WO1998023211A1 - Procede de mesure de la stenose coronarienne - Google Patents

Procede de mesure de la stenose coronarienne Download PDF

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Publication number
WO1998023211A1
WO1998023211A1 PCT/IL1997/000392 IL9700392W WO9823211A1 WO 1998023211 A1 WO1998023211 A1 WO 1998023211A1 IL 9700392 W IL9700392 W IL 9700392W WO 9823211 A1 WO9823211 A1 WO 9823211A1
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WO
WIPO (PCT)
Prior art keywords
velocity
blood
heart
stenosis
time period
Prior art date
Application number
PCT/IL1997/000392
Other languages
English (en)
Inventor
Zvi Friedman
Menachem Halmann
Original Assignee
Diasonics Israel Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diasonics Israel Ltd. filed Critical Diasonics Israel Ltd.
Priority to JP52448698A priority Critical patent/JP2001506517A/ja
Priority to AU51328/98A priority patent/AU5132898A/en
Priority to EP97946026A priority patent/EP0955888A1/fr
Publication of WO1998023211A1 publication Critical patent/WO1998023211A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/06—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/13—Tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/54—Control of the diagnostic device
    • A61B8/543—Control of the diagnostic device involving acquisition triggered by a physiological signal

Definitions

  • the present invention relates to ultrasonic diagnostic imaging systems, and more particularly to such systems which are capable of performing measurements of stenosis in coronaries using Doppler ultrasound techniques.
  • diagnostic ultrasound imaging systems provide a comprehensive evaluation of the subject's health condition.
  • the efficacy of ultrasound techniques has resulted in wide-spread acceptance of ultrasound imaging diagnosis by both patients and physicians.
  • diagnostic ultrasound imaging systems generate images of anatomical structures within the patient by transmitting ultra-high frequency sound waves (typically in the order of 3.0 to 10.0 MHz) and then analyzing the waves reflected from internal structures in the body.
  • the most widely used ultrasonic diagnostic systems display structural information of organs in the form of two-dimensional images of selected cross sections of an organ being examined. These images are widely known as "sector scans".
  • the ultrasound is swept across the organ in the form of a "cross sectional scan" The scan is ordinarily performed in real time so that the dynamics of anatomical structures can be visualized.
  • the blood-flow information is provided by utilizing the Doppler principle.
  • the Doppler principle is implemented by generating a beam comprising pulses of ultrasonic energy that are directed toward a blood vessel in which blood flow information is desired.
  • the moving blood cells in the blood vessel reflect the ultrasound energy and either increase or decrease the frequency of the reflected energy depending on the direction of the blood flow relative to the imager.
  • the magnitude of the frequency shift and the direction of the frequency shift are detected so that the velocity and the direction of the blood flow may be ascertained. Accordingly, using the Doppler principle it is well known to determine the velocity of the blood flowing in blood vessels at relatively precise locations.
  • blood flow velocity can be used to determine a stenotic condition of blood vessels.
  • a sharp increase in the flow velocity at a specific location on the blood vessel is a strong indication of a stenotic condition, i.e., that plaque has built up on the interior walls of the blood vessel decreasing the cross sectional area of the affected blood vessel.
  • stenosis determinations in the coronaries are generally made by using other imaging modalities.
  • Digital subtraction angiography is a preferred method.
  • stenosis measurements have been made using magnetic resonance imaging systems and/or computerized tomographic x-ray systems.
  • the computerized tomographic x-ray systems subjects the patients to x-ray radiation.
  • CT systems are large and bulky and certainly not generally available in a doctors office.
  • a special trip to a radiation center or hospital is necessary for undertaking stenosis examinations by computerized tomography.
  • each of these available alternatives utilizes expensive equipment which is not generally available, for example in a physician's office for routine examination. Thus, even when such systems are used they can not easily be used to monitor changes in the patient's condition.
  • a first aspect of the present invention is concerned with the determination of the velocity of blood in moving blood vessels, especially in coronary blood vessels.
