WO1998020033A3 - Renaturation and purification of viral interleukin-10 (vIL-10) - Google Patents

Renaturation and purification of viral interleukin-10 (vIL-10) Download PDF

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Publication number
WO1998020033A3
WO1998020033A3 PCT/US1997/019608 US9719608W WO9820033A3 WO 1998020033 A3 WO1998020033 A3 WO 1998020033A3 US 9719608 W US9719608 W US 9719608W WO 9820033 A3 WO9820033 A3 WO 9820033A3
Authority
WO
WIPO (PCT)
Prior art keywords
renaturation
purification
vil
viral
viral interleukin
Prior art date
Application number
PCT/US1997/019608
Other languages
French (fr)
Other versions
WO1998020033A2 (en
Inventor
A Satish Menon
Yuming Xu
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to AU51950/98A priority Critical patent/AU5195098A/en
Publication of WO1998020033A2 publication Critical patent/WO1998020033A2/en
Publication of WO1998020033A3 publication Critical patent/WO1998020033A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
    • C12N2710/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Methods which are useful for renaturation and/or purification of viral counterparts of the cytokine interleukin-10. Mature viral IL-10 exhibits sequence differences from cellular IL-10 clustered primarily at the amino terminus, and the sequence differences are reflected in different biological and physicochemical properties. Renaturation and purification strategies are provided.
PCT/US1997/019608 1996-11-06 1997-11-05 RENATURATION AND PURIFICATION OF VIRAL INTERLEUKIN-10 (vIL-10) WO1998020033A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU51950/98A AU5195098A (en) 1996-11-06 1997-11-05 Renaturation and purification of viral interleukin-10 (vil-10)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3070596P 1996-11-06 1996-11-06
US60/030,705 1996-11-06

Publications (2)

Publication Number Publication Date
WO1998020033A2 WO1998020033A2 (en) 1998-05-14
WO1998020033A3 true WO1998020033A3 (en) 1998-07-23

Family

ID=21855585

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/019608 WO1998020033A2 (en) 1996-11-06 1997-11-05 RENATURATION AND PURIFICATION OF VIRAL INTERLEUKIN-10 (vIL-10)

Country Status (2)

Country Link
AU (1) AU5195098A (en)
WO (1) WO1998020033A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1314739A1 (en) * 2001-11-22 2003-05-28 Bayer Ag Process for renaturation of recombinant, disulfide containing proteins at high protein concentrations in the presence of amines
CN107108712A (en) * 2014-12-23 2017-08-29 阿尔莫生物科技股份有限公司 The method for improving recombinant protein yield

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993017698A1 (en) * 1992-03-04 1993-09-16 Schering Corporation Use of interleukin-10 to suppress graft-vs.-host disease
US5368854A (en) * 1992-08-20 1994-11-29 Schering Corporation Use of IL-10 to treat inflammatory bowel disease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993017698A1 (en) * 1992-03-04 1993-09-16 Schering Corporation Use of interleukin-10 to suppress graft-vs.-host disease
US5368854A (en) * 1992-08-20 1994-11-29 Schering Corporation Use of IL-10 to treat inflammatory bowel disease

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HERMANN, R.: "Protein Folding", 1993, EUROPEAN PATENT OFFICE, ISBN 90-9006173-8, XP002056863 *

Also Published As

Publication number Publication date
AU5195098A (en) 1998-05-29
WO1998020033A2 (en) 1998-05-14

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