WO1998028010A3 - Use of moieties for binding to hyaluronan and icam-1 - Google Patents

Use of moieties for binding to hyaluronan and icam-1 Download PDF

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Publication number
WO1998028010A3
WO1998028010A3 PCT/CA1997/001002 CA9701002W WO9828010A3 WO 1998028010 A3 WO1998028010 A3 WO 1998028010A3 CA 9701002 W CA9701002 W CA 9701002W WO 9828010 A3 WO9828010 A3 WO 9828010A3
Authority
WO
WIPO (PCT)
Prior art keywords
icam
hyaluronan
moieties
binding
formula
Prior art date
Application number
PCT/CA1997/001002
Other languages
French (fr)
Other versions
WO1998028010A2 (en
Inventor
Samuel Simon Asculai
Eva Anne Turley
Peter Mccourt
Original Assignee
Hyal Pharma Corp
Samuel Simon Asculai
Eva Anne Turley
Peter Mccourt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA002193941A external-priority patent/CA2193941A1/en
Priority claimed from CA002195386A external-priority patent/CA2195386A1/en
Application filed by Hyal Pharma Corp, Samuel Simon Asculai, Eva Anne Turley, Peter Mccourt filed Critical Hyal Pharma Corp
Priority to AU54742/98A priority Critical patent/AU5474298A/en
Publication of WO1998028010A2 publication Critical patent/WO1998028010A2/en
Publication of WO1998028010A3 publication Critical patent/WO1998028010A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

The use of an effective amount of a compound having the general formula RR1N(CH2)mNR2R3 or containing the moiety of formula (I) for the inhibition of the ICAM-1, wherein R and R1 are selected from H and (II) and R2 and R3 are selected from H, (III), (IV) and (V) and wherein m is an integer from 1-12.
PCT/CA1997/001002 1996-12-24 1997-12-23 Use of moieties for binding to hyaluronan and icam-1 WO1998028010A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU54742/98A AU5474298A (en) 1996-12-24 1997-12-23 Use of moieties for binding to hyaluronan and icam-1

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CA002193941A CA2193941A1 (en) 1996-12-24 1996-12-24 Use of moieties for binding to hyaluronan and icam-1
CA2,193,941 1996-12-24
CA002195386A CA2195386A1 (en) 1997-01-17 1997-01-17 Use of moieties for binding to hyaluronan and icam-1
CA2,195,386 1997-01-17

Publications (2)

Publication Number Publication Date
WO1998028010A2 WO1998028010A2 (en) 1998-07-02
WO1998028010A3 true WO1998028010A3 (en) 1999-08-19

Family

ID=25678946

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1997/001002 WO1998028010A2 (en) 1996-12-24 1997-12-23 Use of moieties for binding to hyaluronan and icam-1

Country Status (2)

Country Link
AU (1) AU5474298A (en)
WO (1) WO1998028010A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003220529B2 (en) 2002-03-27 2006-09-07 Immunex Corporation Methods for increasing polypeptide production

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0416250A2 (en) * 1989-08-01 1991-03-13 The Research Foundation Of State University Of New York N-acylurea and O-acylisourea derivatives of hyaluronic acid
WO1994002517A1 (en) * 1992-07-28 1994-02-03 Anika Research, Inc. Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0416250A2 (en) * 1989-08-01 1991-03-13 The Research Foundation Of State University Of New York N-acylurea and O-acylisourea derivatives of hyaluronic acid
WO1994002517A1 (en) * 1992-07-28 1994-02-03 Anika Research, Inc. Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
RAJA R H ET AL: "PREPARATION OF ALKYLAMINE AND IODINE-125 RADIO LABELED DERIVATIVES OF HYALURONIC-ACID UNIQUELY MODIFIED AT THE REDUCING END", ANAL BIOCHEM, 1984, VOL. 139, NO. 1, PAGE(S) 168-177., XP002070193 *
YANNARIELLO-BROWN, JUDITH ET AL: "Identification of the calcium-independent endocytic hyaluronan receptor in rat liver sinusoidal endothelial cells using a photoaffinity cross-linking reagent", J. BIOL. CHEM., VOL. 267, NO. 28, PAGE(S) 20451-6, 5 October 1992 (1992-10-05), XP002070192 *

Also Published As

Publication number Publication date
AU5474298A (en) 1998-07-17
WO1998028010A2 (en) 1998-07-02

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