WO1998044926B1 - Antimicrobial compositions - Google Patents
Antimicrobial compositionsInfo
- Publication number
- WO1998044926B1 WO1998044926B1 PCT/US1998/006468 US9806468W WO9844926B1 WO 1998044926 B1 WO1998044926 B1 WO 1998044926B1 US 9806468 W US9806468 W US 9806468W WO 9844926 B1 WO9844926 B1 WO 9844926B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- oil
- agent
- antimicrobial agent
- lemon
- group
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 6
- 230000000845 anti-microbial Effects 0.000 title abstract 2
- 239000004599 antimicrobial Substances 0.000 claims abstract 43
- 239000003795 chemical substances by application Substances 0.000 claims abstract 37
- 239000003921 oil Substances 0.000 claims 34
- 235000019198 oils Nutrition 0.000 claims 34
- 239000010619 basil oil Substances 0.000 claims 28
- 229940018006 basil oil Drugs 0.000 claims 28
- 235000019501 Lemon oil Nutrition 0.000 claims 18
- 240000003136 Rosmarinus officinalis Species 0.000 claims 18
- 239000010501 lemon oil Substances 0.000 claims 18
- 235000015639 rosmarinus officinalis Nutrition 0.000 claims 18
- 230000002401 inhibitory effect Effects 0.000 claims 17
- 241000602648 Passiflora mucronata Species 0.000 claims 16
- 229940072008 Glycyrrhiza glabra extract Drugs 0.000 claims 14
- 240000004737 Ocimum americanum Species 0.000 claims 14
- 235000004195 Ocimum x citriodorum Nutrition 0.000 claims 14
- 239000010627 cedar oil Substances 0.000 claims 14
- 235000013399 edible fruits Nutrition 0.000 claims 14
- YBHILYKTIRIUTE-UHFFFAOYSA-N Berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 claims 13
- 229940093265 Berberine Drugs 0.000 claims 13
- 229930015400 berberine Natural products 0.000 claims 13
- 239000010632 citronella oil Substances 0.000 claims 13
- 241000894006 Bacteria Species 0.000 claims 12
- WIIZWVCIJKGZOK-RKDXNWHRSA-N Chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 claims 11
- 229960005091 Chloramphenicol Drugs 0.000 claims 11
- 229930007907 citral Natural products 0.000 claims 9
- 229940043350 citral Drugs 0.000 claims 9
- WTEVQBCEXWBHNA-YFHOEESVSA-N neral Chemical compound CC(C)=CCC\C(C)=C/C=O WTEVQBCEXWBHNA-YFHOEESVSA-N 0.000 claims 9
- 241000605986 Fusobacterium nucleatum Species 0.000 claims 6
- 241000605862 Porphyromonas gingivalis Species 0.000 claims 6
- 241000194019 Streptococcus mutans Species 0.000 claims 6
- 229940031008 Streptococcus mutans Drugs 0.000 claims 6
- 241000194023 Streptococcus sanguinis Species 0.000 claims 6
- 230000001717 pathogenic Effects 0.000 claims 6
- 241000186044 Actinomyces viscosus Species 0.000 claims 5
- 239000005792 Geraniol Substances 0.000 claims 4
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 claims 4
- 210000000214 Mouth Anatomy 0.000 claims 4
- 229930008393 geraniol Natural products 0.000 claims 4
- 229940113087 geraniol Drugs 0.000 claims 4
- GLZPCOQZEFWAFX-JXMROGBWSA-N β-Geraniol Chemical compound CC(C)=CCC\C(C)=C\CO GLZPCOQZEFWAFX-JXMROGBWSA-N 0.000 claims 4
- -1 cocamidopropyl dimethylglycine Chemical compound 0.000 claims 3
- 241000186046 Actinomyces Species 0.000 claims 1
- 230000002195 synergetic Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract 1
Abstract
Antimicrobial compositions comprising at least two antimicrobial agents exhibit reduced MIC values relative to the MIC for the agents making up the combination when measured alone. The compositions are useful as therapeutic agents such as in oral hygiene products.
