WO1998051788A3 - Method and construct for inhibition of cell migration - Google Patents
Method and construct for inhibition of cell migration Download PDFInfo
- Publication number
- WO1998051788A3 WO1998051788A3 PCT/NL1998/000259 NL9800259W WO9851788A3 WO 1998051788 A3 WO1998051788 A3 WO 1998051788A3 NL 9800259 W NL9800259 W NL 9800259W WO 9851788 A3 WO9851788 A3 WO 9851788A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nucleic acid
- domain
- protein
- hybrid polypeptide
- acid molecule
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000013152 negative regulation of cell migration Effects 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 abstract 5
- 108020004707 nucleic acids Proteins 0.000 abstract 5
- 150000007523 nucleic acids Chemical class 0.000 abstract 5
- 229920001184 polypeptide Polymers 0.000 abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- 102000004169 proteins and genes Human genes 0.000 abstract 5
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 210000004962 mammalian cell Anatomy 0.000 abstract 3
- 239000013598 vector Substances 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 239000012636 effector Substances 0.000 abstract 2
- 238000003780 insertion Methods 0.000 abstract 2
- 230000037431 insertion Effects 0.000 abstract 2
- 230000002463 transducing effect Effects 0.000 abstract 2
- 238000010361 transduction Methods 0.000 abstract 2
- 230000026683 transduction Effects 0.000 abstract 2
- 238000001890 transfection Methods 0.000 abstract 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 abstract 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 abstract 1
- 241000696272 Gull adenovirus Species 0.000 abstract 1
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 230000004709 cell invasion Effects 0.000 abstract 1
- 230000012292 cell migration Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 210000002744 extracellular matrix Anatomy 0.000 abstract 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 1
- 230000002797 proteolythic effect Effects 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
- 230000007838 tissue remodeling Effects 0.000 abstract 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 1
- 239000013603 viral vector Substances 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ500656A NZ500656A (en) | 1997-05-12 | 1998-05-11 | Vector containing a nucleic acid insertion expressing a hybrid polypeptide with a protease inhibitor domain and a receptor binding domain |
EP98923197A EP0981606A2 (en) | 1997-05-12 | 1998-05-11 | Method and construct for inhibition of cell migration |
CA002289117A CA2289117A1 (en) | 1997-05-12 | 1998-05-11 | Method and construct for inhibition of cell migration |
AU75536/98A AU7553698A (en) | 1997-05-12 | 1998-05-11 | Method and construct for inhibition of cell migration |
JP54907798A JP2001525669A (en) | 1997-05-12 | 1998-05-11 | Methods and constructs for inhibiting cell migration |
NO995564A NO995564L (en) | 1997-05-12 | 1999-11-12 | Method and construction for cell migration inhibition |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97201423 | 1997-05-12 | ||
EP97201423.7 | 1997-05-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998051788A2 WO1998051788A2 (en) | 1998-11-19 |
WO1998051788A3 true WO1998051788A3 (en) | 1999-05-20 |
Family
ID=8228315
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/NL1998/000259 WO1998051788A2 (en) | 1997-05-12 | 1998-05-11 | Method and construct for inhibition of cell migration |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0981606A2 (en) |
