dispensed is placed. As the patient inhales, air is drawn into the cavity through at least two air inlet slots. The arrangement of the air inlet slots cause the air to rotate within the cavity. The swirling motion of the air disperses the medicament within the cavity and picks up the powder. The required amount of powder is drawn up an outlet nozzle in a rotating column of air and out through a nasal adapter.

Description

INTRANASAL ADMINISTRATION DEVICE
The present invention relates to devices by which powdered medicaments may be intranasally administered.
Devices adapted for the intranasal administration of powdered medicaments are known. However, such devices are only suitable for administering small amounts of powdered medicaments.
According to the present invention, there is provided a device specifically adapted for the intranasal administration of powdered medicaments. The device comprises a body portion which is preferably in two parts, a cavity in which the substance to be administered is deposited, at least two air inlet slots in communication with the cavity, an outlet nozzle communicating with the cavity and a nasal adapter which in operation communicates between the patient's nostril and the outlet nozzle.
The air inlet slots which are in communication with the cavity are adapted so that air flowing through them into the cavity is caused to rotate within the cavity. The swirling motion of the air effects the dispersal of the medicament within the cavity and ensures that the required amount of the medicament is efficiently expelled from the cavity and out through the outlet nozzle. The air inlet slots may radiate outwards from the cavity at an angle which is upwardly inclined in relation to the plane of the cavity. Preferably, the air inlet slots are in tangential communication with the cavity. In a particularly preferred embodiment, the air inlet slots are in tangential communication with the cavity and radiate outwards from the cavity at an angle which is upwardly inclined in relation to the plane of the cavity.
For effective dispersal of the medicament within the cavity and efficient discharge of the medicament from the cavity the device will posses at least two air inlet slots. Preferably the device will comprise three air inlet slots.
During the intranasal administration of powdered medicaments it is important that an effective seal is formed between the nose of the patient and the nasal adapter through which the substance flows. If an inefficient seal is formed, as the patient inhales through his nose air will leak in around the seal and an insufficient dose of the medicament may be discharged from the device. The nasal adapter of the present device is specifically adapted to ensure that in substantially all of the patients using the device an effective seal is formed between the nasal adapter and the patient's nose, thereby ensuring efficient operation of the device. The nasal adapter will be suitably shaped to provide a snug fit with the patient's nostril. Preferably, the nasal adapter will be a hollow tapering member projecting from the body potion of the device such that as the member projects away from the body portion of the device the exterior diameter of the adapter decreases.
The medicament to be administered by the device flows from the cavity to the nasal adapter via the outlet nozzle. By judicious choice of dimensions, the outlet nozzle may adapted to ensure that the medicament is administered to the patient at an effective rate.
The device may be fabricated from any suitable material. Suitable materials include plastics, card, paper and metals. Preferred materials comprise thermo- plastic elastomers. A particularly preferred material is acrylonitrile-butadiene- styrene.
Preferably, the body portion of the device is composed of two parts; one part, conventionally called the cover member, partly enclosing the other part, conventionally called the base. The cover member includes the outlet nozzle which communicates with the cavity. The base includes the cavity and the air inlet slots. Preferably, the cover member may be removably attached to the base, such attachment may be accomplished by any suitable means for example by gripping engagement, snap fit connection or screw thread engagement. However, the cover member may be in hinged engagement with the base portion of the device, pivotal movement about the hinge allowing access to the cavity. When the two parts of the device are in engagement, there is an opening between the cover member and the base to allow air to flow through into the air inlet slots and on into the cavity. Incorporation of a detachable cover member allows the device to be refilled and thereby used more than once. The device may also be presented in a form suitably adapted for the administration of only one single dose. Moreover, the device may be adapted for the administration of a plurality of doses, for example by providing a reservoir of the medicament which can be metered out into the required unit dose quantities.
For operation, the medicament to be dispensed is placed within the cavity. As the patient inhales, air is drawn in to the cavity through the air inlet slots. The arrangement of the air inlet slots cause the air to rotate within the cavity. The swirling motion of the air disperses the medicament within the cavity and picks up the powder. Optionally the device may incorporate baffles to ensure efficient dispersal of the medicament. The required amount of powder is drawn up the outlet nozzle in a rotating column of air and out through the nasal adapter and enters the patient's nose.
Although the device according to the invention has thus far been described for use in intranasal administration of medicaments, it is also suitable for the administration of medicaments by inhalation. The necessary adaptation for this mode of administration will be readily apparent to those skilled in the art and may take the form of a mouthpiece rather than a nasal adapter.
The device is adapted to deliver up to 20 mg of powder, suitably up to 15 mg of powder, preferably up to 10 mg of powder.
A preferred embodiment of the invention is described in detail below, by example only, with reference to the accompanying drawings, wherein:
Figure 1 is a section view through the complete dispensing device; Figure 2 is a plan view of the cover member from below;
Figure 3 is a section view through the cover member;
Figure 4 is a perspective view of the cover member from above;
Figure 5 is a perspective view of the cover member from below;
Figure 6 is a section view through the base of the device; Figure 7 is a perspective view of the base from above; and Figure 8 is a plan view of the base of the device.
As illustrated in Figure 1 the device comprises two portions, the cover member (1 ) and the base (2). In operation the medicament to be dispensed is placed in the cavity (3), the nasal adapter (4) is sealed against the nostril of the patient and the patient inhales, thereby air is drawn in through the small space (5) between the cover member (1 ) and the base (2). The air flows into the cavity (3) via the air inlet slots (6) which by their arrangement cause the air to rotate within the cavity (3). The swirling motion of the air disperses the medicament within the cavity (3) and picks up the powder. The powder is drawn up the outlet nozzle (7) in a rotating column of air and out through the nasal adapter (4).
Figures 2, 3, 4 and 5 illustrate the cover member (1 ) of the device, which comprises the outlet nozzle (7). The outlet nozzle (7) is formed by a cylindrical aperture which extends all the way through the cover member (1 ). The outlet nozzle (7) protrudes from the cover member at one end to form the nasal adapter (4) and protrudes form the cover member at the other end to engage with the cavity (3). The circumference of the cover member is raised to form a rim (8) which engages on the base of the device. The nasal adapter (4) is a hollow tapering member projecting from the cover member (1 ) of the device such that as the member projects away from the body portion of the device the exterior diameter of the nasal adapter (4) decreases.
Figures 6, 7 and 8 illustrate the base of the device (2) which comprises the cavity (3) in which the substance to be administered is deposited and the air inlet slots (6a, 6b, 6c). The three the air inlet slots (6a, 6b, 6c) are equally spaced around the cavity and are in tangential communication with the cavity radiating outwards from the cavity at an upwardly inclined angle in relation to the plane of the cavity.

