WO1998016645A3 - Composes et procedes pour diagnostiquer la tuberculose - Google Patents

Composes et procedes pour diagnostiquer la tuberculose Download PDF

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Publication number
WO1998016645A3
WO1998016645A3 PCT/US1997/018214 US9718214W WO9816645A3 WO 1998016645 A3 WO1998016645 A3 WO 1998016645A3 US 9718214 W US9718214 W US 9718214W WO 9816645 A3 WO9816645 A3 WO 9816645A3
Authority
WO
WIPO (PCT)
Prior art keywords
tuberculosis
polypeptides
compounds
methods
diagnosis
Prior art date
Application number
PCT/US1997/018214
Other languages
English (en)
Other versions
WO1998016645A2 (fr
Inventor
Steven G Reed
Yasir A W Skeiky
Davin C Dillon
Antonio Campos-Neto
Raymond Houghton
Thomas S Vedvick
Daniel R Twardzik
Michael J Lodes
Original Assignee
Corixa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/818,111 external-priority patent/US6338852B1/en
Application filed by Corixa Corp filed Critical Corixa Corp
Priority to BR9712298-0A priority Critical patent/BR9712298A/pt
Priority to AU47505/97A priority patent/AU4750597A/en
Priority to JP10518432A priority patent/JP2001500383A/ja
Priority to EP97910030A priority patent/EP0934415A2/fr
Priority to CA002268036A priority patent/CA2268036A1/fr
Priority to IL12938997A priority patent/IL129389A0/xx
Publication of WO1998016645A2 publication Critical patent/WO1998016645A2/fr
Publication of WO1998016645A3 publication Critical patent/WO1998016645A3/fr
Priority to NO991693A priority patent/NO991693L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention porte sur des composés et des procédés servant à diagnostiquer la tuberculose. Les composés de l'invention comprennent des polypeptides contenant au moins une partie antigénique d'une ou plusieurs protéines de M. tuberculosis et des séquences d'ADN codant lesdits polypeptides. Des trousses de diagnostic contenant lesdits polypeptides ou séquences d'ADN et un réactif de dépistage approprié peuvent être utilisés pour dépister une infection M. tuberculosis chez des patients ou dans des échantillons biologiques. L'invention porte aussi sur des anticorps dirigés contre lesdits polypeptides.
PCT/US1997/018214 1996-10-11 1997-10-07 Composes et procedes pour diagnostiquer la tuberculose WO1998016645A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
BR9712298-0A BR9712298A (pt) 1996-10-11 1997-10-07 Polipeptìdeo, molécula de dna, vetor de expressão recombinante, célula hospedeira, processo para detectar infecção por m. tuberculosis em uma amostra biológica, kit diagnóstico, anticorpos monoclonal, e, policlonal, e, proteìna de fusão
AU47505/97A AU4750597A (en) 1996-10-11 1997-10-07 Compounds and methods for diagnosis of tuberculosis
JP10518432A JP2001500383A (ja) 1996-10-11 1997-10-07 結核診断用の化合物および方法
EP97910030A EP0934415A2 (fr) 1996-10-11 1997-10-07 Composes et procedes pour diagnostiquer la tuberculose
CA002268036A CA2268036A1 (fr) 1996-10-11 1997-10-07 Composes et procedes pour diagnostiquer la tuberculose
IL12938997A IL129389A0 (en) 1996-10-11 1997-10-07 Compounds and methods for diagnsosis of tuberculosis
NO991693A NO991693L (no) 1996-10-11 1999-04-09 Forbindelser og metoder for diagnose av tuberkulose

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72962296A 1996-10-11 1996-10-11
US08/818,111 US6338852B1 (en) 1995-09-01 1997-03-13 Compounds and methods for diagnosis of tuberculosis
US08/818,111 1997-03-13
US08/729,622 1997-03-13

Publications (2)

Publication Number Publication Date
WO1998016645A2 WO1998016645A2 (fr) 1998-04-23
WO1998016645A3 true WO1998016645A3 (fr) 1998-08-06

Family

ID=27111919

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/018214 WO1998016645A2 (fr) 1996-10-11 1997-10-07 Composes et procedes pour diagnostiquer la tuberculose

Country Status (11)

