EP0935753A4 - Assay and cell line for the identification of growth hormone mimetics - Google Patents

Assay and cell line for the identification of growth hormone mimetics

Info

Publication number
EP0935753A4
EP0935753A4 EP97946307A EP97946307A EP0935753A4 EP 0935753 A4 EP0935753 A4 EP 0935753A4 EP 97946307 A EP97946307 A EP 97946307A EP 97946307 A EP97946307 A EP 97946307A EP 0935753 A4 EP0935753 A4 EP 0935753A4
Authority
EP
European Patent Office
Prior art keywords
assay
identification
cell line
growth hormone
hormone mimetics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97946307A
Other languages
German (de)
French (fr)
Other versions
EP0935753A1 (en
Inventor
Charles I Rosenblum
Aurawan Vongskierttikachor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0935753A1 publication Critical patent/EP0935753A1/en
Publication of EP0935753A4 publication Critical patent/EP0935753A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/61—Growth hormones [GH] (Somatotropin)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP97946307A 1996-10-31 1997-10-27 Assay and cell line for the identification of growth hormone mimetics Withdrawn EP0935753A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2923796P 1996-10-31 1996-10-31
US29237P 1996-10-31
PCT/US1997/019350 WO1998019158A1 (en) 1996-10-31 1997-10-27 Assay and cell line for the identification of growth hormone mimetics

Publications (2)

Publication Number Publication Date
EP0935753A1 EP0935753A1 (en) 1999-08-18
EP0935753A4 true EP0935753A4 (en) 1999-12-08

Family

ID=21847984

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97946307A Withdrawn EP0935753A4 (en) 1996-10-31 1997-10-27 Assay and cell line for the identification of growth hormone mimetics

Country Status (3)

Country Link
EP (1) EP0935753A4 (en)
CA (1) CA2270179A1 (en)
WO (1) WO1998019158A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2332121A1 (en) * 1998-06-30 2000-01-06 The Procter & Gamble Company Methods for inhibiting tef-3 activity

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994019485A1 (en) * 1993-02-19 1994-09-01 Edison Animal Biotechnology Center, Ohio University A method for detecting compounds with growth hormone and growth hormone receptor activity
US5436128A (en) * 1990-08-07 1995-07-25 Salk Institute Biotechnology/Industrial Associates Assay methods and compositions for detecting and evaluating the intracellular transduction of an extracellular signal

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5445941A (en) * 1993-06-21 1995-08-29 Eli Lilly And Company Method for screening anti-osteoporosis agents
US5506102A (en) * 1993-10-28 1996-04-09 Ligand Pharmaceuticals Incorporated Methods of using the A form of the progesterone receptor to screen for antagonists of steroid intracellar receptor-mediated transcription

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5436128A (en) * 1990-08-07 1995-07-25 Salk Institute Biotechnology/Industrial Associates Assay methods and compositions for detecting and evaluating the intracellular transduction of an extracellular signal
WO1994019485A1 (en) * 1993-02-19 1994-09-01 Edison Animal Biotechnology Center, Ohio University A method for detecting compounds with growth hormone and growth hormone receptor activity

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GOUJON L ET AL: "Cytoplasmic sequences of the growth hormone receptor necessary for signal transduction.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1994 FEB 1) 91 (3) 957-61., XP002117555 *
See also references of WO9819158A1 *

Also Published As

Publication number Publication date
WO1998019158A1 (en) 1998-05-07
EP0935753A1 (en) 1999-08-18
CA2270179A1 (en) 1998-05-07

Similar Documents

Publication Publication Date Title
HUP0001020A3 (en) Stanol composition and the use thereof
AU3008997A (en) Antagonists of gonadotropin releasing hormone
AU4468797A (en) Alkylation and acylation reactions
AU3071397A (en) Antagonists of gonadotropin releasing hormone
GB9727296D0 (en) Assay and kit for determining the condition of cells
AU4472197A (en) Physical distribution/transportation system and integrated physical distribution system
IL119644A (en) Rapid microbiological assay
AU3141197A (en) Antagonists of gonadotropin releasing hormone
EP1015474A4 (en) Don-1 gene and polypeptides and uses therefor
GB9622255D0 (en) Feeding bottle and valve member for use therein
GB9306742D0 (en) Electrochemical assay
AU3656497A (en) Traf2-associated protein kinase and assays
IL126923A0 (en) Mammalian tolloid-like gene and protein
PL331523A1 (en) Azolotrizines and azolopyrimidines
AUPN024994A0 (en) Assay and peptides for use therein
EP0935753A4 (en) Assay and cell line for the identification of growth hormone mimetics
GB9704162D0 (en) Assay methods and means
AUPO350296A0 (en) Mixing and transporting device
HUP9900068A3 (en) Fuse-switch and/or fuse-disconnector
GB9813778D0 (en) Assay methods and means
GB9606272D0 (en) Gene and peptides
GB9710700D0 (en) Electroplating and like processes
GB2320510B (en) Roofing system and components thereof
GB9614477D0 (en) Assay
CA2188481A1 (en) Assay Container with Insert and Method of Use

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19990531

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

RIC1 Information provided on ipc code assigned before grant

Free format text: 6G 01N 33/50 A, 6G 01N 33/74 B, 6C 12N 5/10 B, 6C 12Q 1/68 B

A4 Supplementary search report drawn up and despatched

Effective date: 19991025

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20000201