WO1999010763A1 - Sample holder which can process data and method for analysing samples - Google Patents
Sample holder which can process data and method for analysing samples Download PDFInfo
- Publication number
- WO1999010763A1 WO1999010763A1 PCT/EP1998/005227 EP9805227W WO9910763A1 WO 1999010763 A1 WO1999010763 A1 WO 1999010763A1 EP 9805227 W EP9805227 W EP 9805227W WO 9910763 A1 WO9910763 A1 WO 9910763A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sample
- sample holder
- data
- electronic circuit
- analysis
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
- G01N2035/00742—Type of codes
- G01N2035/00782—Type of codes reprogrammmable code
Definitions
- the invention relates to a data processing-capable microscopy sample holder and to a method for analyzing microscopic samples and data processing-compatible microcospice sample holders.
- sample carriers are used to hold samples or preparations that can be examined microscopically or in another way, in particular non-destructively.
- the preparations / samples can e.g. are tissue parts or fluids of the human body that are to be examined for cancer detection.
- sample carriers are labeled. So far, the sample carriers have been provisionally labeled with a pen immediately after the sample has been applied to them, and only later, when they are examined in the laboratory, provided with permanent identification. It is common for this to be done with special pens directly on the sample holder or on labels that are attached to the sample holder. Label stickers with machine-readable bar codes are also increasingly being used. Please refer to the article "AccuMed International, Inc. Meeting in the Challenges in Cervical Cancer Screening: The AcCell Series 2000 Automated Slide Handling and Data Management System", published in Acta Cytol. 40, No.l, 1 996, S 26-30.
- the machine-readable label stickers already allow the sample holder concerned to be automatically recognized at the various work stations, but they are not used to record or process further data.
- the data belonging to the preparation or the case, such as patient data, examination results etc., must be stored separately on paper or in a database. Even in the case of EDP networking of the various stations of the examination with the database, the spatial separation of the sample carrier from the associated data is disadvantageous, since access to the database requires access to the data network.
- the object of the present invention is therefore to provide a data processing-capable sample carrier and a method for analyzing samples which offer expanded possibilities for data storage.
- the data processing-capable microscopy sample carrier has two areas, a first area of which is intended for the permanent acceptance of a microscopic sample and a second area is used to identify the sample, and an electronic circuit designed as a microchip with a writable, readable, non-volatile memory fitted.
- the sample carrier is advantageously a flat plate.
- at least one area can be transparent to the wavelength range of an analysis device.
- the analysis device is an optical microscope
- the sample carrier can be made of glass, for example.
- the electronic circuit is advantageously implemented as a microchip.
- the electronic circuit can essentially consist of a microchip (for example a "smart chip") with a non-volatile memory.
- the electronic circuit can be equipped with contacts which can be used to write and read data into and out of the circuit.
- the writing in and reading out of data can be implemented in another way, in particular inductively, capacitively or optically.
- the data need not be text data alone.
- the data can also contain image information and / or speech information relating to the sample.
- the electronic circuit can include a microprocessor.
- the memory can contain a control program for the microprocessor.
- the memory can then also contain an application program for analyzing the sample by the electronic circuit.
- the electronic circuit can be detachably connected to the sample holder.
- the sample carrier according to the invention can be used for the analysis of samples which are applied in a first area of the sample holder, data and / or programs relating to the sample being stored in the second area in the electronic circuit.
- the sample carrier can advantageously be used in such a way that the electronic circuit is read out in a data processing system and that read out data and / or programs are used for an analysis, for example in medical diagnostics.
- sample holder according to the invention results from the fact that the sample and the electronic circuit on the sample holder according to the invention have a defined spatial relationship to one another. Distances or dimensions of structures (for example of conductor tracks of a chip of the electronic circuit) can be used as calibration objects for the analysis device, for example for determining the optical magnification. Furthermore, the chip surface be used for a brightness or color balance of the analysis device. Then complex additional calibration objects can be omitted.
- the invention has a number of further advantages.
- the sample can be identified exchanger easier and more reliable than is possible in the prior Tech ⁇ technology.
- the data is always translated together with the Probetragern because sample and associated data on the same samples exchanger, so that separation is prevented in different units befin ⁇ .
- the formation can thus be transported patient in ⁇ "paperless” together with the sample, and it can be a smart and economic control of the sample flow can be realized.
