WO1998047002A3 - Polyvalent presenter combinatorial libraries and their uses - Google Patents

Polyvalent presenter combinatorial libraries and their uses Download PDF

Info

Publication number
WO1998047002A3
WO1998047002A3 PCT/US1998/006963 US9806963W WO9847002A3 WO 1998047002 A3 WO1998047002 A3 WO 1998047002A3 US 9806963 W US9806963 W US 9806963W WO 9847002 A3 WO9847002 A3 WO 9847002A3
Authority
WO
WIPO (PCT)
Prior art keywords
polyvalent
presenters
viewing
receptor
polyvalency
Prior art date
Application number
PCT/US1998/006963
Other languages
French (fr)
Other versions
WO1998047002A2 (en
Inventor
Seok-Ki Choi
Mathai Mammen
George M Whitesides
John Griffin
Original Assignee
Advanced Medicine Inc
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Medicine Inc, Harvard College filed Critical Advanced Medicine Inc
Priority to AU69570/98A priority Critical patent/AU6957098A/en
Publication of WO1998047002A2 publication Critical patent/WO1998047002A2/en
Publication of WO1998047002A3 publication Critical patent/WO1998047002A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/08—Polyoxyalkylene derivatives
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention is based, on our viewing of receptor-ligand interactions and polyvalency in a non-conventional, global manner based on an understanding of how a multicomponent polyvalent presenter interacts with a collection of target binding sites. This differs from the conventional manner of viewing such interactions on a more individualistic basis as a plurality of separate uncoupled receptor-ligand interactions. The non-conventional, global manner of viewing receptor-ligand interactions and polyvalency in biological systems has led us to the realization that the polyvalency can be used as a basis, e.g. a primary basis, for rational drug design and further, that polyvalent agents have universal applications for treating many different diseases or conditions. The non-conventional, global manner of viewing receptor-ligand interactions has led us even further to the realization that the choice of a particular ligand based on its individual binding capability need not be the most important parameter in designing a polyvalent drug. For instance, weakly binding ligands can be used in polyvalent presenters of the present invention. Based, in part, on the foregoing, the present invention provides methods for preparing and screening combinatorial libraries, i.e., arrays, of polyvalent presenters. The polyvalent presenters are generally formed by constructing and arranging a plurality of functional group components R3 (e.g., ligands), on a plurality of framework components (e.g. polymeric backbones), thereby forming an array of polyvalent presenters. Once formed, the array of polyvalent presenters can be screened for useful properties, and the polyvalent presenters identified as having useful properties can, in turn, be used to treat a disease or condition.
PCT/US1998/006963 1997-04-11 1998-04-09 Polyvalent presenter combinatorial libraries and their uses WO1998047002A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU69570/98A AU6957098A (en) 1997-04-11 1998-04-09 Polyvalent presenter combinatorial libraries and their uses

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US4328897P 1997-04-11 1997-04-11
US60/043,288 1997-04-11
US4391897P 1997-04-15 1997-04-15
US60/043,918 1997-04-15

Publications (2)

Publication Number Publication Date
WO1998047002A2 WO1998047002A2 (en) 1998-10-22
WO1998047002A3 true WO1998047002A3 (en) 1999-03-04

Family

ID=26720249

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/006963 WO1998047002A2 (en) 1997-04-11 1998-04-09 Polyvalent presenter combinatorial libraries and their uses

Country Status (2)

