WO1998017660A1 - Antagonistes du recepteur de phenyl spiroethercycloalkyl tachykinine - Google Patents

Antagonistes du recepteur de phenyl spiroethercycloalkyl tachykinine Download PDF

Info

Publication number
WO1998017660A1
WO1998017660A1 PCT/US1997/019346 US9719346W WO9817660A1 WO 1998017660 A1 WO1998017660 A1 WO 1998017660A1 US 9719346 W US9719346 W US 9719346W WO 9817660 A1 WO9817660 A1 WO 9817660A1
Authority
WO
WIPO (PCT)
Prior art keywords
phenyl
oxaspiro
fluorophenyl
ene
nonane
Prior art date
Application number
PCT/US1997/019346
Other languages
English (en)
Inventor
Charles G. Caldwell
Yuan-Ching Chiang
Conrad Dorn
Paul Finke
Jeffrey Hale
Malcolm Maccoss
Sander Mills
Albert Robichaud
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9625843.9A external-priority patent/GB9625843D0/en
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Priority to AU52398/98A priority Critical patent/AU5239898A/en
Publication of WO1998017660A1 publication Critical patent/WO1998017660A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Cette invention a trait à certains nouveaux composés représentés par la formule structurale (I) ou à leurs sels acceptables du point de vue pharmaceutique. Dans cette formule R?3, R6, R7, R8, R11, R12, R13¿, m, n et les lignes pointillées sont définis dans le descriptif. Elle concerne également des formulations pharmaceutiques contenant ces composés comme ingrédients actifs ainsi que l'utilisation des nouveaux composés et de leurs formulations dans le traitement d'un certain nombre de troubles. Les composés de l'invention, qui sont des antagonistes du récepteur de la tachykinine, se révèlent efficaces dans le traitement de maladies inflammatoires, de douleurs ou de migraines, ainsi que de l'asthme et des vomissements.
PCT/US1997/019346 1996-10-25 1997-10-22 Antagonistes du recepteur de phenyl spiroethercycloalkyl tachykinine WO1998017660A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU52398/98A AU5239898A (en) 1996-10-25 1997-10-22 Phenyl spiroethercycloalkyl tachykinin receptor antagonists

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2925896P 1996-10-25 1996-10-25
US60/029,258 1996-10-25
GBGB9625843.9A GB9625843D0 (en) 1996-12-12 1996-12-12 Phenyl spiroethercycloalkyl tachykinn receptor antagonists
GB9625843.9 1996-12-12

Publications (1)

Publication Number Publication Date
WO1998017660A1 true WO1998017660A1 (fr) 1998-04-30

Family

ID=26310613

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/019346 WO1998017660A1 (fr) 1996-10-25 1997-10-22 Antagonistes du recepteur de phenyl spiroethercycloalkyl tachykinine

Country Status (2)

Country Link
AU (1) AU5239898A (fr)
WO (1) WO1998017660A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013004766A1 (fr) 2011-07-04 2013-01-10 Ferrari Giulio Antagonistes des récepteurs nk-1 pour traiter une néovascularisation cornéenne
CN107522674A (zh) * 2017-08-14 2017-12-29 贵州大学 一种3,5‑二甲基‑4‑芳基异噁唑的制备工艺
WO2019162519A1 (fr) 2018-02-26 2019-08-29 Ospedale San Raffaele S.R.L. Antagonistes nk-1 destinés à être utilisés dans le traitement de la douleur oculaire
WO2021180885A1 (fr) 2020-03-11 2021-09-16 Ospedale San Raffaele S.R.L. Traitement d'une déficience en cellules souches

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300524A (en) * 1991-03-06 1994-04-05 British Bio-Technology Limited Spirocyclic PAF antagonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300524A (en) * 1991-03-06 1994-04-05 British Bio-Technology Limited Spirocyclic PAF antagonists

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013004766A1 (fr) 2011-07-04 2013-01-10 Ferrari Giulio Antagonistes des récepteurs nk-1 pour traiter une néovascularisation cornéenne
CN107522674A (zh) * 2017-08-14 2017-12-29 贵州大学 一种3,5‑二甲基‑4‑芳基异噁唑的制备工艺
WO2019162519A1 (fr) 2018-02-26 2019-08-29 Ospedale San Raffaele S.R.L. Antagonistes nk-1 destinés à être utilisés dans le traitement de la douleur oculaire
WO2021180885A1 (fr) 2020-03-11 2021-09-16 Ospedale San Raffaele S.R.L. Traitement d'une déficience en cellules souches

Also Published As

Publication number Publication date
AU5239898A (en) 1998-05-15

Similar Documents

Publication Publication Date Title
US5877191A (en) Phenyl spiroethercycloalkyl tachykinin receptor antagonists
AU722883B2 (en) Cyclopentyl tachykinin receptor antagonists
US5750549A (en) Cycloalkyl tachykinin receptor antagonists
US5929094A (en) Heteroaryl spiroethercycloalkyl tachykinin receptor antagonists
RU2140914C1 (ru) Замещенные гетероциклы или их фармацевтически приемлемая соль, фармацевтическая композиция для блокады рецепторов нейрокинина-1 у млекопитающих, способ для блокады рецепторов нейрокинина-1 у млекопитающих
US5728695A (en) Spiroketal derivatives, compositions containing them and their use as therapeutic agents
US6060469A (en) Spiro-piperidine derivatives and their use as tachykinin antagonists
US5610159A (en) N-oxides of morpholine derivatives and their use as therapeutic agents
US5633266A (en) Azacyclic compounds compositions containing them and their use as tachykinin antagonists
JPH09507500A (ja) ｇｅｍ二置換アザシクロ系のタキキニン拮抗薬
JP4212112B2 (ja) 非ペプチジルバソプレッシンＶ１ａアンタゴニスト
US6458830B1 (en) Tetrahydropyran derivatives and their use as therapeutic agents
CA2693126A1 (fr) Nouveaux derives d'acide dicarboxylique utilises comme agonistes du recepteur s1p1
JPH09509935A (ja) モルホリンタキキニン受容体拮抗薬のプロドラッグ
WO1995021819A1 (fr) Composes azacycliques a substitution aralcoxy et aralkylthio utilises comme antagonistes de la tachykinine
JPH06510034A (ja) アザ環式化合物、それらの製造方法、及びそれらを含む医薬組成物
JPH09506628A (ja) モルホリンおよびチオモルホリン系のタキキニン受容体拮抗薬
JPH09507484A (ja) 置換モルホリン誘導体およびその治療剤としての使用
AU2013243353B2 (en) Fused cyclopentyl antagonists of CCR2
IL179280A (en) Converted 2-quinolyl-oxazole compounds and pharmaceutical compositions containing them for the treatment of PDE4-related diseases
EP4021905A1 (fr) Inhibiteurs de l'adrénorécepteur adrac2
EP1322596B1 (fr) Antagonistes zwitt rioniques du r cepteur de la tachykinine
EP0880528B1 (fr) Derives de spiro-cetal et leur utilisation en tant qu'agents therapeutiques
WO1998017276A1 (fr) Antagonistes heteroaryle spiroethercycloalkyle de recepteurs de la tachykinine
WO1998017660A1 (fr) Antagonistes du recepteur de phenyl spiroethercycloalkyl tachykinine

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AU AZ BA BB BG BR BY CA CN CU CZ EE GE HU ID IL IS JP KG KR KZ LC LK LR LT LV MD MG MK MN MX NO NZ PL RO RU SG SI SK SL TJ TM TR TT UA US UZ VN YU AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH KE LS MW SD SZ UG ZW AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: CA