  • one or more of a number of features are present in order to allow for such measurement.
  • the velocity measurements are made when the heart is substantially stationary.
  • preferred embodiments of the invention include temporal gating, so the Doppler data acquisition will be performed during this time period of lack of motion of the heart muscle.
  • the gating is based either on the patients on-line ECG or on the analysis of the Doppler signal itself.
  • the velocity is determined only within a region of interest. This reduces the amount of data which is acquired so that the data can be acquired a very short period, for example during the short periods when the heart is generally at rest.
  • the velocity is determined only at a plurality of sample points at which the coronaries are present. This further reduces the amount of data which must be acquired.
  • a second aspect of the invention is concerned with the determination of the magnitude of a coronary stenosis.
  • the stenosis is measured by determining the velocity at one or more positions upstream and/or downstream of the stenosis and within the stenosis.
  • the percent stenosis can then be determined from the ratio of the velocities of the blood within and outside of the stenosis.
  • the method of determining the velocity of the first aspect is utilized in finding the stenosis.
  • a plurality of sector scans is acquired, preferably when the heart is generally stationary.
  • the position of the coronaries is determined and the velocity is determined in each sector scan for the various coronary arteries. From this information, the position of a stenosis is determined and the velocity at the stenosis and at a one or more positions up or down stream of the stenosis is measured. The percent stenosis is determined from the ratio of the velocities. If there is stenosis, then there will be a marked increase in the velocity of blood flow at the areas of stenosis in the coronaries.
  • the velocity of the blood taken at different axial points of the coronary determines whether or not there is stenosis in the coronaries. Accordingly, a plurality of planar "cuts" are preferably taken of the heart and Doppler measurements are provided at the coronaries immediately prior to the systolic contraction. The area of interest is divided into a multitude of sample volumes and multiple Doppler measurements are simultaneously accomplished to identify the coronaries and to make the velocity measurements at the coronaries in the image plane.
  • the velocity measurements are, in a preferred embodiment of the invention, made in accordance with the system of U.S. patent 5,419,332 although other methods of blood velocity measurement known in the art may be used in the practice of the invention. The contents of that patent is hereby incorporated by reference in this disclosure.
  • the "rest" time of the heart muscle is in the order of 100-200 msec. This is a sufficient time period in order to obtain sufficient data for a spectral Doppler image and especially with the use of multiple gates to simultaneously monitor a plurality of coronaries. Alternatively, this time can be lengthened using certain medications.
  • a method for measurement of blood velocity in coronary blood vessels comprising: determining a time period at which the heart is relatively stationary; and determining the velocity of blood at one or more points in one or more coronary blood vessels utilizing ultrasound based method during said determined time period.
  • the ultrasound based method is a non-invasive method.
  • the method utilizes Doppler ultrasound for determining the velocity of the blood.
  • determining a time period at which the heart is relatively stationary comprises utilizing an ECG measurement.
  • determining a time period at which the heart is relatively stationary comprises utilizing a Doppler ultrasound measurement.
  • the time period at which the heart is relatively stationary is the time period immediately prior to systole.
  • the time period at which the heart is relatively stationary comprises the time period immediately prior to systole.
  • the ultrasound system is gated to acquire data only during said time period at which the heart is relatively stationary.
  • a preferred embodiment of the invention includes: transmitting ultrasound signals along at least one line, said at least on line intersecting a point at which a coronary is located; and locating said intersection point along each of the lines at the coronaries and determining the velocity of blood flow at the intersection point based on signals received from the blood in the coronaries.
