WO1999007324A3 - Conjugates targeted to the interleukin-2 receptor - Google Patents
Conjugates targeted to the interleukin-2 receptor Download PDFInfo
- Publication number
- WO1999007324A3 WO1999007324A3 PCT/US1998/016290 US9816290W WO9907324A3 WO 1999007324 A3 WO1999007324 A3 WO 1999007324A3 US 9816290 W US9816290 W US 9816290W WO 9907324 A3 WO9907324 A3 WO 9907324A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- receptor
- interleukin
- composition
- chemical agent
- water soluble
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000506921A JP2003516305A (en) | 1997-08-05 | 1998-08-05 | Conjugates targeted to interleukin-2 receptor |
AU87698/98A AU8769898A (en) | 1997-08-05 | 1998-08-05 | Conjugates targeted to the interleukin-2 receptor |
CA002299368A CA2299368A1 (en) | 1997-08-05 | 1998-08-05 | Conjugates targeted to the interleukin-2 receptor |
EP98939226A EP1011705A4 (en) | 1997-08-05 | 1998-08-05 | Conjugates targeted to the interleukin-2 receptor |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91404297A | 1997-08-05 | 1997-08-05 | |
US08/914,042 | 1997-08-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999007324A2 WO1999007324A2 (en) | 1999-02-18 |
WO1999007324A3 true WO1999007324A3 (en) | 1999-04-15 |
Family
ID=25433849
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/016290 WO1999007324A2 (en) | 1997-08-05 | 1998-08-05 | Conjugates targeted to the interleukin-2 receptor |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1011705A4 (en) |
JP (1) | JP2003516305A (en) |
AU (1) | AU8769898A (en) |
CA (1) | CA2299368A1 (en) |
WO (1) | WO1999007324A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6251866B1 (en) | 1997-08-05 | 2001-06-26 | Watson Laboratories, Inc. | Conjugates targeted to the interleukin-2 receptor |
JP2003530299A (en) * | 1999-03-08 | 2003-10-14 | ゲルハルト グラウプナー, | Methods and compositions for targeted drug delivery |
CA2398395A1 (en) * | 2000-02-18 | 2001-08-23 | Watson Pharmaceuticals, Inc. | Conjugates targeted to target receptors |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4917888A (en) * | 1985-06-26 | 1990-04-17 | Cetus Corporation | Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation |
US5059413A (en) * | 1988-04-18 | 1991-10-22 | Xoma Corporation | Scintigraphic monitoring of immunotoxins using radionuclides and heterobifunctional chelators |
US5149528A (en) * | 1987-04-10 | 1992-09-22 | Zymogenetics, Inc. | Cytotoxic protein from Trichosanthes kirilowii |
US5258453A (en) * | 1992-01-21 | 1993-11-02 | University Of Utah | Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light |
US5326559A (en) * | 1991-05-16 | 1994-07-05 | Miller D Douglas | Treatment of accelerated atheosclerosis with interleukin-2 receptor targeted molecules |
US5541297A (en) * | 1988-04-01 | 1996-07-30 | Immunomedics, Inc. | Therapeutic conjugates of toxins and drugs |
US5571507A (en) * | 1992-02-25 | 1996-11-05 | Seragen, Inc. | Methods of treating diabetes |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ74797A3 (en) * | 1994-09-13 | 1997-08-13 | Theratech | Composition for specific intracellular introduction of a chemical agent and method of such introduction |
ZA972087B (en) * | 1996-03-15 | 1997-10-24 | Theratech Inc | Targeting macromolecular produgs to T lymphocytes. |
US6251866B1 (en) * | 1997-08-05 | 2001-06-26 | Watson Laboratories, Inc. | Conjugates targeted to the interleukin-2 receptor |
-
1998
- 1998-08-05 WO PCT/US1998/016290 patent/WO1999007324A2/en not_active Application Discontinuation
- 1998-08-05 EP EP98939226A patent/EP1011705A4/en not_active Withdrawn
- 1998-08-05 JP JP2000506921A patent/JP2003516305A/en not_active Withdrawn
- 1998-08-05 CA CA002299368A patent/CA2299368A1/en not_active Abandoned
- 1998-08-05 AU AU87698/98A patent/AU8769898A/en not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4917888A (en) * | 1985-06-26 | 1990-04-17 | Cetus Corporation | Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation |
US5149528A (en) * | 1987-04-10 | 1992-09-22 | Zymogenetics, Inc. | Cytotoxic protein from Trichosanthes kirilowii |
US5541297A (en) * | 1988-04-01 | 1996-07-30 | Immunomedics, Inc. | Therapeutic conjugates of toxins and drugs |
US5059413A (en) * | 1988-04-18 | 1991-10-22 | Xoma Corporation | Scintigraphic monitoring of immunotoxins using radionuclides and heterobifunctional chelators |
US5326559A (en) * | 1991-05-16 | 1994-07-05 | Miller D Douglas | Treatment of accelerated atheosclerosis with interleukin-2 receptor targeted molecules |
US5258453A (en) * | 1992-01-21 | 1993-11-02 | University Of Utah | Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light |
US5571507A (en) * | 1992-02-25 | 1996-11-05 | Seragen, Inc. | Methods of treating diabetes |
Non-Patent Citations (2)
Title |
---|
PASTAN I. et al., "Recombinant Toxins for Cancer Treatment", SCIENCE, 22 November 1991, Vol. 254, pages 1173-1177. * |
See also references of EP1011705A4 * |
Also Published As
Publication number | Publication date |
---|---|
EP1011705A2 (en) | 2000-06-28 |
JP2003516305A (en) | 2003-05-13 |
WO1999007324A2 (en) | 1999-02-18 |
AU8769898A (en) | 1999-03-01 |
EP1011705A4 (en) | 2000-09-20 |
CA2299368A1 (en) | 1999-02-18 |
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