WO1999006059A3 - Methods and compositions relating to no-mediated cytotoxicity - Google Patents
Methods and compositions relating to no-mediated cytotoxicity Download PDFInfo
- Publication number
- WO1999006059A3 WO1999006059A3 PCT/US1998/015781 US9815781W WO9906059A3 WO 1999006059 A3 WO1999006059 A3 WO 1999006059A3 US 9815781 W US9815781 W US 9815781W WO 9906059 A3 WO9906059 A3 WO 9906059A3
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- WO
- WIPO (PCT)
- Prior art keywords
- present
- methods
- diabetes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A61K38/446—Superoxide dismutase (1.15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/13—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
- C12Y114/13039—Nitric-oxide synthase (NADPH dependent) (1.14.13.39)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y115/00—Oxidoreductases acting on superoxide as acceptor (1.15)
- C12Y115/01—Oxidoreductases acting on superoxide as acceptor (1.15) with NAD or NADP as acceptor (1.15.1)
- C12Y115/01001—Superoxide dismutase (1.15.1.1)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5038—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving detection of metabolites per se
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/507—Pancreatic cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2510/00—Detection of programmed cell death, i.e. apoptosis
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU86717/98A AU8671798A (en) | 1997-07-30 | 1998-07-30 | Methods and compositions relating to no-mediated cytotoxicity |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5509297P | 1997-07-30 | 1997-07-30 | |
US60/055,092 | 1997-07-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999006059A2 WO1999006059A2 (en) | 1999-02-11 |
WO1999006059A3 true WO1999006059A3 (en) | 1999-08-05 |
Family
ID=21995540
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/015781 WO1999006059A2 (en) | 1997-07-30 | 1998-07-30 | Methods and compositions relating to no-mediated cytotoxicity |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU8671798A (en) |
WO (1) | WO1999006059A2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2257284C (en) * | 1996-05-31 | 2005-10-04 | Sankyo Company Limited | Remedy for autoimmune diseases |
DE19921537A1 (en) * | 1999-05-11 | 2000-11-23 | Dieter Hoersch | Treating carbohydrate metabolism disorders, especially diabetes, comprises activating insulin-secreting b-cells using glucagon-related peptide, glucose-dependent insulinotropic polypeptide, exendin-4 or related drugs |
WO2001005943A2 (en) * | 1999-07-14 | 2001-01-25 | Betagene, Inc. | Lcat recombinant cell line compositions and methods |
AU2002213925A1 (en) | 2000-09-18 | 2002-03-26 | Osteometer Biotech As | Use of glp-1 and flp-2 peptides for treatment of bone disorders |
US7371721B2 (en) | 2000-09-18 | 2008-05-13 | Sanos Bioscience A/S | Use of GLP-2 and related compounds for the treatment, prevention, diagnosis, and prognosis of bone-related disorders and calcium homeostasis related syndromes |
US6943001B2 (en) | 2001-08-03 | 2005-09-13 | Diversa Corporation | Epoxide hydrolases, nucleic acids encoding them and methods for making and using them |
EP1578987A2 (en) | 2001-08-03 | 2005-09-28 | Diversa Corporation | Epoxide hydrolases, nucleic acids encoding them and methods for making and using them |
WO2005046718A1 (en) * | 2003-11-06 | 2005-05-26 | Ohio University | Diagnosis and hyperinsulinemia and type ii diabetes and protection against same based on genes differentially expressed in pancreas cells (12.1) |