  • a method for measurement of stenosis in a coronary blood vessel comprising: determining the velocity of the blood at the location of the stenosis utilizing ultrasound; determining the velocity of the blood at one or more points in the vessel upstream and/or downstream of the stenosis utilizing ultrasound; and computing the stenosis from the measured velocity at the stenosis and away from the stenosis.
  • the velocity of the blood is measured according to one the methods described above.
  • the location of a stenosis is determined prior to making said velocity measurements.
  • the location of a stenosis is determined based on said velocity measurements.
  • the method includes: scanning the heart with ultrasound; acquiring a plurality of ultrasound sector scan images of the heart at different locations in the heart; examining each of the sector scan images using spectral Doppler signals to locate multiple coronaries; gating the spectral Doppler signals to occur when the heart is at relative rest; and determining the velocity of blood flow in the coronaries in each of the sector scan images by using the spectral Doppler signals.
  • the method includes: locating multiple coronaries in each of the sectors; acquiring as much velocity information as possible during the gating period; moving to the next sector to locate the multiple coronaries and to determine as much blood velocity information as possible during the gating period; and returning to each of the sectors to complete the determination of the velocity information as necessary.
  • the method includes determining the velocity of blood flow in each coronary in each sector before moving on to the next sector for measurements.
  • examining each of the sector scan images to locate coronaries includes: traversing selected sectors by a plurality of beams for determining where along each of the beams multiple coronaries are located; and simultaneously Doppler scanning each of the multiple coronaries in parallel to provide the blood flow velocity information in parallel with the sector scan.
  • the method includes preventing misalignment between the sector scan images and flow images.
  • preventing misalignment includes the simultaneous generation of both the sector scan images and the Doppler images.
  • preventing misalignment comprises: projecting a tracking element onto the coronaries, and locking the tracking element onto the coronaries in the sector scan images.
  • locking comprises using a TV tracker.
  • apparatus for measurement of blood velocity in coronary blood vessels comprising: a controller which determines a time period at which the heart is relatively stationary; and an ultrasonic measurement system, preferably, non-invasive, preferably Doppler, which determines the velocity of blood at one or more points in one or more coronary blood vessels during said determined time period.
  • the controller comprises an ECG monitor which supplies electrical signals indicative of the motion of the heart.
  • the controller utilizes a Doppler ultrasound measurement in determining the time period.
  • the time period at which the heart is relatively stationary is the time period immediately prior to systole.
  • the time period at which the heart is relatively stationary comprises the time period immediately prior to systole.
  • the ultrasound system is gated to acquire data only during said time period at which the heart is relatively stationary.
  • said ultrasonic measurement system transmits ultrasound signals along at least one line which intersects a point at which a coronary is located; and said controller locates said intersection point along each of the lines at the coronaries and determines the velocity of blood flow at the intersection point based on signals received from the blood in the coronaries.
  • apparatus for measurement of stenosis in a coronary blood vessel comprising: an ultrasonic measurement system which measures the velocity of the blood at the location of the stenosis and determines the velocity of the blood at one or more points in the vessel upstream and/or downstream of the stenosis; and a controller which computes the severity of the stenosis from the measured velocity at the stenosis and away from the stenosis.
  • the ultrasonic measurement system and the controller comprise the apparatus described above.
  • the ultrasonic measurement system and the controller utilize a method for determining stenosis as described above.
  • Fig. 1 is a pictorial representation of the heart with coronaries at or slightly below the surface thereof;
  • Fig. 2 is a sectional view of a coronary having a build-up of plaque therein causing stenosis;
  • Fig. 3 is a pictorial view of the heart with a plurality of sectional cuts there through made using an ultrasonic probe placed adjacent to the patient's body and varying the angle of the probe to provide the multiple sectors scans;
