WO1998046645A3 - Method for the production of antihuman antigen receptors and uses thereof - Google Patents

Method for the production of antihuman antigen receptors and uses thereof Download PDF

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Publication number
WO1998046645A3
WO1998046645A3 PCT/EP1998/002180 EP9802180W WO9846645A3 WO 1998046645 A3 WO1998046645 A3 WO 1998046645A3 EP 9802180 W EP9802180 W EP 9802180W WO 9846645 A3 WO9846645 A3 WO 9846645A3
Authority
WO
WIPO (PCT)
Prior art keywords
human
receptors
chains
production
antigen
Prior art date
Application number
PCT/EP1998/002180
Other languages
French (fr)
Other versions
WO1998046645A2 (en
Inventor
Peter Kufer
Tobias Raum
Original Assignee
Micromet Ges Fuer Biomedizinis
Peter Kufer
Tobias Raum
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU76431/98A priority Critical patent/AU742045B2/en
Priority to US09/403,107 priority patent/US7227002B1/en
Application filed by Micromet Ges Fuer Biomedizinis, Peter Kufer, Tobias Raum filed Critical Micromet Ges Fuer Biomedizinis
Priority to DE69800716T priority patent/DE69800716T2/en
Priority to PL98344190A priority patent/PL193780B1/en
Priority to AT98924115T priority patent/ATE200679T1/en
Priority to IL13206298A priority patent/IL132062A0/en
Priority to JP54349498A priority patent/JP3876002B2/en
Priority to HU0100794A priority patent/HU221818B1/en
Priority to BRPI9809391A priority patent/BRPI9809391B8/en
Priority to CA002286879A priority patent/CA2286879C/en
Priority to KR10-1999-7009425A priority patent/KR100516133B1/en
Priority to EP98924115A priority patent/EP0970126B1/en
Priority to DK98924115T priority patent/DK0970126T3/en
Priority to KR1020057008975A priority patent/KR100663319B1/en
Priority to SI9830024T priority patent/SI0970126T1/en
Publication of WO1998046645A2 publication Critical patent/WO1998046645A2/en
Publication of WO1998046645A3 publication Critical patent/WO1998046645A3/en
Priority to IL132062A priority patent/IL132062A/en
Priority to NO19994983A priority patent/NO315904B1/en
Priority to HK00104307A priority patent/HK1026911A1/en
Priority to GR20010401081T priority patent/GR3036229T3/en
Priority to US11/860,242 priority patent/US7632925B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Described is a method for the production of an anti-human antigen receptor that is low or not immunogenic in humans comprising the steps of selecting a combination of functionally rearranged VH and VL immunoglobulin chains wherein at least said VH chain is derived from essentially unprimed mature human B-lymphocytes or from essentially anergic human B cells and said VL chain is derived from a naturally occurring human B cell repertoire, said chains being expressed from a recombinant vector and using an in vitro display system for binding to a human antigen. Furthermore, receptors that are low or not immunogenic in humans and directed to human antigens are provided, said receptors being obtainable by the method of the invention. Said receptors are preferably antibodies or fragments thereof or immunoconjugates comprising the VH/VL chains of said antibody. In particular, receptors are described directed to human tumor antigens, preferably to the human tumor antigen 17-1A, also known as EpCAM, EGP or GA 733-2. Finally, kits useful for carrying out the method of the invention and pharmaceutical compositions comprising the aforementioned receptors are provided.
PCT/EP1998/002180 1997-04-14 1998-04-14 Method for the production of antihuman antigen receptors and uses thereof WO1998046645A2 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
KR10-1999-7009425A KR100516133B1 (en) 1997-04-14 1998-04-14 Novel method for the production of anti-human antigen receptors and uses thereof
CA002286879A CA2286879C (en) 1997-04-14 1998-04-14 Novel method for the production of anti-human antigen receptors and uses thereof
DE69800716T DE69800716T2 (en) 1997-04-14 1998-04-14 NEW METHOD FOR PRODUCING ANTI-HUMAN ANTIGENT RECEPTORS AND THEIR USE
PL98344190A PL193780B1 (en) 1997-04-14 1998-04-14 Novel method for the production of anti-human antigen receptors and uses thereof
AT98924115T ATE200679T1 (en) 1997-04-14 1998-04-14 NEW METHOD FOR PRODUCING ANTI-HUMAN ANTIGEN RECEPTORS AND THEIR USES
IL13206298A IL132062A0 (en) 1997-04-14 1998-04-14 Novel method for the production of anti-human antigen receptors and uses thereof
JP54349498A JP3876002B2 (en) 1997-04-14 1998-04-14 Novel methods for producing anti-human antigen receptors and their use
HU0100794A HU221818B1 (en) 1997-04-14 1998-04-14 Novel method for the production of anti-human antigen receptors and uses thereof
EP98924115A EP0970126B1 (en) 1997-04-14 1998-04-14 Novel method for the production of antihuman antigen receptors and uses thereof
AU76431/98A AU742045B2 (en) 1997-04-14 1998-04-14 Novel method for the production of anti-human antigen receptors and uses thereof
BRPI9809391A BRPI9809391B8 (en) 1997-04-14 1998-04-14 process for producing an anti-human antigen receptor, human antibody and pharmaceutical composition
US09/403,107 US7227002B1 (en) 1997-04-14 1998-04-14 Human antibodies that bind human 17-A1/EpCAM tumor antigen
DK98924115T DK0970126T3 (en) 1997-04-14 1998-04-14 Hitherto unknown method for the preparation of anti-human antigen receptors and uses thereof
KR1020057008975A KR100663319B1 (en) 1997-04-14 1998-04-14 A human antibody specific for the human 17-1A antigen and uses thereof
SI9830024T SI0970126T1 (en) 1997-04-14 1998-04-14 Novel method for the production of antihuman antigen receptors and uses thereof
IL132062A IL132062A (en) 1997-04-14 1999-09-24 Method for the production of anti-human antigen receptors and uses thereof
NO19994983A NO315904B1 (en) 1997-04-14 1999-10-13 Process for Preparation of Anti-Human Antigen Receptor, Human Antibody, and Pharmaceutical Preparation
HK00104307A HK1026911A1 (en) 1997-04-14 2000-07-12 Novel method for the production of antihuman antigen receptors and uses thereof
GR20010401081T GR3036229T3 (en) 1997-04-14 2001-07-16 Method for the production of antihuman antigen receptors and uses thereof
US11/860,242 US7632925B2 (en) 1997-04-14 2007-09-24 Antibodies that bind human 17-A1/EpCAM tumor antigen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97106109.8 1997-04-14
EP97106109 1997-04-14

