WO1999006557A3 - Mammalian cell membrane proteins; related reagents - Google Patents

Mammalian cell membrane proteins; related reagents Download PDF

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Publication number
WO1999006557A3
WO1999006557A3 PCT/US1998/015316 US9815316W WO9906557A3 WO 1999006557 A3 WO1999006557 A3 WO 1999006557A3 US 9815316 W US9815316 W US 9815316W WO 9906557 A3 WO9906557 A3 WO 9906557A3
Authority
WO
WIPO (PCT)
Prior art keywords
mammalian cell
cell membrane
membrane proteins
related reagents
proteins
Prior art date
Application number
PCT/US1998/015316
Other languages
French (fr)
Other versions
WO1999006557A2 (en
Inventor
Alexander B H Bakker
Joseph H Phillips Jr
Lewis L Lanier
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to AU86614/98A priority Critical patent/AU8661498A/en
Priority to EP98937993A priority patent/EP1003861B1/en
Priority to DE69836082T priority patent/DE69836082T2/en
Priority to JP2000505298A priority patent/JP2001512017A/en
Publication of WO1999006557A2 publication Critical patent/WO1999006557A2/en
Publication of WO1999006557A3 publication Critical patent/WO1999006557A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The purification and isolation of various genes which encode mammalian cell surface polypeptides. Nucleic acids, proteins, antibodies, and other reagents useful in modulating development of cells, e.g., lymphoid and myeloid, are provided, along with methods for their use.
PCT/US1998/015316 1997-08-01 1998-07-31 Mammalian cell membrane proteins; related reagents WO1999006557A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU86614/98A AU8661498A (en) 1997-08-01 1998-07-31 Mammalian cell membrane proteins; related reagents
EP98937993A EP1003861B1 (en) 1997-08-01 1998-07-31 Mammalian cell membrane proteins; related reagents
DE69836082T DE69836082T2 (en) 1997-08-01 1998-07-31 MEMBRANE PROTEINS FROM MAMMALIAN CELLS; RELATED REAGENTS
JP2000505298A JP2001512017A (en) 1997-08-01 1998-07-31 Mammalian cell membrane proteins; related reagents

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US90490597A 1997-08-01 1997-08-01
US6371797P 1997-10-29 1997-10-29
US99082097A 1997-12-15 1997-12-15
US6969297P 1997-12-16 1997-12-16
US8916898P 1998-06-12 1998-06-12
US60/069,692 1998-06-12
US08/990,820 1998-06-12
US60/063,717 1998-06-12
US08/904,905 1998-06-12
US60/089,168 1998-06-12

Publications (2)

Publication Number Publication Date
WO1999006557A2 WO1999006557A2 (en) 1999-02-11
WO1999006557A3 true WO1999006557A3 (en) 1999-05-20

Family

ID=27535631

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/015316 WO1999006557A2 (en) 1997-08-01 1998-07-31 Mammalian cell membrane proteins; related reagents

Country Status (8)

Country Link
EP (3) EP1003861B1 (en)
JP (3) JP2001512017A (en)
AT (2) ATE341626T1 (en)
AU (1) AU8661498A (en)
DE (1) DE69836082T2 (en)
ES (1) ES2274574T3 (en)
PT (1) PT1003861E (en)
WO (1) WO1999006557A2 (en)

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US7196164B2 (en) 1997-07-08 2007-03-27 Human Genome Sciences, Inc. Secreted protein HHTLF25
EP1557425A3 (en) * 1997-07-08 2005-08-17 Human Genome Sciences, Inc. 123 human secreted proteins
WO2002024940A2 (en) * 2000-09-20 2002-03-28 Institut National De La Sante Et De La Recherche Medicale (I.N.S.E.R.M.) Means for the identification of compounds capable of inhibiting karap-transduced signals
US7858094B2 (en) 2000-12-08 2010-12-28 Geneprint Corporation TREM-1 splice variant for use in modifying immune responses
CA2433474A1 (en) * 2001-02-23 2002-09-06 Human Genome Sciences, Inc. 70 human secreted proteins
CA2585719A1 (en) * 2004-11-08 2006-05-18 Schering Corporation Tumor association of mdl-1 and methods
TW200738752A (en) * 2006-01-31 2007-10-16 Bayer Schering Pharma Ag Modulation of MDL-1 activity for treatment of inflammatory disease
JP2010526066A (en) 2007-04-23 2010-07-29 シェーリング コーポレイション Anti-MDL-1 antibody
EP2675467A4 (en) * 2011-02-18 2014-06-25 Merck Sharp & Dohme Use of mdl-1 antagonists to treat spondylarthropathy
WO2013043516A1 (en) 2011-09-23 2013-03-28 Merck Sharp & Dohme Corp. Mdl-1 ligand
SG11201402283PA (en) 2011-11-16 2014-06-27 Boehringer Ingelheim Int Anti il-36r antibodies
AR090915A1 (en) 2012-05-04 2014-12-17 Intervet Int Bv PROTEIN OF FUSION OF PROTEIN LINFOPOYETINA ESTROMAL TIMICA CANINA WITH THE REGION FC OF IGG
WO2014117121A1 (en) * 2013-01-28 2014-07-31 St. Jude Children's Research Hospital, Inc. A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease
JP2016510342A (en) * 2013-02-15 2016-04-07 トーマス・ジェファーソン・ユニバーシティＴｈｏｍａｓ Ｊｅｆｆｅｒｓｏｎ Ｕｎｉｖｅｒｓｉｔｙ Kit for tumor imaging
AU2015259877B2 (en) 2014-05-15 2021-02-25 National University Of Singapore Modified natural killer cells and uses thereof
US10577417B2 (en) * 2014-09-17 2020-03-03 Novartis Ag Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
CN117384929A (en) 2017-03-27 2024-01-12 新加坡国立大学 Polynucleotide encoding chimeric receptor expressed by cell
CN108728527B (en) * 2018-06-06 2020-06-09 青岛泱深生物医药有限公司 HCST gene as target for diagnosing and treating preeclampsia
EP3773918A4 (en) 2019-03-05 2022-01-05 Nkarta, Inc. Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy
EA202192405A1 (en) 2019-03-08 2022-01-13 Бёрингер Ингельхайм Интернациональ Гмбх COMPOSITIONS OF ANTIBODIES AGAINST IL-36R
TW202225190A (en) 2020-07-17 2022-07-01 德商百靈佳殷格翰國際股份有限公司 Anti-il-36r antibodies for the treatment of neutrophilic dermatoses