  • Fig. 4 is a plan view of a single one of the sectional scans showing a coronary approximately perpendicular to the plane;
  • Fig. 5 graphically shows the velocity of the blood and corresponding Doppler shift through the heart cycle period;
  • Fig. 6 shows schematically the velocity of the blood in a blood vessel upstream of the stenosis, downstream of the stenosis and at the stenotic portion of the blood vessel; and
  • Fig. 7 is a block diagram of the preferred embodiment of the ultrasound system used to determine the velocity of blood in different axial sections of the coronaries.
  • FIG. 1 As indicated in the pictorial showing of the heart 11 in Fig. 1, there is more than one coronary at the surface of the heart. By way of example, two coronaries 12 and 13 are shown in Fig. 1.
  • the heart muscle is a pump that is almost always in motion as it goes through the diastolic and systolic movements.
  • Fig. 2 shows a blood vessel 14 having walls 16 and 17 of an initial thickness; but, having plaque 18 built up on the walls to diminish the inner diameter of the blood vessel. It is an object of the present invention to determine the degree of the stenosis. Stenosis can be determined and is determined in the instant case by measuring the velocity of the blood as it passes through different cross sectional areas in the blood vessel. As the plaque builds up, the cross sectional area through which the blood flow diminishes, the velocity of the blood in the restricted area (indicated by a ⁇ ow 19) increases according to the Bernoulli theorem.
  • Fig. 3 shows an ultrasound a ⁇ ay transducer 21 mounted external to and juxtaposed to the body of the patient. During the scanning, the transducer is moved to change the angle at which it transmits ultrasonic beams into the patient. In this manner, a plurality of sector scans shown as sector scans a, b, c, d, e and f by way of example are obtained. An individual sector scan section d, for example, is shown at Fig. 4, which is described in detail below.
  • the positions of the stenosis is determined, at least approximately, prior to the scanning.
  • the position of a stenosis is determined from the velocity measurements themselves, for example by graphing the measured velocities along a coronary vessel and determining the position of a stenosis from an anomalous increase in velocity.
  • the actual window of time for making the scan and acquiring data is approximately 50- 200 milliseconds which is the time during which the heart is almost stationary. That amount of time surprisingly proves sufficient, since only the determination of velocity is required. If sufficient data is not acquired during the first heart scan, the scan is repeated during a later cardiac cycle. The longest time during which the heart muscle is substantially stationary is immediately prior to the systolic movement of the heart.
  • Fig. 5 shows, at curve 26, the Doppler frequency shift of the ultrasound beam centered at the heart muscle.
  • the frequency shift graph represents changes in the velocity of the blood versus time.
  • the curve 26 of course shows changes corresponding to the diastolic and systolic rhythm of the heart.
  • the muscle velocity is normally increasing during the systolic action of the heart and normally decreasing the time of the diastolic movement of the heart.
  • the diastolic action of the heart will take place at 27 on curve 26 while the systolic movement of the heart occurs at 28 on curve 26.
  • the instances of minimum heart movement, or practically no heart movement takes place at sections 29 and 30 immediately prior to the beginning of the systolic or diastolic movement of the heart, respectively.
  • Fig. 6 shows how the velocity of the blood at the stenosis section of the blood vessel such as section 24 of blood vessel 14 provides a peak velocity at 34 in Fig. 6. Prior to the stenosis section 36, the velocity is much smaller than the peak velocity at 34 and more or less steady. The same steady state velocity measurement is obtained after the stenosis section shown at 37 in Fig. 7.
  • the amount of stenosis may vary along the length of the stenosis and that some blockage may be present outside the "stenosis.”
  • the regions 34, 36 and 37 do not generally have the smooth form shown in Fig. 6.
  • the apparatus block diagram showing of Fig. 7 shows the system for simultaneously determining the velocity at multiple gates or volumes in each of the scan sectors so that a minimal amount of time is actually required for obtaining the vascular blood velocity.
  • the velocity measurement is determinative of whether or not a stenotic condition exists.
  • Fig. 7 shows a Doppler channel 41 for measuring blood velocity.