Claims

Claims
1. A device specifically adapted for the intranasal administration of powdered medicaments. The device comprises a body portion, a cavity in which the substance to be administered is deposited, at least two air inlet slots in communication with the cavity, an outlet nozzle communicating with the cavity and a nasal adapter which in operation communicates between the patient's nostril and the outlet nozzle.
2. A device according to claim 1 wherein the air inlet slots are in tangential communication with the cavity and radiate outwards from the cavity at an angle which is upwardly inclined in relation to the plane of the cavity.
3. A device according to claim 1 or claim 2 wherein the nasal adapter is a hollow tapering member projecting from the body potion of the device such that as the member projects away from the body portion of the device the exterior diameter of the adapter decreases.
4. A device according to any of claims 1 to 3 wherein the body portion is composed of two parts; one part partly enclosing the other part.
5. A device according to claim 4 wherein the cover member partly encloses the base.
6. A device according to claim 4 or claim 5 wherein when the two parts of the device are in engagement, there is an opening between the cover member and the base to allow air to flow through into the air inlet slots and on into the cavity.
7. A device according to any of claims 4 to 6 wherein the cover member is removably attached to the base.
8. A device according to claim 7 wherein the cover member includes the outlet nozzle which communicates with the cavity.
9. A device according to claim 7 wherein the base includes the cavity and the air inlet slots.
10. A device according to claim 9 which is adapted to deliver up to 10 mg of powder.
PCT/EP1998/005900 1997-09-18 1998-09-17 Intranasal administration device WO1999013930A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU10231/99A AU1023199A (en) 1997-09-18 1998-09-17 Intranasal administration device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9719775.0 1997-09-18
GBGB9719775.0A GB9719775D0 (en) 1997-09-18 1997-09-18 Device

Publications (1)

Publication Number Publication Date
WO1999013930A1 true WO1999013930A1 (en) 1999-03-25

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Family Applications (1)

