WO1998057153A1 - Fluorometre a semi-conducteurs et ses procedes d'utilisation - Google Patents

Fluorometre a semi-conducteurs et ses procedes d'utilisation Download PDF

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Publication number
WO1998057153A1
WO1998057153A1 PCT/US1998/012054 US9812054W WO9857153A1 WO 1998057153 A1 WO1998057153 A1 WO 1998057153A1 US 9812054 W US9812054 W US 9812054W WO 9857153 A1 WO9857153 A1 WO 9857153A1
Authority
WO
WIPO (PCT)
Prior art keywords
fluorometer
sample
fluorescence
chemical treatment
additive
Prior art date
Application number
PCT/US1998/012054
Other languages
English (en)
Inventor
Joseph C. Alfano
Michael J. Fehr
Martin R. Godfrey
John E. Hoots
Kevin J. Moeggenborg
Narasimha M. Rao
Jeffrey P. Rasimas
Karen R. Tubergen
James E. Whitten
Original Assignee
Nalco Chemical Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nalco Chemical Company filed Critical Nalco Chemical Company
Priority to EP98928987A priority Critical patent/EP0988524A1/fr
Priority to AU80657/98A priority patent/AU737221B2/en
Priority to KR1019997011694A priority patent/KR100707512B1/ko
Priority to JP50316899A priority patent/JP2002514308A/ja
Publication of WO1998057153A1 publication Critical patent/WO1998057153A1/fr
Priority to HK00106687A priority patent/HK1027624A1/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N21/643—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" non-biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

L'invention concerne la représentation en images (éventuellement avec une lentille) de la fluorescence provenant d'une diode laser (12) ou d'une source d'excitation de diode électroluminescente (112) sur un détecteur à photodiodes au silicium (16, 116). Un filtre optique (18, 118) est placé entre la cellule échantillon (20, 120) et le détecteur à photodiodes pour renvoyer une lumière d'excitation diffusée. La sortie de la photodiode est amplifiée (22, 122) pour produire une tension de sortie proportionnelle à la quantité de fluorescence touchant le détecteur à photodiodes. Puisque la fluorescence est proportionnelle à la concentration de fluorophore présente dans le flux échantillon, et que la concentration de fluorophore est elle-même proportionnelle à la concentration d'un agent de traitement chimique ou d'un autre additif présent, on peut effectuer une surveillance continue de la sortie en tension, ce qui permet d'obtenir une mesure en temps réel de la quantité d'agent de traitement chimique ou d'un autre additif présent dans le système.
PCT/US1998/012054 1997-06-11 1998-06-09 Fluorometre a semi-conducteurs et ses procedes d'utilisation WO1998057153A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP98928987A EP0988524A1 (fr) 1997-06-11 1998-06-09 Fluorometre a semi-conducteurs et ses procedes d'utilisation
AU80657/98A AU737221B2 (en) 1997-06-11 1998-06-09 Solid-state fluorometer and methods of use therefor
KR1019997011694A KR100707512B1 (ko) 1997-06-11 1998-06-09 고체상 형광계 및 그 사용방법
JP50316899A JP2002514308A (ja) 1997-06-11 1998-06-09 半導体蛍光光度計およびその使用方法
HK00106687A HK1027624A1 (en) 1997-06-11 2000-10-23 Solid-state fluorometer and methods of use therefor.

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US87304697A 1997-06-11 1997-06-11
US08/873,046 1997-06-11
US87745297A 1997-06-17 1997-06-17
US08/877,452 1997-06-17
US8746698A 1998-05-28 1998-05-28
US09/087,466 1998-05-28

Publications (1)

Publication Number Publication Date
WO1998057153A1 true WO1998057153A1 (fr) 1998-12-17

Family

ID=27375685

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/012054 WO1998057153A1 (fr) 1997-06-11 1998-06-09 Fluorometre a semi-conducteurs et ses procedes d'utilisation

Country Status (10)