  • the Doppler channel is shown as comprising a transmitting-receiving unit 42 operating in conjunction with an oscillator, or frequency generator 43.
  • the transmitting portion of the unit 42 transmits pulses of ultrasound waves typically in the order of 2-10 MHz through a transducer, or probe 44.
  • the transducer 44 also acts to receive the signals obtained as sound waves when they are reflected by the walls of the heart and coronaries in the subject 45.
  • the receiving portion of transmitter receiver 42 receives the echoes and transmits them through a demodulator 46 and through a two dimensional imaging channel 47.
  • the demodulator 46 provides in-phase (I) and quadrature (Q) signals.
  • the signals from the demodulator 46 and the two dimensional imaging channel 47 are sent to a processor 48 for image processing.
  • the processed signals are sent to display unit 49 which displays image 51.
  • the displayed image 51 as shown in Fig. 4 generally includes an anatomical image of the sector scanned and encompasses the region of interest 22.
  • Fig. 4 shows a portion of scan d of Fig. 3
  • a region of interest 22 is traversed by a plurality of beams such as beams 52, 53 and 54. Coronaries 12-15 are identified.
  • data is acquired only along (or in the vicinity of) the beams on which coronaries are located. This substantially reduces the amount of data to be acquired and allows for
  • a heart gate monitor 63 is provided.
  • the monitor causes the transmittal of the Doppler pulses to occur immediately prior to the systolic movement of the heart, when the heart muscle is almost at rest. That enables obtaining data regarding the flow without the disturbance of the large movements of the heart muscle, which can now be easily filtered out with a high-pass filter, if necessary.
  • the length of the time gate may be made responsive to the amount of data required and the actual time structure of the movement of the heart.
  • the sector scan is taken during the quiet period of the heart muscle when there is minimum or almost no movement of the heart muscle.
  • the first sector scan determines the location of the coronaries.
  • the scan is repeated on the next heart cycle to determine the actual velocity preferably simultaneously at each sample point on each sector scan by repeating the transmission of the Doppler pulse preferably simultaneously along each of the beams that traverses the coronaries. If necessary a third spectral scan is taken during the next heart cycle until the velocity of the blood in each of the coronaries is determined.
  • the transducer angle is changed so that another sector of the heart is examined.
  • the same procedure is followed until each of the sector scans and velocity measurements of the blood of the coronaries as shown in Fig. 3 is accomplished. Because multiple gates are used, the time required is manageable.
  • a single sector scan can be accomplished and the blood velocity in all of the coronaries on the single sector measured simultaneously.
  • the same sector may be scanned repeatedly until sufficient data is obtained to determine the velocity in each of the coronaries. The scan is then moved to the next sector. This process is repeated until sufficient flow information for the coronaries is acquired to determine whether or not there is indeed a stenosis condition and what is its magnitude.
  • each of the multiple gates are interrogated in parallel to provide the blood flow velocity information in parallel.
  • a typical mode of operation would be that the user preselects a region of interest which a system will then investigate. Since the time required for a full spectral Doppler image acquisition of each sector is in the order of 2-4 cardiac cycles, the complete stenosis determination can take place in approximately 6-18 seconds.
  • the actual acquisition of data is gated.
  • the analysis of the data is gated to limit it to the points of interest.
  • the processor 48 preferably also prevents misalignment of the spectral Doppler imaging (SDI) between the scan images and the flow images, that is, the two-dimensional gray scale image and the flow parameters showing on the sector scan image. This is accomplished by the simultaneous generation of both the sector scan image and the Doppler image.
  • SDI spectral Doppler imaging
  • Another misalignment prevention procedure may be required since repetitions are necessary for each of the sector scans due to the short time available in the time immediately prior to the systolic movement of the heart.
  • This misalignment prevention procedure includes a step of projecting and locking cross-hairs onto the region of interest in the scan sector images.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
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Abstract

