WO1998039034A3 - Verwendung von anti-cd44 antikörper enthaltenden präparationen zur behandlung bestimmter tumore und zur unterdrückung von immunreaktionen - Google Patents

Verwendung von anti-cd44 antikörper enthaltenden präparationen zur behandlung bestimmter tumore und zur unterdrückung von immunreaktionen Download PDF

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Publication number
WO1998039034A3
WO1998039034A3 PCT/EP1998/001089 EP9801089W WO9839034A3 WO 1998039034 A3 WO1998039034 A3 WO 1998039034A3 EP 9801089 W EP9801089 W EP 9801089W WO 9839034 A3 WO9839034 A3 WO 9839034A3
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WO
WIPO (PCT)
Prior art keywords
treatment
antibodies
immune reactions
suppression
preparations containing
Prior art date
Application number
PCT/EP1998/001089
Other languages
English (en)
French (fr)
Other versions
WO1998039034A2 (de
Inventor
Peter Herrlich
Helmut Ponta
Jan Simon
Johannes Weiss
Original Assignee
Boehringer Ingelheim Int
Karlsruhe Forschzent
Peter Herrlich
Helmut Ponta
Jan Simon
Johannes Weiss
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int, Karlsruhe Forschzent, Peter Herrlich, Helmut Ponta, Jan Simon, Johannes Weiss filed Critical Boehringer Ingelheim Int
Priority to CA002281934A priority Critical patent/CA2281934A1/en
Priority to JP53812198A priority patent/JP2001513794A/ja
Priority to EP98912401A priority patent/EP0967996A2/de
Publication of WO1998039034A2 publication Critical patent/WO1998039034A2/de
Publication of WO1998039034A3 publication Critical patent/WO1998039034A3/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2884—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD44
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Die vorliegende Erfindung betrifft die Verwendung von anti-CD44 Antikörpern von sowohl des konstanten (sCD44) als auch des variablen Teils von CD44 (vCD44) für die Behandlung bestimmter Tumore und anderen Erkrankungen, die mit einer Entartung und Aktivierung von Langerhans-Zellen (LC) und dendritischen Zellen (DC) innerhalb eines Säugetierkörpers einschließlich des Menschen assoziiert sind, und zur Behandlung unerwünschter Immunreaktionen. Ein weiter Gegenstand der vorliegenden Erfindung betrifft ein ex vivo Kulturverfahren zur Herstellung von dendritischen Zellen.
PCT/EP1998/001089 1997-03-04 1998-02-26 Verwendung von anti-cd44 antikörper enthaltenden präparationen zur behandlung bestimmter tumore und zur unterdrückung von immunreaktionen WO1998039034A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002281934A CA2281934A1 (en) 1997-03-04 1998-02-26 Use of preparations containing anti-cd44 antibodies for the treatment of certain tumours and for the supression of immune reactions
JP53812198A JP2001513794A (ja) 1997-03-04 1998-02-26 特定の腫瘍の治療および免疫反応を抑制するための、抗−ｃｄ４４抗体含有調製物の使用
EP98912401A EP0967996A2 (de) 1997-03-04 1998-02-26 Verwendung von anti-cd44 antikörper enthaltenden präparationen zur behandlungbstimmter tumore und zur unterdrückung von immunreaktionen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19708713A DE19708713C2 (de) 1997-03-04 1997-03-04 Verwendung von anti-CD44 Antikörpern enthaltenden Präparationen zur Behandlung bestimmter Tumore und zur Unterdrückung von Immunreaktionen
DE19708713.2 1997-03-04

Publications (2)

Publication Number Publication Date
WO1998039034A2 WO1998039034A2 (de) 1998-09-11
WO1998039034A3 true WO1998039034A3 (de) 1998-12-17

Family

ID=7822156

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/001089 WO1998039034A2 (de) 1997-03-04 1998-02-26 Verwendung von anti-cd44 antikörper enthaltenden präparationen zur behandlung bestimmter tumore und zur unterdrückung von immunreaktionen

Country Status (6)

