WO1998052610A1 - Therapie photodynamique et sonodynamique et agents et systeme utilises a cet effet - Google Patents

Therapie photodynamique et sonodynamique et agents et systeme utilises a cet effet Download PDF

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Publication number
WO1998052610A1
WO1998052610A1 PCT/IL1998/000231 IL9800231W WO9852610A1 WO 1998052610 A1 WO1998052610 A1 WO 1998052610A1 IL 9800231 W IL9800231 W IL 9800231W WO 9852610 A1 WO9852610 A1 WO 9852610A1
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WO
WIPO (PCT)
Prior art keywords
agent
irradiation
releasing
compound capable
biological tissue
Prior art date
Application number
PCT/IL1998/000231
Other languages
English (en)
Inventor
Yoni Iger
Original Assignee
Technion Research And Development Foundation Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technion Research And Development Foundation Ltd. filed Critical Technion Research And Development Foundation Ltd.
Priority to AU74475/98A priority Critical patent/AU7447598A/en
Priority to EP98921707A priority patent/EP0983090A1/fr
Priority to CA002290450A priority patent/CA2290450A1/fr
Publication of WO1998052610A1 publication Critical patent/WO1998052610A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A61K41/0033—Sonodynamic cancer therapy with sonochemically active agents or sonosensitizers, having their cytotoxic effects enhanced through application of ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne une méthode et un système de destruction de tissus biologiques à l'aide de divers types d'irradiations tels que par ultrasons ou par de la lumière, utilisant un agent auxiliaire ou une combinaison d'agents, optionnellement avec un agent pouvant être sensibilisé par l'irradiation. L'agent auxiliaire peut libérer de l'oxygène singulet, des composés oxydants, des radicaux libres ou il peut être un agent capable de subir une réaction exothermique. La présente invention concerne également une méthode mettant un terme à l'activité destructive de divers agents pouvant être sensibilisés par de l'énergie.
PCT/IL1998/000231 1997-05-22 1998-05-20 Therapie photodynamique et sonodynamique et agents et systeme utilises a cet effet WO1998052610A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU74475/98A AU7447598A (en) 1997-05-22 1998-05-20 Photodynamic and sonodynamic therapy and agents and system for use therefor
EP98921707A EP0983090A1 (fr) 1997-05-22 1998-05-20 Therapie photodynamique et sonodynamique et agents et systeme utilises a cet effet
CA002290450A CA2290450A1 (fr) 1997-05-22 1998-05-20 Therapie photodynamique et sonodynamique et agents et systeme utilises a cet effet

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL12089197A IL120891A0 (en) 1997-05-22 1997-05-22 Photodynamic and sonodynamic therapy and agents for use therefor
IL120891 1997-05-22

Publications (1)

Publication Number Publication Date
WO1998052610A1 true WO1998052610A1 (fr) 1998-11-26

Family

ID=11070161

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL1998/000231 WO1998052610A1 (fr) 1997-05-22 1998-05-20 Therapie photodynamique et sonodynamique et agents et systeme utilises a cet effet

Country Status (5)

Country Link
EP (1) EP0983090A1 (fr)
AU (1) AU7447598A (fr)
CA (1) CA2290450A1 (fr)
IL (1) IL120891A0 (fr)
WO (1) WO1998052610A1 (fr)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0965350A1 (fr) * 1997-03-31 1999-12-22 Katsuro Tachibana Procede d'excitation de matiere photosensible
WO2000001413A1 (fr) * 1998-07-06 2000-01-13 Pharmacyclics, Inc. Sensibiliseurs intracellulaires pour traitement sonodynamique
WO2000040266A2 (fr) * 1999-01-04 2000-07-13 The General Hospital Corporation D/B/A Ciblage de follicules sebaces utilise por traiter des troubles de la glande sebacee
WO2000041727A1 (fr) * 1999-01-15 2000-07-20 Light Sciences Corporation Traitement photodynamique transcutane de cellules cibles
WO2001049328A1 (fr) * 2000-01-05 2001-07-12 The American National Red Cross Inactivation photodynamique de pathogenes dans le sang par des phenothiazines et de l'oxygene
WO2002060483A2 (fr) * 2001-01-30 2002-08-08 Governors Of The University Of Alberta Perylenequinones utilisees comme photosensibilisants et sonosensibilisants
US6498945B1 (en) * 1997-05-19 2002-12-24 Amersham Health As Sonodynamic therapy using an ultrasound sensitizer compound
WO2003063901A1 (fr) * 2002-01-29 2003-08-07 Altachem Pharma, Ltd. Hypocrellines amino-substituees utilisables en tant qu'agents sonosensibilisants
EP1393775A1 (fr) * 2002-08-28 2004-03-03 Hitachi, Ltd. Appareil à ultrasons pour utilisation thérapeutique
US6897238B2 (en) 2000-08-16 2005-05-24 General Hospital Corporation Topical aminolevulinic acid-photodynamic therapy for the treatment of acne vulgaris
GB2415373A (en) * 2004-06-23 2005-12-28 Destiny Pharma Ltd Porphyrins for sonodynamic therapy
WO2006019848A1 (fr) * 2004-07-21 2006-02-23 Boston Scientific Scimed, Inc. Revêtements anti-infectieux activés par ultrasons et dispositifs réalisés à partir de ceux-ci
US7244841B2 (en) 2002-12-23 2007-07-17 Destiny Pharma Limited Porphyrin derivatives and their use in photodynamic therapy
US8454991B2 (en) 2006-07-24 2013-06-04 Quest Pharmatech Inc. Method and device for photodynamic therapy
US8506931B2 (en) 2005-08-10 2013-08-13 Quest Pharmatech Inc. Perylenequinone derivatives and uses thereof
US9108045B2 (en) 2007-06-27 2015-08-18 The General Hospital Corporation Method and apparatus for optical inhibition of photodynamic therapy
US11813330B2 (en) 2021-03-04 2023-11-14 Theralase Technologies, Inc. Sonodynamic therapy using sonodynamically activated coordination complexes of transition metals as sensitizing agents