Country Link
EP (1) EP0934415A2 (fr)
JP (1) JP2001500383A (fr)
AU (1) AU4750597A (fr)
BR (1) BR9712298A (fr)
CA (1) CA2268036A1 (fr)
CZ (1) CZ126699A3 (fr)
IL (2) IL129389A0 (fr)
NO (1) NO991693L (fr)
PL (1) PL333304A1 (fr)
TR (1) TR199901569T2 (fr)
WO (1) WO1998016645A2 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6991797B2 (en) 1993-07-02 2006-01-31 Statens Serum Institut M. tuberculosis antigens
US6982085B2 (en) 1997-04-02 2006-01-03 Statens Serum Institut TB diagnostic based on antigens from M. tuberculosis
US6613881B1 (en) * 1997-05-20 2003-09-02 Corixa Corporation Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use
WO1999004005A1 (fr) * 1997-07-16 1999-01-28 Institut Pasteur Polynucleotide codant fonctionellement pour la proteine lhp de mycobacterium tuberculosis, fragments derives biologiquement actifs, et procedes utilisant ce polynucleotide
EP1484405A1 (fr) * 1997-11-10 2004-12-08 Statens Serum Institut Fragments d'acide nucléique et fragments polypeptidiques derivés de M. tuberculosis
US6465633B1 (en) 1998-12-24 2002-10-15 Corixa Corporation Compositions and methods of their use in the treatment, prevention and diagnosis of tuberculosis
US20030027774A1 (en) * 1999-03-18 2003-02-06 Ronald C. Hendrickson Tuberculosis antigens and methods of use therefor
DK1214088T3 (da) 1999-05-04 2009-08-24 Univ New Jersey Med Proteiner udtrykt af Mycobacterium tuberculosis og ikke af BCG og anvendelse heraf som diagnostiske reagenser og vacciner
ATE354663T1 (de) * 1999-10-07 2007-03-15 Corixa Corp Eine mycobacterium tuberculosis kodierende sequenz zur expression von heterologen proteinen
US7009042B1 (en) 1999-10-07 2006-03-07 Corixa Corporation Methods of using a Mycobacterium tuberculosis coding sequence to facilitate stable and high yield expression of the heterologous proteins
US6316205B1 (en) 2000-01-28 2001-11-13 Genelabs Diagnostics Pte Ltd. Assay devices and methods of analyte detection
AU2001241738A1 (en) 2000-02-25 2001-09-03 Corixa Corporation Compounds and methods for diagnosis and immunotherapy of tuberculosis
PT1542732E (pt) 2000-06-20 2009-11-06 Corixa Corp Proteínas de fusão de mycobacterium tuberculosis
WO2002004018A2 (fr) * 2000-07-10 2002-01-17 Colorado State University Research Foundation Vaccin de mi-vie et procédé pour renforcer l'immunité anti-mycobactérienne
AU2002317940B9 (en) 2001-06-22 2008-06-05 The Secretary Of State For Health Mycobacterial antigens expressed under low oxygen tension
EP2196473A1 (fr) 2001-07-04 2010-06-16 Health Protection Agency Antigènes mycobacteriens exprimes pendant la phase de latence
US7105319B2 (en) * 2001-07-25 2006-09-12 Tosoh Corporation Oligonucleotides for detecting tubercle bacillus and method therefor
GB0125535D0 (en) * 2001-10-24 2001-12-12 Microbiological Res Authority Mycobacterial genes down-regulated during latency
US7026465B2 (en) 2002-02-15 2006-04-11 Corixa Corporation Fusion proteins of Mycobacterium tuberculosis
US8475735B2 (en) 2004-11-01 2013-07-02 Uma Mahesh Babu Disposable immunodiagnostic test system
BRPI0518933A2 (pt) 2004-11-16 2008-12-16 Crucell Holland B V E Aeras Gl adenovÍrus recombinante defeituoso de replicaÇço, vetor de polinucleotÍdeo recombinante, vacina multivalente da tuberculose, e, uso do antÍgeno tb10.4 de mycobacterium
EP2457926B1 (fr) 2005-04-29 2014-09-24 GlaxoSmithKline Biologicals S.A. Nouveau procédé pour la prévention ou le traitement d'une infection de tuberculose M.
CA2616766A1 (fr) * 2005-07-26 2007-02-01 University Of Medicine And Dentistry Of New Jersey Profils d'anticorps specifiques d'un etat tuberculeux
CN100999550B (zh) * 2006-01-10 2010-10-06 中国人民解放军第三○九医院 结核分枝杆菌融合蛋白及其应用
GB0618127D0 (en) * 2006-09-14 2006-10-25 Isis Innovation Biomarker
EP2368568A1 (fr) 2006-11-01 2011-09-28 Immport Therapeutics, INC. Compositions et procédés pour antigènes immunodominants
EA201290590A1 (ru) 2010-01-27 2013-03-29 Глаксосмитклайн Байолоджикалс С.А. Модифицированные туберкулезные антигены

