WO1998042324A3 - Methods for modulating neurotrophic factor-associated activity using aldose reductase inhibitors - Google Patents

Methods for modulating neurotrophic factor-associated activity using aldose reductase inhibitors Download PDF

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Publication number
WO1998042324A3
WO1998042324A3 PCT/US1998/005623 US9805623W WO9842324A3 WO 1998042324 A3 WO1998042324 A3 WO 1998042324A3 US 9805623 W US9805623 W US 9805623W WO 9842324 A3 WO9842324 A3 WO 9842324A3
Authority
WO
WIPO (PCT)
Prior art keywords
reductase inhibitors
methods
aldose reductase
neurotrophic factor
associated activity
Prior art date
Application number
PCT/US1998/005623
Other languages
French (fr)
Other versions
WO1998042324A2 (en
WO1998042324A9 (en
Inventor
Frank Longo
Andrew Mizisin
Original Assignee
Univ California
Frank Longo
Andrew Mizisin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/045,194 external-priority patent/US6696407B1/en
Application filed by Univ California, Frank Longo, Andrew Mizisin filed Critical Univ California
Priority to AU64738/98A priority Critical patent/AU6473898A/en
Publication of WO1998042324A2 publication Critical patent/WO1998042324A2/en
Publication of WO1998042324A3 publication Critical patent/WO1998042324A3/en
Publication of WO1998042324A9 publication Critical patent/WO1998042324A9/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]

Abstract

The present invention provides methods of modulating neurotrophic factor-associated activity, especially CNTF-associated levels and activity, using aldose reductase inhibitors. These methods are especially useful in individuals suffering from, or at risk of developing, neurological disorders, including neurodegenerative disorders. The invention also provides methods of palliating neurological disorders and delaying development of neurological disorders using aldose reductase inhibitors.
PCT/US1998/005623 1997-03-21 1998-03-23 Methods for modulating neurotrophic factor-associated activity using aldose reductase inhibitors WO1998042324A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU64738/98A AU6473898A (en) 1997-03-21 1998-03-23 Methods for modulating neurotrophic factor-associated activity using aldose reductase inhibitors

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US82210397A 1997-03-21 1997-03-21
US08/822,103 1997-03-21
US09/045,194 US6696407B1 (en) 1997-03-21 1998-03-20 Huntington's disease treatment comprising administering aldose reductase inhibitors to increase striatal CNTF
US09/045,194 1998-03-20

Publications (3)

Publication Number Publication Date
WO1998042324A2 WO1998042324A2 (en) 1998-10-01
WO1998042324A3 true WO1998042324A3 (en) 1999-01-21
WO1998042324A9 WO1998042324A9 (en) 1999-03-18

Family

ID=26722480

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/005623 WO1998042324A2 (en) 1997-03-21 1998-03-23 Methods for modulating neurotrophic factor-associated activity using aldose reductase inhibitors

Country Status (2)

Country Link
AU (1) AU6473898A (en)
WO (1) WO1998042324A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002895A1 (en) * 1977-12-29 1979-07-11 Imperial Chemical Industries Plc Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof, and process for their manufacture
EP0059596A1 (en) * 1981-03-02 1982-09-08 Ayerst, Mckenna And Harrison Inc. N-Naphthoylglycine derivatives
WO1992016544A1 (en) * 1991-03-21 1992-10-01 Parfums Christian Dior Novel derivative of caffeic acid, oraposide, cosmetic or pharmaceutical, particularly dermatological, composition containing it

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002895A1 (en) * 1977-12-29 1979-07-11 Imperial Chemical Industries Plc Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof, and process for their manufacture
EP0059596A1 (en) * 1981-03-02 1982-09-08 Ayerst, Mckenna And Harrison Inc. N-Naphthoylglycine derivatives
WO1992016544A1 (en) * 1991-03-21 1992-10-01 Parfums Christian Dior Novel derivative of caffeic acid, oraposide, cosmetic or pharmaceutical, particularly dermatological, composition containing it

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
A.A.F. SIMA ET AL.: "PREVENTIVE EFFECT OF LONG-TERM ALDOSE REDUCTASE INHIBITION (PONALRESTAT) ON NERVE CONDUCTION AND SURAL NERVE STRUCTURE IN THE SPONTANEOUSLY DIABETIC BIO-BREEDING RAT", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 85, no. 5, 1990, pages 1410 - 1420, XP002081353 *
A.P. MIZISIN ET AL.: "ALDOSE REDUCTASE INHIBITION INCREASES CNTF-LIKE BIOACTIVITY AND PROTEIN IN SCIATIC NERVES FROM GALACTOSE-FED AND NORMAL RATS", DIABETES, vol. 46, no. 4, April 1997 (1997-04-01), pages 647 - 652, XP002081349 *
A.P. MIZISIN ET AL.: "SCHWANN CELL INJURY IS ATTENUATED BY ALDOSE REDUCTASE INHIBITION IN GALACTOSE INTOXICATION", JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, vol. 52, no. 1, 1993, pages 78 - 86, XP002081350 *
D.A. GREENE ET AL.: "EFFECTS OF ALDOSE REDUCTASE INHIBITORS ON THE PROGRESSION OF NERVE DAMAGE", DIABETIC MEDICINE, vol. 10, no. S2, 1993, pages 31S - 32S, XP002081352 *
D.F. EMERICH ET AL.: "IMPLANTS OF ENCAPSULATED HUMAN CNTF-PRODUCING FIBROBLASTS PREVENT BEHAVIORAL DEFICIT AND STRIATAL DEGENERATION IN A RODENT MODEL OF HUNTINGTON'S DISEASE", THE JOURNAL OF NEUROSCIENCE, vol. 16, no. 16, 1996, pages 5168 - 5181, XP002081356 *
D.R. TOMLINSON ET AL.: "ALDOSE REDUCTASE INHIBITORS AND DIABETIC COMPLICATIONS", PHARMACOLOGY & THERAPEUTICS, vol. 54, no. 2, 1992, pages 151 - 194, XP002081358 *
F. DITTRICH ET AL.: "CILIARY NEUROTROPHIC FACTOR: PHARMACOKINETICS AND ACUTE-PHASE RESPONSE IN RAT", ANNALS OF NEUROLOGY, vol. 35, no. 2, 1994, pages 151 - 163, XP002081357 *
J.B. JASPAN ET AL.: "CLINICAL STUDIES WITH AN ALDOSE REDUCTASE INHIBITOR IN THE AUTONOMIC AND SOMATIC NEUROPATHIES OF DIABETES", METABOLISM, vol. 35, no. 4, 1986, pages 83 - 92, XP002081354 *
M. TERADA ET AL.: "TOLRESTAT IMPROVES NERVE REGENERATION AFTER CRUSH INJURY IN STREPTOZOCIN-INDUCED DIABETIC RATS", METABOLISM, vol. 45, no. 10, pages 1189 - 1195, XP002081351 *
N.A. CALCUTT ET AL.: "REDUCED CILIARY NEURONOTROPHIC FACTOR-LIKE ACTIVITY IN NERVES FROM DIABETIC OR GALACTOSE-FED RATS", BRAIN RESEARCH, vol. 575, no. 2, 1992, pages 320 - 324, XP002081355 *

Also Published As

Publication number Publication date
AU6473898A (en) 1998-10-20
WO1998042324A2 (en) 1998-10-01

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