WO1998058965A3 - B7-binding molecules for treating immune diseases - Google Patents

B7-binding molecules for treating immune diseases Download PDF

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Publication number
WO1998058965A3
WO1998058965A3 PCT/EP1998/003791 EP9803791W WO9858965A3 WO 1998058965 A3 WO1998058965 A3 WO 1998058965A3 EP 9803791 W EP9803791 W EP 9803791W WO 9858965 A3 WO9858965 A3 WO 9858965A3
Authority
WO
WIPO (PCT)
Prior art keywords
molecules
antigen
binding molecules
immune diseases
cross
Prior art date
Application number
PCT/EP1998/003791
Other languages
French (fr)
Other versions
WO1998058965A2 (en
Inventor
Katrien Lorre
Erwin Sablon
Marie-Ange Buyse
Alfons Bosman
Original Assignee
Innogenetics Nv
Katrien Lorre
Erwin Sablon
Buyse Marie Ange
Alfons Bosman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innogenetics Nv, Katrien Lorre, Erwin Sablon, Buyse Marie Ange, Alfons Bosman filed Critical Innogenetics Nv
Priority to EP98939523A priority Critical patent/EP0988321A2/en
Priority to AU88005/98A priority patent/AU8800598A/en
Priority to CA002292415A priority patent/CA2292415A1/en
Publication of WO1998058965A2 publication Critical patent/WO1998058965A2/en
Publication of WO1998058965A3 publication Critical patent/WO1998058965A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to molecules, such as diabodies, tri- and tetravalent antibodies and small antigen binding peptides, which can cross-link or cross-react with the costimulatory molecules B7.1 and B7.2 expressed on professional antigen presenting cells (APCs) leading to the inhibition of antigen-specific T cell activation. The present invention also concerns methods to produce these molecules and use of these molecules to treat diseases, such as transplant rejection, graft versus host disease (GVHD), allergy and autoimmune diseases, where antigen-specific T cell activation is pathogenic.
PCT/EP1998/003791 1997-06-20 1998-06-22 B7-binding molecules for treating immune diseases WO1998058965A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP98939523A EP0988321A2 (en) 1997-06-20 1998-06-22 B7-binding molecules for treating immune diseases
AU88005/98A AU8800598A (en) 1997-06-20 1998-06-22 B7-binding molecules for treating immune diseases
CA002292415A CA2292415A1 (en) 1997-06-20 1998-06-22 B7-binding molecules for treating immune diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97870092.0 1997-06-20
EP97870092 1997-06-20

Publications (2)

Publication Number Publication Date
WO1998058965A2 WO1998058965A2 (en) 1998-12-30
WO1998058965A3 true WO1998058965A3 (en) 1999-05-14

Family

ID=8231013

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/003791 WO1998058965A2 (en) 1997-06-20 1998-06-22 B7-binding molecules for treating immune diseases

Country Status (4)