Claims
AMENDED CLAIMS
[received by the International Bureau on 28 September 1998 (28.09.98); original claims 1-17, 20, 25 and 31 cancelled; original claims 18, 19, 21-24, 26-30 and 32-34 amended; new claims 36-47 added; remaining claim unchanged (5 pages)]
The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:
18. An oral hygiene product comprising: an antimicrobial agent A comprising geraniol; and an antimicrobial agent B selected from the group consisting of berberine, cedarwood oil, chloramphenicol, citronella oil, cocamidopropyl dimethylglycine, Glycyrrhiza glabra extract, juicy fruit basil oil, juniper berries oil, lemon basil oil, lemon oil, and Rosmarinus officinalis oil, antimicrobial agent A and antimicrobial agent B being present in an amount effective to inhibit the growth of oral pathogenic bacteria selected from the group consisting of Actinomyces viscosus, Fusobacterium nucleatum, Porphyromonas gingivalis, Streptococcus mutans, and Streptococcus sanguis.
19. The product of Claim 18, further comprising an antimicrobial agent C different from antimicrobial agent A and antimicrobial agent B selected from the group consisting of berberine, cedarwood oil, chloramphenicol, citronella oil, Glycyrrhiza glabra extract, juicy fruit basil oil, juniper berries oil, lemon basil oil, lemon oil, and Rosmarinus officinalis oil.
21. A method of inhibiting the growth of oral pathogenic bacteria selected from the group consisting of Actinomyces viscosus, Fusobacterium nucleatum, Porphyromonas gingivalis, Streptococcus mutans, and Streptococcus sanguis within an oral cavity comprising the steps of contacting the oral cavity with the product of Claim 18.
22. An oral hygiene product comprising: antimicrobial agent A and antimicrobial agent B in an amount effective to inhibit the growth of oral pathogenic bacteria selected from the group consisting of Actinomyces viscosus, Fusobacterium nucleatum, Porphyromonas gingivalis, Streptococcus mutans, and Streptococcus sanguis wherein agents A and B are selected from the group consisting of berberine, cedarwood oil, chloramphenicol, citral, citronella oil, Glycyrrhiza glabra extract, juicy fruit basil oil, juniper berries oil, lemon basil oil, lemon oil, and Rosmarinus officinalis oil.
58
23. The oral hygiene product of Claim 22, wherein the minimum inhibitory concentration for agent A relative to at least one of the bacteria, in the presence of agent B, is synergistically less than the minimum inhibitory concentration of agent A alone.
24. The oral hygiene product of Claim 23, wherein a minimum inhibitory concentration of agent B relative to at least one of the bacteria, in the presence of agent A, is synergistically less than the minimum inhibitory concentration of agent B alone.
26. The oral hygiene product of Claim 22, wherein agent A is selected from the group consisting of cedarwood oil, berberine, and Glycyrrhiza glabra extract.
27. The oral hygiene product of Claim 22, further comprising antimicrobial agent C, different from agent A and agent B, agent C being present in an amount effective to inhibit the growth of bacteria and selected from the group consisting of berberine, cedarwood oil, chloramphenicol, citral, citronella oil, Glycyrrhiza glabra extract, juicy fruit basil oil, juniper berries oil, lemon basil oil, lemon oil, and Rosmarinus officinalis oil.
28. A method for inhibiting the growth of bacteria within an oral cavity comprising the step: contacting the oral cavity with a composition that includes antimicrobial agent A and antimicrobial agent B in an amount effective to inhibit the growth of oral pathogenic bacteria selected from the group consisting of Actinomyces vicosus, Fusobacterium nucleatum, Porphyromonas gingivalis, Streptococcus mutans, and Streptococcus sanguis, agents A and B selected from the group consisting of berberine, cedarwood oil, chloramphenicol, citral, citronella oil, Glycyrrhiza glabra extract, juicy fruit basil oil, juniper berries oil, lemon basil oil, lemon oil, and Rosmarinus officinalis oil.
29. The method of Claim 28, wherein the minimum inhibitory concentration of agent A relative to at least one of the bacteria in the presence of agent B, is synergistically less than the minimum inhibitory concentration of agent A alone.
30. The method of Claim 29, wherein the minimum inhibitory concentration of agent B relative to at least one of the bacteria, in the presence of agent A, is synertistically less than the minimum inhibitory concentration of agent B alone.
32. The method of Claim 28, wherein the antimicrobial agent A is selected from the group consisting of cedarwood oil, berberine, and Glycyrrhiza glabra extract.