- FIG. 1 shows a first exemplary embodiment of the sample carrier according to the invention
- the sample transducer has two regions 1 and 2, of which the first portion 1 to the On ⁇ exception of sample 1 1 is determined and the second area 2 for the identification of Pro ⁇ be 1 1 is used, wherein the second region 2 having a writable and elec tronic readable ⁇ circuit 21 is provided.
- the sample holder is designed as a flat plate.
- the electronic circuit 21 is implemented as a microchip, which is equipped with contacts 210, with the aid of which the writing and reading of data into and from the circuit 21 is made possible.
- the circuit 21 contains the circuit components required for reading in and reading out and a correspondingly designed memory 21 1 for recording and storing the data.
- the memory is a non-volatile rewritable memory which is known per se.
- the electronic circuit 21 can be assigned to the sample holder permanently or only temporarily.
- the data are sample-related and / or patient-related data.
- the data to be stored in the memory 21 1 are not limited to text data such as accompanying information (identification of the sample, type of sample, patient or personal data). If there is sufficient storage capacity, storage space can be provided to accommodate a variety of additional data. Examples for this are:
- Coordinates of reference points for the microscope on the sample surface - coordinate-specific assignments of examinations and examination results (multi-dimensional mapping information) such as Cell landscapes, nuclear, gene or protein landscapes, images of the samples.
- the electronic circuit 21 additionally contains a microprocessor.
- the memory 21 1 contains an operating program assigned to the microprocessor.
- an application program is contained in the memory 21 1, which is used to analyze the sample in question.
- each sample carrier carries the software associated with sample 1 with it, which additionally increases the reliability of sample analyzes carried out at distributed locations.
- the electronic circuit 21 is equipped with a unit for querying an access authorization for access to the data contained in the electronic circuit 21.
- a "password query” implemented in this way, data protection can be taken into account on the one hand, and on the other hand the data can be better protected against unauthorized changes.
- sample-related data are written into a writable and readable electronic circuit 21 attached to the sample holder, the sample holder being able to be manipulated as desired after the analysis, for example for archiving purposes.
- a sample applied to the sample holder e.g. Tissue sample, microscopically imaged for analysis and the microscopic image graphically processed in a microprocessor and the graphically processed image information written into the electronic circuit.
- the sample carrier according to the invention can be used for the analysis of samples which are applied in a first area of the sample carrier, data relating to the sample being stored in the electronic circuit.
- the sample carrier according to the invention can also be used for the automated examination of the samples. Then the examination devices (e.g. microscope) are to be equipped with appropriate control devices which can access the data stored in the microchips.
- the examination devices e.g. microscope
- appropriate control devices which can access the data stored in the microchips.
- the examination device 5 here consists of a microscope which is coupled to a camera.
- the microchip 21 is written with data and the data is read out by a data reader / writer 6, which is assigned to the examination device 5.
- the data reader / writer 6 can be coupled to the examination device 5 (online processing) or can be implemented separately (offline processing).
- the data input / output or control of the device can take place via a data processing system 7, which can be designed as a computer with peripheral devices.
- the sample carrier can advantageously be used in such a way that the content of the memory 21 1 of the electronic circuit 21 is read in a data processing system and that the content read out is evaluated there for analysis. Furthermore, the sample carrier according to the invention can also be used advantageously in personnel training. For example, interactive lessons can be designed based on the data contained in the microchip of the sample holder.
- the sample holder according to the invention is multimedia-capable.
