WO1998019158A1 - Assay and cell line for the identification of growth hormone mimetics - Google Patents
Assay and cell line for the identification of growth hormone mimetics Download PDFInfo
- Publication number
- WO1998019158A1 WO1998019158A1 PCT/US1997/019350 US9719350W WO9819158A1 WO 1998019158 A1 WO1998019158 A1 WO 1998019158A1 US 9719350 W US9719350 W US 9719350W WO 9819158 A1 WO9819158 A1 WO 9819158A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- growth hormone
- reporter gene
- promoter
- assay
- cell
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/61—Growth hormones [GH] (Somatotropin)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002270179A CA2270179A1 (en) | 1996-10-31 | 1997-10-27 | Assay and cell line for the identification of growth hormone mimetics |
EP97946307A EP0935753A4 (en) | 1996-10-31 | 1997-10-27 | Assay and cell line for the identification of growth hormone mimetics |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2923796P | 1996-10-31 | 1996-10-31 | |
US60/029,237 | 1996-10-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998019158A1 true WO1998019158A1 (en) | 1998-05-07 |
Family
ID=21847984
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/019350 WO1998019158A1 (en) | 1996-10-31 | 1997-10-27 | Assay and cell line for the identification of growth hormone mimetics |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0935753A4 (en) |
CA (1) | CA2270179A1 (en) |
WO (1) | WO1998019158A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000000161A2 (en) * | 1998-06-30 | 2000-01-06 | The Procter & Gamble Company | Methods for identification of tef-3 interacting factors |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5445941A (en) * | 1993-06-21 | 1995-08-29 | Eli Lilly And Company | Method for screening anti-osteoporosis agents |
US5506102A (en) * | 1993-10-28 | 1996-04-09 | Ligand Pharmaceuticals Incorporated | Methods of using the A form of the progesterone receptor to screen for antagonists of steroid intracellar receptor-mediated transcription |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5401629A (en) * | 1990-08-07 | 1995-03-28 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Assay methods and compositions useful for measuring the transduction of an intracellular signal |
AU6353594A (en) * | 1993-02-19 | 1994-09-14 | Edison Animal Biotechnology Center | A method for detecting compounds with growth hormone and growth hormone receptor activity |
-
1997
- 1997-10-27 WO PCT/US1997/019350 patent/WO1998019158A1/en not_active Application Discontinuation
- 1997-10-27 EP EP97946307A patent/EP0935753A4/en not_active Withdrawn
- 1997-10-27 CA CA002270179A patent/CA2270179A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5445941A (en) * | 1993-06-21 | 1995-08-29 | Eli Lilly And Company | Method for screening anti-osteoporosis agents |
US5506102A (en) * | 1993-10-28 | 1996-04-09 | Ligand Pharmaceuticals Incorporated | Methods of using the A form of the progesterone receptor to screen for antagonists of steroid intracellar receptor-mediated transcription |
Non-Patent Citations (4)
Title |
---|
JOURNAL OF BIOLOGICAL CHEMISTRY, 20 October 1995, Volume 270, Number 42, BERGAD P.L. et al., "Growth Hormone Induction of Hepatic Serine Protease Inhibitor 2.1 Transcription is Mediated by Stat5-Related Factor Binding Synergistically to Two Gamma-Activated Sites", pages 24903-24910. * |
JOURNAL OF BIOLOGICAL CHEMISTRY, 26 August 1994, Volume 269, Number 34, LE CAM A. et al., "Cis-Acting Elements Controlling Transcription from Rat Serine Protease Inhibitor 2.1 Gene Promoter", pages 21532-21539. * |
JOURNAL OF MOLECULAR ENDOCRINOLOGY, February 1994, Volume 12, Number 1, ENBERG B. et al., "Growth Hormone (GH) Regulation of a Rat Serine Protease Inhibitor Fusion Gene in Cells Transfected with GH Receptor cDNA", pages 39-46. * |
See also references of EP0935753A4 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000000161A2 (en) * | 1998-06-30 | 2000-01-06 | The Procter & Gamble Company | Methods for identification of tef-3 interacting factors |
WO2000000161A3 (en) * | 1998-06-30 | 2001-01-04 | Procter & Gamble | Methods for identification of tef-3 interacting factors |
Also Published As
Publication number | Publication date |
---|---|
EP0935753A4 (en) | 1999-12-08 |
CA2270179A1 (en) | 1998-05-07 |
EP0935753A1 (en) | 1999-08-18 |
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