Country Link
EP (2) EP0988524A1 (fr)
JP (1) JP2002514308A (fr)
KR (1) KR100707512B1 (fr)
CN (1) CN1183382C (fr)
AU (1) AU737221B2 (fr)
ES (1) ES2403051T3 (fr)
HK (1) HK1027624A1 (fr)
MY (1) MY132154A (fr)
PT (1) PT1496351E (fr)
WO (1) WO1998057153A1 (fr)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2151857A1 (es) * 1999-03-23 2001-01-01 Univ Madrid Autonoma Equipo para la deteccion de alimentos que han sido expuestos a radiacion ionizante para su esterilizacion.
WO2001029539A1 (fr) * 1999-10-20 2001-04-26 Massachusetts Institute Of Technology Systemes et procedes destines a l'analyse par fluorescence de melanges
JP2002535025A (ja) * 1999-01-26 2002-10-22 ニユートン・ラボラトリーズ・インコーポレーテツド 内視鏡用の自己蛍光画像化システム
JP2002541443A (ja) * 1999-04-07 2002-12-03 エム・ブイ・リサーチ・リミテッド 材料検査
EP1284935A1 (fr) * 2000-05-01 2003-02-26 Ondeo Nalco Company Utilisation d'une matrice de controle pour commander des systemes de refroidissement a eau
EP1284929A1 (fr) * 2000-05-01 2003-02-26 Ondeo Nalco Company Regulation automatique des cycles de systemes d'eau de refroidissement
GB2403800B (en) * 2001-12-31 2006-06-07 Brasscorp Ltd LED inspection lamp and LED spot light
EP1794575A1 (fr) * 2004-09-28 2007-06-13 Glaxo Group Limited Appareil et procede de detection de luminescence
US7277168B2 (en) 2000-08-29 2007-10-02 Smithkline Beecham Corporation Method and system for real-time fluorescent determination of trace elements
EP1877757A2 (fr) * 2005-05-02 2008-01-16 Nalco Company Procede d'utilisation d'un fluorometre entierement transistorise dans la surveillance et le controle des substances chimiques presentes dans de l'eau
WO2008043541A2 (fr) * 2006-10-12 2008-04-17 Eppendorf Ag Appareil et procédé pour l'analyse quantitative en temps réel d'échantillons fluorescents
EP2081830A2 (fr) * 2006-09-29 2009-07-29 Glaxo Group Limited Procédé et système destinés à une analyse de spectroscopie de luminescence à phase rapide
JP2011047949A (ja) * 2001-06-28 2011-03-10 Nalco Co 鏡映蛍光光度計
JP2011206546A (ja) * 1999-01-26 2011-10-20 Newton Lab Inc 内視鏡用の自己蛍光画像化システム
US8374802B2 (en) 2007-08-29 2013-02-12 Eppendorf Ag Device and method for radiometric measurement of a plurality of samples
US10558512B2 (en) 2013-02-08 2020-02-11 Xylem Ip Holdings Llc Ballast water tank recirculation treatment system

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RU2007145437A (ru) * 2005-05-10 2009-06-20 Коммонвелт Сайентифик энд Индастриал Рисерч Организейшн (AU) Высокоразрешающее отслеживание материалов производственного процесса с использованием микровнедрений люминесцентных меток
FR2899088B1 (fr) * 2006-03-31 2008-06-27 Mauna Kea Technologies Soc Par "microscopie de fluorescence fibree a base de bleu de methylene."
KR101422467B1 (ko) 2007-02-08 2014-07-24 삼성전자주식회사 미세유체 칩 내의 형광을 검출하기 위한 시스템 및 형광검출 방법
CN101975779B (zh) * 2010-09-07 2012-07-04 河南电力试验研究院 一种基于测定溶液pH值快速评定反渗透阻垢剂性能的方法
JP6143224B2 (ja) * 2013-05-13 2017-06-07 株式会社高井戸第二発動機 流体の流れの計測方法
EP3055677B1 (fr) * 2013-10-11 2019-03-06 Headwaters Incorporated Procédés et dispositif permettant de déterminer la capacité d'adsorption d'agents entraîneurs d'air
US20150125899A1 (en) * 2013-11-07 2015-05-07 Rebecca Willits Fluorescence-assisted counting apparatus for qualitative and/or quantitative measurement of fluorescently tagged particles
JP6567549B2 (ja) 2014-04-30 2019-08-28 インストゥルメンテーション ラボラトリー カンパニー 光学検出によるポイントオブケア凝固アッセイのための方法及びシステム
CN104833820A (zh) * 2015-05-08 2015-08-12 华中科技大学 一种基于荧光示踪技术的流速测量系统及方法
CN106124382B (zh) * 2016-07-01 2019-06-25 东华大学 一种多孔介质滤床悬浮颗粒物堵塞形态可视化分析系统
JP2018146539A (ja) * 2017-03-09 2018-09-20 東亜ディーケーケー株式会社 多波長蛍光分析装置
EP3687689A4 (fr) * 2017-09-28 2021-06-23 The Board of Trustees of the University of Illinois Instrument de biodétection mobile capable de multiples modalités de détection
JP2020003215A (ja) 2018-06-25 2020-01-09 新光電気工業株式会社 フローセル
CN109133388A (zh) * 2018-09-28 2019-01-04 南通善水化工科技发展有限公司 一种开式冷却水系统用复合水处理稳定剂及其制备方法
CN109374589B (zh) * 2018-11-26 2021-08-10 浙江海洋大学 一种采用荧光示踪剂的危险气体监测装置
CN110243785A (zh) * 2019-06-26 2019-09-17 江阴芗菲服饰有限公司 一种浆液浓度变化的在线检测方法

