WO1998056395A1 - Antibiotique naturel a large spectre - Google Patents

Antibiotique naturel a large spectre Download PDF

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Publication number
WO1998056395A1
WO1998056395A1 PCT/IT1997/000133 IT9700133W WO9856395A1 WO 1998056395 A1 WO1998056395 A1 WO 1998056395A1 IT 9700133 W IT9700133 W IT 9700133W WO 9856395 A1 WO9856395 A1 WO 9856395A1
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WO
WIPO (PCT)
Prior art keywords
antibiotic
essential oil
oil
tea tree
weight
Prior art date
Application number
PCT/IT1997/000133
Other languages
English (en)
Inventor
Antonio Sacchetti
Original Assignee
Antonio Sacchetti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antonio Sacchetti filed Critical Antonio Sacchetti
Priority to AU32725/97A priority Critical patent/AU3272597A/en
Priority to PCT/IT1997/000133 priority patent/WO1998056395A1/fr
Publication of WO1998056395A1 publication Critical patent/WO1998056395A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus

Definitions

  • the present invention relates to a natural broad- spectrum antibiotic consisting of the combination of two essential oils of vegetal origin, the antibacterial activity of which is synergically enhanced.
  • Said natural antibiotic is particularly active against both gram-positive and gram-negative bacteria as well as against Candida which is, as known, antibiotic-fas , some antibiotics even assisting the growth of the latter.
  • Still another disadvantage is that such antibiotics, actually being synthesis molecules and then as such foreign and unknown to our biological system (real chemotherapeutic agents) , are considered as foreign molecules so that the defence mechanisms react against them producing the phenomenon of the concurrent reactions (undesired effects in humans) and cause bacteria to be antibiotic-fast.
  • the present invention seeks to provide an antibiotic which unlike the present antibiotics is of quite natural origin and essentially non-toxic, does not produce concurrent reactions, has a broad spectrum and is active against both gram-positive and gram-negative bacteria as well as mycetes and Candida Albicans .
  • the inventor directed his investigations towards the superior vegetal world searching the solution of the above-mentioned problems by combining substances of certain natural origin, the efficacy of which has never changed .
  • the antibacterial action has not only been considered as a simple activity directed to struggle against bacteria but a rather complex, well-balanced activity resulting from multiform synergism aiming at changing microclimate, metabolic exchanges, permeability of the cell walls, and diffusibility of the active principle. In view of this the volatile fractions have nearly always proved to be most active.
  • composition of volatile active fractions which is capable of performing complex, coordinated, well-balanced actions and is formed of two essential oils, i.e. Tea Tree Oil or Essential Oil of Malaleuca Altemifolia and Essential Oil of Thyme in which a synergism has been surprisingly detected in a determined range:
  • the essential oil of thyme is known as a mild antiseptic because of the substantial presence of phenols such as thymol which finds medical applications as vermicide and enteral antiseptic and disinfectant as well as antiseptic and disinfectant of sores, wounds and skin disease.
  • the activity of Tea Tree Oil towards mycosis is likewise known.
  • the activity of the specific mixture has been proved to be clearly higher than the sum of the single components.
  • the broad spectrum shows that the performed actions are very much and very complex: of course, a contribution is given by the fact that the described antibiotic includes not only components having specific antibacterial activity but also other components of the essential fraction which act synergically and in extremely positive manner even if the action mechanisms are not exactly known.