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2244539A1 (en) * 1973-07-13 1975-04-18 Mitsui Pharmaceuticals Tuberculin active proteins and peptides prepn - from tubercle bacillus
FR2265402A1 (en) * 1974-03-29 1975-10-24 Mitsui Pharmaceuticals Tuberculin active proteins and peptides prepn - from tubercle bacillus
EP0419355A1 (fr) * 1989-09-19 1991-03-27 N.V. Innogenetics S.A. Polypeptides et peptides recombinantes, acides nucléiques lesencodantes, et l'utilisation de celles-ci pour le diagnostique de la tuberculose
WO1992021758A1 (fr) * 1991-06-07 1992-12-10 Institut Pasteur Proteines de mycobacterium et applications
WO1994000493A1 (fr) * 1992-06-29 1994-01-06 Archana Kapoor Immunogenes associes a la membrane de mycobacteries
WO1995001440A1 (fr) * 1993-07-02 1995-01-12 Statens Seruminstitut Test cutane de diagnostic de la tuberculose
WO1995001441A1 (fr) * 1993-07-02 1995-01-12 Statens Serumsinstitut Vaccin contre la tuberculose
WO1996023885A1 (fr) * 1995-02-01 1996-08-08 Institut Pasteur Proteines de mycobacteries, microorganismes les produisant et leurs utilisations vaccinales et pour la detection de la tuberculose
WO1997009428A2 (fr) * 1995-09-01 1997-03-13 Corixa Corporation Composes et methodes d'immunotherapie et de diagnostic de la tuberculose
WO1997009429A2 (fr) * 1995-09-01 1997-03-13 Corixa Corporation Composes et methodes de diagnostic de la tuberculose

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2244539A1 (en) * 1973-07-13 1975-04-18 Mitsui Pharmaceuticals Tuberculin active proteins and peptides prepn - from tubercle bacillus
FR2265402A1 (en) * 1974-03-29 1975-10-24 Mitsui Pharmaceuticals Tuberculin active proteins and peptides prepn - from tubercle bacillus
EP0419355A1 (fr) * 1989-09-19 1991-03-27 N.V. Innogenetics S.A. Polypeptides et peptides recombinantes, acides nucléiques lesencodantes, et l'utilisation de celles-ci pour le diagnostique de la tuberculose
WO1992021758A1 (fr) * 1991-06-07 1992-12-10 Institut Pasteur Proteines de mycobacterium et applications
WO1994000493A1 (fr) * 1992-06-29 1994-01-06 Archana Kapoor Immunogenes associes a la membrane de mycobacteries
WO1995001440A1 (fr) * 1993-07-02 1995-01-12 Statens Seruminstitut Test cutane de diagnostic de la tuberculose
WO1995001441A1 (fr) * 1993-07-02 1995-01-12 Statens Serumsinstitut Vaccin contre la tuberculose
WO1996023885A1 (fr) * 1995-02-01 1996-08-08 Institut Pasteur Proteines de mycobacteries, microorganismes les produisant et leurs utilisations vaccinales et pour la detection de la tuberculose
WO1997009428A2 (fr) * 1995-09-01 1997-03-13 Corixa Corporation Composes et methodes d'immunotherapie et de diagnostic de la tuberculose
WO1997009429A2 (fr) * 1995-09-01 1997-03-13 Corixa Corporation Composes et methodes de diagnostic de la tuberculose

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ANDERSEN A B ET AL: "STRUCTURE AND MAPPING OF ANTIGENIC DOMAINS OF PROTEIN ANTIGEN B, A 38,000-MOLECULAR-WEIGHT PROTEIN OF MYCOBACTERIUM TUBERCULOSIS", INFECTION AND IMMUNITY, vol. 57, no. 8, August 1989 (1989-08-01), pages 2481 - 2488, XP002026677 *
ANDERSEN P. ET AL.: "Identification of immunodominant antigens during infection with Mycobacterium tuberculosis", SCANDINAVIAN JOURNAL OF IMMUNOLOGY, vol. 36, 1992, pages 823 - 831, XP002057751 *
AUSUBEL ET AL: "ISOLATION OF PROTEINS FOR MICROSEQUENCE ANALYSIS", CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, 1993, pages 10.19.01 - 10.19.12, XP002026411 *
ROMAIN ET AL: "PREPARATION OF TUBERCULIN ANTIGEN L", ANNALES DE L'INSTITUT PASTEUR / MICROBIOLOGIE, vol. 136B, 1985, pages 235 - 248, XP002026409 *
YOUNG D B ET AL: "SCREENING OF A RECOMBINANT MYCOBACTERIAL DNA LIBRARY WITH POLYCLONAL ANTISERUM AND MOLECULAR WEIGHT ANALYSIS OF EXPRESSED ANTIGENS", INFECTION AND IMMUNITY, vol. 55, no. 6, June 1987 (1987-06-01), pages 1421 - 1425, XP002026410 *

Also Published As

Publication number Publication date
IL129389A0 (en) 2000-02-17
AU4750597A (en) 1998-05-11
CA2268036A1 (fr) 1998-04-23
IL121936A0 (en) 1998-03-10
PL333304A1 (en) 1999-11-22
CZ126699A3 (cs) 1999-09-15
WO1998016645A2 (fr) 1998-04-23
EP0934415A2 (fr) 1999-08-11
NO991693L (no) 1999-06-09
NO991693D0 (no) 1999-04-09
BR9712298A (pt) 2000-10-24
TR199901569T2 (xx) 2000-12-21
JP2001500383A (ja) 2001-01-16

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