EP2896688A1 (en) * | 2014-01-20 | 2015-07-22 | Centre National de la Recherche Scientifique (CNRS) | A method of producing beta pancreatic cells from progenitor cells through the use of hydrogen peroxide |
Citations (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1987001387A1 (en) * | 1985-09-03 | 1987-03-12 | Syn-Tek Ab | A superoxide dismutase |
US4888358A (en) * | 1988-08-25 | 1989-12-19 | Syntex (U.S.A.) Inc. | 13,14-dihydroprostaglandin C-type derivatives |
WO1991018919A1 (en) * | 1990-05-31 | 1991-12-12 | Schering Corporation | Purification of human interleukin-4 from a secreted escherichia coli mutant |
US5231012A (en) * | 1989-06-28 | 1993-07-27 | Schering Corporation | Nucleic acids encoding cytokine synthesis inhibitory factor (interleukin-10) |
WO1994004680A1 (en) * | 1992-08-21 | 1994-03-03 | Schering Corporation | Human interleukin-13 |
WO1994008606A1 (en) * | 1992-10-01 | 1994-04-28 | Schering Corporation | Use of il-10 to prevent or treat insulin-dependent diabetes mellitus |
WO1994014950A1 (en) * | 1992-12-28 | 1994-07-07 | Sii Technoresearch, Inc. | Human variant manganese superoxide dismutase |
WO1995020402A1 (en) * | 1994-01-31 | 1995-08-03 | Ludwig Institute For Cancer Research | Antioxidants and intracellular glutathione raising agents for therapeutic treatments |
EP0676472A1 (en) * | 1987-03-14 | 1995-10-11 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Human manganese superoxide dismutase (hMn-SOD) |
WO1996000790A1 (en) * | 1994-06-29 | 1996-01-11 | Rhone-Poulenc Rorer S.A. | Adenovirus including a gene coding for a superoxide dismutase |
JPH0812573A (en) * | 1994-06-24 | 1996-01-16 | Mitsubishi Chem Corp | Free fatty acid reducing agent |
US5539132A (en) * | 1994-01-24 | 1996-07-23 | Johns Hopkins University | Cerulenin compounds for fatty acid synthesis inhibition |
JPH08228775A (en) * | 1995-02-28 | 1996-09-10 | Otsuka Pharmaceut Factory Inc | Recombinant retrovirus vector, cell having the same vector transduced thereinto, recombinant retrovirus and t lymphocyte infected with the same virus |
WO1997002004A2 (en) * | 1995-06-30 | 1997-01-23 | Eli Lilly And Company | Methods for treating diabetes |
EP0774259A1 (en) * | 1990-12-07 | 1997-05-21 | Novartis AG | New use of organic compounds |
WO1997047656A1 (en) * | 1996-06-13 | 1997-12-18 | Berk Paul D | Method to modulate the facilitated uptake of free fatty acids into cells by a plasma membrane fatty acid binding protein |
-
1998
- 1998-07-30 AU AU86717/98A patent/AU8671798A/en not_active Abandoned
- 1998-07-30 WO PCT/US1998/015781 patent/WO1999006059A2/en active Application Filing
Patent Citations (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1987001387A1 (en) * | 1985-09-03 | 1987-03-12 | Syn-Tek Ab | A superoxide dismutase |
EP0676472A1 (en) * | 1987-03-14 | 1995-10-11 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Human manganese superoxide dismutase (hMn-SOD) |
US4888358A (en) * | 1988-08-25 | 1989-12-19 | Syntex (U.S.A.) Inc. | 13,14-dihydroprostaglandin C-type derivatives |
US5231012A (en) * | 1989-06-28 | 1993-07-27 | Schering Corporation | Nucleic acids encoding cytokine synthesis inhibitory factor (interleukin-10) |
WO1991018919A1 (en) * | 1990-05-31 | 1991-12-12 | Schering Corporation | Purification of human interleukin-4 from a secreted escherichia coli mutant |
EP0774259A1 (en) * | 1990-12-07 | 1997-05-21 | Novartis AG | New use of organic compounds |