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01146829A (ja) * 1987-12-01 1989-06-08 Koshiro Umemura 超音波による腫瘍治療用生理作用増強剤
WO1998001131A1 (fr) * 1996-07-05 1998-01-15 Hitachi, Ltd. Medicaments induisant une action ultrasonore et appareil d'utilisation de ces medicaments

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01146829A (ja) * 1987-12-01 1989-06-08 Koshiro Umemura 超音波による腫瘍治療用生理作用増強剤
WO1998001131A1 (fr) * 1996-07-05 1998-01-15 Hitachi, Ltd. Medicaments induisant une action ultrasonore et appareil d'utilisation de ces medicaments

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 123, no. 12, 18 September 1995, Columbus, Ohio, US; abstract no. 152697, MALIK, Z. ET AL: "Topical application of 5-aminolevulinic acid, DMSO and EDTA: protoporphyrin IX accumulation in skin and tumors of mice" XP002077405 *
CHEMICAL ABSTRACTS, vol. 124, no. 9, 26 February 1996, Columbus, Ohio, US; abstract no. 105881, MISIK, VLADIMIR ET AL: "Peroxyl radical formation in aqueous solutions of N,N- dimethylformamide, N-methylformamide, and dimethylsulfoxide by ultrasound: implications for sonosensitized cell killing" XP002077404 *
CHEMICAL ABSTRACTS, vol. 125, no. 15, 7 October 1996, Columbus, Ohio, US; abstract no. 185070, MISIK, VLADIMIR ET AL: "EPR spin trapping study of the decomposition of azo compounds in aqueous solutions by ultrasound: potential for use as sonodynamic sensitizers for cell killing" XP002077406 *
FREE RADICAL BIOL. MED. (1996), 20(1), 129-38 CODEN: FRBMEH;ISSN: 0891-5849, 1996 *
FREE RADICAL RES. (1996), 25(1), 13-22 CODEN: FRARER;ISSN: 1071-5762 *
J. PHOTOCHEM. PHOTOBIOL., B (1995), 28(3), 213-18 CODEN: JPPBEG;ISSN: 1011-1344, 1995 *
KESSEL D ET AL: "Modes of photodynamic vs. sonodynamic cytotoxicity.", JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY. B, BIOLOGY, (1995 JUN) 28 (3) 219-21. JOURNAL CODE: JLI. ISSN: 1011-1344., Switzerland, XP002077400 *
MIYOSHI N ET AL: "Sonodynamic toxicity of gallium-porphyrin analogue ATX-70 in human leukemia cells.", RADIATION RESEARCH, (1997 JUL) 148 (1) 43-7. JOURNAL CODE: QMP. ISSN: 0033-7587., United States, XP002077402 *
MIYOSHI, N. ET AL: "Effect of gallium-porphyrin analog ATX-70 on nitroxide formation from a cyclic secondary amine by ultrasound: On the mechanism of sonodynamic activation", PHOTOMED. PHOTOBIOL. (1995), 17, 139-40 CODEN: PHPHEA;ISSN: 0912-232X, XP002077399 *
R.J. JEFFERS ET AL.: "Dimethylformamide as an enhancer of cavitation-induced cell lysis in vitro.", J. ACOUSTICAL SOC. AMER., vol. 97, no. 1-6, 1995, pages 669 - 676, XP002077403 *
SHIN-ICHIRO UMEMURA ET AL: "SONOCHEMICAL ACTIVATION OF HEMATOPORPHYRIN: A POTENTIAL MODALITY FOR CANCER TREATMENT", PROCEEDINGS OF THE ULTRASONICS SYMPOSIUM, MONTREAL, OCT. 3 - 6, 1989, vol. VOL. 2, no. -, 3 October 1989 (1989-10-03), MCAVOY B R, pages 955 - 960, XP000139558 *
SUZUKI, TOSHIO ET AL: "A study on sonodynamic therapy-antitumor effect of novel sonodynamic compounds under ultrasound", HETEROCYCLES (1994), 38(6), 1209-11 CODEN: HTCYAM;ISSN: 0385-5414, XP002077401 *

