WO1998052590A3 - Improved delivery of disease modifiers - Google Patents

Improved delivery of disease modifiers Download PDF

Info

Publication number
WO1998052590A3
WO1998052590A3 PCT/CA1998/000448 CA9800448W WO9852590A3 WO 1998052590 A3 WO1998052590 A3 WO 1998052590A3 CA 9800448 W CA9800448 W CA 9800448W WO 9852590 A3 WO9852590 A3 WO 9852590A3
Authority
WO
WIPO (PCT)
Prior art keywords
improved delivery
disease modifiers
disease
hyaluronan
modifiers
Prior art date
Application number
PCT/CA1998/000448
Other languages
French (fr)
Other versions
WO1998052590A2 (en
Inventor
Eva Anne Turley
Original Assignee
Hyal Pharma Corp
Eva Anne Turley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hyal Pharma Corp, Eva Anne Turley filed Critical Hyal Pharma Corp
Priority to JP54972998A priority Critical patent/JP2001526666A/en
Priority to EP98920426A priority patent/EP0998297A2/en
Priority to NZ501270A priority patent/NZ501270A/en
Priority to AU73286/98A priority patent/AU740631B2/en
Publication of WO1998052590A2 publication Critical patent/WO1998052590A2/en
Publication of WO1998052590A3 publication Critical patent/WO1998052590A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A pharmaceutical composition component comprising hyaluronan binding motif (HBM) interposed between a form of hyaluronan having a molecular weight (protein standard) less than 750'000 daltons and a disease modifier which comprises a peptide or protein.
PCT/CA1998/000448 1997-05-22 1998-05-11 Improved delivery of disease modifiers WO1998052590A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP54972998A JP2001526666A (en) 1997-05-22 1998-05-11 Improved release of disease modulators
EP98920426A EP0998297A2 (en) 1997-05-22 1998-05-11 Improved delivery of disease modifiers
NZ501270A NZ501270A (en) 1997-05-22 1998-05-11 Pharmaceutical composition comprising hyaluronan (Mr less than 750,00) and a disease modifier (cytokine, a peptide mimicking a cytokine or a protein mimicking a cytokine) to enhance delivery of disease modifiers
AU73286/98A AU740631B2 (en) 1997-05-22 1998-05-11 Improved delivery of disease modifiers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA2,205,771 1997-05-22
CA002205771A CA2205771C (en) 1997-05-22 1997-05-22 Improved delivery of disease modifiers

Publications (2)

Publication Number Publication Date
WO1998052590A2 WO1998052590A2 (en) 1998-11-26
WO1998052590A3 true WO1998052590A3 (en) 1999-04-22

Family

ID=4160694

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1998/000448 WO1998052590A2 (en) 1997-05-22 1998-05-11 Improved delivery of disease modifiers

Country Status (6)

Country Link
EP (1) EP0998297A2 (en)
JP (1) JP2001526666A (en)
AU (1) AU740631B2 (en)
CA (1) CA2205771C (en)
NZ (1) NZ501270A (en)
WO (1) WO1998052590A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6875753B1 (en) 1996-03-14 2005-04-05 The Governors Of The University Of Alberta Methods for cell mobilization using in vivo treatment with hyaluronan (HA)
US20030082586A1 (en) 1999-06-29 2003-05-01 Millennium Pharmaceuticals, Inc. Antibodies having diagnostic, preventive, therapeutic, and other uses
WO2001080899A2 (en) * 2000-04-20 2001-11-01 Cangene Corporation Rhamm peptide conjugates
WO2004104166A2 (en) * 2003-05-07 2004-12-02 La Jolla Institute For Molecular Medicine Administration of hyaluronic acid to enhance the function of transplanted stem cells
DE102011122236A1 (en) * 2011-12-09 2013-06-13 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh Composition useful e.g. in topical treatment of inflammatory diseases of skin and/or mucous membrane, comprises fusafungine and its derivate, and acidic glycosaminoglycan or its derivatives
FR3002452B1 (en) * 2013-02-28 2016-02-12 Dermaconcept Jmc TOPIC ANTIMICROBIAL DERMATOLOGICAL COMPOSITION
CN108137681B (en) 2015-09-23 2024-06-18 豪夫迈·罗氏有限公司 Optimized variants of anti-VEGF antibodies

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991004058A2 (en) * 1989-09-21 1991-04-04 Norpharmco Inc. Treatment of conditions and disease
WO1993021312A1 (en) * 1992-04-09 1993-10-28 University Of Manitoba Hyaluronan receptor (rhamm = receptor for hyluronan mediated mobility) and hyaluronan binding peptides
WO1996006622A1 (en) * 1991-07-03 1996-03-07 Hyal Pharmaceutical Corporation Hyaluronic acid and derivatives for modulation of cellular activity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991004058A2 (en) * 1989-09-21 1991-04-04 Norpharmco Inc. Treatment of conditions and disease
WO1996006622A1 (en) * 1991-07-03 1996-03-07 Hyal Pharmaceutical Corporation Hyaluronic acid and derivatives for modulation of cellular activity
WO1993021312A1 (en) * 1992-04-09 1993-10-28 University Of Manitoba Hyaluronan receptor (rhamm = receptor for hyluronan mediated mobility) and hyaluronan binding peptides

Also Published As

Publication number Publication date
AU7328698A (en) 1998-12-11
CA2205771A1 (en) 1998-11-22
NZ501270A (en) 2001-08-31
AU740631B2 (en) 2001-11-08
JP2001526666A (en) 2001-12-18
CA2205771C (en) 2002-05-14
WO1998052590A2 (en) 1998-11-26
EP0998297A2 (en) 2000-05-10

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