WO1998057980A1 - Peptides et composes se liant au recepteur de l'interleukine - Google Patents

Peptides et composes se liant au recepteur de l'interleukine Download PDF

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Publication number
WO1998057980A1
WO1998057980A1 PCT/GB1997/001618 GB9701618W WO9857980A1 WO 1998057980 A1 WO1998057980 A1 WO 1998057980A1 GB 9701618 W GB9701618 W GB 9701618W WO 9857980 A1 WO9857980 A1 WO 9857980A1
Authority
WO
WIPO (PCT)
Prior art keywords
seq
peptide
compound
group
xaa
Prior art date
Application number
PCT/GB1997/001618
Other languages
English (en)
Inventor
Ronald William Barrett
Bruce Padon England
Peter Joseph Schatz
Derek Dean Sloan
Min-Jia Chen
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Priority to EP97930613A priority Critical patent/EP0991659A1/fr
Priority to NZ501664A priority patent/NZ501664A/xx
Priority to PCT/GB1997/001618 priority patent/WO1998057980A1/fr
Priority to AU34497/97A priority patent/AU753958B2/en
Priority to JP50391999A priority patent/JP2002512631A/ja
Priority to CA002294519A priority patent/CA2294519A1/fr
Publication of WO1998057980A1 publication Critical patent/WO1998057980A1/fr
Priority to NO996209A priority patent/NO996209L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Rheumatology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des peptides et des mimétiques des peptides qui se lient au récepteur de l'interleukine 5. Ces peptides et ces mimétiques des peptides sont utiles pour traiter des troubles, tels que l'asthme, qui impliquent une mauvaise production de l'interleukine 5 ou une mauvaise réponse à l'interleukine 5 ainsi qu'une accumulation d'éosinophiles. Ces peptides et ces mimétiques présentent également une grande utilité dans des procédés de diagnostique utilisant des peptides marqués et des mimétiques de peptides.
PCT/GB1997/001618 1997-06-16 1997-06-16 Peptides et composes se liant au recepteur de l'interleukine WO1998057980A1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP97930613A EP0991659A1 (fr) 1997-06-16 1997-06-16 Peptides et composes se liant au recepteur de l'interleukine
NZ501664A NZ501664A (en) 1997-06-16 1997-06-16 Peptides and peptide mimetics that bind to the IL-5 receptor
PCT/GB1997/001618 WO1998057980A1 (fr) 1997-06-16 1997-06-16 Peptides et composes se liant au recepteur de l'interleukine
AU34497/97A AU753958B2 (en) 1997-06-16 1997-06-16 Peptides and compounds that bind to the IL-5 receptor
JP50391999A JP2002512631A (ja) 1997-06-16 1997-06-16 Ｉｌ−５受容体に結合するペプチドおよび化合物
CA002294519A CA2294519A1 (fr) 1997-06-16 1997-06-16 Peptides et composes se liant au recepteur de l'interleukine
NO996209A NO996209L (no) 1997-06-16 1999-12-15 Peptider og forbindelser som bindes til IL-5 reseptoren

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GB1997/001618 WO1998057980A1 (fr) 1997-06-16 1997-06-16 Peptides et composes se liant au recepteur de l'interleukine

Publications (1)

Publication Number Publication Date
WO1998057980A1 true WO1998057980A1 (fr) 1998-12-23

Family

ID=10806631

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1997/001618 WO1998057980A1 (fr) 1997-06-16 1997-06-16 Peptides et composes se liant au recepteur de l'interleukine

Country Status (5)

Country Link
EP (1) EP0991659A1 (fr)
JP (1) JP2002512631A (fr)
AU (1) AU753958B2 (fr)
CA (1) CA2294519A1 (fr)
WO (1) WO1998057980A1 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5096704A (en) * 1988-11-03 1992-03-17 Schering Corporation Method of treating eosinophilia

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5096704A (en) * 1988-11-03 1992-03-17 Schering Corporation Method of treating eosinophilia

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MINAMITAKE Y ET AL: "STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN 5 PRODUCED BY CHINESE HAMSTER OVARY CELLS", JOURNAL OF BIOCHEMISTRY, vol. 107, no. 2, 1 February 1990 (1990-02-01), pages 292 - 297, XP000115444 *
R. DEVOS ET AL.: "Interleukin-5 and its receptor: a drug target for eosinophilia associated with chronic allergic disease", J. LEUKOCYTE BIOL., vol. 57, June 1995 (1995-06-01), pages 813 - 819, XP002056891 *

Also Published As

Publication number Publication date
AU753958B2 (en) 2002-10-31
EP0991659A1 (fr) 2000-04-12
CA2294519A1 (fr) 1998-12-23
AU3449797A (en) 1999-01-04
JP2002512631A (ja) 2002-04-23

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