WO1998017202A1 - Methode et dispositif de transplantation veineuse endovasculaire - Google Patents

Methode et dispositif de transplantation veineuse endovasculaire Download PDF

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Publication number
WO1998017202A1
WO1998017202A1 PCT/US1997/018736 US9718736W WO9817202A1 WO 1998017202 A1 WO1998017202 A1 WO 1998017202A1 US 9718736 W US9718736 W US 9718736W WO 9817202 A1 WO9817202 A1 WO 9817202A1
Authority
WO
WIPO (PCT)
Prior art keywords
blood vessel
stent
valve
vein
venous
Prior art date
Application number
PCT/US1997/018736
Other languages
English (en)
Inventor
Alan B. Lumsden
John D. Hughes
Original Assignee
Emory University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emory University filed Critical Emory University
Priority to AU49064/97A priority Critical patent/AU4906497A/en
Publication of WO1998017202A1 publication Critical patent/WO1998017202A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2415—Manufacturing methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2475—Venous valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A61F2002/075—Stent-grafts the stent being loosely attached to the graft material, e.g. by stitching
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2002/30448—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
    • A61F2002/30449—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives the adhesive being cement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/005—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives

Definitions

  • the present invention relates to a device and method for endovascular
  • Venous insufficiency is a widespread problem, affecting up to 20 million people
  • Direct treatment of the primary problems include conventional surgical valve replacement or repair to restore valvular competency, and vein replacement to alleviate
  • the repaired vessel may be prone to thrombosis and dilatation with recurrent obstruction and incompetence, leading to recurrent venous
  • umbilical cord vessels which are designed for conventional surgical implantation.
  • chemically fixed vessel portions may be attached to an external mesh support which
  • Prosthesis is directed to the use of a chemically fixed biological derived conduit that
  • tissue valve for conventional surgical implantation.
  • a process of chemical fixation utilizing glutaraldehyde is used to chemically fix the valve so that it normally remains open and closes upon the exertion of back pressure.
  • a support cage or external prosthesis can be added to strengthen the valve.
  • the present invention provides a device and methods
  • venous valve-stent graft in a vein as a potential new treatment of valvular incompetence.
  • Venous reflux is also a key factor in the widespread and often debilitating
  • the present invention provides a fresh or cyro-preserved
  • the present invention provides a device and a method of endovascular delivery
  • cryopreserved venous tissue An appropriately sized fresh or cyro preserved venous
  • graft is sutured in position within the lumen of a standard endovascular stent, e.g., a Wallstent (Schneider). Deployment is generally directed under fluoroscopic
  • the endovascular venous graft of the present invention is believed to be
  • the endovascular venous grafts of the invention may also contain one or more venous valves as directed by the patient's needs.
  • Figure 1 is a photograph which shows, from top to bottom, an introducer and dilator for
  • Figure 2 is a close up photograph of the stent of one embodiment of the invention containing the venous graft sutured within the lumen of the stent.
  • Figure 3 is a photograph showing at left the graft/stent preloaded on the introducer
  • catheter with dilator in position for deployment.
  • a scalpel is shown at right for
  • Figure 4 is a side elevational drawing of the stent with a venous graft sutured in the
  • Figure 5 is a cross-sectional view of the stent/graft deployed at within a patient's blood
  • the present invention provides a device 10 for
  • endovascular deployment within a first blood vessel 2 comprising: a preselected portion
  • graft vessel can be any vessel of the body but is preferably a vein or an
  • the second blood vessel is a vein and the preselected portion contains at least one valve, however the venous graft need not contain a valve.
  • biocompatable cements such as fibrin
  • the preselected portion of the second blood vessel can be venous graft material that is harvested and deployed as fresh tissue.
  • the preselected portion of the second blood vessel can be venous graft material that is harvested and deployed as fresh tissue.
  • portion of the second blood vessel is cryopreserved tissue.
  • Figures 1-3 are actual color photographs of one embodiment of the device of the
  • the present invention also provides a method of treating a predetermined section
  • a second blood vessel having a predetermined length and diameter and attached to at least a portion of an inner surface of a radially self-expanding stent within
  • the predetermined section can be
  • valve is inspected angioscopically from both the downstream and
  • valve-stent construction and the deployment apparatus are presented as Figures 1-3.
  • the valve was examined for competence and patency using a strip test and
  • Doppler flow probe The segment was excised and sewn inside a self-expanding
  • valve stent was deployed by withdrawing the introducer over a #12F dilator, uncovering
  • the size of the graft, stent and deployment device as well as the type of stent can vary depending upon the particular area of the patient being treated and the pathological condition associated therewith.
  • the stent can be constructed of any of a number of suitable materials all well
  • the venous graft tissue can be harvested fresh and utilized or a cryopreserved specimen can be utilized. Methods are known in the art for cryopreservation of blood
  • vessel tissue such as, for example, those utilized by CryoLife, Inc. of Atlanta, GA.
  • valve leaflets functioned in a normal
  • V-S valve-stent
  • V-S jugular vein through a small cutdown and venotomy.
  • the V-S was deployed by
  • V-S was excised and inspected histologically.
  • luminal clot was attached to the downstream exposed stent struts on two V-S.
  • transplantation maintaining patency and competency, using minimally invasive