Country Link
US (1) US20020160010A1 (de)
EP (1) EP0967996A2 (de)
JP (1) JP2001513794A (de)
CA (1) CA2281934A1 (de)
DE (1) DE19708713C2 (de)
WO (1) WO1998039034A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL133647A0 (en) * 1999-06-08 2001-04-30 Yissum Res Dev Co Novel cd44 variant
US7534605B2 (en) 1999-06-08 2009-05-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases
US8048416B2 (en) * 1999-10-08 2011-11-01 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US7947496B2 (en) * 1999-10-08 2011-05-24 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US8071072B2 (en) 1999-10-08 2011-12-06 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US7419792B2 (en) * 1999-10-08 2008-09-02 Arius Research Inc. Laminin Receptor 1 Precursor Protein (37LRP) epitope delineated by an Hepatocellular carcinoma specific antibody
US20080124327A1 (en) * 1999-10-08 2008-05-29 Arius Research, Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20090004103A1 (en) * 1999-10-08 2009-01-01 Young David S F Cytotoxicity mediation of cells evidencing surface expression of CD44
US20050100542A1 (en) * 1999-10-08 2005-05-12 Young David S. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20030103985A1 (en) 2001-05-18 2003-06-05 Boehringer Ingelheim International Gmbh Cytotoxic CD44 antibody immunoconjugates
US6972324B2 (en) 2001-05-18 2005-12-06 Boehringer Ingelheim Pharmaceuticals, Inc. Antibodies specific for CD44v6
EP1258255A1 (de) * 2001-05-18 2002-11-20 Boehringer Ingelheim International GmbH Konjugate eines Antikörpers zu CD44 und eines Maytansinoids
EP1391213A1 (de) * 2002-08-21 2004-02-25 Boehringer Ingelheim International GmbH Zusammensetzungen und Verfahren zur Behandlung von Krebs mit einem Maytansinoid-CD44-Antikörper Immunokonjugat und chemotherapeutische Mittel
WO2004024750A2 (en) * 2002-09-13 2004-03-25 Dyax Corporation Cd44-binding ligands
WO2005087264A1 (en) * 2004-03-17 2005-09-22 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Cd44-targeting for reducing/preventing ischemia-reperfusion-injury
WO2010102253A2 (en) * 2009-03-06 2010-09-10 Angstrom Pharmaceuticals, Inc. Compositions and methods for modulation of cell migration
CN107001442B (zh) 2014-07-15 2021-04-27 耶路撒冷希伯来大学伊森姆研究发展公司 Cd44的分离的多肽及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0538754A2 (de) * 1991-10-23 1993-04-28 Forschungszentrum Karlsruhe GmbH Verwendung von Antikörper enthaltenden Präparationen zur Immunsuppression
WO1994009811A1 (en) * 1992-10-30 1994-05-11 Duke University An adhesion molecule
WO1995033771A1 (de) * 1994-06-08 1995-12-14 Boehringer Ingelheim International Gmbh MONOKLONALER ANTIKÖRPER GEGEN CD44v6

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4014510A1 (de) * 1990-05-07 1991-11-14 Kernforschungsz Karlsruhe Variante cd44-oberflaechenproteine, diese kodierende c-dna-sequenzen, antikoerper gegen diese proteine sowie ihre verwendung in der diagnostik und therapie
CA2059824A1 (en) * 1991-02-26 1992-08-27 Thomas M. Aune Hybridomas and monoclonal antibodies that inhibit anti-cd3-stimulated t cell proliferation
DE4326573A1 (de) * 1993-08-07 1995-02-23 Boehringer Ingelheim Int Durch Exon v5 des CD44-Gens kodierte Polypeptide als Targets für Immuntherapie und Immunszintigraphie von Tumoren
DE4431297A1 (de) * 1994-09-02 1996-03-07 Boehringer Ingelheim Int Monoklonaler Antikörper gegen CD44v6

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0538754A2 (de) * 1991-10-23 1993-04-28 Forschungszentrum Karlsruhe GmbH Verwendung von Antikörper enthaltenden Präparationen zur Immunsuppression
WO1994009811A1 (en) * 1992-10-30 1994-05-11 Duke University An adhesion molecule
WO1995033771A1 (de) * 1994-06-08 1995-12-14 Boehringer Ingelheim International Gmbh MONOKLONALER ANTIKÖRPER GEGEN CD44v6

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
B. SANDMAIER ET AL.: "An anti-CD44 antibody does not enhance engraftment of DLA-identical marrow after low-dose total body irradiation.", TRANSPLANT IMMUNOLOGY, vol. 4, no. 4, December 1996 (1996-12-01), Sevenoaks, pages 271 - 274, XP002081983 *
F. BRENNAN ET AL.: "Anti-CD44 antibody prevents and ameliorates chronic relapsing experimental allergic encephalomyelitis (CREAE) by inhibiting leukocyte migration to the CNS.", ARTHRITIS & RHEUMATISM, vol. 39, no. 9 suppl., 1996, New York, NY, USA, pages S121, XP002081982 *
H. HAEGEL-KRONENBERGER ET AL.: "Regulation of CD44 isoform expression and CD44-mediated signalling in human dendritic cells.", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol. 417, 1997, New York, NY, USA, pages 83 - 90, XP002081984 *
K-H. HEIDER ET AL.: "Splice variants of the cell surface glycoprotein CD44 associated with metastatic tumour cells are expressed in normal tissues of humans and cynomolgus monkeys.", EUROPEAN JOURNAL OF CANCER, vol. 31A, no. 13/14, December 1995 (1995-12-01), Oxford, GB, pages 2385 - 2391, XP000644485 *

Also Published As

Publication number Publication date
EP0967996A2 (de) 2000-01-05
CA2281934A1 (en) 1998-09-11
DE19708713C2 (de) 2002-11-28
US20020160010A1 (en) 2002-10-31
DE19708713A1 (de) 1998-09-17
WO1998039034A2 (de) 1998-09-11
JP2001513794A (ja) 2001-09-04

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