WO1998042320A3 - Extension of the expression of transgenic proteins by immunomodulation with 15-deoxyspergualine - Google Patents

Extension of the expression of transgenic proteins by immunomodulation with 15-deoxyspergualine Download PDF

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Publication number
WO1998042320A3
WO1998042320A3 PCT/EP1998/001439 EP9801439W WO9842320A3 WO 1998042320 A3 WO1998042320 A3 WO 1998042320A3 EP 9801439 W EP9801439 W EP 9801439W WO 9842320 A3 WO9842320 A3 WO 9842320A3
Authority
WO
WIPO (PCT)
Prior art keywords
deoxyspergualine
immunomodulation
expression
extension
transgenic proteins
Prior art date
Application number
PCT/EP1998/001439
Other languages
German (de)
French (fr)
Other versions
WO1998042320A2 (en
Inventor
Gerhard Seemann
Guenter Cichon
Original Assignee
Hoechst Ag
Gerhard Seemann
Guenter Cichon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag, Gerhard Seemann, Guenter Cichon filed Critical Hoechst Ag
Priority to AU70344/98A priority Critical patent/AU7034498A/en
Publication of WO1998042320A2 publication Critical patent/WO1998042320A2/en
Publication of WO1998042320A3 publication Critical patent/WO1998042320A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to the use of 15-deoxyspergualine in the production of a medicament to enhance transgenic cell tolerance in mammals. The use of 15-deoxyspergualine enables the production of transgenic expression products to be substantially extended even after discontinuation of immunosuppressive treatment.
PCT/EP1998/001439 1997-03-21 1998-03-12 Extension of the expression of transgenic proteins by immunomodulation with 15-deoxyspergualine WO1998042320A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU70344/98A AU7034498A (en) 1997-03-21 1998-03-12 Extension of the expression of transgenic proteins by immunomodulation with 15-deoxyspergualine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1997111803 DE19711803A1 (en) 1997-03-21 1997-03-21 Extension of expression of transgenic proteins by immunomodulating treatment with 15-deoxyspergualin
DE19711803.8 1997-03-21

Publications (2)

Publication Number Publication Date
WO1998042320A2 WO1998042320A2 (en) 1998-10-01
WO1998042320A3 true WO1998042320A3 (en) 1998-12-23

Family

ID=7824119

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/001439 WO1998042320A2 (en) 1997-03-21 1998-03-12 Extension of the expression of transgenic proteins by immunomodulation with 15-deoxyspergualine

Country Status (3)

Country Link
AU (1) AU7034498A (en)
DE (1) DE19711803A1 (en)
WO (1) WO1998042320A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19923961A1 (en) 1999-05-25 2000-11-30 Euro Nippon Kayaku Gmbh Use of 15-deoxyspergualin for the treatment of hyper-reactive inflammatory and autoimmune diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996012406A1 (en) * 1994-10-19 1996-05-02 Genetic Therapy, Inc. Gene therapy involving concurrent and repeated administration of adenoviruses and immunosuppressive agents
WO1997039776A1 (en) * 1996-04-19 1997-10-30 Genetic Therapy, Inc. Gene therapy involving concurrent and repeated administration of adenoviruses and immunosuppressive agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996012406A1 (en) * 1994-10-19 1996-05-02 Genetic Therapy, Inc. Gene therapy involving concurrent and repeated administration of adenoviruses and immunosuppressive agents
WO1997039776A1 (en) * 1996-04-19 1997-10-30 Genetic Therapy, Inc. Gene therapy involving concurrent and repeated administration of adenoviruses and immunosuppressive agents

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
HALLORAN, P.F.: "Rethinking Immunosuppression in Terms of the Redundant and Nonredundant Steps in the Immune Response", TRANSPLANTATION PROCEEDINGS, vol. 28, no. 6, 1996, pages 11 - 18, XP002076660 *
KALDEN ET AL.: "NEW THERAPEUTIC APPROACHES IN AUTOIMMUNE RHEUMATIC DISEASES, WITH SPECIAL EMPHASIS ON RHEUMATOID ARTHRITIS", BRITISH JOURNAL OF RHEUMATOLOGY, vol. 34, no. 3, 1995, pages 193 - 196, XP002076661 *
KERR ET AL.: "DEOXYSPERGUALIN SUPPRESSES LOCAL MACROPHAGE PROLIFERATION IN RAT RENAL ALLOGRAFT REJECTION", TRANSPLANTATION, vol. 58, no. 5, 1994, pages 596 - 601, XP002076657 *
NIKOLIC-PATERSON ET AL.: "Deoxyspergualin Inhibits Mesangial Cell Proliferation and Major Histocompatibility Complex Class II Expression", J. AM. SOC. NEPHROLOGY, vol. 5, no. 11, 1995, pages 1895 - 1902, XP002076656 *
PERICO ET AL.: "Prevention of Transplant Rejection", DRUGS, vol. 54, no. 4, 1997, pages 533 - 570, XP002076654 *
RÄISÄNEN-SOKOLOWSKI ET AL.: "Mechanism of Action of 15-Deoxyspergualin in Allograft Arteriosclerosis in Rat Aortic Transplants", TRANSPLANTATION PROCEEDINGS, vol. 26, no. 5, 1994, pages 3224, XP002076655 *
REYNOLDS: "MARTINDALE - THE EXTRA PHARMACOPOEIA.", 1996, ROYAL PHARMACEUTICAL SOCIETY, LONDON, XP002074427, 224540 *
SMITH ET AL.: "Transient immunosuppression permits successful repetitive intravenous administration of an adenovirus vector", GENE THERAPY, vol. 3, no. 6, 1996, pages 496 - 502, XP002076653 *
TEPPER M.A.: "Deoxyspergualin", ANN. N.Y. ACAD. SCI., vol. 696, 1993, pages 123 - 132, XP002076658 *
WAAGA ET AL.: "In Vitro Analysis of the Mode of Action of the Immuno-suppressive Drug 15-Deoxyspergualin", ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, vol. 44, no. 2-3, 1996, pages 155 - 163, XP002076659 *

Also Published As

Publication number Publication date
AU7034498A (en) 1998-10-20
WO1998042320A2 (en) 1998-10-01
DE19711803A1 (en) 1998-09-24

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