33. The method of Claim 28, wherein the composition that includes antimicrobial agents A and B further comprises an antimicrobial agent C different from agent A and agent B, agent C selected from the group consisting of berberine, cedarwood oil, chloramphenicol, citral, citronella oil, Glycyrrhiza glabra extract, juicy fruit basil oil, juniper berries oil, lemon basil oil, lemon oil, and Rosmarinus officinalis oil.
34. A method of reducing the minimum inhibitory concentration relative to oral pathogenic bacteria selected from the group consistin gof Actinomyces viscosus, Fusobacterium nucleatum, Porphyromonas gingivalis, Streptococcus mutans and Streptococcus sanguis, of an antimicrobial agent A selected from the group consisting of berberine, cedarwood oil, chloramphenicol, citral, citronella oil, geraniol, Glycyrrhiza glabra extract, juicy fruit basil oil, juniper berries oil, lemon basil oil, lemon oil, and Rosmarinus officinalis oil, comprising: combining agent A with an antimicrobial agent B different from agent A, agent B selected from the group consisting of berberine, cedarwood oil, chloramphenicol, citral, citronella oil, geraniol, Glycyrrhiza glabra extract, juicy fruit basil oil, juniper berries oil, lemon basil oil, lemon oil, and Rosmarinus officinalis oil, the minimum inhibitory concentration of agent A in the presence of agent B being less than the minimum inhibitory concentration of agent A alone.
35. The method of Claim 34, wherein the step of combining agent B with agent A results in a synergistic reduction in the minimum inhibitory concentration of agent A.
36. The oral hygiene product of Claim 18, wherein antimicrobial agent B is selected from the group consisting of juniper berries oil, lemon basil oil, lemon oil, Rosmarinus officinalis oil, and cedarwood oil.
37. The oral hygiene product of Claim 22, wherein antimicrobial agent A is cedarwood oil and antimicrobial agent B is selected from the group consisting of berberine and Glycyrrhiza glabra extract.
38. The oral hygiene product of Claim 22, wherein antimicrobial agent A is Glycyrrhiza glabra extract and antimicrobial agent B is selected from the group consisting of citronella oil, juicy fruit basil oil, juniper berries oil, and Rosmarinus officinalis oil.
39. The oral hygiene product of Claim 22, wherein antimicrobial agent A is chloramphenicol and antimicrobial agent B is lemon oil.
40. The oral hygiene product of Claim 22, wherein antimicrobial agent A is citral and antimicrobial agent B is selected from the group consisting of citronella oil, juicy fruit basil oil, juniper berries oil, lemon basil oil, lemon oil, and Rosmarinus officinalis oil.
41. The oral hygiene product of Claim 22, wherein antimicrobial agent A is citronella oil and antimicrobial agent B is selected from the group consisting of juicy fruit basil oil, juniper berries oil, lemon oil, and Rosmarinus officinalis oil.
42. The oral hygiene product of Claim 22, wherein antimicrobial agent A is juicy fruit basil oil and antimicrobial agent B is selected from the group consisting of juniper berries oil, lemon oil, and Rosmarinus officinalis oil.
43. The oral hygiene product of Claim 22, wherein antimicrobial agent A is juniper berries oil and antimicrobial agent B is selected from the group consisting of lemon basil oil, lemon oil, and Rosmarinus officinalis oil.
44. The oral hygiene product of Claim 22, wherein antimicrobial agent A is lemon basil oil and antimicrobial agent B is selected from the group consisting of lemon oil and Rosmarinus officinalis oil.
45. The oral hygiene product of Claim 22, wherein antimicrobial agent A is lemon oil and antimicrobial agent B is Rosmarinus officinalis oil.
46. An oral hygiene product comprising: an antimicrobial agent A comprising cocamidopropyl dimethylglycine; and
6 1
an antimicrobial agent B selected from the group consisting of berberine, cedarwood oil, chloramphenicol, citral, citronella oil, Glycyrrhiza glabra extract, juicy fruit basil oil, juniper berries oil, lemon basil oil, lemon oil, and Rosmarinus officinalis oil, antimicrobial agent A and antimicrobial agent B being present in an amount effective to inhibit the growth of oral pathogenic bacteria selected from the group consisting of Actinomyces viscosus, Fusobacterium nucleatum, Porphyromonas gingivalis, Streptococcus mutans, and Streptococcus sanguis.