Country Link
EP (1) EP0988321A2 (en)
AU (1) AU8800598A (en)
CA (1) CA2292415A1 (en)
WO (1) WO1998058965A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001068133A1 (en) * 2000-03-14 2001-09-20 Genetics Institute, Inc. Use of rapamycin and agents that inhibit b7 activity in immunomodulation
WO2001068132A1 (en) * 2000-03-14 2001-09-20 Genetics Institute, Inc. Use of a combination of agents that modulate b7 activity in inhibiting intestinal allograft rejection
WO2001068134A2 (en) * 2000-03-14 2001-09-20 Genetics Institute, Inc. Therapies that improve graft survival, using antibodies against a b7 antigen
NZ521540A (en) 2000-04-11 2004-09-24 Genentech Inc Multivalent antibodies and uses therefor
US20030031675A1 (en) 2000-06-06 2003-02-13 Mikesell Glen E. B7-related nucleic acids and polypeptides useful for immunomodulation
US6965018B2 (en) 2000-06-06 2005-11-15 Bristol-Myers Squibb Company Antibodies directed to B7-related polypeptide, BSL-2
US7531168B2 (en) 2001-02-16 2009-05-12 Genetics Institute Llc Method for downmodulating immune response in type I diabetes
US20040236088A1 (en) * 2001-08-02 2004-11-25 Heuer Josef Georg Novel polypeptide analogs and fusions and their methods of use
US20060002935A1 (en) 2002-06-28 2006-01-05 Domantis Limited Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
EA012622B1 (en) 2004-06-01 2009-10-30 Домэнтис Лимитед Bispecific fusion antibodies with enhanced serum half-life
US7563443B2 (en) 2004-09-17 2009-07-21 Domantis Limited Monovalent anti-CD40L antibody polypeptides and compositions thereof
CN101724071A (en) 2004-10-08 2010-06-09 杜门蒂斯有限公司 Single domain antibodies against TNFRl and methods of use therefor
NZ555464A (en) 2004-12-02 2010-03-26 Domantis Ltd Bispecific domain antibodies targeting serum albumin and glp-1 or pyy
GB0621513D0 (en) 2006-10-30 2006-12-06 Domantis Ltd Novel polypeptides and uses thereof
WO2010009391A1 (en) 2008-07-18 2010-01-21 Bristol-Myers Squibb Company Compositions monovalent for cd28 binding and methods of use
MX338825B (en) 2008-10-02 2016-05-03 Emergent Product Dev Seattle Cd86 antagonist multi-target binding proteins.
WO2014120916A1 (en) 2013-02-01 2014-08-07 Bristol-Myers Squibb Company Pegylated domain antibodies monovalent for cd28 binding and methods of use
IL254335B2 (en) * 2015-03-16 2023-04-01 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Isolated peptides derived from the b7 ligand dimer interface and uses thereof
JP6936221B2 (en) 2015-11-02 2021-09-15 ファイブ プライム セラピューティクス， インコーポレイテッド CD80 extracellular domain polypeptides and their use in cancer treatment
EP3628070B1 (en) 2017-04-28 2021-09-08 Five Prime Therapeutics, Inc. Cd80 extracellular domain polypeptides for use in increasing central memory t cells
CN110305220B (en) * 2018-03-27 2022-10-11 孙嘉琳 Cancer-targeted enhanced anti-tumor fusion protein and preparation method and application thereof
CN110305221B (en) * 2018-03-27 2022-10-11 孙嘉琳 Enhanced anti-tumor fusion protein, preparation method and application

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995022619A1 (en) * 1994-02-18 1995-08-24 Chiron Corporation B7-1-specific ligands, and their use for the induction of t cell anergy
WO1996014865A1 (en) * 1994-11-10 1996-05-23 Repligen Corporation Methods for inhibiting graft versus host disease in bone marrow transplantation
WO1996040878A1 (en) * 1995-06-07 1996-12-19 Idec Pharmaceuticals Corporation Monkey monoclonal antibodies specific to human b7.1 and/or b7.2 primatized forms, pharmaceutical compositions
WO1998003670A1 (en) * 1996-07-23 1998-01-29 Tanox Pharma B.V. Induction of t cell tolerance using a soluble molecule that can simultaneously block two costimulatory pathways

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995022619A1 (en) * 1994-02-18 1995-08-24 Chiron Corporation B7-1-specific ligands, and their use for the induction of t cell anergy
WO1996014865A1 (en) * 1994-11-10 1996-05-23 Repligen Corporation Methods for inhibiting graft versus host disease in bone marrow transplantation
WO1996040878A1 (en) * 1995-06-07 1996-12-19 Idec Pharmaceuticals Corporation Monkey monoclonal antibodies specific to human b7.1 and/or b7.2 primatized forms, pharmaceutical compositions
WO1998003670A1 (en) * 1996-07-23 1998-01-29 Tanox Pharma B.V. Induction of t cell tolerance using a soluble molecule that can simultaneously block two costimulatory pathways

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
P. ILIADES ET AL.: "Triabodies: single chain Fv fragments without a linker form trivalent trimers.", FEBS LETTERS, vol. 409, no. 3, 16 June 1997 (1997-06-16), AMSTERDAM, NL, pages 437 - 441, XP002047810 *
P. PERRIN ET AL.: "Distinct requirements of lymph node T cells for B7-1 (CD80) and B7-2 (CD86) costimulation in response to concanavalin A.", THE FASEB JOURNAL, vol. 10, no. 6, 30 April 1996 (1996-04-30), BETHESDA, MD, USA, pages A1454, XP002047809 *
P. PERRIN ET AL.: "Mitogenic stimulation of T cells reveals differing contributions for B7-1 (CD80) and B7-2 (CD86) costimulation.", IMMUNOLOGY, vol. 90, no. 4, April 1997 (1997-04-01), OXFORD, GB, pages 534 - 542, XP002047808 *

Also Published As

Publication number Publication date
AU8800598A (en) 1999-01-04
EP0988321A2 (en) 2000-03-29
CA2292415A1 (en) 1998-12-30
WO1998058965A2 (en) 1998-12-30

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