WO1998040495A1 - Doublin, gene participant au developpement neuronal et utilisations de ce gene - Google Patents

Doublin, gene participant au developpement neuronal et utilisations de ce gene Download PDF

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Publication number
WO1998040495A1
WO1998040495A1 PCT/US1998/004584 US9804584W WO9840495A1 WO 1998040495 A1 WO1998040495 A1 WO 1998040495A1 US 9804584 W US9804584 W US 9804584W WO 9840495 A1 WO9840495 A1 WO 9840495A1
Authority
WO
WIPO (PCT)
Prior art keywords
doublin
amino acid
polypeptide
seq
gene
Prior art date
Application number
PCT/US1998/004584
Other languages
English (en)
Inventor
Christopher A. Walsh
Kristina M. Allen
Joseph G. Gleeson
Original Assignee
Beth Israel Deaconess Medical Center Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beth Israel Deaconess Medical Center Inc. filed Critical Beth Israel Deaconess Medical Center Inc.
Priority to AU66941/98A priority Critical patent/AU6694198A/en
Publication of WO1998040495A1 publication Critical patent/WO1998040495A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des molécules d'acide nucléique et de polypeptides 'doublin', qui interviennent dans le développement neuronal, et notamment dans la migration neuronale. L'invention porte à la fois sur des compositions et sur des procédés convenant au diagnostic et au traitement des troubles neuronaux.
PCT/US1998/004584 1997-03-13 1998-03-09 Doublin, gene participant au developpement neuronal et utilisations de ce gene WO1998040495A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU66941/98A AU6694198A (en) 1997-03-13 1998-03-09 Doublin, a gene involved in neuronal development and uses therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81671797A 1997-03-13 1997-03-13
US08/816,717 1997-03-13

Publications (1)

Publication Number Publication Date
WO1998040495A1 true WO1998040495A1 (fr) 1998-09-17

Family

ID=25221435

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/004584 WO1998040495A1 (fr) 1997-03-13 1998-03-09 Doublin, gene participant au developpement neuronal et utilisations de ce gene

Country Status (2)

Country Link
AU (1) AU6694198A (fr)
WO (1) WO1998040495A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001049724A1 (fr) * 1999-12-29 2001-07-12 Fudan University Nouveau polypeptide, proteine lissencephale humaine 43, et polynucleotide codant pour ce polypeptide

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994005811A1 (fr) * 1992-08-31 1994-03-17 Bristol-Myers Squibb Company CLONAGE ET EXPRESSION DU RECEPTEUR β-APP-C100

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994005811A1 (fr) * 1992-08-31 1994-03-17 Bristol-Myers Squibb Company CLONAGE ET EXPRESSION DU RECEPTEUR β-APP-C100

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BAGRODIA S ET AL: "Identification of a mouse p21Cdc42/Rac activated kinase [published erratum appears in J Biol Chem 1996 Jan 12;271(2):1250]", J BIOL CHEM, SEP 29 1995, 270 (39) P22731-7, UNITED STATES, XP002070171 *
GLEESON JG ET AL: "doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein", CELL, 1998, 92, 63-72, XP002070174 *
LUO LQ (REPRINT) ET AL: "Small GTPases in axon outgrowth", PERSPECTIVES ON DEVELOPMENTAL NEUROBIOLOGY, 1996, 4, 199-204, XP002070172 *
MANSER E ET AL: "A brain serine/threonine protein kinase activated by Cdc42 and Rac1.", NATURE, JAN 6 1994, 367 (6458) P40-6, ENGLAND, XP002070169 *
MANSER E ET AL: "Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family.", J BIOL CHEM, OCT 20 1995, 270 (42) P25070-8, UNITED STATES, XP002070170 *
REINER O ET AL: "Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats.", NATURE, AUG 19 1993, 364 (6439) P717-21, ENGLAND, XP002070173 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001049724A1 (fr) * 1999-12-29 2001-07-12 Fudan University Nouveau polypeptide, proteine lissencephale humaine 43, et polynucleotide codant pour ce polypeptide

Also Published As

Publication number Publication date
AU6694198A (en) 1998-09-29

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