47. A method for reducing the minimum inhibitory concentration of an antimicrobial agent A comprising cocamidopropyl dimethylglycine comprising: combining agent A with an antimicrobial agent B different than agent A- agent B selected from the group consisting of berberine, cedarwood oil, chloramphenicol, citral, citronella oil, geraniol, Glycyrrhiza glabra extract, juicy fruit basil oil, juniper berries oil, lemon basil oil, lemon oil, and Rosmarinus officinalis oil, the minimum inhibitory concentration of agent A in the presence of agent B being less thant he minimum inhibitory concentration of agent A alone.
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ333145A NZ333145A (en) | 1997-04-04 | 1998-04-01 | Natural oil extracts as antimicrobial compositions |
| JP10542888A JP2000514834A (en) | 1997-04-04 | 1998-04-01 | Antibacterial composition |
| BR9804815-5A BR9804815A (en) | 1997-04-04 | 1998-04-01 | "antimicrobial compositions" |
| IL12725898A IL127258A0 (en) | 1997-04-04 | 1998-04-01 | Antimicrobial compositions |
| SK1629-98A SK162998A3 (en) | 1997-04-04 | 1998-04-01 | Antimicrobial compositions |
| EP98914411A EP0934067A1 (en) | 1997-04-04 | 1998-04-01 | Antimicrobial compositions |
| AU68771/98A AU727242B2 (en) | 1997-04-04 | 1998-04-01 | Antimicrobial compositions |
| NO985643A NO985643L (en) | 1997-04-04 | 1998-12-03 | Antimicrobial Mixtures |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/832,821 US5939050A (en) | 1997-04-04 | 1997-04-04 | Antimicrobial compositions |
| US08/832,821 | 1997-04-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1998044926A1 WO1998044926A1 (en) | 1998-10-15 |
| WO1998044926B1 true WO1998044926B1 (en) | 1998-11-19 |
Family
ID=25262696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1998/006468 WO1998044926A1 (en) | 1997-04-04 | 1998-04-01 | Antimicrobial compositions |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5939050A (en) |
| EP (1) | EP0934067A1 (en) |
| JP (1) | JP2000514834A (en) |
| KR (1) | KR20000016352A (en) |
| CN (1) | CN1225585A (en) |
| AU (1) | AU727242B2 (en) |
| BR (1) | BR9804815A (en) |
| CA (1) | CA2257500A1 (en) |
| CZ (1) | CZ384798A3 (en) |
| HU (1) | HUP9903759A3 (en) |
| IL (1) | IL127258A0 (en) |
| NO (1) | NO985643L (en) |
| NZ (1) | NZ333145A (en) |
| SK (1) | SK162998A3 (en) |
| WO (1) | WO1998044926A1 (en) |
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| US4966754A (en) * | 1988-08-08 | 1990-10-30 | Aveda Corporation | Preservation of cosmetic compositions |
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| US5009898A (en) * | 1988-09-29 | 1991-04-23 | Kabushiki Kaisha Sangi | Antimicrobial hydroxyapatite powders and methods for preparing them |
| US5190944A (en) * | 1988-12-22 | 1993-03-02 | Rohm And Haas Company | Synergistic microbicidal combinations containing 3-isothiazoline and commercial biocides |
| US5009884A (en) * | 1989-11-15 | 1991-04-23 | Gillette Canada Inc. | Stabilized aqueous stannous fluoride mouthwash |
| US5017363A (en) * | 1989-11-15 | 1991-05-21 | Gillette Canada, Inc. | Stabilized stannous fluoride toothpaste |
| US4961924A (en) * | 1989-11-15 | 1990-10-09 | Gillette Canada Inc. | Stabilized stannous fluoride toothpaste |
| US4992259A (en) * | 1990-01-03 | 1991-02-12 | Johnson & Johnson Consumer Products, Inc. | Stable oral composition of zinc |
| ES2077703T3 (en) * | 1990-03-30 | 1995-12-01 | Suntory Ltd | GLUCOSILTRANSFERASE INHIBITORS, AS WELL AS METHODS FOR THE PREVENTION OF DENTAL CARIES AND ANTI-CARIES FOODS USED BY THESE INHIBITORS. |