Country Link
AU (1) AU6957098A (en)
WO (1) WO1998047002A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7220552B1 (en) 1999-11-19 2007-05-22 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and their use in the disruption of protein-protein interactions
US6887842B1 (en) 1999-11-19 2005-05-03 The Board Of Trustees Of The Leland Stanford Junior University Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug
AU2044001A (en) 1999-11-19 2001-05-30 Board Of Trustees Of The Leland Stanford Junior University Targeted bifunctional molecules and therapies based thereon
EP1951279B1 (en) 2005-10-08 2017-04-12 Apellis Pharmaceuticals, Inc. Compstatin and analogs thereof for eye disorders
JP2008074720A (en) * 2006-09-19 2008-04-03 Noguchi Inst Gm3 sugar chain probe
HUE026001T2 (en) 2007-02-05 2016-04-28 Apellis Pharmaceuticals Inc Compstatin analogues for use in the treatment of inflammatory conditions of the respiratory system
JP6522337B2 (en) 2011-05-11 2019-05-29 アペリス・ファーマシューティカルズ・インコーポレイテッドＡｐｅｌｌｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． Cell-reactive, long-acting or targeted compstatin analogues and uses thereof
JP6618682B2 (en) 2011-06-22 2019-12-11 アペリス・ファーマシューティカルズ・インコーポレイテッドＡｐｅｌｌｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． Treatment of chronic disorders with complement inhibitors
SI3660033T1 (en) 2012-11-15 2021-09-30 Apellis Pharmaceuticals, Inc. Long-acting compstatin analogs and related compositions and methods
CA3001128A1 (en) 2015-10-07 2017-04-13 Apellis Pharmaceuticals, Inc. Use of long-acting compstatin analog for treating a complement-mediated eye disorder
KR20210084552A (en) 2018-10-29 2021-07-07 위스콘신 얼럼나이 리서어치 화운데이션 Dendritic Polymer Complexed with Immune Checkpoint Inhibitors for Enhanced Cancer Immunotherapy
US11564995B2 (en) 2018-10-29 2023-01-31 Wisconsin Alumni Research Foundation Peptide-nanoparticle conjugates
WO2021087021A1 (en) 2019-10-29 2021-05-06 Wisconsin Alumni Research Foundation Peptide-nanoparticle conjugates
CN114113265B (en) * 2021-12-14 2023-08-08 郑州轻工业大学 Aptamer sensor and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998014215A2 (en) * 1996-10-02 1998-04-09 Syntesome Gesellschaft Für Med. Biochemie M.B.H. Glycoconjugates as virus cell adhesion inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998014215A2 (en) * 1996-10-02 1998-04-09 Syntesome Gesellschaft Für Med. Biochemie M.B.H. Glycoconjugates as virus cell adhesion inhibitors

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
BERNKOP-SCHNURCH A ET AL: "Development and in vitro evaluation of systems to protect peptide drugs from aminopeptidase N.", PHARM RES, FEB 1997, VOL. 14, NO. 2, PAGE(S) 181-5, XP002081687 *
CHOI S -K ET AL: "GENERATION AND IN SITU EVALUATION OF LIBRARIES OF POLY(ACRYLIC ACID) PRESENTING SIALOSIDES AS SIDE CHAINS AS POLYVALENT INHIBITORS OF INFLUENZA-MEDIATED HEMAGGLUTINATION", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 119, no. 18, 7 May 1997 (1997-05-07), pages 4103 - 4111, XP002068481 *
CHOI S -K ET AL: "MONOMERIC INHIBITORS OF INFLUENZA NEURAMINIDASE ENHANCE THE HEMAGGLUTINATION INHIBITION ACTIVITIES OF POLYACRYLAMIDES PRESENTING MULTIPLE C-SIALOSIDE GROUPS", CHEMISTRY AND BIOLOGY, vol. 3, no. 2, 1996, pages 97 - 104, XP000650760 *
GAMBARYAN A S ET AL: "SPECIFICATION OF RECEPTOR-BINDING PHENOTYPES OF INFLUENZA VIRUS ISOLATES FROM DIFFERENT HOSTS USING SYNTHETIC SIALYLGLYCOPOLYMERS: NON-EGG-ADAPTED HUMAN H1 AND H3 INFLUENZA A AND INFLUENZA B VIRUSES SHARE A COMMON HIGH BINDING AFFINITY FOR 6'-SIALYL(N-ACETYLLACTOSAMINE)", VIROLOGY, vol. 232, no. 2, 9 June 1997 (1997-06-09), pages 345 - 350, XP002068479 *
GAMIAN A ET AL: "Inhibition of influenza A virus hemagglutinin and induction of interferon by synthetic sialylated glycoconjugates.", CAN J MICROBIOL, MAR 1991, VOL. 37, NO. 3, PAGE(S) 233-7, XP002081684 *
ITOH M ET AL: "SUPPRESSION OF INFLUENZA VIRUS INFECTION BY AN N-THIOACETYLNEURAMINIC ACID ACRYLAMIDE COPOLYMER RESISTANT TO NEURAMINIDASE", VIROLOGY, vol. 212, 1995, pages 340 - 347, XP002036922 *
MATROSOVICH M.N. ET AL: "Synthetic polymeric sialoside inhibitors of influenza virus receptor-binding activity", FEBS LETT., 1990, VOL. 272, NO. 1-2, PAGES 209-212, XP002081685 *
RYE PD ET AL: "Monoclonal antibody LU-BCRU-G7 against a breast tumour-associated glycoprotein recognizes the disaccharide Gal beta 1-3GlcNAc.", GLYCOBIOLOGY, JUN 1995, VOL. 5, NO. 4, PAGE(S) 385-9, XP002081686 *
TADAO NAKAYA: "POLYMERIC GLYCOLIPID ANALOGUES POLYMETHACRYLATES CONTAINING GLUCOSE MOIETIES ATTACHED TO THE POLYMER BACKBONES VIA N-ALKYL CHAINS OF VARIOUS LENGTH", MAKROMOLEKULARE CHEMIE, RAPID COMMUNICATIONS, vol. 14, no. 2, 1 February 1993 (1993-02-01), pages 77 - 83, XP000334494 *
TOKOVENKO I P ET AL: "INHIBITION OF MYCOPLASMA PNEUMONIAE ADHESION IN THE FETUINIC TEST SYSTEM BY SYNTHETIC ANALOGUES AND POLYMEIC FORMS OF NEURAMINIC ACIDS", MIKROBIOLOGICESKIJ ZURNAL, vol. 56, no. 1, 1994, pages 3 - 9, XP002026326 *
VLASOVA EV ET AL: "[Selectin receptors. 5. Monoclonal antibodies to the synthetic antigens SiaLe(a) and SiaLe(x)]", BIOORG KHIM, MAY 1996, VOL. 22, NO. 5, PAGE(S) 358-65, XP002081688 *
ZEMLIANUKHINA TV ET AL: "[Selectin receptors. 2. Synthesis of HSO3-3'Le(a)--a sulfated ligand of the cell adhesion molecule, E-selectin (letter)]", BIOORG KHIM, MAY 1994, VOL. 20, NO. 5, PAGE(S) 556-9, XP002081689 *