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US5008891A (en) * 1989-04-11 1991-04-16 Matsushita Electric Industrial Co., Ltd. Semiconductor light-emitting devices
US5171450A (en) * 1991-03-20 1992-12-15 Nalco Chemical Company Monitoring and dosage control of tagged polymers in cooling water systems
US5411889A (en) * 1994-02-14 1995-05-02 Nalco Chemical Company Regulating water treatment agent dosage based on operational system stresses

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CA2048302A1 (fr) * 1990-08-15 1992-02-16 Victoria P. Meucci Reactif de solubilisation des echantillons dans des epreuves biologiques
EP0533333A3 (en) * 1991-09-19 1993-07-28 Texaco Development Corporation Optical photometry system
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JP3011855B2 (ja) * 1994-06-23 2000-02-21 キヤノン株式会社 塩化物イオンの蛍光分析方法、及びそれに用いる塩化物イオン濃度測定用担体
JP3004558B2 (ja) * 1995-01-23 2000-01-31 株式会社東邦計測研究所 水質測定装置
EP0736767A1 (fr) * 1995-04-07 1996-10-09 Ciba-Geigy Ag Dispositif de détection optique pour des mesures analytiques de substances chimiques

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
US4992380A (en) * 1988-10-14 1991-02-12 Nalco Chemical Company Continuous on-stream monitoring of cooling tower water
US5008891A (en) * 1989-04-11 1991-04-16 Matsushita Electric Industrial Co., Ltd. Semiconductor light-emitting devices
US5171450A (en) * 1991-03-20 1992-12-15 Nalco Chemical Company Monitoring and dosage control of tagged polymers in cooling water systems
US5411889A (en) * 1994-02-14 1995-05-02 Nalco Chemical Company Regulating water treatment agent dosage based on operational system stresses

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HAUSER P C ET AL: "A SOLID-STATE INSTRUMENT FOR FLUORESCENCE CHEMICAL SENSORS USING A BLUE LIGHT-EMITTING DIODE OF HIGH INTENSITY", MEASUREMENT SCIENCE AND TECHNOLOGY, vol. 6, no. 8, 1 August 1995 (1995-08-01), pages 1081 - 1085, XP000525059 *