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- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Optics & Photonics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98946366A EP1034450A1 (en) | 1997-08-21 | 1998-08-18 | Sample holder which can process data and method for analysing samples |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19736470.5 | 1997-08-21 | ||
DE1997136470 DE19736470C2 (en) | 1997-08-21 | 1997-08-21 | Data processing-compatible microscopy sample carrier and method for the analysis of microscopic samples |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999010763A1 true WO1999010763A1 (en) | 1999-03-04 |
Family
ID=7839776
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1998/005227 WO1999010763A1 (en) | 1997-08-21 | 1998-08-18 | Sample holder which can process data and method for analysing samples |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1034450A1 (en) |
DE (1) | DE19736470C2 (en) |
WO (1) | WO1999010763A1 (en) |
Cited By (7)
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---|---|---|---|---|
US6735531B2 (en) * | 1996-10-07 | 2004-05-11 | Lab Vision Corporation | Method and apparatus for automatic tissue staining |
US7083106B2 (en) | 2003-09-05 | 2006-08-01 | Cytyc Corporation | Locally storing biological specimen data to a slide |
JP2007093450A (en) * | 2005-09-29 | 2007-04-12 | Olympus Corp | Inspection system and holder of inspection object thereof |
US7435599B2 (en) | 1998-09-18 | 2008-10-14 | Cytyc Corporation | Method and apparatus for preparing cytological specimens |
US7984616B2 (en) | 2002-11-06 | 2011-07-26 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Low-temperature storage of suspension samples in suspended sample chambers |
AU2005259981B2 (en) * | 2004-06-29 | 2012-01-12 | Dako Denmark A/S | Method of pre-treatment and staining of and support device for a biological sample |
US8830574B2 (en) * | 2006-03-13 | 2014-09-09 | Ikonisys, Inc. | System for read-write control of specimen analysis by automated microscope |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19905490A1 (en) * | 1999-02-10 | 2000-08-17 | Florian Lang | Detachable labeling device for slides comprises stainless steel clip gripping slide and readily slipped on and off, displaying automatically-produced barcode label, for identification during e.g. automatic staining procedure |
DE19955729A1 (en) * | 1999-11-15 | 2001-05-23 | Hospitalia Dienstleistungs & B | Communication system for the interaction of medical laboratories and medical treatment facilities |
US6746851B1 (en) | 2000-01-14 | 2004-06-08 | Lab Vision Corporation | Method for automated staining of specimen slides |
DE10010140A1 (en) * | 2000-03-03 | 2001-09-13 | Leica Microsystems | Automatic system processing e.g. histological and cytological preparations, comprises slides with code identifying them and determining their handling and treatment |
DE10020704B4 (en) | 2000-04-27 | 2006-09-28 | Bioref Gmbh | Biochip for archiving and laboratory medical analysis of biological sample material, process for its production and its use in diagnostic procedures |
DE10052834B4 (en) | 2000-10-24 | 2019-09-19 | Leica Biosystems Nussloch Gmbh | Method of treating objects |
DE10144925A1 (en) * | 2001-09-12 | 2003-03-27 | Fraunhofer Ges Forschung | Cryopreservation method for cells and cell components comprises applying samples to e.g. a CD as a storage substrate and burning position-specific data on to disk. |
DE10060889A1 (en) * | 2000-12-07 | 2002-06-27 | Fraunhofer Ges Forschung | Cryopreservation method for cells and cell components comprises applying samples to e.g. a CD as a storage substrate and burning position-specific data on to disk. |
AU2002219163A1 (en) | 2000-12-07 | 2002-06-18 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Cryostorage method and device |
WO2002074898A2 (en) * | 2001-03-16 | 2002-09-26 | Techne (Cambridge) Ltd | Gradient block temperature control device |
DE10127221A1 (en) * | 2001-05-23 | 2002-11-28 | Lifebits Ag | Carrier, for analysis of chemical or biological sensor molecules, has geometrical surface layout for samples, according to scanning method |
AT413640B (en) * | 2001-09-05 | 2006-04-15 | Ams Engineering Sticht Ges M B | METHOD FOR REMOVING A SAMPLE FROM A SYSTEM |
DE10154843A1 (en) * | 2001-11-08 | 2003-05-28 | Microm Int Gmbh | Method and device for labeling slides for microtomized tissue samples and their processing |
US6998270B2 (en) | 2001-11-26 | 2006-02-14 | Lab Vision Corporation | Automated tissue staining system and reagent container |
