WO1998054148A3 - Quinoline and acridine derivatives as antiarrhythmic agents - Google Patents

Quinoline and acridine derivatives as antiarrhythmic agents Download PDF

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Publication number
WO1998054148A3
WO1998054148A3 PCT/GB1998/001579 GB9801579W WO9854148A3 WO 1998054148 A3 WO1998054148 A3 WO 1998054148A3 GB 9801579 W GB9801579 W GB 9801579W WO 9854148 A3 WO9854148 A3 WO 9854148A3
Authority
WO
WIPO (PCT)
Prior art keywords
quinoline
antiarrhythmic agents
acridine derivatives
arrhythmia
perfluoroalkyl
Prior art date
Application number
PCT/GB1998/001579
Other languages
French (fr)
Other versions
WO1998054148A2 (en
Inventor
Derek Terrar
Edward Gill
Mamas Mamas
Original Assignee
Isis Innovation
Derek Terrar
Edward Gill
Mamas Mamas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Innovation, Derek Terrar, Edward Gill, Mamas Mamas filed Critical Isis Innovation
Priority to EP98924480A priority Critical patent/EP0984941A2/en
Publication of WO1998054148A2 publication Critical patent/WO1998054148A2/en
Publication of WO1998054148A3 publication Critical patent/WO1998054148A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C07D219/12—Amino-alkylamino radicals attached in position 9

Abstract

Compounds having formula (I) or (II) where R is primary or secondary amine or a group -L-Z, Y is H, halogen, alkyl, alkoxy, perfluoroalkyl, nitro or -L-Z, n is 1 to 4, L is a linker chain of 1-20 C, N, O or S atoms, and Z is a calcium channel blocker; have potassium channel blocking activity and are useful for the prophylaxis or therapy of arrhythmia.
PCT/GB1998/001579 1997-05-30 1998-05-29 Quinoline and acridine derivatives as antiarrhythmic agents WO1998054148A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP98924480A EP0984941A2 (en) 1997-05-30 1998-05-29 Quinoline and acridine derivatives as antiarrhythmic agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9711220.5 1997-05-30
GBGB9711220.5A GB9711220D0 (en) 1997-05-30 1997-05-30 Antiarrhythmic agents

Publications (2)

Publication Number Publication Date
WO1998054148A2 WO1998054148A2 (en) 1998-12-03
WO1998054148A3 true WO1998054148A3 (en) 1999-03-04

Family

ID=10813337

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/001579 WO1998054148A2 (en) 1997-05-30 1998-05-29 Quinoline and acridine derivatives as antiarrhythmic agents

Country Status (3)

Country Link
EP (1) EP0984941A2 (en)
GB (1) GB9711220D0 (en)
WO (1) WO1998054148A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012154879A2 (en) 2011-05-09 2012-11-15 Van Andel Research Institute Autophagy inhibitors

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957791A (en) * 1972-09-25 1976-05-18 Sandoz, Inc. Hydroxyalkyl-piperazino-quinoline nitrates
EP0242173A1 (en) * 1986-04-16 1987-10-21 Pfizer Limited Antiarrhythmic agents
EP0281254A1 (en) * 1987-02-07 1988-09-07 Pfizer Limited Antiarrythmic agents
EP0446604A2 (en) * 1990-03-16 1991-09-18 American Cyanamid Company Pyridine and related aza heterocycle derivatives as cardiovascular agents
EP0534844A1 (en) * 1991-09-24 1993-03-31 Roussel Uclaf New derivatives of decahydroquinoline, process for their preparation, intermediaires of the preparation, their use as medicines and compositions containing them
JPH083144A (en) * 1994-06-21 1996-01-09 Chugai Pharmaceut Co Ltd Quinazoline and quinoline derivative
WO1996006084A1 (en) * 1994-08-19 1996-02-29 C & C Research Labs. Novel quinolylamine derivative, process for production thereof, and use thereof as antiarrhythmic agent
WO1997023462A1 (en) * 1995-12-23 1997-07-03 Pfizer Research And Development Company, N.V./S.A. Quinoline and quinazoline compounds useful in therapy
EP0847996A1 (en) * 1996-12-16 1998-06-17 Hoechst Aktiengesellschaft Sulfonamide substituted compounds as K-channel blockers

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957791A (en) * 1972-09-25 1976-05-18 Sandoz, Inc. Hydroxyalkyl-piperazino-quinoline nitrates
EP0242173A1 (en) * 1986-04-16 1987-10-21 Pfizer Limited Antiarrhythmic agents
EP0281254A1 (en) * 1987-02-07 1988-09-07 Pfizer Limited Antiarrythmic agents
EP0446604A2 (en) * 1990-03-16 1991-09-18 American Cyanamid Company Pyridine and related aza heterocycle derivatives as cardiovascular agents
EP0534844A1 (en) * 1991-09-24 1993-03-31 Roussel Uclaf New derivatives of decahydroquinoline, process for their preparation, intermediaires of the preparation, their use as medicines and compositions containing them
JPH083144A (en) * 1994-06-21 1996-01-09 Chugai Pharmaceut Co Ltd Quinazoline and quinoline derivative
WO1996006084A1 (en) * 1994-08-19 1996-02-29 C & C Research Labs. Novel quinolylamine derivative, process for production thereof, and use thereof as antiarrhythmic agent
WO1997023462A1 (en) * 1995-12-23 1997-07-03 Pfizer Research And Development Company, N.V./S.A. Quinoline and quinazoline compounds useful in therapy
EP0847996A1 (en) * 1996-12-16 1998-06-17 Hoechst Aktiengesellschaft Sulfonamide substituted compounds as K-channel blockers

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 119, no. 15, 11 October 1993, Columbus, Ohio, US; abstract no. 151891t, REES ET AL.: "Tacridine inhibits ventricurla fibrilation..." XP002076731 *
CHEMICAL ABSTRACTS, vol. 89, no. 3, 17 July 1978, Columbus, Ohio, US; abstract no. 16708k, MANNHOLD ET AL.: "Investigations on the structure-activity relationships of verapamil" XP002076732 *
DATABASE WPI Section Ch Week 9610, Derwent World Patents Index; Class B02, AN 96-094177, XP002076734 *
DATABASE WPI Section Ch Week 9615, Derwent World Patents Index; Class B02, AN 96-151305, XP002076733 *

Also Published As

Publication number Publication date
EP0984941A2 (en) 2000-03-15
GB9711220D0 (en) 1997-07-23
WO1998054148A2 (en) 1998-12-03

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