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002535025A (ja) * 1999-01-26 2002-10-22 ニユートン・ラボラトリーズ・インコーポレーテツド 内視鏡用の自己蛍光画像化システム
JP2011206546A (ja) * 1999-01-26 2011-10-20 Newton Lab Inc 内視鏡用の自己蛍光画像化システム
ES2151857A1 (es) * 1999-03-23 2001-01-01 Univ Madrid Autonoma Equipo para la deteccion de alimentos que han sido expuestos a radiacion ionizante para su esterilizacion.
JP2002541443A (ja) * 1999-04-07 2002-12-03 エム・ブイ・リサーチ・リミテッド 材料検査
US6791688B2 (en) 1999-10-20 2004-09-14 Massachusetts Institute Of Technology Systems and methods for analyzing mixtures using fluorescense
WO2001029539A1 (fr) * 1999-10-20 2001-04-26 Massachusetts Institute Of Technology Systemes et procedes destines a l'analyse par fluorescence de melanges
EP1284929A4 (fr) * 2000-05-01 2004-08-18 Ondeo Nalco Co Regulation automatique des cycles de systemes d'eau de refroidissement
EP1284935A4 (fr) * 2000-05-01 2004-08-18 Ondeo Nalco Co Utilisation d'une matrice de controle pour commander des systemes de refroidissement a eau
EP1284929A1 (fr) * 2000-05-01 2003-02-26 Ondeo Nalco Company Regulation automatique des cycles de systemes d'eau de refroidissement
EP1284935A1 (fr) * 2000-05-01 2003-02-26 Ondeo Nalco Company Utilisation d'une matrice de controle pour commander des systemes de refroidissement a eau
US7456952B2 (en) 2000-08-29 2008-11-25 Smithkline Beecham Corporation System for real-time fluorescent determination of trace elements
US7277168B2 (en) 2000-08-29 2007-10-02 Smithkline Beecham Corporation Method and system for real-time fluorescent determination of trace elements
JP2011047949A (ja) * 2001-06-28 2011-03-10 Nalco Co 鏡映蛍光光度計
GB2403800B (en) * 2001-12-31 2006-06-07 Brasscorp Ltd LED inspection lamp and LED spot light
EP1794575A4 (fr) * 2004-09-28 2011-06-22 Glaxo Group Ltd Appareil et procede de detection de luminescence
EP1794575A1 (fr) * 2004-09-28 2007-06-13 Glaxo Group Limited Appareil et procede de detection de luminescence
EP1877757A2 (fr) * 2005-05-02 2008-01-16 Nalco Company Procede d'utilisation d'un fluorometre entierement transistorise dans la surveillance et le controle des substances chimiques presentes dans de l'eau
EP1877757A4 (fr) * 2005-05-02 2014-03-26 Nalco Co Procede d'utilisation d'un fluorometre entierement transistorise dans la surveillance et le controle des substances chimiques presentes dans de l'eau
EP2081830A2 (fr) * 2006-09-29 2009-07-29 Glaxo Group Limited Procédé et système destinés à une analyse de spectroscopie de luminescence à phase rapide
EP2081830A4 (fr) * 2006-09-29 2012-05-02 Glaxo Group Ltd Procédé et système destinés à une analyse de spectroscopie de luminescence à phase rapide
WO2008043541A3 (fr) * 2006-10-12 2008-08-14 Eppendorf Ag Appareil et procédé pour l'analyse quantitative en temps réel d'échantillons fluorescents
WO2008043541A2 (fr) * 2006-10-12 2008-04-17 Eppendorf Ag Appareil et procédé pour l'analyse quantitative en temps réel d'échantillons fluorescents
US8674325B2 (en) 2006-10-12 2014-03-18 Eppendorf Ag Method and device for the quantitative real time analysis of fluorescent samples
US8374802B2 (en) 2007-08-29 2013-02-12 Eppendorf Ag Device and method for radiometric measurement of a plurality of samples
US10558512B2 (en) 2013-02-08 2020-02-11 Xylem Ip Holdings Llc Ballast water tank recirculation treatment system

Also Published As

Publication number Publication date
JP2002514308A (ja) 2002-05-14
PT1496351E (pt) 2013-04-23
CN1260043A (zh) 2000-07-12
MY132154A (en) 2007-09-28
KR20010013682A (ko) 2001-02-26
AU8065798A (en) 1998-12-30
HK1027624A1 (en) 2001-01-19
KR100707512B1 (ko) 2007-04-16
EP1496351B1 (fr) 2013-03-27
CN1183382C (zh) 2005-01-05
ES2403051T3 (es) 2013-05-13
EP0988524A1 (fr) 2000-03-29
EP1496351A3 (fr) 2006-03-15
AU737221B2 (en) 2001-08-16
EP1496351A2 (fr) 2005-01-12

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