  • a first advantage of the natural antibiotic according to the invention is that because of its volatility it does not feel the effects of the barriers (epithelia) that the body raises for its defence, this being to its action rate advantage.
  • Another advantage is that it is an apolar, non-ionized composition and then hardly inactivated by the organic matter.
  • a further advantage is that said antibiotic is active for a long time and its action rate is very high.
  • antibiotic may be applied both externally and internally, and the metabolic ways of elimination are the usual ways for the food as such antibiotic is a foodstuff which is non-toxic in the recommended doses and can be easily eliminated.
  • a further advantage is that the antibiotic does not give accumulation phenomenons . Still another advantage is that it has the minimum toxicity and then can be prescribed by the doctor with more confidence in all of the cases in which the affection is not acclaimed. For example, a dentist does not resort to antibiotics except in case of absolute necessity and does not prescribe them on the first swelling or the first abscess signs. However, the latency period brings to an acclaimed infection because of the lack of treatment.
  • the antibiotic of the present invention can be used immediately to struggle against bacteria because it is effective without being toxic and does not cause any other trouble such as the antibiotic-fastness.
  • the advantages for the patient are enormous because the prevention of an infection entails the elimination of many after-effects such as pain, swelling, etc.
  • Another advantage is that no medical prescription is needed for buying such antibiotic and then its diffusion is not limited.
  • the natural composition of the present invention as illustrated thereafter by microbiological tests and photos, has a broad spectrum including also mycetes, which are even more diffused forms very hard to fight by the usual antibiotics.
  • the tested product having the best effectiveness/concentration ratio has the following composition:
  • the concentration of Eucalyptus essential oil ranges from 10% to 50% by weight.
  • the tested antibiotic is a mixture of 2 essential oils, i.e. Tea Tree Oil and Thyme Essential Oil in the amount of 70% and 30%, respectively.
  • Tea Tree Oil and Thyme Essential Oil in the amount of 70% and 30%, respectively.
  • Such mixture was put in contact with different cultures of gram-positive and gram-negative bacteria and Candida Albicans ; the same cultures have been tested with the single natural substances in order to prove the synergical effect of the mixture.
  • TSA Teryptic Soy Agar
  • Staphylococcus Aureus for the test with gram-positive bacteria
  • TSA Teryptic Soy Agar
  • antibiotics used for antibiogram are specific for enterobacteria.
  • the antibiotic of the present invention formed of the combination of Tea Tree Oil and Thyme Essential Oil, has an optimum synergism with respect to the single Tea Tree Oil and Thyme Essential Oil.
  • the new antibiotic shows a very effective action also against Candida which is, as known, antibiotic- fast, some antibiotics even assisting the growth of the latter. It is self-evident from the foregoing that the antibiotic of the present invention can be used alone in a number of compositions for therapeutic use under the form of capsule, tablet, powder, cream, ointment, lotion, paste, solution, syrup, etc.. A variety of ingredients well known in the art may be used in such compositions to achieve the desired characteristics. Therefore, it should be understood that the present invention can be accomplished in a different manner from that specifically described without departing from the scope of the annexed claims .