Also Published As

Publication number Publication date
WO1998047002A2 (en) 1998-10-22
AU6957098A (en) 1998-11-11

Similar Documents

Publication Publication Date Title
WO1998047002A3 (en) Polyvalent presenter combinatorial libraries and their uses
Lam et al. Applications of one-bead one-compound combinatorial libraries and chemical microarrays in signal transduction research
Ji et al. Modularity in the organization of mouse primary visual cortex
WO2002004956A3 (en) Method of identifying conformation-sensitive binding peptides and uses thereof
Kolch et al. The molecular make-up of a tumour: proteomics in cancer research
Boger et al. Multistep convergent solution-phase combinatorial synthesis and deletion synthesis deconvolution
EP1249705A3 (en) Multiplexed molecular analysis apparatus and its fabrication method
DE69534795D1 (en) Screening of organometallic compounds for catalysis
EP1905829A3 (en) Templated molecules and methods for using such molecules
NO933582D0 (en) NEW CONJUGATES AND ANALYSIS FOR SIMULTANEOUS DETECTION OF MULTIPLE LIGANDS
WO1996004557A3 (en) Target specific screens and their use for discovering small organic molecular pharmacophores
CA2309345A1 (en) High throughput method for functionally classifying proteins identified using a genomics approach
WO2002084262A3 (en) Processes for evaluating agricultural and/or food materials; applications; and, products
WO2006014498A3 (en) Universal antibody libraries
Liao et al. Robustness of metacommunities with omnivory to habitat destruction: disentangling patch fragmentation from patch loss
Zuck et al. Ligand-receptor binding measured by laser-scanning imaging
CA2328805A1 (en) Enzyme-protein complex
Goodenough et al. Molecular organization of cell-wall crystals from Chlamydomonas reinhardtii and Volvox carteri
Wilson Biodiversity: New leads for the pharmaceutical and agrochemical industries
EP1420267A3 (en) Radar sensor and radar antenna for monitoring the environment of a motor vehicle
ATE468912T1 (en) DEVICE FOR CONTINUOUS GRANULATING AND METHOD FOR CONTINUOUS GRANULATING POWDER MATERIAL
Lehman et al. Image subtraction approach to screening one-bead-one-compound combinatorial libraries with complex protein mixtures
WO2001040265A3 (en) Ligands for a target molecule and a method for indentifying them
DE60301232T2 (en) Microarray system with microtiter plates
Wang et al. Whisker map organization in somatosensory cortex of awake, behaving mice

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

NENP Non-entry into the national phase

Ref country code: JP

Ref document number: 1998544013

Format of ref document f/p: F

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA