WO1999005180A1 - Collagen type i and type iii adhesive compositions - Google Patents

Collagen type i and type iii adhesive compositions Download PDF

Info

Publication number
WO1999005180A1
WO1999005180A1 PCT/US1998/015382 US9815382W WO9905180A1 WO 1999005180 A1 WO1999005180 A1 WO 1999005180A1 US 9815382 W US9815382 W US 9815382W WO 9905180 A1 WO9905180 A1 WO 9905180A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
collagen
collagen type
monomers
type iii
Prior art date
Application number
PCT/US1998/015382
Other languages
English (en)
French (fr)
Inventor
Thomas B. Neff
Kari I. Kivirikko
Original Assignee
Fibrogen, Inc.
Academy Of Finland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fibrogen, Inc., Academy Of Finland filed Critical Fibrogen, Inc.
Priority to EP98938008A priority Critical patent/EP1000089A4/en
Priority to IL13424998A priority patent/IL134249A0/xx
Priority to AU86627/98A priority patent/AU8662798A/en
Priority to CA002308146A priority patent/CA2308146A1/en
Priority to JP2000504171A priority patent/JP2001511431A/ja
Publication of WO1999005180A1 publication Critical patent/WO1999005180A1/en
Priority to NO20000425A priority patent/NO20000425L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/102—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • C08L89/04—Products derived from waste materials, e.g. horn, hoof or hair
    • C08L89/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin, e.g. gelatin
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J189/00—Adhesives based on proteins; Adhesives based on derivatives thereof
    • C09J189/04—Products derived from waste materials, e.g. horn, hoof or hair
    • C09J189/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin

Definitions

  • pure recombinant collagen type III refers to human collagen type I manufactured by recombinant techniques which is substantially free from other collagen types. The term excludes collagen type III isolated from natural sources.
  • the recombinant collagen type I and III solution may be subsequently subjected to polymerization or cross-linking conditions to produce the polymerized collagen composition of the present invention.
  • Polymerization may be carried out using irradiation, e.g. , UV, gamma, or fluorescent light.
  • UV irradiation may be accomplished in the short wave length range using a standard 254 nm source or using UV laser sources. With a standard 254 nm source, 4-12 watts, polymerization occurs from 10 to 40 minutes, preferably 20 to 30 minutes, at an exposure distance of from 2.5-10 cm, preferably from 2.5 to 5 cm distance. Excess UV exposure will begin to depolymerize the collagen polymers.
  • the polymerizing agent is preferably UV irradiation.
  • the polymerization or cross-linking of the monomeric substituents can be carried out by simply exposing the material to atmospheric oxygen, although the rate of polymerization is appreciably slower than in the case of UV irradiation or chemical agents.
  • Angioplasty is a more invasive and complicated procedure than angiography, since it requires the insertion of a larger sheath than that used in angiography.
  • the sheath is used as a vehicle for introducing the catheter into the artery.
  • angioplasty also requires the use of blood thinners, such as heparin, to prevent clotting during and after the surgical procedure.
  • the anti-clotting agent prevents the body's natural sealing/clotting mechanism and, thus, sealing punctures requires a significant length of time.
  • an adhesive applicator may optionally be inserted into the sheath and is placed into a position near to or contacting the puncture in the artery.
  • manual or mechanical pressure is applied to the artery to reduce the flow of blood at the puncture site. If possible, excess blood/fluid is removed from the puncture site.
  • recombinant collagen type III and/or type I monomer of the present invention may be applied to the puncture on the external surface of the artery and/or within the puncture track.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Surgery (AREA)
  • Materials For Medical Uses (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Polymerisation Methods In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
PCT/US1998/015382 1997-07-28 1998-07-28 Collagen type i and type iii adhesive compositions WO1999005180A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP98938008A EP1000089A4 (en) 1997-07-28 1998-07-28 ADHESIVE COMPOSITIONS BASED ON TYPE I AND TYPE III COLLAGEN
IL13424998A IL134249A0 (en) 1997-07-28 1998-07-28 Collagen type i and type iii adhesive compositions
AU86627/98A AU8662798A (en) 1997-07-28 1998-07-28 Collagen type i and type iii adhesive compositions
CA002308146A CA2308146A1 (en) 1997-07-28 1998-07-28 Collagen type i and type iii adhesive compositions
JP2000504171A JP2001511431A (ja) 1997-07-28 1998-07-28 Ｉ型およびｉｉｉ型コラーゲン接着剤組成物
NO20000425A NO20000425L (no) 1997-07-28 2000-01-27 Kollagen type I og type III klebrende sammensetninger

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5387297P 1997-07-28 1997-07-28
US60/053,872 1997-07-28

Publications (1)

Publication Number Publication Date
WO1999005180A1 true WO1999005180A1 (en) 1999-02-04

Family

ID=21987121

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/015382 WO1999005180A1 (en) 1997-07-28 1998-07-28 Collagen type i and type iii adhesive compositions

Country Status (8)

