WO1998051345A3 - Methode permettant de chasser les leucocytes infiltres dans un tissu - Google Patents

Methode permettant de chasser les leucocytes infiltres dans un tissu Download PDF

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Publication number
WO1998051345A3
WO1998051345A3 PCT/IB1998/000860 IB9800860W WO9851345A3 WO 1998051345 A3 WO1998051345 A3 WO 1998051345A3 IB 9800860 W IB9800860 W IB 9800860W WO 9851345 A3 WO9851345 A3 WO 9851345A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
infiltrated
leukocytes
dislodging
infiltrated leukocytes
Prior art date
Application number
PCT/IB1998/000860
Other languages
English (en)
Other versions
WO1998051345A2 (fr
Inventor
Bosco M C Chan
Bhagirath Singh
Original Assignee
Robarts John P Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robarts John P Res Inst filed Critical Robarts John P Res Inst
Priority to AU73487/98A priority Critical patent/AU7348798A/en
Publication of WO1998051345A2 publication Critical patent/WO1998051345A2/fr
Publication of WO1998051345A3 publication Critical patent/WO1998051345A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2806—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne une méthode qui permet de diminuer le nombre de leucocytes infiltrant les tissus. Cette méthode peut être utilisée pour diminuer le nombre de leucocytes qui infiltrent un greffon après une greffe ou bien un tissu cible chez un individu atteint d'une maladie auto-immune. Elle peut également être employée pour identifier des molécules de la surface cellulaire impliquées dans la production et la persistance des leucocytes infiltrant les tissus.
PCT/IB1998/000860 1997-05-09 1998-05-08 Methode permettant de chasser les leucocytes infiltres dans un tissu WO1998051345A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU73487/98A AU7348798A (en) 1997-05-09 1998-05-08 Method for dislodging infiltrated leukocytes from a tissue

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4603697P 1997-05-09 1997-05-09
US60/046,036 1997-05-09

Publications (2)

Publication Number Publication Date
WO1998051345A2 WO1998051345A2 (fr) 1998-11-19
WO1998051345A3 true WO1998051345A3 (fr) 1999-03-04

Family

ID=21941235

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1998/000860 WO1998051345A2 (fr) 1997-05-09 1998-05-08 Methode permettant de chasser les leucocytes infiltres dans un tissu

Country Status (2)

Country Link
AU (1) AU7348798A (fr)
WO (1) WO1998051345A2 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995019790A1 (fr) * 1994-01-25 1995-07-27 Athena Neurosciences, Inc. Anticorps humanises diriges contre la molecule d'adhesion leucocytaire vla-4
WO1996024673A1 (fr) * 1995-02-10 1996-08-15 Leukosite, Inc. Adressines vasculaires de muqueuses et leurs utilisations
WO1997025351A2 (fr) * 1996-01-04 1997-07-17 Leukosite, Inc. INHIBITEURS D'INTERACTIONS INDUITES PAR MAdCAM-1 ET PROCEDE D'UTILISATION DE CEUX-CI

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995019790A1 (fr) * 1994-01-25 1995-07-27 Athena Neurosciences, Inc. Anticorps humanises diriges contre la molecule d'adhesion leucocytaire vla-4
WO1996024673A1 (fr) * 1995-02-10 1996-08-15 Leukosite, Inc. Adressines vasculaires de muqueuses et leurs utilisations
WO1997025351A2 (fr) * 1996-01-04 1997-07-17 Leukosite, Inc. INHIBITEURS D'INTERACTIONS INDUITES PAR MAdCAM-1 ET PROCEDE D'UTILISATION DE CEUX-CI

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AMARTEY J K ET AL: "The Effect of Antibodies Against Cell-Surface Adhesion Molecules (LFA-1alpha and ICAM-1) on the Migration and Localization of Tc -Labeled Leukocytes in Acute Infection", NUCLEAR MEDICINE AND BIOLOGY, vol. 24, no. 6, August 1997 (1997-08-01), pages 603-605, XP004089535 *
BERLIN P J ET AL: "MONOCLONAL ANTIBODIES AGAINST HUMAN T CELL ADHESION MOLECULES MODULATION OF IMMUNE FUNCTION IN NONHUMAN PRIMATES.", TRANSPLANTATION (BALTIMORE) 53 (4). 1992. 840-849. CODEN: TRPLAU ISSN: 0041-1337, XP002078067 *
CARRENO M P ET AL: "[Cell adhesion molecules and the immune system]. Les molecules d'adhesion et le syst eme immunitaire.", ALLERGIE ET IMMUNOLOGIE, vol. 27, no. 4, April 1995 (1995-04-01), pages 106 - 110, XP002078019 *
TANAKA, YOSHITAKA ET AL: "Inhibition of inflammatory liver injury by a monoclonal antibody against lymphocyte function-associated antigen-1", J. IMMUNOL. (1993), 151 5088-95 CODEN: JOIMA3;ISSN: 0022-1767, XP002078020 *

Also Published As

Publication number Publication date
AU7348798A (en) 1998-12-08
WO1998051345A2 (fr) 1998-11-19

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