Application Number Title Priority Date Filing Date
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AU (1) AU1023199A (en)
GB (1) GB9719775D0 (en)
WO (1) WO1999013930A1 (en)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002096489A2 (en) * 2001-05-26 2002-12-05 Innovata Biomed Limited Inhaler
WO2006031775A2 (en) * 2004-09-13 2006-03-23 Oriel Therapeutics, Inc. Dry powder inhalers that inhibit agglomeration, related devices and methods
WO2006061637A2 (en) * 2004-12-09 2006-06-15 Cambridge Consultants Limited Dry powder inhalers
WO2006066910A1 (en) * 2004-12-20 2006-06-29 Glaxo Group Limited Manifold for use in medicament dispenser
WO2007144614A1 (en) * 2006-06-13 2007-12-21 Cambridge Consultants Limited Dry powder inhalers
US8066002B2 (en) 2004-12-20 2011-11-29 Glaxo Group Limited Manifold for use in medicament dispenser
US8534281B2 (en) 2005-12-12 2013-09-17 Glaxo Group Limited Manifold for use in medicament dispenser
US8757146B2 (en) 2008-02-07 2014-06-24 University Of Washington Through Its Center For Commercialization Circumferential aerosol device
US8851069B2 (en) 2004-04-21 2014-10-07 Innovata Biomed Limited Inhaler
US9550036B2 (en) 2011-03-03 2017-01-24 Impel Neuropharma Inc. Nasal drug delivery device
JP2017538478A (en) * 2014-11-19 2017-12-28 オプティノーズ アズ Intranasal administration
US9919117B2 (en) 2011-05-09 2018-03-20 Impel Neuropharma Inc. Nozzles for nasal drug delivery
US10537692B2 (en) 2013-04-28 2020-01-21 Impel Neuropharma, Inc. Medical unit dose container
IT201900006368A1 (en) * 2019-04-26 2020-10-26 Hsd Holding Smart Device S R L INHALER OF MEDICINAL SUBSTANCES
US11185497B2 (en) 2018-01-05 2021-11-30 Impel Neuropharma, Inc. Intranasal delivery of dihydroergotamine by precision olfactory device
WO2022008824A1 (en) * 2020-07-07 2022-01-13 Aptar France Sas Spray head and device for dispensing a fluid product comprising such a head
US11266799B2 (en) 2015-09-10 2022-03-08 Impel Neuropharma, Inc. In-line nasal delivery device
US11278492B2 (en) 2018-01-05 2022-03-22 Impel Neuropharma, Inc. Intranasal delivery of olanzapine by precision olfactory device
US11395887B2 (en) 2017-11-21 2022-07-26 Impel Pharmaceuticals Inc. Intranasal device with inlet interface
US11517548B2 (en) 2018-07-19 2022-12-06 Impel Pharmaceuticals Inc. Respiratory tract delivery of levodopa and DOPA decarboxylase inhibitor for treatment of Parkinson's Disease
US11571532B2 (en) 2017-11-21 2023-02-07 Impel Pharmaceuticals Inc. Intranasal device with dip tube
US11759585B2 (en) 2019-01-03 2023-09-19 Impel Pharmaceuticals Inc. Nasal drug delivery device with detachable nozzle
US11878109B2 (en) 2019-05-17 2024-01-23 Impel Pharmaceuticals Inc. Single-use nasal delivery device

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US2604094A (en) * 1949-06-25 1952-07-22 Schenley Ind Inc Inhaler
US2672865A (en) * 1950-05-19 1954-03-23 Harry G Willis Inhaler for medicinal substances
GB878106A (en) * 1958-03-03 1961-09-27 Armour & Co Improvements in or relating to powder dispensers
EP0696458A2 (en) * 1994-08-08 1996-02-14 Unisia Jecs Corporation Medical inhaler

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2579280A (en) * 1949-06-25 1951-12-18 Macgregor Instr Company Inhaler
US2604094A (en) * 1949-06-25 1952-07-22 Schenley Ind Inc Inhaler
US2672865A (en) * 1950-05-19 1954-03-23 Harry G Willis Inhaler for medicinal substances
GB878106A (en) * 1958-03-03 1961-09-27 Armour & Co Improvements in or relating to powder dispensers
EP0696458A2 (en) * 1994-08-08 1996-02-14 Unisia Jecs Corporation Medical inhaler