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Publication number Priority date Publication date Assignee Title
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WO1997020046A1 (en) * 1995-11-30 1997-06-05 Schering Corporation Dnam, an nk antigen and adhesion molecule of the immunoglobulin superfamily
WO1998039446A2 (en) * 1997-03-07 1998-09-11 Human Genome Sciences, Inc. 70 human secreted proteins
WO1998049292A2 (en) * 1997-04-30 1998-11-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Polypeptides associated with activator receptors and their biological applications
WO1999006554A2 (en) * 1997-08-01 1999-02-11 Genset 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN MUSCLE AND OTHER MESODERMAL TISSUES
WO1999006548A2 (en) * 1997-08-01 1999-02-11 Genset 5'ESTs FOR NON TISSUE SPECIFIC SECRETED PROTEINS

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Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996026961A2 (en) * 1995-02-28 1996-09-06 National Jewish Center For Immunology And Respiratory Medicine Peptidyl compounds comprising an itim motif which regulate hematopoietic function and their use
WO1997020046A1 (en) * 1995-11-30 1997-06-05 Schering Corporation Dnam, an nk antigen and adhesion molecule of the immunoglobulin superfamily
WO1998039446A2 (en) * 1997-03-07 1998-09-11 Human Genome Sciences, Inc. 70 human secreted proteins
WO1998049292A2 (en) * 1997-04-30 1998-11-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Polypeptides associated with activator receptors and their biological applications
WO1999006554A2 (en) * 1997-08-01 1999-02-11 Genset 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN MUSCLE AND OTHER MESODERMAL TISSUES
WO1999006548A2 (en) * 1997-08-01 1999-02-11 Genset 5'ESTs FOR NON TISSUE SPECIFIC SECRETED PROTEINS

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BLERY M ET AL: "RECONSTITUTED KILLER CELL INHIBITORY RECEPTORS FOR MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I MOLECULES CONTROL MAST CELL ACTIVATION INDUCED VIA IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIFS", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 14, 4 April 1997 (1997-04-04), pages 8989 - 8996, XP002052877 *
K TAKASE ET AL: "A new 12-kilodalton dimer associated with pre-TCR complex and clonotype-independent CD3 complex on immature thymocytes", JOURNAL OF IMMUNOLOGY, vol. 159, no. 2, 15 July 1997 (1997-07-15), pages 741 - 747, XP002084880 *
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Also Published As

Publication number Publication date
EP1798286A3 (en) 2007-11-14
JP4855513B2 (en) 2012-01-18
EP1003861A2 (en) 2000-05-31
EP1798286A2 (en) 2007-06-20
EP1798287A3 (en) 2007-11-14
JP2010099077A (en) 2010-05-06
EP1798286B1 (en) 2011-09-07
WO1999006557A2 (en) 1999-02-11
JP2001512017A (en) 2001-08-21
ES2274574T3 (en) 2007-05-16
JP2010099076A (en) 2010-05-06
EP1003861B1 (en) 2006-10-04
AU8661498A (en) 1999-02-22
ATE341626T1 (en) 2006-10-15
EP1798287A2 (en) 2007-06-20
DE69836082D1 (en) 2006-11-16
PT1003861E (en) 2007-01-31
ATE523593T1 (en) 2011-09-15
DE69836082T2 (en) 2007-05-10

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