Country Link
EP (1) EP1000089A4 (no)
JP (1) JP2001511431A (no)
CN (1) CN1272118A (no)
AU (1) AU8662798A (no)
CA (1) CA2308146A1 (no)
IL (1) IL134249A0 (no)
NO (1) NO20000425L (no)
WO (1) WO1999005180A1 (no)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1105051A1 (en) * 1998-08-10 2001-06-13 Fibrogen, Inc. Collagen type i and type iii hemostatic compositions for use as a vascular sealant and wound dressing
EP1206271A1 (en) * 1999-07-22 2002-05-22 Deroyal Industries, Inc. Composition and method for enhancing wound healing
US11608486B2 (en) 2015-07-02 2023-03-21 Terumo Bct, Inc. Cell growth with mechanical stimuli
US11613727B2 (en) 2010-10-08 2023-03-28 Terumo Bct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US11629332B2 (en) 2017-03-31 2023-04-18 Terumo Bct, Inc. Cell expansion
US11634677B2 (en) 2016-06-07 2023-04-25 Terumo Bct, Inc. Coating a bioreactor in a cell expansion system
US11667876B2 (en) 2013-11-16 2023-06-06 Terumo Bct, Inc. Expanding cells in a bioreactor
US11667881B2 (en) 2014-09-26 2023-06-06 Terumo Bct, Inc. Scheduled feed
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
CN116925240A (zh) * 2023-08-09 2023-10-24 山东多美康生物医药有限公司 一种重组胶原蛋白及其表达方法和应用
US11795432B2 (en) 2014-03-25 2023-10-24 Terumo Bct, Inc. Passive replacement of media
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11999929B2 (en) 2020-04-10 2024-06-04 Terumo Bct, Inc. Methods and systems for coating a cell growth surface

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016507279A (ja) * 2012-12-31 2016-03-10 ファルス，ジョージ，デイヴィッド 大量出血に対する凍結乾燥したフィブリンシーラント
CA3052266A1 (en) * 2017-01-31 2018-08-09 Geniphys, Llc Methods and compositions for matrix preparation
CN109529098A (zh) * 2018-12-03 2019-03-29 广州润虹医药科技股份有限公司 一种外科医用粘合剂

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5219895A (en) * 1991-01-29 1993-06-15 Autogenesis Technologies, Inc. Collagen-based adhesives and sealants and methods of preparation and use thereof
US5618551A (en) * 1994-01-24 1997-04-08 Imedex Biocompatible bioresorbable and non-toxic adhesive composition for surgical use
US5634936A (en) * 1995-02-06 1997-06-03 Scimed Life Systems, Inc. Device for closing a septal defect

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5773577A (en) * 1994-03-03 1998-06-30 Protein Polymer Technologies Products comprising substrates capable of enzymatic cross-linking

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5219895A (en) * 1991-01-29 1993-06-15 Autogenesis Technologies, Inc. Collagen-based adhesives and sealants and methods of preparation and use thereof
US5618551A (en) * 1994-01-24 1997-04-08 Imedex Biocompatible bioresorbable and non-toxic adhesive composition for surgical use
US5634936A (en) * 1995-02-06 1997-06-03 Scimed Life Systems, Inc. Device for closing a septal defect

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1000089A4 *

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1105051A1 (en) * 1998-08-10 2001-06-13 Fibrogen, Inc. Collagen type i and type iii hemostatic compositions for use as a vascular sealant and wound dressing
EP1105051A4 (en) * 1998-08-10 2003-08-06 Fibrogen Inc HEMOSTATIC COMPOSITION BASED ON COLLAGEN I AND II FOR USE AS BLOCKING OF BLOOD TREATS AND AS WUNDAUFLAGE
EP1206271A1 (en) * 1999-07-22 2002-05-22 Deroyal Industries, Inc. Composition and method for enhancing wound healing
EP1206271A4 (en) * 1999-07-22 2003-03-26 Deroyal Ind Inc COMPOSITION AND METHOD FOR IMPROVING WOUND HEALING
US11773363B2 (en) 2010-10-08 2023-10-03 Terumo Bct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US11613727B2 (en) 2010-10-08 2023-03-28 Terumo Bct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US11746319B2 (en) 2010-10-08 2023-09-05 Terumo Bct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US11708554B2 (en) 2013-11-16 2023-07-25 Terumo Bct, Inc. Expanding cells in a bioreactor
US11667876B2 (en) 2013-11-16 2023-06-06 Terumo Bct, Inc. Expanding cells in a bioreactor
US11795432B2 (en) 2014-03-25 2023-10-24 Terumo Bct, Inc. Passive replacement of media
US11667881B2 (en) 2014-09-26 2023-06-06 Terumo Bct, Inc. Scheduled feed
US11608486B2 (en) 2015-07-02 2023-03-21 Terumo Bct, Inc. Cell growth with mechanical stimuli
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11634677B2 (en) 2016-06-07 2023-04-25 Terumo Bct, Inc. Coating a bioreactor in a cell expansion system
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11702634B2 (en) 2017-03-31 2023-07-18 Terumo Bct, Inc. Expanding cells in a bioreactor
US11629332B2 (en) 2017-03-31 2023-04-18 Terumo Bct, Inc. Cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US11999929B2 (en) 2020-04-10 2024-06-04 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
CN116925240A (zh) * 2023-08-09 2023-10-24 山东多美康生物医药有限公司 一种重组胶原蛋白及其表达方法和应用

Also Published As

Publication number Publication date
EP1000089A4 (en) 2001-08-29
NO20000425D0 (no) 2000-01-27
IL134249A0 (en) 2001-04-30
EP1000089A1 (en) 2000-05-17
CN1272118A (zh) 2000-11-01
CA2308146A1 (en) 1999-02-04
NO20000425L (no) 2000-03-23
JP2001511431A (ja) 2001-08-14
AU8662798A (en) 1999-02-16

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