Cited By (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002096489A3 (en) * 2001-05-26 2003-11-27 Innovata Biomed Ltd Inhaler
JP2004527347A (en) * 2001-05-26 2004-09-09 イノバータ・バイオメッド・リミテッド apparatus
WO2002096489A2 (en) * 2001-05-26 2002-12-05 Innovata Biomed Limited Inhaler
US8851069B2 (en) 2004-04-21 2014-10-07 Innovata Biomed Limited Inhaler
WO2006031775A3 (en) * 2004-09-13 2006-05-26 Oriel Therapeutics Inc Dry powder inhalers that inhibit agglomeration, related devices and methods
WO2006031775A2 (en) * 2004-09-13 2006-03-23 Oriel Therapeutics, Inc. Dry powder inhalers that inhibit agglomeration, related devices and methods
US8365725B2 (en) 2004-09-13 2013-02-05 Oriel Therapeutics, Inc. Dry powder inhalers that inhibit agglomeration, related devices and methods
US9027551B2 (en) 2004-09-13 2015-05-12 Oriel Therapeutics, Inc. Dry powder inhalers that inhibit agglomeration, related devices and methods
WO2006061637A2 (en) * 2004-12-09 2006-06-15 Cambridge Consultants Limited Dry powder inhalers
WO2006061637A3 (en) * 2004-12-09 2006-08-24 Cambridge Consultants Dry powder inhalers
AU2005313107B2 (en) * 2004-12-09 2010-11-04 Cambridge Consultants Limited Dry powder inhalers
US8261739B2 (en) 2004-12-09 2012-09-11 Cambridge Consultants Limited Dry powder inhalers
WO2006066910A1 (en) * 2004-12-20 2006-06-29 Glaxo Group Limited Manifold for use in medicament dispenser
JP2008523858A (en) * 2004-12-20 2008-07-10 グラクソ グループ リミテッド Manifold for use in drug dispensers
US8066002B2 (en) 2004-12-20 2011-11-29 Glaxo Group Limited Manifold for use in medicament dispenser
US8590531B2 (en) 2004-12-20 2013-11-26 Glaxo Group Limited Manifold for use in medicament dispenser
US8534281B2 (en) 2005-12-12 2013-09-17 Glaxo Group Limited Manifold for use in medicament dispenser
US8820324B2 (en) 2006-06-13 2014-09-02 Cambridge Consultants Limited Hinged dry powder inhaler comprising a circulating airflow chamber
WO2007144614A1 (en) * 2006-06-13 2007-12-21 Cambridge Consultants Limited Dry powder inhalers
US8757146B2 (en) 2008-02-07 2014-06-24 University Of Washington Through Its Center For Commercialization Circumferential aerosol device
US10016582B2 (en) 2008-02-07 2018-07-10 University Of Washington Through Its Center For Commercialization Circumferential aerosol device
US9550036B2 (en) 2011-03-03 2017-01-24 Impel Neuropharma Inc. Nasal drug delivery device
US11730903B2 (en) 2011-03-03 2023-08-22 Impel Pharmaceuticals Inc. Nasal drug delivery device
US10507295B2 (en) 2011-03-03 2019-12-17 Impel Neuropharma, Inc. Nasal drug delivery device
US10940278B2 (en) 2011-05-09 2021-03-09 Impel Neuropharma, Inc. Nozzles for nasal drug delivery
US11890412B2 (en) 2011-05-09 2024-02-06 Impel Pharmaceuticals Inc. Nozzles for nasal drug delivery
US9919117B2 (en) 2011-05-09 2018-03-20 Impel Neuropharma Inc. Nozzles for nasal drug delivery
US11007332B2 (en) 2011-05-09 2021-05-18 Impel Neuropharma, Inc. Nozzles for nasal drug delivery
US10537692B2 (en) 2013-04-28 2020-01-21 Impel Neuropharma, Inc. Medical unit dose container
US11191910B2 (en) 2013-04-28 2021-12-07 Impel Neuropharma, Inc. Medical unit dose container
US10940277B2 (en) 2014-11-19 2021-03-09 Optinose As Intranasal administration
JP2017538478A (en) * 2014-11-19 2017-12-28 オプティノーズ アズ Intranasal administration
US11052204B2 (en) 2014-11-19 2021-07-06 Optinose As Intranasal administration
JP2017538477A (en) * 2014-11-19 2017-12-28 オプティノーズ アズ Intranasal administration
US11730904B2 (en) 2014-11-19 2023-08-22 Optinose, Inc. Intranasal administration
US11707586B2 (en) 2014-11-19 2023-07-25 OptiNose Inc. Intranasal administration
US11266799B2 (en) 2015-09-10 2022-03-08 Impel Neuropharma, Inc. In-line nasal delivery device
US11395887B2 (en) 2017-11-21 2022-07-26 Impel Pharmaceuticals Inc. Intranasal device with inlet interface
US11878110B2 (en) 2017-11-21 2024-01-23 Impel Pharmaceuticals Inc. Intranasal device with inlet interface
US11571532B2 (en) 2017-11-21 2023-02-07 Impel Pharmaceuticals Inc. Intranasal device with dip tube
US11185497B2 (en) 2018-01-05 2021-11-30 Impel Neuropharma, Inc. Intranasal delivery of dihydroergotamine by precision olfactory device
US11278492B2 (en) 2018-01-05 2022-03-22 Impel Neuropharma, Inc. Intranasal delivery of olanzapine by precision olfactory device
US11752100B2 (en) 2018-01-05 2023-09-12 Impel Pharmaceuticals Inc. Intranasal delivery of olanzapine by precision olfactory device
US11517548B2 (en) 2018-07-19 2022-12-06 Impel Pharmaceuticals Inc. Respiratory tract delivery of levodopa and DOPA decarboxylase inhibitor for treatment of Parkinson's Disease
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GB9719775D0 (en) 1997-11-19
AU1023199A (en) 1999-04-05

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