WO1999011292A3 - Compositions and methods for treating arthritis utilizing gene therapy - Google Patents

Compositions and methods for treating arthritis utilizing gene therapy Download PDF

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Publication number
WO1999011292A3
WO1999011292A3 PCT/US1998/018308 US9818308W WO9911292A3 WO 1999011292 A3 WO1999011292 A3 WO 1999011292A3 US 9818308 W US9818308 W US 9818308W WO 9911292 A3 WO9911292 A3 WO 9911292A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compositions
gene therapy
treating arthritis
utilizing gene
Prior art date
Application number
PCT/US1998/018308
Other languages
French (fr)
Other versions
WO1999011292A9 (en
WO1999011292A2 (en
Inventor
James E Mccormack
Sunil Chada
Douglas J Jolly
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Priority to EP98945862A priority Critical patent/EP1009444A2/en
Priority to JP2000508393A priority patent/JP2001514235A/en
Publication of WO1999011292A2 publication Critical patent/WO1999011292A2/en
Publication of WO1999011292A3 publication Critical patent/WO1999011292A3/en
Publication of WO1999011292A9 publication Critical patent/WO1999011292A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13051—Methods of production or purification of viral material
    • C12N2740/13052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Methods are provided for treating or preventing arthritis, comprising the general step of administering to a mammal a therapeutically effective amount of a retroviral vector which directs the expression of an anti-arthritic agent, wherein the retroviral vector is administered at a titer of greater than 107 cfu/ml.
PCT/US1998/018308 1997-09-02 1998-09-02 Compositions and methods for treating arthritis utilizing gene therapy WO1999011292A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP98945862A EP1009444A2 (en) 1997-09-02 1998-09-02 Compositions and methods for treating arthritis utilizing gene therapy
JP2000508393A JP2001514235A (en) 1997-09-02 1998-09-02 Compositions and methods for treating arthritis utilizing gene therapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5603997P 1997-09-02 1997-09-02
US60/056,039 1997-09-02

Publications (3)

Publication Number Publication Date
WO1999011292A2 WO1999011292A2 (en) 1999-03-11
WO1999011292A3 true WO1999011292A3 (en) 1999-07-01
WO1999011292A9 WO1999011292A9 (en) 1999-08-05

Family

ID=22001771

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/018308 WO1999011292A2 (en) 1997-09-02 1998-09-02 Compositions and methods for treating arthritis utilizing gene therapy

Country Status (3)

Country Link
EP (1) EP1009444A2 (en)
JP (1) JP2001514235A (en)
WO (1) WO1999011292A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE270110T1 (en) * 2000-04-05 2004-07-15 Ipf Pharmaceuticals Gmbh MEDICINAL PRODUCT CONTAINING TISSUE INHIBITOR OF METALLOPROTEINASES-2 (TIMP-2) AS AN OSTEOANABOLIC SUBSTANCE

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0334301A1 (en) * 1988-03-21 1989-09-27 Chiron Viagene, Inc. Recombinant retroviruses
WO1992011359A1 (en) * 1990-12-20 1992-07-09 University Of Pittsburgh Of The Commonwealth System Of Higher Education A truncated interleukin-1 receptor gene for the treatment of arthritis
WO1994020517A1 (en) * 1993-03-08 1994-09-15 University Of Pittsburgh Of The Commonwealth System Of Higher Education Gene transfer for treating a connective tissue of a mammalian host
WO1995016353A1 (en) * 1993-12-14 1995-06-22 University Of Pittsburgh Of The Commonwealth System Of Higher Education Systemic gene treatment of connective tissue diseases
WO1996006941A1 (en) * 1994-08-26 1996-03-07 Hoechst Aktiengesellschaft Genetic therapy of diseases caused by the immune system, said therapy using a cell-specific active substance regulated by the cell cycle
WO1996021014A2 (en) * 1994-12-30 1996-07-11 Chiron Corporation Production and administration of high titer recombinant retroviruses
WO1998000541A2 (en) * 1996-07-03 1998-01-08 Chiron Corporation Methods for administration of recombinant gene delivery vehicles for treatment of human disease

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0334301A1 (en) * 1988-03-21 1989-09-27 Chiron Viagene, Inc. Recombinant retroviruses
WO1992011359A1 (en) * 1990-12-20 1992-07-09 University Of Pittsburgh Of The Commonwealth System Of Higher Education A truncated interleukin-1 receptor gene for the treatment of arthritis
WO1994020517A1 (en) * 1993-03-08 1994-09-15 University Of Pittsburgh Of The Commonwealth System Of Higher Education Gene transfer for treating a connective tissue of a mammalian host
WO1995016353A1 (en) * 1993-12-14 1995-06-22 University Of Pittsburgh Of The Commonwealth System Of Higher Education Systemic gene treatment of connective tissue diseases
WO1996006941A1 (en) * 1994-08-26 1996-03-07 Hoechst Aktiengesellschaft Genetic therapy of diseases caused by the immune system, said therapy using a cell-specific active substance regulated by the cell cycle
WO1996021014A2 (en) * 1994-12-30 1996-07-11 Chiron Corporation Production and administration of high titer recombinant retroviruses
WO1998000541A2 (en) * 1996-07-03 1998-01-08 Chiron Corporation Methods for administration of recombinant gene delivery vehicles for treatment of human disease

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BANDARA G ET AL: "GENE TRANSFER TO SYNOVIOCYTES: PROSPECTS FOR GENE TREATMENT OF ARTHRITIS", DNA AND CELL BIOLOGY, vol. 11, no. 3, 1 April 1992 (1992-04-01), pages 227 - 231, XP000577115 *
EVANS C H ET AL: "GENE TRANSFER TO JOINTS FOR ARTHRITIS THERAPY", JOURNAL OF CELLULAR BIOCHEMISTRY, no. SUPPL. 16F, 1 January 1992 (1992-01-01), pages 46, XP000566580 *
HUNG G L ET AL: "SUPPRESSION OF INTRA-ARTICULAR RESPONSES TO INTERLEUKIN-1 BY TRANSFER OF THE INTERLEUKIN-1 RECEPTOR ANTAGONIST GENE TO SYNOVIUM", GENE THERAPY, vol. 1, no. 1, 1 January 1994 (1994-01-01), pages 64 - 69, XP000671119 *
ROBBINS P D ET AL: "RETROVIRAL VECTORS FOR USE IN HUMAN GENE THERAPY FOR CANCER, GAUCHER DISEASE, AND ARTHRITIS", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 716, 31 May 1994 (1994-05-31), pages 72 - 89, XP000565748 *

Also Published As

Publication number Publication date
WO1999011292A9 (en) 1999-08-05
EP1009444A2 (en) 2000-06-21
JP2001514235A (en) 2001-09-11
WO1999011292A2 (en) 1999-03-11

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