DE10240814A1 (en) * | 2002-08-30 | 2004-03-25 | Glocker, Michael O., Prof. Dr. | Sample holder with special provision for information storage in addition to samples of e.g. biological, medical or chemical nature, is connected with transponder |
DE10324329B4 (en) * | 2003-05-29 | 2008-05-15 | Leica Microsystems Cms Gmbh | Object carrier device for examination with a microscope |
US20050094263A1 (en) * | 2003-10-31 | 2005-05-05 | Vincent Vaccarelli | Microscope slide designed for educational purposes |
DE102004024960A1 (en) * | 2004-05-21 | 2005-12-15 | Bruker Daltonik Gmbh | Vessel for the cultivation of microbe colonies, from a primary sample of blood or urine, has an electronic label for remote machine writing/reading to store identity data |
DE102004031570B4 (en) * | 2004-06-12 | 2008-04-10 | Leica Microsystems Cms Gmbh | Object carrier device for examination with a microscope |
DE102004064072B4 (en) | 2004-06-12 | 2020-06-10 | Leica Microsystems Cms Gmbh | Object slide device for receiving an object to be examined with a microscope or to be analyzed with a laboratory analysis system, and method |
DE102004048099B4 (en) * | 2004-09-30 | 2018-05-09 | Carl Zeiss Microscopy Gmbh | Microscope configuration determination |
DE102005039949A1 (en) * | 2005-08-24 | 2007-03-01 | Olympus Soft Imaging Solutions Gmbh | Optical recording and / or reproducing unit |
US7848019B2 (en) * | 2007-12-10 | 2010-12-07 | Cytyc Corporation | Microscope calibration apparatus and method and stage including calibration apparatus |
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US4159875A (en) * | 1976-10-21 | 1979-07-03 | Abbott Laboratories | Specimen holder |
DE2735077A1 (en) * | 1977-08-04 | 1979-02-15 | Eppendorf Geraetebau Netheler | Composite cuvette and reaction vessel - has two reagent chambers and separate cuvette portion made of glass or plastics |
JP2541081B2 (en) * | 1992-08-28 | 1996-10-09 | 日本電気株式会社 | Biosensor and method of manufacturing and using biosensor |
-
1997
- 1997-08-21 DE DE1997136470 patent/DE19736470C2/en not_active Expired - Fee Related
-
1998
- 1998-08-18 WO PCT/EP1998/005227 patent/WO1999010763A1/en not_active Application Discontinuation
- 1998-08-18 EP EP98946366A patent/EP1034450A1/en not_active Ceased
Patent Citations (6)
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WO1989008264A1 (en) * | 1988-03-04 | 1989-09-08 | Ballies Uwe W | Process for automatic, fully selective analysis of blood or its constituents |
EP0347579A2 (en) * | 1988-06-01 | 1989-12-27 | Daimler-Benz Aerospace Aktiengesellschaft | Device having a specific support structure for receiving, analysing and treating samples |
EP0637750A2 (en) * | 1993-08-05 | 1995-02-08 | Roche Diagnostics GmbH | Method for analysing sample fluids |
US5561556A (en) * | 1994-04-21 | 1996-10-01 | Compucyte Corporation | Slide analysis system with slide having self contained microscope analysis information |
DE4417079A1 (en) * | 1994-05-17 | 1995-12-07 | Fraunhofer Ges Forschung | Microscope slide |
WO1996036436A1 (en) * | 1995-04-25 | 1996-11-21 | Irori | Remotely programmable matrices with memories and uses thereof |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6735531B2 (en) * | 1996-10-07 | 2004-05-11 | Lab Vision Corporation | Method and apparatus for automatic tissue staining |
US7435599B2 (en) | 1998-09-18 | 2008-10-14 | Cytyc Corporation | Method and apparatus for preparing cytological specimens |
US7984616B2 (en) | 2002-11-06 | 2011-07-26 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Low-temperature storage of suspension samples in suspended sample chambers |
US7083106B2 (en) | 2003-09-05 | 2006-08-01 | Cytyc Corporation | Locally storing biological specimen data to a slide |
US7395974B2 (en) | 2003-09-05 | 2008-07-08 | Cytyc Corporation | Locally storing biological specimen data to a slide |
AU2005259981B2 (en) * | 2004-06-29 | 2012-01-12 | Dako Denmark A/S | Method of pre-treatment and staining of and support device for a biological sample |
US8283176B2 (en) | 2004-06-29 | 2012-10-09 | Dako Denmark A/S | Method of pre-treatment and staining of a biological sample and device for support of a biological sample and methods of using such device |
JP2007093450A (en) * | 2005-09-29 | 2007-04-12 | Olympus Corp | Inspection system and holder of inspection object thereof |
US8830574B2 (en) * | 2006-03-13 | 2014-09-09 | Ikonisys, Inc. | System for read-write control of specimen analysis by automated microscope |
Also Published As
Publication number | Publication date |
---|---|
DE19736470C2 (en) | 2001-02-22 |
DE19736470A1 (en) | 1999-03-04 |
EP1034450A1 (en) | 2000-09-13 |
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