JP (1) | JP2001525669A (en) |
AU (1) | AU7553698A (en) |
CA (1) | CA2289117A1 (en) |
NO (1) | NO995564L (en) |
NZ (1) | NZ500656A (en) |
WO (1) | WO1998051788A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999055365A1 (en) | 1998-04-30 | 1999-11-04 | Cornell Research Foundation, Inc. | Adenoviral vectors with tandem fiber proteins |
EP1112372A1 (en) | 1998-09-11 | 2001-07-04 | Genvec, Inc. | Alternatively targeted adenovirus |
DE10020125A1 (en) * | 2000-04-18 | 2001-10-25 | Friedrich Schiller Uni Jena Bu | Agent for stimulating bone regrowth, useful as insert after surgery for bone cancer, comprises single sequence expressing a fusion of growth factor and protease inhibitor |
EP1903113A1 (en) * | 2000-12-18 | 2008-03-26 | Arriva Pharmaceuticals, Inc. | Multifunctional protease inhibitors and their use in treatment of disease |
AU4166102A (en) * | 2000-12-18 | 2002-07-01 | Arriva Pharmaceuticals Inc | Multifunctional protease inhibitors and their use in treatment of disease |
US7247704B2 (en) | 2000-12-18 | 2007-07-24 | Arriva Pharmaceuticals, Inc. | Multifunctional protease inhibitors and their use in treatment of disease |
JP4475561B2 (en) | 2001-10-11 | 2010-06-09 | メルク・シャープ・エンド・ドーム・コーポレイション | Hepatitis C virus vaccine |
ES2344253T3 (en) * | 2001-10-11 | 2010-08-23 | MERCK SHARP & DOHME CORP. | VACCINE AGAINST THE VIRUS OF HEPATITIS C. |
Citations (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988009344A1 (en) * | 1987-05-21 | 1988-12-01 | Creative Biomolecules, Inc. | Targeted multifunctional proteins |
EP0383599A2 (en) * | 1989-02-17 | 1990-08-22 | Merck & Co. Inc. | Protein anti-cancer agent |
EP0404750A1 (en) * | 1989-05-26 | 1990-12-27 | Washington University | Tissue inhibitor of metalloproteases (TIMP-2) |
EP0439954A2 (en) * | 1989-12-22 | 1991-08-07 | Seragen, Inc. | Hybrid molecules having translocation region and cell-binding region |
WO1991012328A1 (en) * | 1990-02-15 | 1991-08-22 | Fowlkes Dana M | Totally synthetic affinity reagents |
WO1992002553A1 (en) * | 1990-08-03 | 1992-02-20 | Delta Biotechnology Limited | Tumor cell binding molecule with protease inhibiting region |
EP0623676A1 (en) * | 1989-05-19 | 1994-11-09 | Amgen Inc. | Metalloproteinase inhibitor |
WO1995011987A1 (en) * | 1993-10-29 | 1995-05-04 | Incyte Pharmaceuticals, Inc. | Chimeric proteins including protease nexin-1 variants |
WO1995013091A1 (en) * | 1993-11-12 | 1995-05-18 | International Technology Management Associates, Ltd. | Methods of repairing connective tissues |
WO1995017885A1 (en) * | 1993-12-27 | 1995-07-06 | Rutgers, The State University Of New Jersey | Inhibitors of urokinase plasminogen activator |
WO1995021601A2 (en) * | 1994-01-11 | 1995-08-17 | Protein Engineering Corporation | Kallikrein-inhibiting 'kunitz domain' proteins and analogues thereof |
WO1995028955A1 (en) * | 1994-04-22 | 1995-11-02 | Gliemann Joergen | PEPTIDES BINDING TO THE α2-MACROGLOBULIN RECEPTOR/LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN |
US5504001A (en) * | 1987-11-25 | 1996-04-02 | Zymogenetics, Inc. | Hybrid plasminogen activator |
WO1996023814A1 (en) * | 1995-02-03 | 1996-08-08 | Cell Genesys, Inc. | Chimeric receptor molecules for delivery of co-stimulatory signals |
WO1996034009A1 (en) * | 1995-04-27 | 1996-10-31 | Rutgers, The State University Of New Jersey | Chimeric nucleic acids and proteins for inhibiting hiv-1 expression |
WO1997000949A1 (en) * | 1995-06-20 | 1997-01-09 | Massachusetts Institute Of Technology | Z-dna binding protein and applications |