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention concerne un antibiotique naturel à large spectre constitué par un mélange d'huile essentielle de Malaleuca Alternifolia (huile de théier) et d'huile essentielle de thym selon un rapport respectif de 50-90 % et de 50-10 % en poids.
PCT/IT1997/000133 1997-06-12 1997-06-12 Antibiotique naturel a large spectre WO1998056395A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU32725/97A AU3272597A (en) 1997-06-12 1997-06-12 Natural broad-spectrum antibiotic
PCT/IT1997/000133 WO1998056395A1 (fr) 1997-06-12 1997-06-12 Antibiotique naturel a large spectre

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IT1997/000133 WO1998056395A1 (fr) 1997-06-12 1997-06-12 Antibiotique naturel a large spectre

Publications (1)

Publication Number Publication Date
WO1998056395A1 true WO1998056395A1 (fr) 1998-12-17

Family

ID=11332720

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT1997/000133 WO1998056395A1 (fr) 1997-06-12 1997-06-12 Antibiotique naturel a large spectre

Country Status (2)

Country Link
AU (1) AU3272597A (fr)
WO (1) WO1998056395A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999066796A1 (fr) * 1998-06-22 1999-12-29 Wisconsin Alumni Research Foundation Procede pour sensibiliser des cellules microbiennes vis-a-vis de composes antimicrobiens
US8337923B2 (en) 2003-08-22 2012-12-25 Dupont Nutrition Biosciences Aps Encapsulated antimicrobial material
WO2013069890A1 (fr) * 2011-11-09 2013-05-16 Woongjin Coway Co., Ltd Antimicrobiens naturels et article les comprenant
US10271557B2 (en) 2003-08-22 2019-04-30 Dupont Nutrition Biosciences Aps Composition comprising a bacteriocin and an extract from a plant of the Labiatae family
CN115554335A (zh) * 2022-03-29 2023-01-03 广州果熊生物科技有限公司 一种母婴用防护精油及制备使用方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2706770A1 (en) * 1993-06-21 1994-12-30 Pelletier Jacques Formula for the treatment of tuberculosis.
JPH0859453A (ja) * 1994-08-26 1996-03-05 Kanebo Ltd 皮膚化粧料

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2706770A1 (en) * 1993-06-21 1994-12-30 Pelletier Jacques Formula for the treatment of tuberculosis.
JPH0859453A (ja) * 1994-08-26 1996-03-05 Kanebo Ltd 皮膚化粧料

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
A.M. JANSSEN ET AL.: "SCREENING OF SOME ESSENTIAL OILS FOR THEIR ACTIVITIES ON DERMATOPHYTES", PHARMACEUTISCH WEEKBLAD SCIENTIFIC EDITION, vol. 10, 1988, pages 277 - 280, XP002055776 *
MARIA LIS-BALCHIN ET AL.: "BIOACTIVITY OF NEW ZEALAND MEDICINAL PLANT ESSENTIAL OILS.", ACTA HORTICULTURAE, no. 426, 1996, pages 13 - 30, XP002055778 *
PATENT ABSTRACTS OF JAPAN vol. 096, no. 007 31 July 1996 (1996-07-31) *
RAMANOELINA A.R.P. ET AL.: "CONTRIBUTION A L'ETUDE DE L'ACTION ANTIBACTERIENNE DE QUELQUES HUILES ESSENTIELLES EXTRAITES DE PLANTES MALGACHES.", ARCHIVES DE L'INSTITUT PASTEUR DE MADAGASCAR, vol. 53, no. 1, 1987, pages 217 - 226, XP002055775 *
S.M. HUSSEIN AYOUB: "ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF SOME LIBYAN AROMATIC PLANTS.", PLANTA MEDICA, vol. 56, no. 6, December 1990 (1990-12-01), pages 644 - 645, XP002055777 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999066796A1 (fr) * 1998-06-22 1999-12-29 Wisconsin Alumni Research Foundation Procede pour sensibiliser des cellules microbiennes vis-a-vis de composes antimicrobiens
US6319958B1 (en) 1998-06-22 2001-11-20 Wisconsin Alumni Research Foundation Method of sensitizing microbial cells to antimicrobial compound
US8337923B2 (en) 2003-08-22 2012-12-25 Dupont Nutrition Biosciences Aps Encapsulated antimicrobial material
US10271557B2 (en) 2003-08-22 2019-04-30 Dupont Nutrition Biosciences Aps Composition comprising a bacteriocin and an extract from a plant of the Labiatae family
WO2013069890A1 (fr) * 2011-11-09 2013-05-16 Woongjin Coway Co., Ltd Antimicrobiens naturels et article les comprenant
US9968100B2 (en) 2011-11-09 2018-05-15 Coway Co., Ltd Natural antimicrobials and article comprising the same
CN115554335A (zh) * 2022-03-29 2023-01-03 广州果熊生物科技有限公司 一种母婴用防护精油及制备使用方法
CN115554335B (zh) * 2022-03-29 2023-11-21 广州果熊生物科技有限公司 一种防护精油及制备方法

Also Published As

Publication number Publication date
AU3272597A (en) 1998-12-30

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