WO1998018822A3 - Novel human lim proteins - Google Patents

Novel human lim proteins Download PDF

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Publication number
WO1998018822A3
WO1998018822A3 PCT/US1997/018717 US9718717W WO9818822A3 WO 1998018822 A3 WO1998018822 A3 WO 1998018822A3 US 9718717 W US9718717 W US 9718717W WO 9818822 A3 WO9818822 A3 WO 9818822A3
Authority
WO
WIPO (PCT)
Prior art keywords
hlim
provides
expression
treatment
diseases associated
Prior art date
Application number
PCT/US1997/018717
Other languages
French (fr)
Other versions
WO1998018822A2 (en
Inventor
Surya K Goli
Jennifer L Hillman
Olga Bandman
Original Assignee
Incyte Pharma Inc
Surya K Goli
Jennifer L Hillman
Olga Bandman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharma Inc, Surya K Goli, Jennifer L Hillman, Olga Bandman filed Critical Incyte Pharma Inc
Priority to CA002272825A priority Critical patent/CA2272825A1/en
Priority to EP97910998A priority patent/EP0931095A2/en
Priority to AU48241/97A priority patent/AU4824197A/en
Publication of WO1998018822A2 publication Critical patent/WO1998018822A2/en
Publication of WO1998018822A3 publication Critical patent/WO1998018822A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention provides three human LIM proteins (designated individually as HLIM-1, HLIM-2, and HLIM-3, and collectively as HLIM) and polynucleotides which identify and encode HLIM. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HLIM and a method for producing HLIM. The invention also provides for use of HLIM and agonists, antibodies, or antagonists specifically binding HLIM, in the prevention and treatment of diseases associated with expression of HLIM. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HLIM for the treatment of diseases associated with the expression of HLIM. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HLIM.
PCT/US1997/018717 1996-10-28 1997-10-10 Novel human lim proteins WO1998018822A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002272825A CA2272825A1 (en) 1996-10-28 1997-10-10 Novel human lim proteins
EP97910998A EP0931095A2 (en) 1996-10-28 1997-10-10 Novel human lim proteins
AU48241/97A AU4824197A (en) 1996-10-28 1997-10-10 Novel human lim proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/739,485 1996-10-28
US08/739,485 US5863898A (en) 1996-10-29 1996-10-29 Human lim proteins

Publications (2)

Publication Number Publication Date
WO1998018822A2 WO1998018822A2 (en) 1998-05-07
WO1998018822A3 true WO1998018822A3 (en) 1998-07-16

Family

ID=24972529

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/018717 WO1998018822A2 (en) 1996-10-28 1997-10-10 Novel human lim proteins

Country Status (5)

Country Link
US (2) US5863898A (en)
EP (1) EP0931095A2 (en)
AU (1) AU4824197A (en)
CA (1) CA2272825A1 (en)
WO (1) WO1998018822A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5767262A (en) * 1996-03-15 1998-06-16 President And Fellows Of Harvard College Smooth muscle cell LIM protein
US6514935B1 (en) 1997-03-14 2003-02-04 President And Fellows Of Harvard Methods of treating hypertension
CA2341302A1 (en) * 1998-09-03 2000-03-16 Incyte Pharmaceuticals, Inc. Lim domain protein homolog
US6942981B1 (en) 1999-05-14 2005-09-13 Arbor Vita Corporation Method of determining interactions with PDZ-domain polypeptides
US20050037969A1 (en) * 1999-05-14 2005-02-17 Arbor Vita Corporation Molecular interactions in hematopoietic cells
US20060148711A1 (en) * 1999-05-14 2006-07-06 Arbor Vita Corporation Molecular interactions in neurons
US20030049695A1 (en) * 2001-02-16 2003-03-13 Lu Peter S. PDZ domain interactions and lipid rafts
DE10004857A1 (en) * 2000-02-03 2001-08-16 Schering Ag MLP gene, nucleic acids, polypeptides and their use
KR100421464B1 (en) * 2000-07-11 2004-03-10 지성규 Manufacturing Method of Absortive Copper-Oligopeptide in The Human Body
US20040229298A1 (en) * 2000-11-11 2004-11-18 Lu Peter S. Methods and compositions for treating cervical cancer
US6770797B2 (en) * 2001-06-01 2004-08-03 Rhode Island Hospital Non-Transgenic nonhuman model for Alzheimer's Disease using a AD7c-NTP nucleic acid
US8415315B2 (en) 2004-05-06 2013-04-09 University Of Central Florida Research Foundation, Inc. Methods and compositions for inhibiting the proliferation of cancer cells

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ARBER S. ET AL.: "Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiation", CELL, vol. 79, 21 October 1994 (1994-10-21), pages 221 - 231, XP002051945 *
DATABASE : EMBL SEQUENCES EMBL, Heidelberg, FRG; 7 May 1996 (1996-05-07), WEISKIRCHEN R. ET AL.: "human cysteine-rich protein 2", XP002051947 *
JAIN M.K. ET AL.: "Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells", J. BIOL.CHEM., vol. 271, no. 17, April 1996 (1996-04-01), pages 10194 - 10199, XP002052120 *
WANG X. ET AL.: "Human cysteine-rich protein", J. BIOL. CHEM., vol. 267, no. 13, May 1992 (1992-05-01), pages 9176 - 9184, XP002051944 *

Also Published As

Publication number Publication date
US20020170079A1 (en) 2002-11-14
EP0931095A2 (en) 1999-07-28
CA2272825A1 (en) 1998-05-07
WO1998018822A2 (en) 1998-05-07
AU4824197A (en) 1998-05-22
US5863898A (en) 1999-01-26

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