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Manufacturing & Machinery (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne un dispositif (10) destiné à être déployé à l'intérieur d'un premier vaisseau sanguin (2), qui comprend une partie présélectionnée d'un second vaisseau sanguin (4), ayant une longueur et un diamètre prédéterminés, fixée sur au moins une partie de la surface interne (6) d'un extenseur à dilatation radiale automatique (8). Le greffon (4), constitué du second vaisseau, peut être n'importe quel vaisseau de l'organisme, mais de préférence une veine ou une artère. Des sutures (12) peuvent être utilisées pour fixer l'extenseur (8) sur le second vaisseau (4).
PCT/US1997/018736 1996-10-22 1997-10-21 Methode et dispositif de transplantation veineuse endovasculaire WO1998017202A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU49064/97A AU4906497A (en) 1996-10-22 1997-10-21 Method and apparatus for endovascular venous transplantation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2874696P 1996-10-22 1996-10-22
US60/028,746 1996-10-22

Publications (1)

Publication Number Publication Date
WO1998017202A1 true WO1998017202A1 (fr) 1998-04-30

Family

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Application Number Title Priority Date Filing Date
PCT/US1997/018736 WO1998017202A1 (fr) 1996-10-22 1997-10-21 Methode et dispositif de transplantation veineuse endovasculaire

Country Status (2)

Country Link
AU (1) AU4906497A (fr)
WO (1) WO1998017202A1 (fr)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1933766A2 (fr) * 2005-09-21 2008-06-25 Medtronic, Inc. Valve cardiaque composite fabriquee a l'aide de techniques d'usinage au laser des tissus
US8353953B2 (en) 2009-05-13 2013-01-15 Sorin Biomedica Cardio, S.R.L. Device for the in situ delivery of heart valves
US8403982B2 (en) 2009-05-13 2013-03-26 Sorin Group Italia S.R.L. Device for the in situ delivery of heart valves
US8512397B2 (en) 2009-04-27 2013-08-20 Sorin Group Italia S.R.L. Prosthetic vascular conduit
US8540768B2 (en) 2005-02-10 2013-09-24 Sorin Group Italia S.R.L. Cardiac valve prosthesis
US8685084B2 (en) 2011-12-29 2014-04-01 Sorin Group Italia S.R.L. Prosthetic vascular conduit and assembly method
US8808369B2 (en) 2009-10-05 2014-08-19 Mayo Foundation For Medical Education And Research Minimally invasive aortic valve replacement
US8834563B2 (en) 2008-12-23 2014-09-16 Sorin Group Italia S.R.L. Expandable prosthetic valve having anchoring appendages
US8840661B2 (en) 2008-05-16 2014-09-23 Sorin Group Italia S.R.L. Atraumatic prosthetic heart valve prosthesis
US9056008B2 (en) 2006-12-19 2015-06-16 Sorin Group Italia S.R.L. Instrument and method for in situ development of cardiac valve prostheses
US9161836B2 (en) 2011-02-14 2015-10-20 Sorin Group Italia S.R.L. Sutureless anchoring device for cardiac valve prostheses
US9168105B2 (en) 2009-05-13 2015-10-27 Sorin Group Italia S.R.L. Device for surgical interventions
US9248017B2 (en) 2010-05-21 2016-02-02 Sorin Group Italia S.R.L. Support device for valve prostheses and corresponding kit
US9289289B2 (en) 2011-02-14 2016-03-22 Sorin Group Italia S.R.L. Sutureless anchoring device for cardiac valve prostheses
US9848981B2 (en) 2007-10-12 2017-12-26 Mayo Foundation For Medical Education And Research Expandable valve prosthesis with sealing mechanism
US9867695B2 (en) 2004-03-03 2018-01-16 Sorin Group Italia S.R.L. Minimally-invasive cardiac-valve prosthesis
US10058313B2 (en) 2011-05-24 2018-08-28 Sorin Group Italia S.R.L. Transapical valve replacement
WO2022084013A1 (fr) * 2020-10-23 2022-04-28 Biotronik Ag Procédé automatisé pour la fixation efficace de marqueurs à rayons x dans des implants vasculaires
US11504231B2 (en) 2018-05-23 2022-11-22 Corcym S.R.L. Cardiac valve prosthesis