WO1994004680A1 (en) * | 1992-08-21 | 1994-03-03 | Schering Corporation | Human interleukin-13 |
WO1994008606A1 (en) * | 1992-10-01 | 1994-04-28 | Schering Corporation | Use of il-10 to prevent or treat insulin-dependent diabetes mellitus |
WO1994014950A1 (en) * | 1992-12-28 | 1994-07-07 | Sii Technoresearch, Inc. | Human variant manganese superoxide dismutase |
US5539132A (en) * | 1994-01-24 | 1996-07-23 | Johns Hopkins University | Cerulenin compounds for fatty acid synthesis inhibition |
WO1995020402A1 (en) * | 1994-01-31 | 1995-08-03 | Ludwig Institute For Cancer Research | Antioxidants and intracellular glutathione raising agents for therapeutic treatments |
JPH0812573A (en) * | 1994-06-24 | 1996-01-16 | Mitsubishi Chem Corp | Free fatty acid reducing agent |
WO1996000790A1 (en) * | 1994-06-29 | 1996-01-11 | Rhone-Poulenc Rorer S.A. | Adenovirus including a gene coding for a superoxide dismutase |
JPH08228775A (en) * | 1995-02-28 | 1996-09-10 | Otsuka Pharmaceut Factory Inc | Recombinant retrovirus vector, cell having the same vector transduced thereinto, recombinant retrovirus and t lymphocyte infected with the same virus |
WO1997002004A2 (en) * | 1995-06-30 | 1997-01-23 | Eli Lilly And Company | Methods for treating diabetes |
WO1997047656A1 (en) * | 1996-06-13 | 1997-12-18 | Berk Paul D | Method to modulate the facilitated uptake of free fatty acids into cells by a plasma membrane fatty acid binding protein |
Non-Patent Citations (11)
Title |
---|
ARREAZA G.A. ET AL: "Interleukin-4; Potential Immunoregulatory Agent in Therapy of Insulin-Dependent Diabetes Mellitus", CLIN. IMMUNOTHER., vol. 6, no. 4, 1996, pages 251 - 260, XP002086507 * |
CHEMICAL ABSTRACTS, vol. 125, no. 25, 1996, Columbus, Ohio, US; abstract no. 326040t, TOKUI M. ET AL: "Studies on the Prevention of Diabetes in NOD Mice by Intramuscular Administration of Plasmid Expressing GAD and IL-4" page 1148; XP002086509 * |
DATABASE WPI Section Ch Week 9428, Derwent World Patents Index; Class B04, AN 94-234688, XP002086510 * |
DATABASE WPI Section Ch Week 9612, Derwent World Patents Index; Class B03, AN 96-112633, XP002099923 * |
DATABASE WPI Section Ch Week 9646, Derwent World Patents Index; Class B04, AN 96-459143, XP002086511 * |
DIABETES FRONT., vol. 7, no. 4, 1996, pages 420 * |
HOHMEIER. H.-E. ET AL: "Stable Expression of Manganase Superoxide Dismutase (MnSOD) in Insulinoma Cells Prevents IL-1 beta- induced Cytotoxicity and Reduces Nitric Oxide Production", J. CLIN. INVEST., vol. 101, no. 9, May 1998 (1998-05-01), pages 1811 - 1820, XP002086508 * |
KALDEN J R ET AL: "BIOLOGIC AGENTS IN THE TREATMENT OF INFLAMMATORY RHEUMATIC DISEASES", CURRENT OPINION IN RHEUMATOLOGY, vol. 9, no. 3, May 1997 (1997-05-01), pages 206 - 212, XP002048556 * |
MUZZIN P ET AL: "CORRECTION OF OBESITY AND DIABETES IN GENETICALLY OBESE MICE BY LEPTIN GENE THERAPY", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 93, December 1996 (1996-12-01), pages 14804 - 14808, XP002042615 * |
SHIMABUKURO M. ET AL: "Fatty Acid-Induced Beta Cell Apoptosis: A Link Between Obesity and Diabetes", PROC. NATL. ACAD. SCI. USA, vol. 95, March 1998 (1998-03-01), pages 2498 - 2502, XP002099922 * |
SUTER S.L. ET AL: "Metabolic Effects of New Oral Hypoglycemic AGent CS-405 in NIDDM Subjects", DIABETES CARE, vol. 15, no. 2, 1992, pages 193 - 203, XP002099921 * |
Also Published As
Publication number | Publication date |
---|---|
AU8671798A (en) | 1999-02-22 |
WO1999006059A2 (en) | 1999-02-11 |
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