WO1998050325A3 - Blocs de construction de derives de 1,2-amino-alcools - Google Patents

Blocs de construction de derives de 1,2-amino-alcools Download PDF

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Publication number
WO1998050325A3
WO1998050325A3 PCT/US1998/009383 US9809383W WO9850325A3 WO 1998050325 A3 WO1998050325 A3 WO 1998050325A3 US 9809383 W US9809383 W US 9809383W WO 9850325 A3 WO9850325 A3 WO 9850325A3
Authority
WO
WIPO (PCT)
Prior art keywords
group
independently
protecting group
aminoalcohols
building blocks
Prior art date
Application number
PCT/US1998/009383
Other languages
English (en)
Other versions
WO1998050325A2 (fr
Inventor
Richard L Gabriel
Jurjus Jurayj
Original Assignee
Pharm Eco Lab Inc
Richard L Gabriel
Jurjus Jurayj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharm Eco Lab Inc, Richard L Gabriel, Jurjus Jurayj filed Critical Pharm Eco Lab Inc
Priority to AU72937/98A priority Critical patent/AU744060B2/en
Priority to JP54851198A priority patent/JP2001525810A/ja
Priority to EP98920336A priority patent/EP0984926A2/fr
Priority to CA002289120A priority patent/CA2289120A1/fr
Priority to IL13281298A priority patent/IL132812A0/xx
Publication of WO1998050325A2 publication Critical patent/WO1998050325A2/fr
Publication of WO1998050325A3 publication Critical patent/WO1998050325A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/10—Isocyanides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/13—Amines containing three or more amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne de nouveaux composés représentés par la formule structurale (XX), (XXI) ou (XXII) dans lesquelles R1, R21 et R22 sont indépendamment un groupe aliphatique, un groupe aliphatique substitué, un groupe aromatique ou un groupe aromatique substitué; R2 et R12 sont indépendamment -NR4R5 ou -N?+ C-; R¿3 est -H ou un groupe protecteur d'alcool; R4 et R5 sont indépendamment -H ou un groupe protecteur d'amine; R11 est une chaîne latérale d'un amino acide naturel ou une chaîne latérale protégée d'un amino acide naturel; et R1 et R2 ainsi que R11 et R12, pris ensemble avec le groupe méthine auquel ils sont liés, peuvent former une fraction représentée par la formule structurale (XXIII); R6 est -H ou un groupe protecteur d'amine; R7 est -H, -OH ou -OR8; R8 est un groupe protecteur d'alcool. L'invention concerne également des procédés de préparation desdits composés.
PCT/US1998/009383 1997-05-09 1998-05-08 Blocs de construction de derives de 1,2-amino-alcools WO1998050325A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU72937/98A AU744060B2 (en) 1997-05-09 1998-05-08 Building blocks derived from 1,2-aminoalcohols
JP54851198A JP2001525810A (ja) 1997-05-09 1998-05-08 １，２−アミノアルコールから誘導される部分構造
EP98920336A EP0984926A2 (fr) 1997-05-09 1998-05-08 Blocs de construction de derives de 1,2-amino-alcools
CA002289120A CA2289120A1 (fr) 1997-05-09 1998-05-08 Blocs de construction de derives de 1,2-amino-alcools
IL13281298A IL132812A0 (en) 1997-05-09 1998-05-08 Building blocks derived from 1,2-aminoalcohols

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4612997P 1997-05-09 1997-05-09
US60/046,129 1997-05-09

Publications (2)

Publication Number Publication Date
WO1998050325A2 WO1998050325A2 (fr) 1998-11-12
WO1998050325A3 true WO1998050325A3 (fr) 1999-02-11

Family

ID=21941779

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/009383 WO1998050325A2 (fr) 1997-05-09 1998-05-08 Blocs de construction de derives de 1,2-amino-alcools

Country Status (6)

Country Link
EP (1) EP0984926A2 (fr)
JP (1) JP2001525810A (fr)
AU (1) AU744060B2 (fr)
CA (1) CA2289120A1 (fr)
IL (1) IL132812A0 (fr)
WO (1) WO1998050325A2 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4864051A (en) * 1988-09-02 1989-09-05 E. R. Squibb & Sons, Inc. Process for preparing 2-methoxyisobutylisonitrile
WO1997009051A1 (fr) * 1995-09-05 1997-03-13 Cambridge Neuroscience, Inc. Analogues pour interactions specifiques oligosaccharide-neureguline et leurs utilisations

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4864051A (en) * 1988-09-02 1989-09-05 E. R. Squibb & Sons, Inc. Process for preparing 2-methoxyisobutylisonitrile
WO1997009051A1 (fr) * 1995-09-05 1997-03-13 Cambridge Neuroscience, Inc. Analogues pour interactions specifiques oligosaccharide-neureguline et leurs utilisations

Also Published As

Publication number Publication date
IL132812A0 (en) 2001-03-19
CA2289120A1 (fr) 1998-11-12
EP0984926A2 (fr) 2000-03-15
AU744060B2 (en) 2002-02-14
JP2001525810A (ja) 2001-12-11
AU7293798A (en) 1998-11-27
WO1998050325A2 (fr) 1998-11-12

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