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352240A (en) * 1989-05-31 1994-10-04 Promedica International, Inc. Human heart valve replacement with porcine pulmonary valve
US5500014A (en) * 1989-05-31 1996-03-19 Baxter International Inc. Biological valvular prothesis
US5556414A (en) * 1995-03-08 1996-09-17 Wayne State University Composite intraluminal graft
US5645581A (en) * 1993-11-30 1997-07-08 Zurbruegg; Heinz Robert Vascular prosthesis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352240A (en) * 1989-05-31 1994-10-04 Promedica International, Inc. Human heart valve replacement with porcine pulmonary valve
US5500014A (en) * 1989-05-31 1996-03-19 Baxter International Inc. Biological valvular prothesis
US5645581A (en) * 1993-11-30 1997-07-08 Zurbruegg; Heinz Robert Vascular prosthesis
US5556414A (en) * 1995-03-08 1996-09-17 Wayne State University Composite intraluminal graft

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9867695B2 (en) 2004-03-03 2018-01-16 Sorin Group Italia S.R.L. Minimally-invasive cardiac-valve prosthesis
US8920492B2 (en) 2005-02-10 2014-12-30 Sorin Group Italia S.R.L. Cardiac valve prosthesis
US9486313B2 (en) 2005-02-10 2016-11-08 Sorin Group Italia S.R.L. Cardiac valve prosthesis
US9895223B2 (en) 2005-02-10 2018-02-20 Sorin Group Italia S.R.L. Cardiac valve prosthesis
US8540768B2 (en) 2005-02-10 2013-09-24 Sorin Group Italia S.R.L. Cardiac valve prosthesis
EP1933766A2 (fr) * 2005-09-21 2008-06-25 Medtronic, Inc. Valve cardiaque composite fabriquee a l'aide de techniques d'usinage au laser des tissus
EP1933766A4 (fr) * 2005-09-21 2011-04-27 Medtronic Inc Valve cardiaque composite fabriquee a l'aide de techniques d'usinage au laser des tissus
US9056008B2 (en) 2006-12-19 2015-06-16 Sorin Group Italia S.R.L. Instrument and method for in situ development of cardiac valve prostheses
US9848981B2 (en) 2007-10-12 2017-12-26 Mayo Foundation For Medical Education And Research Expandable valve prosthesis with sealing mechanism
US10966823B2 (en) 2007-10-12 2021-04-06 Sorin Group Italia S.R.L. Expandable valve prosthesis with sealing mechanism
US8840661B2 (en) 2008-05-16 2014-09-23 Sorin Group Italia S.R.L. Atraumatic prosthetic heart valve prosthesis
US10098733B2 (en) 2008-12-23 2018-10-16 Sorin Group Italia S.R.L. Expandable prosthetic valve having anchoring appendages
US8834563B2 (en) 2008-12-23 2014-09-16 Sorin Group Italia S.R.L. Expandable prosthetic valve having anchoring appendages
US8512397B2 (en) 2009-04-27 2013-08-20 Sorin Group Italia S.R.L. Prosthetic vascular conduit
US8403982B2 (en) 2009-05-13 2013-03-26 Sorin Group Italia S.R.L. Device for the in situ delivery of heart valves
US8353953B2 (en) 2009-05-13 2013-01-15 Sorin Biomedica Cardio, S.R.L. Device for the in situ delivery of heart valves
US9168105B2 (en) 2009-05-13 2015-10-27 Sorin Group Italia S.R.L. Device for surgical interventions
US8808369B2 (en) 2009-10-05 2014-08-19 Mayo Foundation For Medical Education And Research Minimally invasive aortic valve replacement
US9248017B2 (en) 2010-05-21 2016-02-02 Sorin Group Italia S.R.L. Support device for valve prostheses and corresponding kit
US9289289B2 (en) 2011-02-14 2016-03-22 Sorin Group Italia S.R.L. Sutureless anchoring device for cardiac valve prostheses
US9161836B2 (en) 2011-02-14 2015-10-20 Sorin Group Italia S.R.L. Sutureless anchoring device for cardiac valve prostheses
US10058313B2 (en) 2011-05-24 2018-08-28 Sorin Group Italia S.R.L. Transapical valve replacement
US8685084B2 (en) 2011-12-29 2014-04-01 Sorin Group Italia S.R.L. Prosthetic vascular conduit and assembly method
US9138314B2 (en) 2011-12-29 2015-09-22 Sorin Group Italia S.R.L. Prosthetic vascular conduit and assembly method
US11504231B2 (en) 2018-05-23 2022-11-22 Corcym S.R.L. Cardiac valve prosthesis
US11969341B2 (en) 2018-05-23 2024-04-30 Corcym S.R.L. Cardiac valve prosthesis
WO2022084013A1 (fr) * 2020-10-23 2022-04-28 Biotronik Ag Procédé automatisé pour la fixation efficace de marqueurs à rayons x dans des implants vasculaires

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Publication number Publication date
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