| US5094843A (en) * | 1990-09-10 | 1992-03-10 | Beecham Inc. | Antimicrobial toothpaste |
| US5135747A (en) * | 1991-05-17 | 1992-08-04 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Deodorant/antiperspirant products with fragrance and encapsulated odor counteractant |
| US5256402A (en) * | 1991-09-13 | 1993-10-26 | Colgate-Palmolive Company | Abrasive tooth whitening dentifrice of improved stability |
| US5145666A (en) * | 1991-10-23 | 1992-09-08 | The Proctor & Gamble Co. | Methods of reducing plaque and gingivitis with reduced staining |
| US5213790A (en) * | 1991-10-23 | 1993-05-25 | The Procter & Gamble Co. | Methods of reducing plaque and gingivitis with reduced staining |
| US5281410A (en) * | 1991-10-23 | 1994-01-25 | The Proctor & Gamble Company | Methods of reducing plaque and gingivitis with reduced staining |
| US5468489A (en) * | 1991-10-29 | 1995-11-21 | Sangi Co., Ltd. | Dentifrice containing antibacterial material |
| US5298238A (en) * | 1991-11-07 | 1994-03-29 | Warner-Lambert Company | Liquid oral compositions comprising deterpenated and fractionated flavor oils |
| JPH05271073A (en) * | 1992-02-10 | 1993-10-19 | Takasago Internatl Corp | Anti (pseudomonas aeruginosa) agent |
| US5374418A (en) * | 1992-02-13 | 1994-12-20 | Kao Corporation | Composition for use in oral cavity |
| US5281411A (en) * | 1992-07-31 | 1994-01-25 | The Procter & Gamble Company | Oral compositions |
| US5378465A (en) * | 1993-05-24 | 1995-01-03 | Zeines; Victor | Solution for application to an oral cavity |
| US5376374A (en) * | 1993-05-24 | 1994-12-27 | Zelaya; Luz M. | Oral rinse composition |
| US5472684A (en) * | 1993-06-02 | 1995-12-05 | Colgate Palmolive Company | Oral compositions for plaque and gingivitis |
| JPH0789819A (en) * | 1993-09-17 | 1995-04-04 | Jumoku Chushutsu Seibun Riyou Gijutsu Kenkyu Kumiai | Good smelling microbicidal composition |
| US5338537A (en) * | 1993-10-05 | 1994-08-16 | The Procter & Gamble Company | Oral compositions |
| JP3468865B2 (en) * | 1994-08-19 | 2003-11-17 | 高砂香料工業株式会社 | Antimicrobial composition |
| FR2743722B1 (en) * | 1996-01-23 | 1998-05-15 | Puyravaud Michelle | PROCESS FOR OBTAINING A MASK FOR ACNE AND FOR DILATED PORES |
| EP0805198A1 (en) * | 1996-05-03 | 1997-11-05 | The Procter & Gamble Company | Cleaning compositions |
-
1997
- 1997-04-04 US US08/832,821 patent/US5939050A/en not_active Expired - Fee Related
-
1998
- 1998-04-01 CZ CZ983847A patent/CZ384798A3/en unknown
- 1998-04-01 IL IL12725898A patent/IL127258A0/en unknown
- 1998-04-01 BR BR9804815-5A patent/BR9804815A/en not_active Application Discontinuation
- 1998-04-01 SK SK1629-98A patent/SK162998A3/en unknown
- 1998-04-01 EP EP98914411A patent/EP0934067A1/en not_active Withdrawn
- 1998-04-01 CN CN98800567A patent/CN1225585A/en active Pending
- 1998-04-01 WO PCT/US1998/006468 patent/WO1998044926A1/en not_active Application Discontinuation
- 1998-04-01 AU AU68771/98A patent/AU727242B2/en not_active Ceased
- 1998-04-01 JP JP10542888A patent/JP2000514834A/en active Pending
- 1998-04-01 NZ NZ333145A patent/NZ333145A/en unknown
- 1998-04-01 CA CA002257500A patent/CA2257500A1/en not_active Abandoned
- 1998-04-01 HU HU9903759A patent/HUP9903759A3/en unknown
- 1998-04-01 KR KR1019980709926A patent/KR20000016352A/en not_active Application Discontinuation
- 1998-12-03 NO NO985643A patent/NO985643L/en not_active Application Discontinuation
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