WO1997025422A1 (en) * | 1996-01-08 | 1997-07-17 | Nissin Food Products Co., Ltd. | Cancerous metastasis inhibitor |
-
1998
- 1998-05-11 JP JP54907798A patent/JP2001525669A/en not_active Ceased
- 1998-05-11 EP EP98923197A patent/EP0981606A2/en not_active Withdrawn
- 1998-05-11 CA CA002289117A patent/CA2289117A1/en not_active Abandoned
- 1998-05-11 WO PCT/NL1998/000259 patent/WO1998051788A2/en not_active Application Discontinuation
- 1998-05-11 NZ NZ500656A patent/NZ500656A/en unknown
- 1998-05-11 AU AU75536/98A patent/AU7553698A/en not_active Abandoned
-
1999
- 1999-11-12 NO NO995564A patent/NO995564L/en not_active Application Discontinuation
Patent Citations (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988009344A1 (en) * | 1987-05-21 | 1988-12-01 | Creative Biomolecules, Inc. | Targeted multifunctional proteins |
US5504001A (en) * | 1987-11-25 | 1996-04-02 | Zymogenetics, Inc. | Hybrid plasminogen activator |
EP0383599A2 (en) * | 1989-02-17 | 1990-08-22 | Merck & Co. Inc. | Protein anti-cancer agent |
EP0623676A1 (en) * | 1989-05-19 | 1994-11-09 | Amgen Inc. | Metalloproteinase inhibitor |
EP0404750A1 (en) * | 1989-05-26 | 1990-12-27 | Washington University | Tissue inhibitor of metalloproteases (TIMP-2) |
EP0439954A2 (en) * | 1989-12-22 | 1991-08-07 | Seragen, Inc. | Hybrid molecules having translocation region and cell-binding region |
WO1991012328A1 (en) * | 1990-02-15 | 1991-08-22 | Fowlkes Dana M | Totally synthetic affinity reagents |
WO1992002553A1 (en) * | 1990-08-03 | 1992-02-20 | Delta Biotechnology Limited | Tumor cell binding molecule with protease inhibiting region |
WO1995011987A1 (en) * | 1993-10-29 | 1995-05-04 | Incyte Pharmaceuticals, Inc. | Chimeric proteins including protease nexin-1 variants |
WO1995013091A1 (en) * | 1993-11-12 | 1995-05-18 | International Technology Management Associates, Ltd. | Methods of repairing connective tissues |
WO1995017885A1 (en) * | 1993-12-27 | 1995-07-06 | Rutgers, The State University Of New Jersey | Inhibitors of urokinase plasminogen activator |
WO1995021601A2 (en) * | 1994-01-11 | 1995-08-17 | Protein Engineering Corporation | Kallikrein-inhibiting 'kunitz domain' proteins and analogues thereof |
WO1995028955A1 (en) * | 1994-04-22 | 1995-11-02 | Gliemann Joergen | PEPTIDES BINDING TO THE α2-MACROGLOBULIN RECEPTOR/LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN |
WO1996023814A1 (en) * | 1995-02-03 | 1996-08-08 | Cell Genesys, Inc. | Chimeric receptor molecules for delivery of co-stimulatory signals |
WO1996034009A1 (en) * | 1995-04-27 | 1996-10-31 | Rutgers, The State University Of New Jersey | Chimeric nucleic acids and proteins for inhibiting hiv-1 expression |
WO1997000949A1 (en) * | 1995-06-20 | 1997-01-09 | Massachusetts Institute Of Technology | Z-dna binding protein and applications |
WO1997025422A1 (en) * | 1996-01-08 | 1997-07-17 | Nissin Food Products Co., Ltd. | Cancerous metastasis inhibitor |
Non-Patent Citations (1)
Title |
---|
QUAX P H A ET AL: "Inhibition of neointima formation in cultured human saphenous vein segments by an adenovirus expressing an urokinase receptor binding plasmin inhibitor", CIRCULATION, vol. 96, no. 8-Suppl., 21 October 1997 (1997-10-21), us, pages I669, XP002084540 * |
Also Published As
Publication number | Publication date |
---|---|
EP0981606A2 (en) | 2000-03-01 |
NO995564L (en) | 2000-01-11 |
NO995564D0 (en) | 1999-11-12 |
JP2001525669A (en) | 2001-12-11 |
CA2289117A1 (en) | 1998-11-19 |
AU7553698A (en) | 1998-12-08 |
NZ500656A (en) | 2001-11-30 |
WO1998051788A2 (en) | 1998-11-19 |
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