WO1998049303A3 - Compositions and methods for conferring tick immunity and preventing tick borne diseases - Google Patents

Compositions and methods for conferring tick immunity and preventing tick borne diseases Download PDF

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Publication number
WO1998049303A3
WO1998049303A3 PCT/US1998/008371 US9808371W WO9849303A3 WO 1998049303 A3 WO1998049303 A3 WO 1998049303A3 US 9808371 W US9808371 W US 9808371W WO 9849303 A3 WO9849303 A3 WO 9849303A3
Authority
WO
WIPO (PCT)
Prior art keywords
tick
methods
polypeptides
compositions
conferring
Prior art date
Application number
PCT/US1998/008371
Other languages
French (fr)
Other versions
WO1998049303A2 (en
Inventor
Fred S Kantor
Erol Fikrig
Sylvette Nazario
Subrata Das
Original Assignee
Univ Yale
Fred S Kantor
Erol Fikrig
Sylvette Nazario
Subrata Das
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Yale, Fred S Kantor, Erol Fikrig, Sylvette Nazario, Subrata Das filed Critical Univ Yale
Priority to AU72584/98A priority Critical patent/AU7258498A/en
Priority to JP54721298A priority patent/JP2001523964A/en
Priority to CA002288433A priority patent/CA2288433A1/en
Priority to EP98919901A priority patent/EP1017806A2/en
Publication of WO1998049303A2 publication Critical patent/WO1998049303A2/en
Publication of WO1998049303A3 publication Critical patent/WO1998049303A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43527—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from ticks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Insects & Arthropods (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Methods and compositions for conferring tick immunity and preventing or reducing the transmission of tick-borne pathogens. I. scapularis polypeptides and fragments, fusion and multimeric proteins, DNA molecules encoding them, antibodies directed against the polypeptides, fusion proteins or multimeric proteins. Vaccines comprising I. scapularis polypeptides alone or in addition to other protective polypeptides. Methods comprising the polypeptides, antibodies and vaccines.
PCT/US1998/008371 1997-04-29 1998-04-29 Compositions and methods for conferring tick immunity and preventing tick borne diseases WO1998049303A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU72584/98A AU7258498A (en) 1997-04-29 1998-04-29 Compositions and methods for conferring tick immunity and preventing tick borne diseases
JP54721298A JP2001523964A (en) 1997-04-29 1998-04-29 Compositions and methods for conferring tick immunity and for preventing tick-borne diseases
CA002288433A CA2288433A1 (en) 1997-04-29 1998-04-29 Compositions and methods for conferring tick immunity and preventing tick borne diseases
EP98919901A EP1017806A2 (en) 1997-04-29 1998-04-29 Compositions and methods for conferring tick immunity and preventing tick borne diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4315497P 1997-04-29 1997-04-29
US60/043,154 1997-04-29

Publications (2)

Publication Number Publication Date
WO1998049303A2 WO1998049303A2 (en) 1998-11-05
WO1998049303A3 true WO1998049303A3 (en) 1999-01-28

Family

ID=21925774

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/008371 WO1998049303A2 (en) 1997-04-29 1998-04-29 Compositions and methods for conferring tick immunity and preventing tick borne diseases

Country Status (5)

Country Link
EP (1) EP1017806A2 (en)
JP (1) JP2001523964A (en)
AU (1) AU7258498A (en)
CA (1) CA2288433A1 (en)
WO (1) WO1998049303A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000027873A2 (en) * 1998-11-06 2000-05-18 Research Corporation Technologies, Inc. Interleukin-2 binding protein from arthropods
WO2001040469A2 (en) * 1999-12-03 2001-06-07 Yale University Tick antigens and compositions and methods comprising them
AU2001232052A1 (en) 2000-02-11 2001-08-20 Evolutec Limited Cytokine inhibitory molecules from tick salivary glands
WO2022241312A1 (en) * 2021-05-14 2022-11-17 University Of Maryland, College Park Tick mouthpart antigens as effective anti-tick vaccines

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CRAIG L.E. ET AL.: "Acquired resistance and antibody response of raccoons (Procyon lotor) to sequential feedings of Ixodes scapularis (Acari: Ixodidae)", VETERINARY PARASITOLOGY, vol. 63, 1996, pages 291 - 301, XP002085403 *
GALBE J. AND OLIVER J.H. JR.: "Immune response of lizards and rodents to larval Ixodes scapularis (Acari: Ixodidae)", JOURNAL OF MEDICAL ENTOMOLOGY, vol. 29, no. 5, September 1992 (1992-09-01), pages 774 - 783, XP002085405 *
WHEELER C.M. ET AL.: "Salivary gland antigens of Ixodes dammini are glycoproteins that have interspecies cross-reactivity", JOURNAL OF PARASITOLOGY, vol. 77, no. 6, 1991, pages 965 - 973, XP000610701 *
WIKEL S.K. ET AL.: "Infestation with pathogen-free nymphs of the tick Ixodes scapularis induces host resistance to transmission of Borrelia burgdorferi by ticks", INFECTION AND IMMUNITY, vol. 65, no. 1, January 1997 (1997-01-01), pages 335 - 338, XP002085404 *

Also Published As

Publication number Publication date
JP2001523964A (en) 2001-11-27
AU7258498A (en) 1998-11-24
WO1998049303A2 (en) 1998-11-05
CA2288433A1 (en) 1998-11-05
EP1017806A2 (en) 2000-07-12

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