La présente invention concerne un procédé permettant de mesures la vitesse d'écoulement du sang dans les vaisseaux coronaires. Ce procédé consiste à déterminer un intervalle de temps pendant lequel le coeur est relativement stationnaire, puis, en recourant à une technique d'ultrasons, à déterminer la vitesse d'écoulement du sang en un ou plusieurs points d'un ou de plusieurs vaisseaux coronaires pendant l'intervalle de temps considéré.
PCT/IL1997/000392 1996-11-28 1997-11-27 Procede de mesure de la stenose coronarienne WO1998023211A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP52448698A JP2001506517A (ja) 1996-11-28 1997-11-27 冠動脈における狭窄計測法
AU51328/98A AU5132898A (en) 1996-11-28 1997-11-27 Coronary stenosis measurements
EP97946026A EP0955888A1 (fr) 1996-11-28 1997-11-27 Procede de mesure de la stenose coronarienne

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL119713 1996-11-28
IL11971396A IL119713A0 (en) 1996-11-28 1996-11-28 Coronary stenosis measurements

Publications (1)

Publication Number Publication Date
WO1998023211A1 true WO1998023211A1 (fr) 1998-06-04

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Application Number Title Priority Date Filing Date
PCT/IL1997/000392 WO1998023211A1 (fr) 1996-11-28 1997-11-27 Procede de mesure de la stenose coronarienne

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EP (1) EP0955888A1 (fr)
JP (1) JP2001506517A (fr)
AU (1) AU5132898A (fr)
IL (1) IL119713A0 (fr)
WO (1) WO1998023211A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002069805A1 (fr) * 2001-03-02 2002-09-12 Palti Yoram Prof Procédé et dispositif de détection de sténose artérielle
CN104066377A (zh) * 2012-09-25 2014-09-24 东芝医疗系统株式会社 X射线诊断装置以及医用图像处理装置
EP2886058A1 (fr) * 2013-12-18 2015-06-24 Samsung Medison Co., Ltd. Appareil et procédé d'affichage du degré de sténose dans une image ultrasonore

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9066679B2 (en) 2004-08-31 2015-06-30 University Of Washington Ultrasonic technique for assessing wall vibrations in stenosed blood vessels
EP1784130A4 (fr) * 2004-08-31 2014-11-19 Univ Washington Technique ultrasonore destinee a evaluer des vibrations de parois dans des vaisseaux sanguins stenoses
JP5300171B2 (ja) * 2005-06-30 2013-09-25 株式会社東芝 超音波診断装置、超音波画像処理装置及び超音波画像処理プログラム

Citations (4)

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Publication number Priority date Publication date Assignee Title
FR2591884A1 (fr) * 1985-12-17 1987-06-26 Washington Res Found Procede non envahissant de diagnostic de la stenose vasculaire
US5327893A (en) * 1992-10-19 1994-07-12 Rensselaer Polytechnic Institute Detection of cholesterol deposits in arteries
US5383463A (en) * 1993-08-02 1995-01-24 Friedman; Zvi Mapping of flow parameters
US5419332A (en) 1993-08-02 1995-05-30 Sabbah; Benjamin Mapping of flow parameters

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2591884A1 (fr) * 1985-12-17 1987-06-26 Washington Res Found Procede non envahissant de diagnostic de la stenose vasculaire
US5327893A (en) * 1992-10-19 1994-07-12 Rensselaer Polytechnic Institute Detection of cholesterol deposits in arteries
US5383463A (en) * 1993-08-02 1995-01-24 Friedman; Zvi Mapping of flow parameters
US5419332A (en) 1993-08-02 1995-05-30 Sabbah; Benjamin Mapping of flow parameters

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002069805A1 (fr) * 2001-03-02 2002-09-12 Palti Yoram Prof Procédé et dispositif de détection de sténose artérielle
US6730030B2 (en) 2001-03-02 2004-05-04 Yoram Palti Method and apparatus for detecting arterial stenosis
CN104066377A (zh) * 2012-09-25 2014-09-24 东芝医疗系统株式会社 X射线诊断装置以及医用图像处理装置
US20150087956A1 (en) * 2012-09-25 2015-03-26 Toshiba Medical Systems Corporation X-ray diagnostic apparatus and medical image processing apparatus
EP2901930A4 (fr) * 2012-09-25 2016-07-13 Toshiba Medical Sys Corp Dispositif de diagnostic par rayons x et dispositif de traitement d'images médicales
US10736593B2 (en) 2012-09-25 2020-08-11 Canon Medical Systems Corporation X-ray diagnostic apparatus and medical image processing apparatus
EP2886058A1 (fr) * 2013-12-18 2015-06-24 Samsung Medison Co., Ltd. Appareil et procédé d'affichage du degré de sténose dans une image ultrasonore

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IL119713A0 (en) 1997-02-18
AU5132898A (en) 1998-06-22
JP2001506517A (ja) 2001-05-22
EP0955888A1 (fr) 1999-11-17

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