WO2003084469A3 - Tissue-specific endothelial membrane proteins - Google Patents

Tissue-specific endothelial membrane proteins Download PDF

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Publication number
WO2003084469A3
WO2003084469A3 PCT/US2003/010195 US0310195W WO03084469A3 WO 2003084469 A3 WO2003084469 A3 WO 2003084469A3 US 0310195 W US0310195 W US 0310195W WO 03084469 A3 WO03084469 A3 WO 03084469A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
specific
ligand
therapeutic moiety
linker
Prior art date
Application number
PCT/US2003/010195
Other languages
French (fr)
Other versions
WO2003084469A2 (en
Inventor
Paul W Roben
Anthony C Stevens
Original Assignee
Utah Ventures Ii L P
Paul W Roben
Anthony C Stevens
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Utah Ventures Ii L P, Paul W Roben, Anthony C Stevens filed Critical Utah Ventures Ii L P
Priority to AU2003222185A priority Critical patent/AU2003222185A1/en
Priority to CA002481334A priority patent/CA2481334A1/en
Priority to GB0423854A priority patent/GB2403222A/en
Publication of WO2003084469A2 publication Critical patent/WO2003084469A2/en
Priority to US10/794,899 priority patent/US20040146516A1/en
Publication of WO2003084469A3 publication Critical patent/WO2003084469A3/en
Priority to GBGB0424024.8A priority patent/GB0424024D0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Methods and compositions for targeting of pharmaceuticals or other therapeutics to specific tissues using tissue-specific endothelial membrane proteins are provided. The compositions comprise a therapeutic complex composed of a ligand, a linker, and a therapeutic moiety, where the therapeutic moiety can enter the cell. The ligand can be an antibody or other molecule that binds to a tissue-specific protein on the endothelial membrane of a specific tissue. The ligand does not activate a receptor, but may activate endocytosis. The therapeutic moiety could be a drug, gene, antisense oligonucleotide, contrast agent, protein, toxin, or any type of molecule that acts on the specific tissue. The linker is preferably cleaved upon going to the interior of the cell. Alternatively, the linker may simply be the bond between the ligand and the therapeutic moiety. Alternatively, a lipophilic prodrug may be cleaved and may enter the cell due to its lipophilic properties.
PCT/US2003/010195 1999-06-17 2003-03-31 Tissue-specific endothelial membrane proteins WO2003084469A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2003222185A AU2003222185A1 (en) 2002-04-01 2003-03-31 Tissue-specific endothelial membrane proteins
CA002481334A CA2481334A1 (en) 2002-04-01 2003-03-31 Tissue-specific endothelial membrane proteins
GB0423854A GB2403222A (en) 2002-04-01 2003-03-31 Tissue-specific endothelial membrane proteins
US10/794,899 US20040146516A1 (en) 1999-06-17 2004-03-05 Lumen-exposed molecules and methods for targeted delivery
GBGB0424024.8A GB0424024D0 (en) 2002-04-01 2004-10-29 Tissue-specific endothelial membrane proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36945202P 2002-04-01 2002-04-01
US60/369,452 2002-04-01

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/794,899 Continuation-In-Part US20040146516A1 (en) 1999-06-17 2004-03-05 Lumen-exposed molecules and methods for targeted delivery

Publications (2)

Publication Number Publication Date
WO2003084469A2 WO2003084469A2 (en) 2003-10-16
WO2003084469A3 true WO2003084469A3 (en) 2004-06-10

Family

ID=28791952

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/010195 WO2003084469A2 (en) 1999-06-17 2003-03-31 Tissue-specific endothelial membrane proteins

Country Status (4)

Country Link
AU (1) AU2003222185A1 (en)
CA (1) CA2481334A1 (en)
GB (2) GB2403222A (en)
WO (1) WO2003084469A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3101034A1 (en) 2004-02-12 2016-12-07 Morphotek, Inc. Monoclonal antibodies that specifically bind to folate receptor alpha
FR2883873B1 (en) 2005-03-31 2009-07-10 Pharmamens Sarl AGE INHIBITORS
US20060239910A1 (en) 2005-04-22 2006-10-26 Morphotek Inc. Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells
EP2434288B1 (en) 2006-09-25 2014-07-30 Universiteit Maastricht Means and methods for diagnosing and/or treating a subject at risk of developing heart failure
FI20075278A0 (en) * 2007-04-20 2007-04-20 Biotie Therapies Corp Novel completely human anti-VAP-1 monoclonal antibodies
ES2642516T3 (en) 2007-09-04 2017-11-16 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Deletions in domain II of Pseudomonas exotoxin A that reduce non-specific toxicity
EP3052483B1 (en) 2013-10-01 2019-02-06 GlaxoSmithKline Intellectual Property Development Limited Compounds for affinity chromatography
CN112535726B (en) * 2019-09-05 2023-09-12 南京安吉生物科技有限公司 Tumor marker AQUAPRIN 2 protein and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994002178A1 (en) * 1992-07-27 1994-02-03 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Targeting of liposomes to the blood-brain barrier
US5977307A (en) * 1989-09-07 1999-11-02 Alkermes, Inc. Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins
US20030082176A1 (en) * 2001-04-30 2003-05-01 Symbiontics, Inc. Subcellular targeting of therapeutic proteins

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977307A (en) * 1989-09-07 1999-11-02 Alkermes, Inc. Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins
WO1994002178A1 (en) * 1992-07-27 1994-02-03 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Targeting of liposomes to the blood-brain barrier
US20030082176A1 (en) * 2001-04-30 2003-05-01 Symbiontics, Inc. Subcellular targeting of therapeutic proteins

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FISHER R.S. ET AL.: "Potential new methods for antiepileptic drug delivery", CNS DRUGS, vol. 16, no. 9, 2002, pages 579 - 593, XP002972018 *

Also Published As

Publication number Publication date
GB0423854D0 (en) 2004-12-01
GB0424024D0 (en) 2004-12-01
WO2003084469A2 (en) 2003-10-16
AU2003222185A1 (en) 2003-10-20
CA2481334A1 (en) 2003-10-16
GB2403222A (en) 2004-12-29

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