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09/403,107 A-371-Of-International US7227002B1 (en) 1997-04-14 1998-04-14 Human antibodies that bind human 17-A1/EpCAM tumor antigen
US10/325,694 Division US20030148463A1 (en) 1997-04-14 2002-12-19 Novel method for the production of anti-human antigen receptors and uses thereof

Publications (2)

Publication Number Publication Date
WO1998046645A2 WO1998046645A2 (en) 1998-10-22
WO1998046645A3 true WO1998046645A3 (en) 1999-04-15

Family

ID=8226694

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/002180 WO1998046645A2 (en) 1997-04-14 1998-04-14 Method for the production of antihuman antigen receptors and uses thereof

Country Status (25)

Country Link
US (1) US7227002B1 (en)
EP (1) EP0970126B1 (en)
JP (1) JP3876002B2 (en)
KR (2) KR100516133B1 (en)
CN (1) CN100387621C (en)
AT (1) ATE200679T1 (en)
AU (1) AU742045B2 (en)
BR (1) BRPI9809391B8 (en)
CA (1) CA2286879C (en)
CU (1) CU23268A3 (en)
CZ (1) CZ294425B6 (en)
DE (1) DE69800716T2 (en)
DK (1) DK0970126T3 (en)
ES (1) ES2172149T3 (en)
GR (1) GR3036229T3 (en)
HK (1) HK1026911A1 (en)
HU (1) HU221818B1 (en)
IL (2) IL132062A0 (en)
NO (1) NO315904B1 (en)
PL (1) PL193780B1 (en)
PT (1) PT970126E (en)
RU (1) RU2224766C2 (en)
SI (1) SI0970126T1 (en)
TR (1) TR199902553T2 (en)
WO (1) WO1998046645A2 (en)

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US9139642B2 (en) 2010-07-09 2015-09-22 Crucell Holland B.V. Anti-human respiratory syncytial virus (RSV) antibodies and methods of use
US9220774B2 (en) 2011-11-01 2015-12-29 Bionomics Inc. Methods of treating cancer by administering anti-GPR49 antibodies
US9221907B2 (en) 2011-11-01 2015-12-29 Bionomics Inc. Anti-GPR49 monoclonal antibodies
US9221906B2 (en) 2011-11-01 2015-12-29 Bionomics Inc. Methods of inhibiting solid tumor growth by administering GPR49 antibodies
US9244074B2 (en) 2011-06-07 2016-01-26 University Of Hawaii Biomarker of asbestos exposure and mesothelioma
US9273142B2 (en) 2012-04-04 2016-03-01 Siamab Therapeutics, Inc. Glycan-interacting compounds
US9399676B2 (en) 2013-05-06 2016-07-26 Scholar Rock, Inc. Compositions and methods for growth factor modulation
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