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0965350A4 (fr) * 1997-03-31 2000-04-05 Katsuro Tachibana Procede d'excitation de matiere photosensible
EP0965350A1 (fr) * 1997-03-31 1999-12-22 Katsuro Tachibana Procede d'excitation de matiere photosensible
US6498945B1 (en) * 1997-05-19 2002-12-24 Amersham Health As Sonodynamic therapy using an ultrasound sensitizer compound
WO2000001413A1 (fr) * 1998-07-06 2000-01-13 Pharmacyclics, Inc. Sensibiliseurs intracellulaires pour traitement sonodynamique
WO2000040266A2 (fr) * 1999-01-04 2000-07-13 The General Hospital Corporation D/B/A Ciblage de follicules sebaces utilise por traiter des troubles de la glande sebacee
WO2000040266A3 (fr) * 1999-01-04 2001-01-18 Gen Hospital Corp D B A Ciblage de follicules sebaces utilise por traiter des troubles de la glande sebacee
US6183773B1 (en) 1999-01-04 2001-02-06 The General Hospital Corporation Targeting of sebaceous follicles as a treatment of sebaceous gland disorders
US6600951B1 (en) 1999-01-04 2003-07-29 The General Hospital Corporation Targeting of sebaceous follicles as a Treatment of sebaceous gland disorders
WO2000041727A1 (fr) * 1999-01-15 2000-07-20 Light Sciences Corporation Traitement photodynamique transcutane de cellules cibles
US6602274B1 (en) 1999-01-15 2003-08-05 Light Sciences Corporation Targeted transcutaneous cancer therapy
WO2001049328A1 (fr) * 2000-01-05 2001-07-12 The American National Red Cross Inactivation photodynamique de pathogenes dans le sang par des phenothiazines et de l'oxygene
US6897238B2 (en) 2000-08-16 2005-05-24 General Hospital Corporation Topical aminolevulinic acid-photodynamic therapy for the treatment of acne vulgaris
WO2002060483A2 (fr) * 2001-01-30 2002-08-08 Governors Of The University Of Alberta Perylenequinones utilisees comme photosensibilisants et sonosensibilisants
WO2002060483A3 (fr) * 2001-01-30 2003-12-24 Univ Alberta Perylenequinones utilisees comme photosensibilisants et sonosensibilisants
WO2003063901A1 (fr) * 2002-01-29 2003-08-07 Altachem Pharma, Ltd. Hypocrellines amino-substituees utilisables en tant qu'agents sonosensibilisants
EP1393775A1 (fr) * 2002-08-28 2004-03-03 Hitachi, Ltd. Appareil à ultrasons pour utilisation thérapeutique
US7125387B2 (en) 2002-08-28 2006-10-24 Hitachi, Ltd. Ultrasonic apparatus for therapeutical use
US7244841B2 (en) 2002-12-23 2007-07-17 Destiny Pharma Limited Porphyrin derivatives and their use in photodynamic therapy
US8084602B2 (en) * 2002-12-23 2011-12-27 Destiny Pharma Limited Porphyrin derivatives and their use in photodynamic therapy
GB2415373A (en) * 2004-06-23 2005-12-28 Destiny Pharma Ltd Porphyrins for sonodynamic therapy
WO2006019848A1 (fr) * 2004-07-21 2006-02-23 Boston Scientific Scimed, Inc. Revêtements anti-infectieux activés par ultrasons et dispositifs réalisés à partir de ceux-ci
US7356368B2 (en) 2004-07-21 2008-04-08 Boston Scientific Scimed, Inc. Light-activated anti-infective coatings and devices made thereof
US8506931B2 (en) 2005-08-10 2013-08-13 Quest Pharmatech Inc. Perylenequinone derivatives and uses thereof
US8758725B2 (en) 2005-08-10 2014-06-24 Quest Pharmatech Inc. Perylenequinone derivatives and uses thereof
US8454991B2 (en) 2006-07-24 2013-06-04 Quest Pharmatech Inc. Method and device for photodynamic therapy
US9108045B2 (en) 2007-06-27 2015-08-18 The General Hospital Corporation Method and apparatus for optical inhibition of photodynamic therapy
US11813330B2 (en) 2021-03-04 2023-11-14 Theralase Technologies, Inc. Sonodynamic therapy using sonodynamically activated coordination complexes of transition metals as sensitizing agents

Also Published As

Publication number Publication date
IL120891A0 (en) 1997-09-30
CA2290450A1 (fr) 1998-11-26
EP0983090A1 (fr) 2000-03-08
AU7447598A (en) 1998-12-11

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